Suppression of LPS-induced tau hyperphosphorylation by serum amyloid A
Open accessAbstract
BACKGROUND: Accumulation of hyperphosphorylated tau is a major neuropathological feature of tauopathies including Alzheimer's disease (AD). Serum amyloid A (SAA), an acute-phase protein with cytokine-like property, has been implicated in amyloid deposition. It remains unclear whether SAA affects tau hyperphosphorylation. METHODS: Potential involvement of SAA in tau hyperphosphorylation was examined using intracerebral injection of SAA, and in Saa3 (-/-) mice receiving systemic administration of lipopolysaccharide (LPS). Induced SAA expression and microglial activation were evaluated in these mice using real-time PCR and/or immunofluorescence staining. Cultured primary neuronal cells were treated with condition media (CM) from SAA-stimulated primary microglial cells. The alteration in tau hyperphosphorylation was determined using Western blotting. RESULTS: Saa3 is the predominant form of SAA proteins induced by LPS in the mouse brain that co-localizes with neurons. Overexpression of SAA by intracerebral injection attenuated tau hyperphosphorylation in the brain. Conversely, Saa3 deficiency enhanced tau phosphorylation induced by systemic LPS administration. Intracerebral injection of SAA also induced the activation of microglia in the brains. IL-10 released to CM from SAA-stimulated microglia attenuated tau hyperphosphorylation in cultured primary neurons. IL-10 neutralizing antibody reversed the effect of SAA in the attenuation of tau phosphorylation. CONCLUSIONS: LPS-induced expression of SAA proteins in the brain leads to the activation of microglia and release of IL-10, which in turn suppresses tau hyperphosphorylation in a mouse model of systemic inflammation.
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Systemic administration of LPS leads to microglial activation in the mouse brain, which results in tau hyperphosphorylation at specific sites.
“Our and other studies found that systemic administration of lipopolysaccharide (LPS, inducer of inflammation) leads to microglial activation in the mouse brain, which results in tau hyperphosphorylation at specific sites [117, 118].”
From Tau and neuroinflammation in Alzheimer’s disease: interplay mechanisms and clinical translation (2023) · cites this paper as [117]
Overexpression of SAA by intracerebral injection attenuates tau hyperphosphorylation, and the mechanism is related to SAA-induced secretion of IL-10 from microglia.
“Overexpression of SAA by intracerebral injection attenuates tau hyperphosphorylation, and the mechanism is related to SAA-induced secretion of IL-10 from microglia [117].”
From Tau and neuroinflammation in Alzheimer’s disease: interplay mechanisms and clinical translation (2023) · cites this paper as [117]
Deficiency of serum amyloid A (SAA) enhances tau phosphorylation induced by systemic LPS administration.
“Our previous studies indicate that the deficiency of serum amyloid A (SAA), an acute-phase protein with cytokine-like properties, enhances tau phosphorylation induced by systemic LPS administration [117].”
From Tau and neuroinflammation in Alzheimer’s disease: interplay mechanisms and clinical translation (2023) · cites this paper as [117]
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Self-citation
- Authors
- Liu, J., Wang, D., Li, S.-Q., Yu, Y., & Ye, R. D.
- Affiliations
- Shanghai Jiao Tong University (CN)
- Corresponding author
- Yu, Yang
- Ye, Richard D.
- Venue
- Journal of Neuroinflammation
- Published
- 2016-02-02
- Volume
- 13
- Issue
- 1
- Pages
- 28-28
- ISSN
- 1742-2094 (ISSN-L)
- PMC
- PMC4736117
- OpenAlex
- W2257305614
- Cited by
- 58
- References
- 48
- Citations by year
- 2026: 4 · 2025: 6 · 2024: 7 · 2023: 4 · 2022: 7 · 2021: 5 · 2020: 10 · 2019: 7 · 2018: 5 · 2017: 3
- FWCI
- 4.03
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- Journal of Neuroinflammation (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- National Natural Science Foundation of China (31270941, 81200843, 81571027)
- National Basic Research Program of China (2012CB518001)
- the Specialized Research Fund for the Doctoral Program of Higher Education of China (20120073110069, 20120073120091)
- Universidade de Macau (CPG2015-00018-ICMS, SRG2015-00047-ICMS-QRCM)
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Life Sciences › Neuroscience › Neurology › Neurological Disease Mechanisms and Treatments
- Keywords
- serum amyloid A, serum amyloid A3, tau hyperphosphorylation, lipopolysaccharide, microglial activation, IL-10, neuroinflammation, Alzheimer's disease, tauopathy, acute phase proteins, intracerebral injection
- MeSH terms
- Serum Amyloid A Protein, Animals, Brain, Cells, Cultured, Dose-Response Relationship, Drug, Gene Expression Regulation, Lipopolysaccharides, Mice, Inbred C57BL, Mice, Transgenic, Microtubule-Associated Proteins, Neuroglia, Neurons, Phosphorylation, Cytokines, Interleukin-10, tau Proteins, Culture Media, Conditioned, Statistics, Nonparametric, Mice, Antibodies, Neutralizing
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