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Targeted deletion of the mouse Mitoferrin1 gene: from anemia to protoporphyria
Open accessAbstract
Mitoferrin1 is 1 of 2 homologous mitochondrial iron transporters and is required for mitochondrial iron delivery in developing erythroid cells. We show that total deletion of Mfrn1 in embryos leads to embryonic lethality. Selective deletion of Mfrn1 in adult hematopoietic tissues leads to severe anemia because of a deficit in erythroblast formation. Deletion of Mfrn1 in hepatocytes has no phenotype or biochemical effect under normal conditions. In the presence of increased porphyrin synthesis, however, deletion of Mfrn1 in hepatocytes results in a decreased ability to convert protoporphyrin IX into heme, leading to protoporphyria, cholestasis, and bridging cirrhosis. Our results show that the activity of mitoferrin1 is required to manage an increase in heme synthesis. The data also show that alterations in heme synthesis within hepatocytes can lead to protoporphyria and hepatotoxicity.
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Mitoferrin1 and Mitoferrin2 are responsible for the mitochondrial import of iron.
“The mitoferrin transporters (Mitoferrin1 and Mitoferrin2) are responsible for the mitochondrial import of iron (Shaw et al., 2006; Troadec et al., 2011; Chung et al., 2014).”
From The Role of Iron Regulation in Immunometabolism and Immune-Related Disease (2019) · cites this paper as Troadec et al., 2011
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Additional file 1 of Mitoferrin2 is a synthetic lethal target for chromosome 8p deleted cancers
Krieg, S., Rohde, T., Rausch, T., Butthof, L., Wendler-Link, L., Eckert, C., Breuhahn, K., Galy, B., Korbel, J. O., Billmann, M., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26054632
Additional file 2 of Mitoferrin2 is a synthetic lethal target for chromosome 8p deleted cancers
Krieg, S., Rohde, T., Rausch, T., Butthof, L., Wendler-Link, L., Eckert, C., Breuhahn, K., Galy, B., Korbel, J. O., Billmann, M., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26054762
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Metadata
- Authors
- Troadec, M.-B., Warner, D., Wallace, J., Thomas, K., Spangrude, G. J., Phillips, J., Khalimonchuk, O., Paw, B. H., Ward, D. M., & Kaplan, J.
- Affiliations
- Departments of Pathology and
- University of Utah (US)
- Brigham and Women's Hospital (US)
- Venue
- Blood
- Publisher
- American Society of Hematology
- Published
- 2011-05-19
- Volume
- 117
- Issue
- 20
- Pages
- 5494-5502
- ISSN
- 0006-4971 (ISSN-L)
- 1528-0020
- PMC
- PMC3109720
- OpenAlex
- W1986119180
- Cited by
- 97
- References
- 19
- Citations by year
- 2026: 3 · 2025: 5 · 2024: 12 · 2023: 9 · 2022: 5 · 2021: 7 · 2020: 4 · 2019: 6 · 2018: 7 · 2017: 9 · 2016: 4 · 2015: 5 · 2014: 7 · 2013: 4 · 2012: 7
- FWCI
- 2.58
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Blood (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Lincoln (University of Nebraska) (submittedVersion)
- HAL (submittedVersion)
- Funders
- University of Utah
- National Institutes of Health (HL032262)
- National Heart, Lung, and Blood Institute (P01HL032262)
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK070838, R01DK052380, DK052380, U54DK083909)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Porphyrin Metabolism and Disorders
- Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Heme Oxygenase-1 and Carbon Monoxide
- Keywords
- mitochondrial iron transport, embryonic lethality, anemia, protoporphyria, heme biosynthesis, protoporphyrin IX, hepatocytes, cholestasis, hepatotoxicity, gene targeting
- MeSH terms
- Anemia, Animals, Base Sequence, Female, Heme, Iron, Male, Mice, Inbred C57BL, Mitochondria, Pregnancy, Protoporphyrins, DNA Primers, Mice, Knockout, Gene Targeting, Embryo Loss, Hepatocytes, Membrane Transport Proteins, Protoporphyria, Erythropoietic, Mice
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