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Molecular Basis of Bile Acid-FXR-FGF15/19 Signaling Axis
Open accessAbstract
Bile acids (BAs) are a group of amphiphilic molecules consisting of a rigid steroid core attached to a hydroxyl group with a varying number, position, and orientation, and a hydrophilic side chain. While BAs act as detergents to solubilize lipophilic nutrients in the small intestine during digestion and absorption, they also act as hormones. Farnesoid X receptor (FXR) is a nuclear receptor that forms a heterodimer with retinoid X receptor α (RXRα), is activated by BAs in the enterohepatic circulation reabsorbed via transporters in the ileum and the colon, and plays a critical role in regulating gene expression involved in cholesterol, BA, and lipid metabolism in the liver. The FXR/RXRα heterodimer also exists in the distal ileum and regulates production of fibroblast growth factor (FGF) 15/FGF19, a hormone traveling via the enterohepatic circulation that activates hepatic FGF receptor 4 (FGFR4)-β-klotho receptor complex and regulates gene expression involved in cholesterol, BA, and lipid metabolism, as well as those regulating cell proliferation. Agonists for FXR and analogs for FGF15/19 are currently recognized as a promising therapeutic target for metabolic syndrome and cholestatic diseases.
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“these metabolites have emerged as important modulators of the MGB axis, functioning directly via BA receptors in the ENS and brain or indirectly via GLP-1 or the FXR-FGF15/19 axis (297, 319).”
From Signalling cognition: The gut microbiota and hypothalamic-pituitary-adrenal axis (2023) · cites this paper as [319]
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Metadata
- Authors
- Katafuchi, T., & Makishima, M.
- Affiliations
- Nihon University (JP)
- Corresponding author
- Katafuchi, Takeshi
- Venue
- International Journal of Molecular Sciences
- Publisher
- MDPI AG
- Published
- 2022-05-27
- Volume
- 23
- Issue
- 11
- Pages
- 6046
- ISSN
- 1422-0067 (ISSN-L)
- PMC
- PMC9181207
- OpenAlex
- W4281710331
- Cited by
- 193
- References
- 183
- Citations by year
- 2026: 69 · 2025: 52 · 2024: 38 · 2023: 25 · 2022: 9
- FWCI
- 3.81
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- International Journal of Molecular Sciences (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- Japan Society for the Promotion of Science KAKENHI (20K22746)
- Topics
- Health Sciences › Medicine › Oncology › Drug Transport and Resistance Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fibroblast Growth Factor Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Cholesterol and Lipid Metabolism
- Keywords
- bile acids, farnesoid X receptor, FGF receptor 4, β-Klotho, enterohepatic circulation, nuclear receptor signaling, retinoid X receptor alpha, bile acid metabolism, lipid metabolism, cholesterol metabolism, metabolic syndrome, FXR agonists
- MeSH terms
- Bile Acids and Salts, Cholesterol, Fibroblast Growth Factors, Liver, Signal Transduction, Receptors, Cytoplasmic and Nuclear
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