The DOI matches its Crossref record; 133 of the 133 references it cites were found in a registry or an index.
Benzo[a]pyrene—Environmental Occurrence, Human Exposure, and Mechanisms of Toxicity
Open accessAbstract
Benzo[a]pyrene (B[a]P) is the main representative of polycyclic aromatic hydrocarbons (PAHs), and has been repeatedly found in the air, surface water, soil, and sediments. It is present in cigarette smoke as well as in food products, especially when smoked and grilled. Human exposure to B[a]P is therefore common. Research shows growing evidence concerning toxic effects induced by this substance. This xenobiotic is metabolized by cytochrome P450 (CYP P450) to carcinogenic metabolite: 7β,8α-dihydroxy-9α,10α-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene (BPDE), which creates DNA adducts, causing mutations and malignant transformations. Moreover, B[a]P is epigenotoxic, neurotoxic, and teratogenic, and exhibits pro-oxidative potential and causes impairment of animals’ fertility. CYP P450 is strongly involved in B[a]P metabolism, and it is simultaneously expressed as a result of the association of B[a]P with aromatic hydrocarbon receptor (AhR), playing an essential role in the cancerogenic potential of various xenobiotics. In turn, polymorphism of CYP P450 genes determines the sensitivity of the organism to B[a]P. It was also observed that B[a]P facilitates the multiplication of viruses, which may be an additional problem with the widespread COVID-19 pandemic. Based on publications mainly from 2017 to 2022, this paper presents the occurrence of B[a]P in various environmental compartments and human surroundings, shows the exposure of humans to this substance, and describes the mechanisms of its toxicity.
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Cited by
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Bocheva, G., Slominski, R. M., & Slominski, A. T. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241310502 · Cited by 94
Kwong, H.-S., Paloni, M., Grandvuillemin, L., Sirounian, S., Ancelin, A., Lai-Kee-Him, J., Grimaldi, M., Carivenc, C., Lancey, C., Ragan, T. J., et al. (2024) · Journal of Molecular Biology · doi:10.1016/j.jmb.2023.168411 · Cited by 40
Metadata
- Authors
- Bukowska, B., Mokra, K., & Michałowicz, J.
- Venue
- International Journal of Molecular Sciences
- Publisher
- MDPI AG
- Published
- 2022-06-06
- Volume
- 23
- Issue
- 11
- Pages
- 6348
- ISSN
- 1422-0067 (ISSN-L)
- OpenAlex
- W4281742670
- Cited by
- 470
- References
- 133
- FWCI
- 30.54
- Type
- journal article
- Language
- en
- Open access
- gold
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