Molecular Basis of Bile Acid-FXR-FGF15/19 Signaling Axis

Bile salt biotransformations by human intestinal bacteria

Ridlon, J. M., Kang, D.-J., & Hylemon, P. B. (2006) · Journal of Lipid Research · doi:10.1194/jlr.r500013-jlr200 · Cited by 2,829

Identification of a nuclear receptor for bile acids

Makishima, M., Okamoto, A. Y., Repa, J. J., Tu, H., Learned, R. M., Luk, A., Hull, M. V., Lustig, K. D., Mangelsdorf, D. J., & Shan, B. (1999) · Science · doi:10.1126/science.284.5418.1362 · Cited by 2,714

Gut microbiota regulates bile acid metabolism by reducing the levels of tauro-beta-muricholic acid, a naturally occurring FXR antagonist

Sayin, S. I., Wahlström, A., Felin, J., Jäntti, S., Marschall, H.-U., Bamberg, K., Angelin, B., Hyötyläinen, T., Orešič, M., & Bäckhed, F. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2013.01.003 · Cited by 2,331

Bile Acids: Natural Ligands for an Orphan Nuclear Receptor

Parks, D. J., Blanchard, S. G., Bledsoe, R. K., Chandra, G., Consler, T. G., Kliewer, S. A., Stimmel, J. B., Willson, T. M., Zavacki, A. M., Moore, D. D., et al. (1999) · Science · doi:10.1126/science.284.5418.1365 · Cited by 2,274

The Enzymes, Regulation, and Genetics of Bile Acid Synthesis

Russell, D. W. (2003) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.72.121801.161712 · Cited by 2,069

A regulatory cascade of the nuclear receptors FXR, SHP-1, and LRH-1 represses bile acid biosynthesis

Goodwin, B., Jones, S. A., Price, R. R., Watson, M. A., McKee, D. D., Moore, L. B., Galardi, C., Wilson, J. G., Lewis, M. C., Roth, M. E., et al. (2000) · Molecular Cell · doi:10.1016/s1097-2765(00)00051-4 · Cited by 1,940

Fibroblast growth factor 15 functions as an enterohepatic signal to regulate bile acid homeostasis

Inagaki, T., Choi, M., Moschetta, A., Peng, L., Cummins, C. L., McDonald, J. G., Luo, G., Jones, S. A., Goodwin, B., Richardson, J. A., et al. (2005) · Cell Metabolism · doi:10.1016/j.cmet.2005.09.001 · Cited by 1,865

Targeted Disruption of the Nuclear Receptor FXR/BAR Impairs Bile Acid and Lipid Homeostasis

Sinal, C. J., Tohkin, M., Miyata, M., Ward, J. M., Lambert, G., & Gonzalez, F. J. (2000) · Cell · doi:10.1016/s0092-8674(00)00062-3 · Cited by 1,819

Endogenous Bile Acids Are Ligands for the Nuclear Receptor FXR/BAR

Wang, H., Chen, J., Hollister, K., Sowers, L. C., & Forman, B. M. (1999) · Molecular Cell · doi:10.1016/s1097-2765(00)80348-2 · Cited by 1,636

A G Protein-coupled Receptor Responsive to Bile Acids

Kawamata, Y., Fujii, R., Hosoya, M., Harada, M., Yoshida, H., Miwa, M., Fukusumi, S., Habata, Y., Itoh, T., Shintani, Y., et al. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m209706200 · Cited by 1,628

Signalling cognition: The gut microbiota and hypothalamic-pituitary-adrenal axis

Rusch, J. A., Layden, B. T., & Dugas, L. R. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1130689 · Cited by 415

A new perspective on NAFLD: Focusing on the crosstalk between peroxisome proliferator-activated receptor alpha (PPARα) and farnesoid X receptor (FXR)

Zhou, S., You, H., Qiu, S., Yu, D., Bai, Y., He, J., Cao, H., Che, Q., Guo, J., & Su, Z. (2022) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2022.113577 · Cited by 71

Gut Microbiota Dysbiosis and Its Impact on Type 2 Diabetes: From Pathogenesis to Therapeutic Strategies

Yu, Y., Ding, Y., Wang, S., & Jiang, L. (2025) · Metabolites · doi:10.3390/metabo15060397 · Cited by 72

Sedanolide alleviates DSS-induced colitis by modulating the intestinal FXR-SMPD3 pathway in mice

Li, S., Zhuge, A., Chen, H., Han, S., Shen, J. F., Wang, K., Xia, J., He, X., Jiang, S., Wu, Y., et al. (2024) · Journal of Advanced Research · doi:10.1016/j.jare.2024.03.026 · Cited by 51

Connecting the Gut Microbiota and Neurodegenerative Diseases: the Role of Bile Acids

Wang, S., Xu, C., Liu, H., Wei, W., Zhou, X., Qian, H., Zhou, L., Zhang, H., Wu, L. M., Chen, Z., et al. (2023) · Molecular Neurobiology · doi:10.1007/s12035-023-03340-9 · Cited by 51

New insights into the role of Klotho in inflammation and fibrosis: molecular and cellular mechanisms

Zhao, X., Han, D., Zhao, C., Yang, F., Wang, Z., Gao, Y., Jin, M., & Tao, R. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1454142 · Cited by 48

Exploring the Significance of Gut Microbiota in Diabetes Pathogenesis and Management—A Narrative Review

Młynarska, E., Wasiak, J., Gajewska, A., Steć, G., Jasińska, J., Rysz, J., & Franczyk, B. (2024) · Nutrients · doi:10.3390/nu16121938 · Cited by 46

Gut microbiota–bile acid–intestinal Farnesoid X receptor signaling axis orchestrates cadmium-induced liver injury

Liu, Y., Kang, W., Liu, S., Li, J., Liu, J., Chen, X., Gan, F., & Huang, K. (2022) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2022.157861 · Cited by 46

Tauroursodeoxycholic Acid Improves Nonalcoholic Fatty Liver Disease by Regulating Gut Microbiota and Bile Acid Metabolism

Wang, H., Guo, Y. Z., Han, W., Liang, M., Xiao, X., Jiang, X., & Yu, W. (2024) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.4c04630 · Cited by 38

Spaceflight alters host-gut microbiota interactions

González, E., Lee, M., Tierney, B. T., Lytell, N., Flores, P., Mishra, M., Beckett, L., Finkelstein, A., Mo, A., Walton, P., et al. (2024) · npj Biofilms and Microbiomes · doi:10.1038/s41522-024-00545-1 · Cited by 41

Type 2 Diabetes and the Multifaceted Gut-X Axes

Guo, H., Pan, L.-T., Wu, Q., Wang, L., Huang, Z., Wang, J., Wang, L., Fang, X., Dong, S., Zhu, Y., et al. (2025) · Nutrients · doi:10.3390/nu17162708 · Cited by 38

Astragalus saponins protect against extrahepatic and intrahepatic cholestatic liver fibrosis models by activation of farnesoid X receptor

Zhang, L., Shi, J., Shen, Q., Fu, Y., Qi, S., Wu, J., Chen, J., Zhang, H., Mu, Y., Chen, G., et al. (2023) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2023.116833 · Cited by 35

The role of bile acid metabolism in the occurrence and development of NAFLD

Bing, H., & Li, Y. (2022) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2022.1089359 · Cited by 34

Upregulation of Taurine Biosynthesis and Bile Acid Conjugation with Taurine through FXR in a Mouse Model with Human-like Bile Acid Composition

Miyazaki, T., Ueda, H., Ikegami, T., & Honda, A. (2023) · Metabolites · doi:10.3390/metabo13070824 · Cited by 33

Role of bile acids in overweight and obese children and adolescents

Giannini, C., Mastromauro, C., Scapaticci, S., Gentile, C., & Chiarelli, F. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.1011994 · Cited by 32

Supplementation of Silymarin Alone or in Combination with Salvianolic Acids B and Puerarin Regulates Gut Microbiota and Its Metabolism to Improve High-Fat Diet-Induced NAFLD in Mice

Wang, X., Jin, Y., Di, C., Zeng, Y., Zhou, Y., Chen, Y., Pan, Z., Li, Z., & Ling, W. (2024) · Nutrients · doi:10.3390/nu16081169 · Cited by 29

Primary Biliary Cholangitis and Primary Sclerosing Cholangitis Therapy Landscape

Bhushan, S. R., Sohal, A., & Kowdley, K. V. (2024) · The American Journal of Gastroenterology · doi:10.14309/ajg.0000000000003174 · Cited by 31

Gut–Liver Axis as a Therapeutic Target for Drug-Induced Liver Injury

Tao, W., Fan, Q., & Wei, J. (2024) · Current Issues in Molecular Biology · doi:10.3390/cimb46020078 · Cited by 29

Pharmacology of boldine: summary of the field and update on recent advances

Sáez, J. C., Burrell, J. C., Cahill, C. M., Cullen, D. K., Devi, L. A., Gilbert, R. J., Graham, Z., Gurvich, V. J., Havton, L. A., Iyengar, R., et al. (2024) · Frontiers in Pharmacology · doi:10.3389/fphar.2024.1427147 · Cited by 26

A Novel Frontier in Gut–Brain Axis Research: The Transplantation of Fecal Microbiota in Neurodegenerative Disorders

Eslami, M., Adampour, Z., Dowlat, B. F., Yaghmayee, S., Tabaei, F. M., Oksenych, V., & Naderian, R. (2025) · Biomedicines · doi:10.3390/biomedicines13040915 · Cited by 27

Physical exercise plays a role in rebalancing the bile acids of enterohepatic axis in non‐alcoholic fatty liver disease

Zhang, M., Xiao, B., Chen, X., Ou, B., & Wang, S. (2023) · Acta Physiologica · doi:10.1111/apha.14065 · Cited by 28

Collaborative Metabolism: Gut Microbes Play a Key Role in Canine and Feline Bile Acid Metabolism

Rowe, J. C., & Winston, J. A. (2024) · Veterinary Sciences · doi:10.3390/vetsci11020094 · Cited by 26

Effects of cholesterol-lowering probiotics on non-alcoholic fatty liver disease in FXR gene knockout mice

Yang, M., Wang, H., Bukhari, I., Ye, Z., Huang, H., Yu, Y., Sun, X., Mi, Y., Lü, M., & Zheng, P. (2023) · Frontiers in Nutrition · doi:10.3389/fnut.2023.1121203 · Cited by 25

Progress in Biomarkers Related to Biliary Atresia

Kong, F., Dong, R., Chen, G., Sun, S., Yang, Y., Jiang, J., Meng, L., Chen, H., Zhu, J., & Zheng, S. (2024) · Journal of Clinical and Translational Hepatology · doi:10.14218/jcth.2023.00260 · Cited by 23

Lingguizhugan oral solution alleviates MASLD by regulating bile acids metabolism and the gut microbiota through activating FXR/TGR5 signaling pathways

Wang, J., Zang, J., Yang, Y., Liu, Y., Cao, H., Guo, R., Zhang, L., Liu, M., Zhang, Z., Li, X., et al. (2024) · Frontiers in Pharmacology · doi:10.3389/fphar.2024.1426049 · Cited by 23

Role of Microbiota-Modified Bile Acids in the Regulation of Intracellular Organelles and Neurodegenerative Diseases

Kiriyama, Y., & Nochi, H. (2023) · Genes · doi:10.3390/genes14040825 · Cited by 22

Roseburia intestinalis relieves intrahepatic cholestasis of pregnancy through bile acid/FXR-FGF15 in rats

Sun, H., Su, X., Liu, Y., Li, G., & Du, Q. (2023) · iScience · doi:10.1016/j.isci.2023.108392 · Cited by 22

A Review: Cytochrome P450 in Alcoholic and Non-Alcoholic Fatty Liver Disease

Jiang, Y., Cao, Y.-M., Cao, Y., Yan, T., Jia, C., & He, P. (2024) · Diabetes Metabolic Syndrome and Obesity · doi:10.2147/dmso.s449494 · Cited by 22

Review: interactions between microplastics and the gastrointestinal microbiome

Eichinger, J., Tretola, M., Seifert, J., & Brügger, D. (2024) · Italian Journal of Animal Science · doi:10.1080/1828051x.2024.2377642 · Cited by 22

The bile acid profile

Liu, Z., & You, C. (2024) · Clinica Chimica Acta · doi:10.1016/j.cca.2024.120004 · Cited by 22

Triterpenoids from ilicis rotundae cortex ameliorate hyperlipidemia by affecting bile acids-hepatointestinal FXR axis

Zeng, W., Sun, M., Cao, J., Chen, C., Jiang, S., Wang, Y., Yang, W.-Q., Zhao, Z., & Jin, J. (2025) · Phytomedicine · doi:10.1016/j.phymed.2025.156537 · Cited by 21

Clostridium Scindens Protects Against Vancomycin‐Induced Cholestasis and Liver Fibrosis by Activating Intestinal FXR‐FGF15/19 Signaling

Xiao, J., Hou, Y., Luo, X., Zhu, Y., Li, W., Li, B., Zhou, L., Chen, X., Guo, Y., Zhang, X., et al. (2024) · Advanced Science · doi:10.1002/advs.202406445 · Cited by 21

ALDH2 deficiency exacerbates MCD-diet induced MASLD by modulating bile acid metabolism

Luo, J., Lu, Z., Zhong, Z., Pi, M., Xiong, Y., Li, L., Chen, T., Chen, Y., Wang, C., Liu, Z., et al. (2023) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2023.12.017 · Cited by 20

Bile Acid Diarrhea: From Molecular Mechanisms to Clinical Diagnosis and Treatment in the Era of Precision Medicine

Yang, D., Lyu, C., He, K., Pang, K., Guo, Z., & Wu, D. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25031544 · Cited by 20

Advances in the pathophysiology, diagnosis and management of chronic diarrhoea from bile acid malabsorption: a systematic review

Ciaula, A. D., Khalil, M., Baffy, G., & Portincasa, P. (2024) · European Journal of Internal Medicine · doi:10.1016/j.ejim.2024.07.008 · Cited by 20

Metabolite-mediated crosstalk: unraveling the interactions between gut microbiota and host in fatty liver hemorrhagic syndrome of laying hens

Zhang, S., Zhao, X., He, X., Shi, W., & Ma, N. (2026) · Journal of Animal Science and Biotechnology/Journal of animal science and biotechnology · doi:10.1186/s40104-025-01319-1 · Cited by 20

Ampelopsis grossedentata improves type 2 diabetes mellitus through modulating the gut microbiota and bile acid metabolism

Hu, Y., Li, M., Ding, L., Peng, C., Wu, Y., Liu, W., Zhao, D., Qin, L., Guo, X., Wu, L., et al. (2023) · Journal of Functional Foods · doi:10.1016/j.jff.2023.105622 · Cited by 18

Gut-Brain Axis Modulation of Metabolic Disorders: Exploring the Intertwined Neurohumoral Pathways and Therapeutic Prospects

Bhalla, D., Dinesh, S., Sharma, S., & Sathisha, G. J. (2024) · Neurochemical Research · doi:10.1007/s11064-023-04084-7 · Cited by 18

ZeXieYin formula alleviates atherosclerosis by regulating SBAs levels through the FXR/FGF15 pathway and restoring intestinal barrier integrity

Zhou, S., Hua, S., Chen, X., Ni, M., Liu, J., Wang, Y.-Q., Wu, W., Ding, A., Qin, Z., Yang, X., et al. (2025) · Chinese Medicine · doi:10.1186/s13020-025-01116-y · Cited by 16

Dendrobium officinale aqueous extract regulates bile acid synthesis to improve acute alcoholic liver injury in mice

Ye, J., Wu, D., Wu, X., Qin, L., Yang, M., Lu, Y., Tan, D., & He, Y. (2023) · Food Bioscience · doi:10.1016/j.fbio.2023.103087 · Cited by 16

Polysaccharide-mediated modulation of gut microbiota in the treatment of liver diseases: Promising approach with significant challenges

Yang, Y., Fan, G., Lan, J., Li, X., Li, X., & Liu, R. (2024) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2024.135566 · Cited by 16

The role of brain–liver–gut Axis in neurological disorders

Li, P., Xie, L., Yang, W., Feng, S., Mao, W., Ye, L., Cheng, H., Wu, X., & Mao, X. (2025) · Burns & Trauma · doi:10.1093/burnst/tkaf011 · Cited by 16

Microbial Metabolites as Ligands to Xenobiotic Receptors: Chemical Mimicry as Potential Drugs of the Future

Dvořák, Z., Li, H., & Mani, S. (2022) · Drug Metabolism and Disposition · doi:10.1124/dmd.122.000860 · Cited by 16

Therapeutic implications of obeticholic acid, a farnesoid X receptor agonist, in the treatment of liver fibrosis

Azizsoltani, A., Niknam, B., Taghizadeh-Teymorloei, M., Ghoodjani, E., Dianat-Moghadam, H., & Alizadeh, E. (2025) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2025.118249 · Cited by 15

Flavonoids as modulators of gut-liver axis: emerging therapeutic strategies for MAFLD

Hao, M., Wang, Z., Wang, L., Yimamu, A., Su, X., Zhang, M., Li, X., Zhang, Q., & Sun, Z. (2025) · Frontiers in Pharmacology · doi:10.3389/fphar.2025.1657751 · Cited by 15

Suppression of the gut microbiota–bile acid– FGF19 axis in patients with atrial fibrillation

Zuo, K., Chen, F., Gao, Y., Fu, Y., Wang, H., Li, J., Zhong, J., Yang, X., & Xu, L. (2023) · Cell Proliferation · doi:10.1111/cpr.13488 · Cited by 15

Nuclear factor interleukin 3 and metabolic dysfunction-associated fatty liver disease development

Lin, Y.-N., Hsu, J., Wang, C.-L., Huang, Y.-C., Wang, J.-Y., Wu, C., & Wu, L. (2024) · Communications Biology · doi:10.1038/s42003-024-06565-z · Cited by 15

Edible fungi polysaccharides modulate gut microbiota and lipid metabolism: A review

Xu, H., Xue, Z., Wang, P., Lee, Q., Chen, Z., Liu, B., Liu, X., & Zeng, F. (2024) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2024.137427 · Cited by 15

Discovery of (E)-3-(3-((2-Cyano-4′-dimethylaminobiphenyl-4-ylmethyl)cyclohexanecarbonylamino)-5-fluorophenyl)acrylic Acid Methyl Ester, an Intestine-Specific, FXR Partial Agonist for the Treatment of Nonalcoholic Steatohepatitis

Shim, S., Krishnaiah, M., Sankham, M. R., Kim, I., Lee, Y., Shin, I., Oh, A., Lee, H. J., Vu, T. N. L., Park, J., et al. (2022) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.2c00641 · Cited by 14

Antibiotic cocktail-induced changes in gut microbiota drive alteration of bile acid metabolism to restrain Th17 differentiation through the FXR–NLRP3 axis

Shao-Yu, Y., Niu, D., Chen, J., Li, W.-Y., Wang, X., Meng, Q.-W., Song, W.-J., Yang, Y., Wang, H., Li, R., et al. (2025) · Gut Microbes · doi:10.1080/19490976.2025.2582944 · Cited by 15

Contaminant biomonitoring augmented with a qPCR array indicates hepatic mRNA gene expression effects in wild-collected seabird embryos

King, M. D., Su, G. Y., Crump, D., Farhat, A., Marlatt, V. L., Lee, S. L., Williams, T. D., & Elliott, J. E. (2023) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2023.166784 · Cited by 13

Fluoride induces hepatointestinal damage and vitamin B2 mitigation by regulating IL-17A and Bifidobacterium in ileum

Liang, C., Zhuang, C., Cheng, C., Bai, J., Wu, Y., Li, X., Yang, J., Li, B., Fu, W., Zhu, Q., et al. (2024) · Journal of Advanced Research · doi:10.1016/j.jare.2024.07.034 · Cited by 14

Multi-omics reveals the alleviating effect of berberine on ulcerative colitis through modulating the gut microbiome and bile acid metabolism in the gut-liver axis

Yu, J., Zheng, Y., Liu, C., Xie, Z., Liu, Q., Yang, S., Tian, Q., Song, C., & Chen, S. (2024) · Frontiers in Pharmacology · doi:10.3389/fphar.2024.1494210 · Cited by 13

Gut microbiota-bile acids-glucagon like peptide-1 axis contributes the resistance to high fat diet-induced obesity in mice

Chen, C., Liu, L., Zhong, Y., Wang, M., Ai, Y., Hou, Y., Chen, H., Lin, X., Zhang, Y., Ding, M., et al. (2023) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2023.109358 · Cited by 14

Water-soluble Poria cocos polysaccharide improves alcoholic liver disease via modulation of gut microbiota-mediated intestinal bile acids-farnesoid X receptor

Huang, J., Yu, L., Zhang, C., Fang, Y., Zhou, X., Wang, R., Xing, L., Wang, L., Yu, N., Peng, D., et al. (2025) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2025.148202 · Cited by 12

Unveiling the power of microenvironment in liver regeneration: an in-depth overview

Hu, Y., Wang, R., An, N. A., Li, C., Wang, Q., Cao, Y., Li, C., Liu, J., & Wang, Y. (2023) · Frontiers in Genetics · doi:10.3389/fgene.2023.1332190 · Cited by 12

Triclosan exposure causes abnormal bile acid metabolism through IL-1β-NF-κB-Fxr signaling pathway

Liu, J., Xu, F., Guo, M., & Song, Y. (2024) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2024.116989 · Cited by 12

A critical role for Phocaeicola vulgatus in negatively impacting metformin response in diabetes

Chen, M., Peng, Y., Hu, Y., Kang, Z., Chen, T., Zhang, Y., Chen, X., Li, Q., Yuan, Z., Wu, Y., et al. (2025) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2025.02.008 · Cited by 14

Host–Microbiome Interaction in the Intensive Care Unit

Neag, M. A., Mitre, A. O., Pomana, I. G., Velescu, M. A., Militaru, C. F., Nagy, G. A., & Melincovici, C. S. (2025) · Diseases · doi:10.3390/diseases13080250 · Cited by 12

Zebrafish ppp1r21 mutant as a model for the study of primary biliary cholangitis

Wu, C., Zhang, W., Luo, Y., Cheng, C., Wang, X., Jiang, Y., Li, S., Luo, L., & Yang, Y. (2023) · Journal of genetics and genomics/Journal of Genetics and Genomics · doi:10.1016/j.jgg.2023.05.013 · Cited by 12

Protective effects and mechanism of Sangyu granule on acetaminophen-induced liver injury in mice

Xiao, K., Li, H., Li, Y., Zhan, B., Fang, X., Zhao, B., Zhang, X., Wu, Y., Wang, F., & Jia, Y. (2024) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2024.118282 · Cited by 12

Gut Microbiota and Liver Regeneration: A Synthesis of Evidence on Structural Changes and Physiological Mechanisms

Kiseleva, Y. V., Zharikova, T. S., Maslennikov, R. V., Temirbekov, S. M., Olsufieva, A. V., Polyakova, O. L., Pontes‐Silva, A., & Zharikov, Y. O. (2024) · Journal of Clinical and Experimental Hepatology · doi:10.1016/j.jceh.2024.101455 · Cited by 11

Decoding coffee cardiometabolic potential: Chemical composition, nutritional, and health relationships

Karagöz, M. F., Koçyiğit, E., Koçak, T., Özturan-Şirin, A., İçer, M. A., Ağagündüz, D., & Coreta-Gomes, F. M. (2024) · Comprehensive Reviews in Food Science and Food Safety · doi:10.1111/1541-4337.13414 · Cited by 11

Hepatic and intestinal tissue-specific Fxr deficiency alters bile acid homeostasis in female mice

Jiang, J., Fan, M., Yuan, W., Yue, D., Wang, Z., Yang, L., Huang, W., Jin, L., Wang, X., & Ding, L. (2025) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00387.2024 · Cited by 11

Role of ACSL4 in modulating farnesoid X receptor expression and M2 macrophage polarization in HBV‐induced hepatocellular carcinoma

Chen, W., Xu, H., Guo, L., Zheng, F., Yao, J., & Wang, L. (2024) · MedComm · doi:10.1002/mco2.706 · Cited by 10

Kuhuang alleviates liver fibrosis by modulating gut microbiota-mediated hepatic IFN signaling and bile acid synthesis

Shen, B., Zhou, C., Gu, T., Shen, Z., Guo, Y., Dai, W., Liu, Y., Zhang, J., Lu, L., & Dong, H. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.1080226 · Cited by 10

Microalgae-Derived Bioactive Compounds for Liver Health: Mechanisms, Therapeutic Potential, and Translational Challenges

Sun, W., Du, M., Shen, G., Lai, D., & Wang, J. (2026) · Phycology · doi:10.3390/phycology6010009 · Cited by 9

Pharmacology and therapeutics of bile acid synthesis and modification enzymes in metabolic diseases

Ding, L., Jin, L., & Huang, W. (2026) · Pharmacological Reviews · doi:10.1016/j.pharmr.2026.100115 · Cited by 9

Effect of FXR agonist GW4064 in the treatment of hilar cholangiocarcinoma in rats

Wang, J., Zhang, M., Luo, M., Qin, S., & Xia, X. (2022) · Scientific Reports · doi:10.1038/s41598-022-23539-5 · Cited by 9

An Intestinal FXR Agonist Mitigates Dysbiosis, Intestinal Tight Junctions, and Inflammation in High‐Fat Diet‐Fed Mice

Petito‐da‐Silva, T. I., Villardi, F. M., Penna‐de‐Carvalho, A., Mandarim‐de‐Lacerda, C. A., Souza‐Mello, V., & Barbosa‐da‐Silva, S. (2023) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.202300148 · Cited by 9

Research Progress on Anti-Hyperlipidemia Peptides Derived from Foods

Zhao, M., Qiao, K., Zhang, L., Li, L., Chen, S., Chen, L., & Zhang, Y. (2025) · Nutrients · doi:10.3390/nu17071181 · Cited by 8

Fibroblast growth factor 19-fibroblast growth factor receptor 4 axis: From oncogenesis to targeted-immunotherapy in advanced hepatocellular carcinoma

Zhan, T., Feng, X., Huang, H., Zhan, J.-C., Liu, X.-K., & Cheng, Q. (2025) · World Journal of Gastrointestinal Oncology · doi:10.4251/wjgo.v17.i9.108649 · Cited by 8

The microbiota-gut-brain axis in Huntington’s disease: Evidence, mechanisms and therapeutic opportunities

Gu, Y., Wang, M., & Mao, Y. (2026) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2026.101247 · Cited by 9

The supplementation of the multi-strain probiotics WHHPRO™ alleviates high-fat diet-induced metabolic symptoms in rats via gut-liver axis

Chen, C., Gao, K., Chen, Z., Zhang, Q., Ke, X., Mao, B., Fan, Q., Li, Y., & Chen, S. (2024) · Frontiers in Nutrition · doi:10.3389/fnut.2023.1324691 · Cited by 8

Molecular basis of progressive familial intrahepatic cholestasis 3. A proteomics study

Guerrero, L., Carmona‐Rodríguez, L., Santos, F. M., Ciordia, S., Aroeira, L. S., Hierro, L., Pérez‐Montero, P., Vicent, D., & Corrales, F. J. (2024) · BioFactors · doi:10.1002/biof.2041 · Cited by 8

Sanye tablet regulates gut microbiota and bile acid metabolism to attenuate hepatic steatosis

Qi, Y., Du, S., Li, W., Qiu, X., Zhou, F., Bai, L., Zhang, B., Mi, Z.-X., Qian, W., Li, L., et al. (2025) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2025.119514 · Cited by 7

The Prebiotic Effect of Kaempferol in Regulating Bile Acid Metabolism

Li, X., Huang, G., Khan, I., Ding, Z., Hsiao, W. L. W., & Liu, Z. (2025) · Food Science & Nutrition · doi:10.1002/fsn3.70023 · Cited by 7

Molecular mechanisms and clinical applications of gut microbiota-derived bioactive compounds in metabolic dysfunction-associated fatty liver disease

Ma, C., Wang, J., Song, X., Wang, X., & Zong, S. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1682755 · Cited by 7

Gut microbiota–cholesterol crosstalk in cardiovascular diseases: mechanisms, metabolites, and therapeutic modulation

Abavisani, M., Sajjadi, S. M., Ebadpour, N., Karav, S., & Sahebkar, A. (2025) · Nutrition & Metabolism · doi:10.1186/s12986-025-01051-7 · Cited by 7

FXR in bone metabolism: An emerging regulator

Rizvi, S. M. M. H., Aihemaiti, S., Kan, Y., Tao, S., & Liu, H. (2026) · iScience · doi:10.1016/j.isci.2026.114842 · Cited by 8

Bile acid signaling, metabolism, and aging

Sun, J., Zhang, S., Jin, L., & Huang, W. (2026) · Liver Research · doi:10.1016/j.livres.2026.02.002 · Cited by 7

Makisterone A attenuates experimental cholestasis by activating the farnesoid X receptor

Kang, P., & Li, S. (2022) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2022.07.030 · Cited by 7

Inulin and Lycium barbarum polysaccharides mitigate the diabetic inflammatory response by modulating bile acid metabolism to enhance regulatory T cell (Treg) activation in a rat model of diabetes

Lü, H., Luo, H., Li, P., Yang, Y., Cao, S., Zhang, Y., Ma, H., Zhao, Q., Zheng, Y., & Wang, H. (2025) · Frontiers in Endocrinology · doi:10.3389/fendo.2025.1705635 · Cited by 6

Isorhamnetin alleviates diet induced MASLD in mice by modulating gut microbiota and bile acid metabolism

Guo, Y., Xu, X., Han, A., Song, F., Zhang, Y., Jiang, X., & Yu, W. (2026) · Phytomedicine · doi:10.1016/j.phymed.2026.157987 · Cited by 6

Advances in research on the effects of bile acids and their receptors on intestinal function

Cheng, Y., Zhang, L., Zhang, M., & Yu, J. (2026) · Frontiers in Nutrition · doi:10.3389/fnut.2026.1821418 · Cited by 6

Association Between Gadoxetic Acid-Enhanced Magnetic Resonance Imaging, Organic Anion Transporters, and Farnesoid X Receptor in Benign Focal Liver Lesions

van Rosmalen, B. V., Visentin, M., Furumaya, A., van Delden, O. M., Geert Kazemier, M., van Gulik, T. M., Verheij, J., & Stieger, B. (2023) · Drug Metabolism and Disposition · doi:10.1124/dmd.123.001492 · Cited by 6

Microbiota–gut–brain axis and related therapeutics in Alzheimer’s disease: prospects for multitherapy and inflammation control

Li, J., Zhang, F., Zhao, L., & Dong, C. (2023) · Reviews in the Neurosciences · doi:10.1515/revneuro-2023-0006 · Cited by 6

Deficiency of Epithelial PIEZO1 Alleviates Liver Steatosis Induced by High-Fat Diet in Mice

Xu, Z., Xu, S., Liu, X., Cheng, L., Liu, X., Xie, X., Zhou, D., Wang, D., Chen, J., Deng, X., et al. (2025) · International Journal of Biological Sciences · doi:10.7150/ijbs.102906 · Cited by 5

Fibroblast growth factor 19 regulates polycystic ovary syndrome progression via FGFR4-ERK-NRF2 pathway

Qu, J., Qiu, M., Wang, J., Chen, Z., Chen, M., Teng, X., & Li, Y. (2025) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2025.1626938 · Cited by 5

Probiotic VSL#3 alleviates intrahepatic cholestasis of pregnancy by upregulating farnesoid X receptor-fibroblast growth factor 15 through regulation of the gut microbiota

Zeng, Z., Li, H., Yang, W., Li, L., Ni, P., Chen, Q., Zhou, W., Peng, J. P., & Huang, L. (2025) · Journal of Reproductive Immunology · doi:10.1016/j.jri.2025.104653 · Cited by 5

Mitigative effect of natural resistant starch from kudzu on intestinal-hepatic injury in mice exposed to high-fat diet and dextran sulfate sodium

Dong, H., Zhu, F., Yang, M., Zhang, L., Liu, X., Zhang, H., Huang, Y., Zhu, W., & Xie, L. (2026) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2026.151338 · Cited by 5

Vegetable oil intake:The distinctive trilateral relationship of bile acid, gut microbiota and health

Lin, X., Wu, J., & Li, Z. (2025) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2025.105001 · Cited by 6

Geniposide induces hepatotoxicity via the bile acid-induced activation of NLRP3 inflammasome and regulation of the FXR/PERK/TXNIP pathway

Jin, Z., Cheng, S., Liu, B., Liu, Y., Wei, Y., Hao, X., & Li, H. (2025) · Toxicology Letters · doi:10.1016/j.toxlet.2025.111740 · Cited by 5

Dietary Resistant Starch Regulates Bile Acid Metabolism by Modulating the FXR/LRH-1 Signaling Pathway in Broilers

Wang, Z., Zhan, C., Zhang, Y., Zhang, L., Li, J., Xing, T., Zhao, L., Wang, J., & Gao, F. (2023) · Agriculture · doi:10.3390/agriculture13112159 · Cited by 5

Vertical sleeve gastrectomy improves glucose-insulin homeostasis by enhancing β-cell function and survival via FGF15/19

Soares, G. M., Balbo, S. L., Bronczek, G. A., Vettorazzi, J. F., Marmentini, C., Zangerolamo, L., Velloso, L. A., & Carneiro, E. M. (2023) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00218.2023 · Cited by 5

FXR Antagonist FLG249 Lowers Hepatic Triacylglycerol and Serum Cholesterol Level in High-Fat Diet-Induced Obese Mice

Iguchi, Y., Yamashita, Y., Gohda, K., Oda, K., Fujimori, K., Sera, Y., Imanaka, T., Yamaguchi, M., Une, M., & Teno, N. (2024) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.b24-00311 · Cited by 5

Chenodeoxycholic acid regulates fibroblast growth factor 23 gene expression via estrogen-related receptor γ in human hepatoma Huh7 cells

Fan, Y., Kim, H., Jung, Y. S., Na, S., Radhakrishnan, K., & Choi, H. (2023) · Steroids · doi:10.1016/j.steroids.2023.109257 · Cited by 5

Replacement of fish meal with full fat Hermetia illucens modulates hepatic FXR signaling in juvenile rainbow trout (Oncorhynchus mykiss): Exploring a potential role of ecdysteroids

Cocci, P., Angeletti, M., Mosconi, G., Olivotto, I., Zarantoniello, M., & Palermo, F. A. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e40302 · Cited by 4

Galactooligosaccharide-Metabolism-Related Genes of Bifidobacterium pseudocatenulatum Contribute to the Regulation of Glucose and Lipid Metabolism in Type 2 Diabetic Mice

Lin, G., Zhang, B., Qu, Z., Guo, M., Shang, K., Zhao, J., Li, H., & Wang, G. (2025) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.4c05616 · Cited by 4

Mendelian randomization analysis of blood metabolites and immune cell mediators in relation to GVHD and relapse

Yu, X., Chen, Y., Lei, L., Li, P., Lin, D., Shen, Y. H., Hou, C. J., Chen, J., Fan, Y., Jin, Y. C., et al. (2025) · BMC Medicine · doi:10.1186/s12916-025-04026-w · Cited by 4

Recent Advances in the Digestive, Metabolic and Therapeutic Effects of Farnesoid X Receptor and Fibroblast Growth Factor 19: From Cholesterol to Bile Acid Signaling

Ciaula, A. D., Bonfrate, L., Baj, J., Khalil, M., Garruti, G., Stellaard, F., Wang, H. H., Wang, D. Q. ‐., & Portincasa, P. (2022) · Nutrients · doi:10.3390/nu14234950 · Cited by 76

Bile Acids as Hormones: The FXR-FGF15/19 Pathway

Kliewer, S. A., & Mangelsdorf, D. J. (2015) · Digestive Diseases · doi:10.1159/000371670 · Cited by 424

Nuclear bile acid signaling through the farnesoid X receptor

Mazuy, C., Helleboid‐Chapman, A., Staels, B., & Lefèbvre, P. (2014) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-014-1805-y · Cited by 113

The Role of FGF19 and MALRD1 in Enterohepatic Bile Acid Signaling

Wang, L. X., Frey, M. R., & Kohli, R. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.799648 · Cited by 42

Endocrine Actions of Bile Acids Via Nuclear Receptors and FGFs

Inagaki, T., Choi, M., Mangelsdorf, D. J., & Kliewer, S. A. (2007) · The FASEB Journal · doi:10.1096/fasebj.21.5.a147-a