Cited by 239Adenosine and Purinergic SignalingNeuroinflammation and Neurodegeneration MechanismsPain Mechanisms and Treatments

The DOI matches its Crossref record; 97 of the 97 references it cites were found in a registry or an index.

Microglia and Neuroinflammation: What Place for P2RY12?

Open access

Gómez Morillas, Albert, Besson, Valérie C., Lerouet, Dominique·2021·International Journal of Molecular Sciences

DOI 10.3390/ijms22041636PMC PMC7915979

Open this paper in CoChat — free account Open PDF

Abstract

Microglia are immune brain cells involved in neuroinflammation. They express a lot of proteins on their surface such as receptors that can be activated by mediators released in the microglial environment. Among these receptors, purinergic receptor expression could be modified depending on the activation status of microglia. In this review, we focus on P2Y receptors and more specifically on P2RY12 that is involved in microglial motility and migration, the first step of neuroinflammation process. We describe the purinergic receptor families, P2RY12 structure, expression and physiological functions. The pharmacological and genetic tools for studying this receptor are detailed thereafter. Last but not least, we report the contribution of microglial P2RY12 to neuroinflammation in acute and chronic brain pathologies in order to better understand P2RY12 microglial role.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.3390/ijms22041636

Cites

97 of 97 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

An RNA-Sequencing Transcriptome and Splicing Database of Glia, Neurons, and Vascular Cells of the Cerebral Cortex
Zhang, Y., Chen, K., Sloan, S. A., Bennett, M. L., Scholze, A. R., O'Keeffe, S., Phatnani, H. P., Guarnieri, P., Caneda, C., Ruderisch, N., et al. (2014) · The Journal of Neuroscience · doi:10.1523/jneurosci.1860-14.2014 · Cited by 4,875
Microglia Function in the Central Nervous System During Health and Neurodegeneration
Colonna, M., & Butovsky, O. (2017) · Annual Review of Immunology · doi:10.1146/annurev-immunol-051116-052358 · Cited by 2,894
Identification of a unique TGF-β–dependent molecular and functional signature in microglia
Butovsky, O., Jedrychowski, M. P., Moore, C. S., Cialic, R., Lanser, A. J., Gabriely, G., Koeglsperger, T., Dake, B., Wu, P. M., Doykan, C. E., et al. (2014) · Nature Neuroscience · doi:10.1038/nn.3599 · Cited by 2,543
Purinergic Nerves
Burnstock, G. (1972) · Pharmacological Reviews · doi:10.1016/s0031-6997(25)06930-3 · Cited by 1,852
Neuroinflammation: The Devil Is in the Details
DiSabato, D. J., Quan, N., & Godbout, J. P. (2016) · Journal of Neurochemistry · doi:10.1111/jnc.13607 · Cited by 1,640
A polarizing question: do M1 and M2 microglia exist?
Ransohoff, R. M. (2016) · Nature Neuroscience · doi:10.1038/nn.4338 · Cited by 1,573
The P2Y12 receptor regulates microglial activation by extracellular nucleotides
Haynes, S. E., Hollopeter, G., Yang, G., Kurpius, D., Dailey, M. E., Gan, W.-B., & Julius, D. (2006) · Nature Neuroscience · doi:10.1038/nn1805 · Cited by 1,542
Microglia in physiology and disease
Wolf, S. A., Boddeke, H. W. G. M., & Kettenmann, H. (2017) · Annual Review of Physiology · doi:10.1146/annurev-physiol-022516-034406 · Cited by 1,426
Heterogeneity of Microglial Activation in the Innate Immune Response in the Brain
Colton, C. A. (2009) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-009-9164-4 · Cited by 916
Inflammasomes in neuroinflammatory and neurodegenerative diseases
Voet, S., Srinivasan, S., Lamkanfi, M., & van Loo, G. (2019) · EMBO Molecular Medicine · doi:10.15252/emmm.201810248 · Cited by 761

Flagged first, then by citations

Show all 96 references

Sorted by citations

Items 201–239 of 239

Additional file 21 of Unravelling cell type-specific responses to Parkinson’s Disease at single cell resolution
Martirosyan, A., Ansari, R. A., Pestana, F., Hebestreit, K., Gasparyan, H., Aleksanyan, R., Hnatova, S., Poovathingal, S. K., Marneffe, C., Thal, D. R., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26670168
Additional file 3 of Disease and brain region specific immune response profiles in neurodegenerative diseases with pure and mixed protein pathologies
Bathe, T., Hery, G. P., Villareal, J. A. B., Phillips, J. L., Cohen, E. M., Sharma, R. V., Tsering, W., & Prokop, S. (2024) · Figshare · doi:10.6084/m9.figshare.26702599
Additional file 7 of Ganglioglioma deep transcriptomics reveals primitive neuroectoderm neural precursor-like population
Regal, J. A., García, M. E. G., Jain, V., Chandramohan, V., Ashley, D. M., Gregory, S. G., Thompson, E. M., López, G. Y., & Reitman, Z. J. (2024) · Figshare · doi:10.6084/m9.figshare.26577689
Additional file 3 of Unravelling cell type-specific responses to Parkinson’s Disease at single cell resolution
Martirosyan, A., Ansari, R. A., Pestana, F., Hebestreit, K., Gasparyan, H., Aleksanyan, R., Hnatova, S., Poovathingal, S. K., Marneffe, C., Thal, D. R., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26670114
Additional file 13 of Unravelling cell type-specific responses to Parkinson’s Disease at single cell resolution
Martirosyan, A., Ansari, R. A., Pestana, F., Hebestreit, K., Gasparyan, H., Aleksanyan, R., Hnatova, S., Poovathingal, S. K., Marneffe, C., Thal, D. R., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26670144
Additional file 9 of Ganglioglioma deep transcriptomics reveals primitive neuroectoderm neural precursor-like population
Regal, J. A., García, M. E. G., Jain, V., Chandramohan, V., Ashley, D. M., Gregory, S. G., Thompson, E. M., López, G. Y., & Reitman, Z. J. (2024) · Figshare · doi:10.6084/m9.figshare.26577695
Additional file 18 of Unravelling cell type-specific responses to Parkinson’s Disease at single cell resolution
Martirosyan, A., Ansari, R. A., Pestana, F., Hebestreit, K., Gasparyan, H., Aleksanyan, R., Hnatova, S., Poovathingal, S. K., Marneffe, C., Thal, D. R., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26670159
Additional file 10 of Unravelling cell type-specific responses to Parkinson’s Disease at single cell resolution
Martirosyan, A., Ansari, R. A., Pestana, F., Hebestreit, K., Gasparyan, H., Aleksanyan, R., Hnatova, S., Poovathingal, S. K., Marneffe, C., Thal, D. R., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26670135
Additional file 1 of Ganglioglioma deep transcriptomics reveals primitive neuroectoderm neural precursor-like population
Regal, J. A., García, M. E. G., Jain, V., Chandramohan, V., Ashley, D. M., Gregory, S. G., Thompson, E. M., López, G. Y., & Reitman, Z. J. (2024) · Figshare · doi:10.6084/m9.figshare.26577671
Additional file 3 of Ganglioglioma deep transcriptomics reveals primitive neuroectoderm neural precursor-like population
Regal, J. A., García, M. E. G., Jain, V., Chandramohan, V., Ashley, D. M., Gregory, S. G., Thompson, E. M., López, G. Y., & Reitman, Z. J. (2024) · Figshare · doi:10.6084/m9.figshare.26577677
Additional file 11 of Ganglioglioma deep transcriptomics reveals primitive neuroectoderm neural precursor-like population
Regal, J. A., García, M. E. G., Jain, V., Chandramohan, V., Ashley, D. M., Gregory, S. G., Thompson, E. M., López, G. Y., & Reitman, Z. J. (2024) · Figshare · doi:10.6084/m9.figshare.26577701
Additional file 6 of Ganglioglioma deep transcriptomics reveals primitive neuroectoderm neural precursor-like population
Regal, J. A., García, M. E. G., Jain, V., Chandramohan, V., Ashley, D. M., Gregory, S. G., Thompson, E. M., López, G. Y., & Reitman, Z. J. (2024) · Figshare · doi:10.6084/m9.figshare.26577686
Additional file 1 of Disease and brain region specific immune response profiles in neurodegenerative diseases with pure and mixed protein pathologies
Bathe, T., Hery, G. P., Villareal, J. A. B., Phillips, J. L., Cohen, E. M., Sharma, R. V., Tsering, W., & Prokop, S. (2024) · Figshare · doi:10.6084/m9.figshare.26702593
Additional file 2 of Ganglioglioma deep transcriptomics reveals primitive neuroectoderm neural precursor-like population
Regal, J. A., García, M. E. G., Jain, V., Chandramohan, V., Ashley, D. M., Gregory, S. G., Thompson, E. M., López, G. Y., & Reitman, Z. J. (2024) · Figshare · doi:10.6084/m9.figshare.26577674
Infection of 5xFAD mice with a mouse-adapted SARS-CoV-2 does not alter Alzheimer’s disease neuropathology yet induces wide-spread changes in gene expression across diverse cell typesPreprint
Furman, S., Zayou, L., Tsourmas, K. I., Javonillo, D. I., Olivarria, G. M., Cheng, Y., Pachow, C., Fernandez, K., Le, L., Edwards, R. A., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2025.12.19.695600
Investigating the Role of Cortical Microglia in a Mouse Model of Viral Infection-Induced Seizures
Balachandar, L., Buxton, L., Kearns, I. R., Stefanic, M. F., Bell, L., DePaula-Silva, A. B., & Wilcox, K. S. (2026) · eNeuro · doi:10.1523/eneuro.0374-25.2026
The role of microglia in the pathogenesis of multiple sclerosis
Karchevskaya, A. E., Nabiev, S. R., Oganesyan, I. Y., & Voskresenskaya, O. N. (2026) · Neurology neuropsychiatry Psychosomatics · doi:10.14412/2074-2711-2026-1-4-13
Transcriptomic landscape of microglia in mouse models of social dysfunction and oxytocin-mediated recovery
Tsurutani, M., Sato, H., Hagihara, M., Cho, D., Kadota, M., Kondo, T., & Miyamichi, K. (2026) · iScience · doi:10.1016/j.isci.2026.117412
Repeated neonatal sevoflurane exposure causes adolescent anxiety/depression via microglial P2Y12R-Wnt/β-catenin pathway-mediated neurogenesis deficits
Wang, X., Zhao, H., Dai, H., Chen, C., Wang, J., & Li, H. (2026) · NeuroToxicology · doi:10.1016/j.neuro.2026.103415
Impact de la consommation de fructose sur la microglie et la santé cérébrale
Coursan, A. (2024) · theses.fr (ABES) · doi:10.70675/c509f961z7098z4c0bz92b0z8ba14be2e725
Features of retina remodeling during its physiological aging and age-related macular degeneration
Зуева, М. В., Kotelin, V. I., & Neroeva, N. V. (2026) · Russian Ophthalmological Journal · doi:10.21516/2072-0076-2026-19-1-179-184
Supplémentatiοn οrale en glutamine et répοnse hypοthalamique au cοurs de l'οbésité induite par l'alimentatiοn.
Dreux, V. (2024) · theses.fr (ABES) · doi:10.70675/6950ff04z6881z49e4za50fzda020671b294
Neuronal and microglial function of P2X4 receptor in Amyotrophic lateral sclerosis and its potential use as a biomarker
Carracedo, S. (2025) · doi:10.70675/90187a78z317az4e8az8d9bzf6408d7134f6
A GPCR atlas across human microglial states in Alzheimer's disease: Insights from snRNA-seq and hiPSC models
Zhang, B., Zhao, R., Li, X.-Y., Wei, Z.-H., Wang, D.-M., & Lu, M.-H. (2026) · Experimental Neurology · doi:10.1016/j.expneurol.2026.115845
An-Gong-Niu-Huang-Wan ameliorates neurovascular uncoupling and facilitates recovery after cerebral ischemic stroke by mediating P2X7 receptor inhibition
Zhang, X., Zhou, H., Pei, J., Xu, R., Xue, L., Zhang, Y., Qi, P., Zhang, X., Fu, L., Zhang, C., et al. (2026) · Phytomedicine · doi:10.1016/j.phymed.2026.158326
Oxidative memory in microglia: persistent OSI-driven polarization and ıts modulation by mitochondrial dynamics (Mdivi-1)
Yıldırım, M. E., & Ayhan, B. (2026) · Experimental Brain Research · doi:10.1007/s00221-026-07326-6
Microglia extracellular traps (MiETs) in Neurodegeneration: Mechanisms, Evidence Gaps, and Untapped Therapeutic Promise
Sha, L., & Jha, S. (2026) · Advances in immunology · doi:10.1016/bs.ai.2026.04.008
Ex vivo application of gut microbiota–derived postbiotics in human paediatric cortical tissue
Rungoo, Y., Chiano, M. D., Duwat, C., Poulot-Becq-Giraudon, Y., Bakouh, N., Giuliani, S.-Y., Letenneur, V., Derounian, R., Dossi, E., Huberfeld, G., et al. (2026) · Global Pediatrics · doi:10.1016/j.gpeds.2026.100355
Vascular-associated bacterial burden and neuroinflammatory transcriptional responses observed in models of pneumonic plague
Smith, B. A., Klimko, C. P., Rodriguez, C. I., Rill, N. O., Davies, M. L., Dankmeyer, J. L., Hunter, M., Braun, C. T., Hernandez-Viezcas, Y., Xander, C. J., et al. (2026) · Frontiers in Microbiology · doi:10.3389/fmicb.2026.1865125
Accumulation of lipid droplets in microglia following neonatal brain hypoxia-ischemia
Fan, L., Lei, Y., Li, S., Zhang, G., Li, Y., Wu, B., Ferriero, D. M., Pan, P., Guan, Z., & Jiang, X. (2026) · Journal of Neuroinflammation · doi:10.1186/s12974-026-03982-1
Gut microbiota dysbiosis-induced neuroinflammation and IL-22/STAT3 activation in emotional disorders
Feng, X., Hu, Y., Zhu, L., Lu, X., Sun, L., Liu, J., Jin, J., Ji, X., & Zhao, L. (2026) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2026.106979
P2X4 purinergic receptor loss alters macrophage homeostasis, cytokine secretion, and phagocytosis in a myeloid-specific P2X4 purinergic receptor knockout mouse
Manoharan, V., Rains, K. M., Ibarra, T. R., Vaidhyalingham, A. B., Pistone, T. R., Awogbesan, P. O., Caramella, F., Kelso, C. D., Jarrett, J. O., Llanos, M. Q., et al. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1916582
Molecularity of GPCR signaling involved in neuroinflammation
Kiran, N. S., & Chatterjee, A. (2026) · Elsevier eBooks · doi:10.1016/b978-0-443-33887-8.00008-8
A method for distinguishing and separating retinal microglia from infiltrating macrophages during an ocular inflammatory event
McPherson, S. W., Burgstaler, L., Sherman, J., Patin, A., & Roehrich, H. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1951506
Photoelectrochemical Fiber Cytometry With 60 nm Tip Size for Measuring Serotonin Dynamics at Edges of Cleft and Varicosities
Shangguan, Y., Li, J., Liu, Z., Chen, Y., Liang, M., Wang, X., Chen, J., Yin, D., & Tian, Y. (2026) · Angewandte Chemie International Edition · doi:10.1002/anie.8236222
Photoelectrochemical Fiber Cytometry With 60 nm Tip Size for Measuring Serotonin Dynamics at Edges of Cleft and Varicosities
Shangguan, Y., Li, J., Liu, Z., Chen, Y., Liang, M., Wang, X., Chen, J., Yin, D., & Tian, Y. (2026) · Angewandte Chemie · doi:10.1002/ange.8236222
Anticonvulsant, anxiolytic, and cognitive protective effects of P2Y12 receptor inhibition in a pentylenetetrazol-induced epilepsy model and the potential role of the opioidergic system
Torun, İ. E., Torun, C., & Namulodı, S. (2026) · Anadolu Kliniği Tıp Bilimleri Dergisi · doi:10.21673/anadoluklin.2006621
Microglia and immune signaling as architects of the brain
Kim, A., Solek, C. M., & Ruthazer, E. S. (2026) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2026.1936860
Role of macrophages in immunometabolism and neurodegeneration
Mishra, P., Khan, A., Doshi, Z., Tungare, K., & Nand, S. (2026) · Elsevier eBooks · doi:10.1016/b978-0-443-44253-7.00018-7

Authors: Gómez Morillas, A., Besson, V. C., & Lerouet, D.
Affiliations: UMR-S1144–Optimisation Thérapeutique en Neuropsychopharmacologie (OTeN), Faculté de Pharmacie de Paris, 4 Avenue de l’Observatoire, Université de Paris, 75006 Paris, France
Université Paris Cité (FR)
Corresponding author: Lerouet, Dominique
ORCID: Gómez Morillas, Albert
Besson, Valérie C.
Lerouet, Dominique
Venue: International Journal of Molecular Sciences
Publisher: MDPI AG
Published: 2021-02-06
Volume: 22
Issue: 4
Pages: 1636
ISSN: 1422-0067 (ISSN-L)
DOI: 10.3390/ijms22041636
PMC: PMC7915979
OpenAlex: W3126430294
Cited by: 214
References: 96
Citations by year: 2026: 36 · 2025: 50 · 2024: 72 · 2023: 32 · 2022: 18 · 2021: 6
FWCI: 5.93
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
creativecommons.org/licenses/by/4.0/ (vor)
Locations: International Journal of Molecular Sciences (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders: Fondation des Gueules Cassées
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Physiology › Adenosine and Purinergic Signaling
Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Health Sciences › Medicine › Physiology (medical) › Pain Mechanisms and Treatments
Keywords: microglia, neuroinflammation, P2Y12 receptor, P2Y receptors, purinergic receptors, microglial motility, microglial migration, pharmacological tools, genetic instruments
MeSH terms: Brain, Brain Diseases, Cell Movement, Humans, Inflammation, Lymphocyte Activation, Signal Transduction, Microglia, Receptors, Purinergic P2Y12

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Microglia and Neuroinflammation: What Place for P2RY12?

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks