The DOI matches its Crossref record; 355 of the 356 references it cites were found in a registry or an index.
The Dual Role of Mesenchymal Stem Cells in Cancer Pathophysiology: Pro-Tumorigenic Effects versus Therapeutic Potential
Open accessAbstract
Mesenchymal stem/stromal cells (MSCs) are multipotent cells involved in numerous physiological events, including organogenesis, the maintenance of tissue homeostasis, regeneration, or tissue repair. MSCs are increasingly recognized as playing a major, dual, and complex role in cancer pathophysiology through their ability to limit or promote tumor progression. Indeed, these cells are known to interact with the tumor microenvironment, modulate the behavior of tumor cells, influence their functions, and promote distant metastasis formation through the secretion of mediators, the regulation of cell–cell interactions, and the modulation of the immune response. This dynamic network can lead to the establishment of immunoprivileged tissue niches or the formation of new tumors through the proliferation/differentiation of MSCs into cancer-associated fibroblasts as well as cancer stem cells. However, MSCs exhibit also therapeutic effects including anti-tumor, anti-proliferative, anti-inflammatory, or anti-oxidative effects. The therapeutic interest in MSCs is currently growing, mainly due to their ability to selectively migrate and penetrate tumor sites, which would make them relevant as vectors for advanced therapies. Therefore, this review aims to provide an overview of the double-edged sword implications of MSCs in tumor processes. The therapeutic potential of MSCs will be reviewed in melanoma and lung cancers.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The cited source says what the claim attributes to it.
In the citing paper
“The migration of MSC to the TME is regulated by numerous factors, including adhesion molecules (VCAM), chemokines (CCL2, CCL5, CCL22, CXCL8, and SDF-1/CXCL12), cytokines (IL-1, IL-6, TGF-β, and TNF-α), insulin GF (IGF-1), PDGF, hypoxia-inducible factor (HIF-1), reactive oxygen species (ROS), and many more [77].”
From Mesenchymal stromal cells in bone marrow niche of patients with multiple myeloma: a double-edged sword (2025) · cites this paper as [77]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
1 retracted
Items 201–355 of 355
Xu, M.-H., Gao, X., Luo, D., Zhou, X., Xiong, W., & Liu, G. (2014) · PLoS ONE · doi:10.1371/journal.pone.0087893 · Cited by 127
Zhao, J., Liu, P., Ma, J., Li, D., Yang, H., Chen, W., & Jiang, Y. (2019) · International Journal of Nanomedicine · doi:10.2147/ijn.s224160 · Cited by 126
Oncolytic virotherapy: Challenges and solutions
Goradel, N. H., Baker, A. T., Arashkia, A., Ebrahimi, N., Ghorghanlu, S., & Negahdari, B. (2020) · Current Problems in Cancer · doi:10.1016/j.currproblcancer.2020.100639 · Cited by 125
Mesenchymal stromal cells: misconceptions and evolving concepts
Phinney, D. G., & Sensebé, L. (2013) · Cytotherapy · doi:10.1016/j.jcyt.2012.11.005 · Cited by 125
Stromal Expression of MMP-13 Is Required for Melanoma Invasion and Metastasis
Zigrino, P., Kuhn, I., Bäuerle, T., Zamek, J., Fox, J. W., Neumann, S., Licht, A. H., Schorpp‐Kistner, M., Angel, P. E., & Mauch, C. (2009) · Journal of Investigative Dermatology · doi:10.1038/jid.2009.130 · Cited by 119
Recent discoveries concerning the tumor - mesenchymal stem cell interactions
Lazennec, G., & Lam, P. Y. (2016) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2016.10.004 · Cited by 117
Role of MSC in the Tumor Microenvironment
Hass, R. (2020) · Cancers · doi:10.3390/cancers12082107 · Cited by 116
Oncologic Trogocytosis of an Original Stromal Cells Induces Chemoresistance of Ovarian Tumours
Rafii, A., Mirshahi, P., Poupot, M., Faussat, A., Simon, A., Ducros, E., Mery-Lamarche, E., Couderc, B. C., Lis, R., Capdet, J., et al. (2008) · PLoS ONE · doi:10.1371/journal.pone.0003894 · Cited by 116
Poggi, A. D., Varesano, S., & Zocchi, M. R. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.00262 · Cited by 113
Lis, R., Touboul, C., Mirshahi, P., Ali, F., Mathew, S. A., Nolan, D. J., Maleki, M., Abdalla, S. A., Raynaud, C. M., Querleu, D., et al. (2010) · International Journal of Cancer · doi:10.1002/ijc.25619 · Cited by 111
Tumor-educated mesenchymal stem cells promote pro-metastatic phenotype
Hill, B. S., Pelagalli, A., Passaro, N., & Zannetti, A. (2017) · Oncotarget · doi:10.18632/oncotarget.20265 · Cited by 111
Isolation and characterisation of mesenchymal stem cells derived from human placenta tissue
Vellasamy, S. (2012) · World Journal of Stem Cells · doi:10.4252/wjsc.v4.i6.53 · Cited by 109
Frisbie, L. G., Buckanovich, R. J., & Coffman, L. G. (2022) · Stem Cells · doi:10.1093/stmcls/sxac036 · Cited by 107
Kwon, O.-J., Kang, E., Choi, J.-W., Kim, S. W., & Yun, C. (2013) · Journal of Controlled Release · doi:10.1016/j.jconrel.2013.03.030 · Cited by 106
Development of Novel Adenoviral Vectors to Overcome Challenges Observed With HAdV-5–based Constructs
Alonso-Padilla, J., Papp, T., Kaján, G. L., Benkő, M., Havenga, M. J. E., Lemckert, A. A. C., Harrach, B., & Baker, A. H. (2015) · Molecular Therapy · doi:10.1038/mt.2015.194 · Cited by 105
Mesenchymal stem cells in cancer progression and anticancer therapeutic resistance
Xuan, X., Tian, C., Zhao, M., Sun, Y., & Huang, C. (2021) · Cancer Cell International · doi:10.1186/s12935-021-02300-4 · Cited by 104
Isolation and Expansion of Mesenchymal Stem/Stromal Cells Derived from Human Placenta Tissue
Pelekanos, R., Sardesai, V. S., Futrega, K., Lott, W. B., Kuhn, M., & Doran, M. R. (2016) · Journal of Visualized Experiments · doi:10.3791/54204 · Cited by 103
Cancer-mediated adipose reversion promotes cancer cell migration via IL-6 and MCP-1
Fujisaki, K., Fujimoto, H., Sangai, T., Nagashima, T., Sakakibara, M., Shiina, N., Kuroda, M., Aoyagi, Y., & Miyazaki, M. (2015) · Breast Cancer Research and Treatment · doi:10.1007/s10549-015-3318-2 · Cited by 101
Mohr, A., Albarenque, S. M., Deedigan, L., Yu, R., Reidy, M., Fulda, S., & Zwacka, R. M. (2010) · Stem Cells · doi:10.1002/stem.533 · Cited by 100
Teng, I.-W., Hou, P., Lee, K., Chu, P., Yeh, K., Jin, V. X., Tseng, M., Tsai, S., Chang, Y., Wu, C., et al. (2011) · Cancer Research · doi:10.1158/0008-5472.can-10-3418 · Cited by 99
Multicolor Immunophenotyping: Human Immune System Hematopoiesis
Wood, B. L. (2004) · Methods in cell biology · doi:10.1016/s0091-679x(04)75023-2 · Cited by 99
Mueller, L. P., Luetzkendorf, J., Widder, M., Nerger, K., Caysa, H., & Mueller, T. (2010) · Cancer Gene Therapy · doi:10.1038/cgt.2010.68 · Cited by 98
Chen, Y., Teng, F. Y. H., & Tang, B. L. (2006) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-006-6019-5 · Cited by 98
Melzer, C., von der Ohe, J., & Hass, R. (2018) · Cell Communication and Signaling · doi:10.1186/s12964-018-0215-4 · Cited by 98
Tu, B., Zhu, J., Liu, S., Wang, L., Fan, Q., Hao, Y., Fan, C., & Tang, T.-T. (2016) · Oncotarget · doi:10.18632/oncotarget.10219 · Cited by 95
Zhao, X., Wu, X., Qian, M., Song, Y., Wu, D. L., & Zhang, W. (2018) · Cancer Letters · doi:10.1016/j.canlet.2018.04.026 · Cited by 94
Mirzaei, H., Sahebkar, A., Avan, A., Jaafari, M. R., Salehi, R., Salehi, H., Baharvand, H., Rezaei, A., Hadjati, J., Pawelek, J. M., et al. (2016) · Current Medicinal Chemistry · doi:10.2174/0929867323666151217122033 · Cited by 94
Mesenchymal Stem Cells Induce Directional Migration of Invasive Breast Cancer Cells through TGF-β
McAndrews, K. M., McGrail, D. J., Ravikumar, N., & Dawson, M. (2015) · Scientific Reports · doi:10.1038/srep16941 · Cited by 93
Matrix metalloproteinase expression in breast cancer
Bartsch, J. E., Staren, E. D., & Appert, H. E. (2003) · Journal of Surgical Research · doi:10.1016/s0022-4804(03)00007-6 · Cited by 93
The Emerging Roles of Pericytes in Modulating Tumor Microenvironment
Sun, R., Kong, X., Qiu, X., Huang, C., & Wong, P. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.676342 · Cited by 92
Mesenchymal stem cell-released oncolytic virus: an innovative strategy for cancer treatment
Darestani, N. G., Rudova, A., Al-Gazally, M. E., Zekiy, A. O., Ansari, M. J., Zabibah, R. S., Jawad, M. A., Al-Shalah, S. A. J., Rizaev, J. A., Alnassar, Y. S., et al. (2023) · Cell Communication and Signaling · doi:10.1186/s12964-022-01012-0 · Cited by 92
Khan, K. A., Naylor, A. J., Khan, A. O., Noy, P. J., Mambretti, M., Lodhia, P., Athwal, J., Korzystka, A., Buckley, C. D., Willcox, B. E., et al. (2017) · Oncogene · doi:10.1038/onc.2017.214 · Cited by 91
Krueger, T. E. G., Thorek, D. L. J., Meeker, A. K., Isaacs, J. T., & Brennen, W. N. (2018) · The Prostate · doi:10.1002/pros.23738 · Cited by 90
The Immunomodulatory Effects of Mesenchymal Stem Cells on Regulatory B Cells
Liu, J., Liu, Q., & Chen, X. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.01843 · Cited by 88
Dual function of perivascular fibroblasts in vascular stabilization in zebrafish
Rajan, A. M., Ma, R. C., Kocha, K. M., Zhang, D. J., & Huang, P. (2020) · PLoS Genetics · doi:10.1371/journal.pgen.1008800 · Cited by 87
Yang, Y., Otte, A., & Hass, R. (2014) · Stem Cells and Development · doi:10.1089/scd.2014.0413 · Cited by 87
Brady, J. J., Neal, J., Sadakar, N., & Gasque, P. (2004) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/63.12.1274 · Cited by 86
Self-citationLi, S.-W., Huang, K.-J., Wu, J., Hu, M. S.-M., Sanyal, M., Hu, M., Longaker, M. T., & Lorenz, H. P. (2015) · Stem Cells Translational Medicine · doi:10.5966/sctm.2014-0150 · Cited by 86
Zhang, T., Huang, B. Y., Wu, H., Wu, J., Li, L., Li, Y.-X., Hu, Y., Han, M. Y., Shen, Y., Tabata, Y., et al. (2015) · Journal of Controlled Release · doi:10.1016/j.jconrel.2015.05.007 · Cited by 85
Naderi, E. H., Skah, S., Ugland, H. G., Myklebost, O., Sandnes, D., Torgersen, M. L., Josefsen, D., Ruud, E., Naderi, S., & Blomhoff, H. K. (2015) · Molecular Cancer · doi:10.1186/s12943-014-0278-9 · Cited by 85
Ovarian Carcinoma-Associated Mesenchymal Stem Cells Arise from Tissue-Specific Normal Stroma
Coffman, L. G., Pearson, A. T., Frisbie, L. G., Freeman, Z. T., Christie, E. L., Bowtell, D. D. L., & Buckanovich, R. J. (2018) · Stem Cells · doi:10.1002/stem.2932 · Cited by 83
NF-κB Activity Regulates Mesenchymal Stem Cell Accumulation at Tumor Sites
Uchibori, R., Tsukahara, T., Mizuguchi, H., Saga, Y., Urabe, M., Mizukami, H., Kume, A., & Ozawa, K. (2012) · Cancer Research · doi:10.1158/0008-5472.can-12-0088 · Cited by 83
Miklikova, S., Matúšková, M., Boháč, M., Toro, L., Durinikova, E., Tyčiaková, S., Demková, L., Gurský, J., & Kučerová, L. (2016) · Cell Communication and Signaling · doi:10.1186/s12964-016-0127-0 · Cited by 82
Gallo, M., Luca, A. D., Lamura, L., & Normanno, N. (2011) · Annals of Oncology · doi:10.1093/annonc/mdr159 · Cited by 81
Zhang, T., Huang, B. Y., Yuan, Z., Hu, Y., Tabata, Y., & Gao, J. (2013) · Nanomedicine Nanotechnology Biology and Medicine · doi:10.1016/j.nano.2013.06.003 · Cited by 81
Targeting FSTL1 Prevents Tumor Bone Metastasis and Consequent Immune Dysfunction
Kudo‐Saito, C., Fuwa, T., Murakami, K., & Kawakami, Y. (2013) · Cancer Research · doi:10.1158/0008-5472.can-13-1364 · Cited by 80
Wu, X., Liu, Y., Wang, G., Xu, X., Cai, Y., Wang, H., Li, Y., Meng, H., Dai, F., & Jin, J.-D. (2016) · Scientific Reports · doi:10.1038/srep21420 · Cited by 79
Liver-derived human mesenchymal stem cells: a novel therapeutic source for liver diseases
Wang, Y., Yu, X., Chen, E., & Li, L. (2016) · Stem Cell Research & Therapy · doi:10.1186/s13287-016-0330-3 · Cited by 77
Lecourt, S., Marolleau, J., Fromigué, O., Vauchez, K., Andriamanalijaona, R., Ternaux, B., Lacassagne, M.-N., Robert, I., Boumédiene, K., Chéreau, F., et al. (2010) · Experimental Cell Research · doi:10.1016/j.yexcr.2010.04.020 · Cited by 77
Hassan, G., Kasem, I., Soukkarieh, C., & Aljamali, M. N. (2017) · International Journal of Stem Cells · doi:10.15283/ijsc17028 · Cited by 77
Han, Z., Tian, Z., Lv, G., Zhang, L., Jiang, G., Sun, K., Wang, C., Bu, X., Li, R., Shi, Y., et al. (2010) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2010.01215.x · Cited by 76
Dubon, M. J., Yu, J., Choi, S., & Park, K. (2018) · Journal of Cellular Physiology · doi:10.1002/jcp.25863 · Cited by 76
Dreuw, A., Hermanns, H. M., Heise, R., Joussen, S., Rodríguez, F., Marquardt, Y., Jugert, F. K., Merk, H. F., Heinrich, P. C., & Baron, J. M. (2005) · Journal of Investigative Dermatology · doi:10.1111/j.0022-202x.2004.23499.x · Cited by 76
Swamydas, M., Ricci, K., Rego, S. L., & Dréau, D. (2013) · Cell Adhesion & Migration · doi:10.4161/cam.25138 · Cited by 76
Reciprocal modulation of mesenchymal stem cells and tumor cells promotes lung cancer metastasis
Fregni, G., Quinodoz, M., Möller, E., Vuille, J. A., Galland, S., Fusco, C., Martin, P., Letovanec, I., Provero, P., Rivolta, C., et al. (2018) · EBioMedicine · doi:10.1016/j.ebiom.2018.02.017 · Cited by 75
The importance of being CAFs (in cancer resistance to targeted therapies)
Rizzolio, S., Giordano, S., & Corso, S. (2022) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-022-02524-w · Cited by 75
The Perivascular Niche and Self-Renewal of Stem Cells
Oh, M., & Nor, J. E. (2015) · Frontiers in Physiology · doi:10.3389/fphys.2015.00367 · Cited by 75
Mesenchymal stem cells promote tumor angiogenesis via the action of transforming growth factor β1
LI, G.-C., ZHANG, H.-W., ZHAO, Q.-C., SUN, L., YANG, J.-J., HONG, L., FENG, F., & CAI, L. (2016) · Oncology Letters · doi:10.3892/ol.2015.3997 · Cited by 72
Correa, D., Somoza, R. A., Lin, P. Y., Schiemann, W. P., & Caplan, A. I. (2015) · International Journal of Cancer · doi:10.1002/ijc.29709 · Cited by 72
O’Malley, G., Heijltjes, M. T., Houston, A. M., Rani, S., Ritter, T., Egan, L. J., & Ryan, A. E. (2016) · Oncotarget · doi:10.18632/oncotarget.11354 · Cited by 72
CD248: A therapeutic target in cancer and fibrotic diseases
Teicher, B. A. (2019) · Oncotarget · doi:10.18632/oncotarget.26590 · Cited by 72
Overall survival in patients with metastatic melanoma
Song, X., Zhao, Z., Barber, B., Farr, A. M., Ivanov, B., & Novich, M. (2015) · Current Medical Research and Opinion · doi:10.1185/03007995.2015.1021904 · Cited by 71
Mesenchymal stem cells isolated from peripheral blood and umbilical cord Wharton’s jelly
Trivanović, D. I., Kocić, J., Mojsilović, S. B., Krstić, J., Ilić, V. L., Djordjević, I. O., Santibanez, J. F., Jovčić, G., Terzić, M., & Bugarski, D. S. (2013) · Srpski arhiv za celokupno lekarstvo · doi:10.2298/sarh1304178t · Cited by 71
Abbasi, B., Shamsasenjan, K., Ahmadi, M., Beheshti, S. A., & Saleh, M. (2022) · Stem Cell Research & Therapy · doi:10.1186/s13287-022-02777-4 · Cited by 70
Miyazaki, Y., Oda, T., Inagaki, Y., Kushige, H., Saitō, Y., Mori, N., Takayama, Y., Kumagai, Y., Mitsuyama, T., & Kida, Y. S. (2021) · Scientific Reports · doi:10.1038/s41598-021-84058-3 · Cited by 70
Cell Surface Markers for Mesenchymal Stem Cells: A Scoping Review
Fonseca, L. N., Bolívar-Moná, S., Agudelo, T., Beltran-Medina, L. D., Camargo, D., Correa, N. F., del Castillo-Forero, A., de Castro, S. F., Reina, V. F., García, G., et al. (2022) · Heliyon · doi:10.1016/j.heliyon.2023.e13464 · Cited by 70
The Role of MSCs in the Tumor Microenvironment and Tumor Progression
Ahn, S. Y. (2020) · Anticancer Research · doi:10.21873/anticanres.14284 · Cited by 70
Rodini, C. O., da Silva, P. B. G., Assoni, A. F., Carvalho, V. M., & Okamoto, O. K. (2018) · Oncotarget · doi:10.18632/oncotarget.25346 · Cited by 70
Proinflammatory Cytokine Effects on Mesenchymal Stem Cell Therapy for the Ischemic Heart
Abarbanell, A. M., Coffey, A. C., Fehrenbacher, J. W., Beckman, D. J., Herrmann, J. L., Weil, B. R., & Meldrum, D. R. (2009) · The Annals of Thoracic Surgery · doi:10.1016/j.athoracsur.2009.02.093 · Cited by 69
Moniri, M. R., Sun, X.-Y., Rayat, J., Dai, D., Ao, Z., He, Z., Verchere, C. B., Dai, L.-J., & Warnock, G. L. (2012) · Cancer Gene Therapy · doi:10.1038/cgt.2012.46 · Cited by 68
Human adipose tissue-derived mesenchymal stem cells inhibit melanoma growth in vitro and in vivo.
Ahn, J., Coh, Y.-R., Lee, H. W., Shin, I.-S., Kang, S., & Youn, H. (2015) · PubMed · Cited by 68
Mesenchymal Stem Cell: A Friend or Foe in Anti-Tumor Immunity
Harrell, C. R., Volarevic, A., Djonov, V. G., Jovicic, N., & Volarevic, V. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222212429 · Cited by 67
Ah-Pine, F., Khettab, M., Bedoui, Y., Slama, Y., Daniel, M., Doray, B., & Gasque, P. (2023) · Acta Neuropathologica Communications · doi:10.1186/s40478-023-01605-x · Cited by 66
Self-citationYao, S., Li, X., Liu, J., Sun, Y., Wang, Z., & Jiang, Y. (2017) · Drug Delivery · doi:10.1080/10717544.2017.1375580 · Cited by 66
Ahn, J. O., Lee, H. W., Seo, K., Kang, S. K., Ra, J. C., & Youn, H. Y. (2013) · PLoS ONE · doi:10.1371/journal.pone.0074897 · Cited by 65
Pradier, A., Passweg, J. R., Villard, J., & Kindler, V. (2010) · Cell Transplantation · doi:10.3727/096368910x536545 · Cited by 65
Kazimirsky, G., Jiang, W., Slavin, S., Ziv-Av, A., & Brodie, C. (2016) · Stem Cell Research & Therapy · doi:10.1186/s13287-016-0414-0 · Cited by 65
Béchet, D., Auger, F., Couleaud, P., Marty, E., Ravasi, L., Durieux, N., Bonnet, C., Plénat, F., Frochot, C., Mordon, S. R., et al. (2015) · Nanomedicine Nanotechnology Biology and Medicine · doi:10.1016/j.nano.2014.12.007 · Cited by 64
Jeon, E. S., Heo, S. C., Lee, I. H., Choi, Y. J., Park, J., Choi, K. U., Park, D. Y., Suh, D. S., Yoon, M., & Kim, J. H. (2010) · Experimental & Molecular Medicine · doi:10.3858/emm.2010.42.4.027 · Cited by 64
Mesenchymal Stromal Cells Can Regulate the Immune Response in the Tumor Microenvironment
Poggi, A. D., & Giuliani, M. (2016) · Vaccines · doi:10.3390/vaccines4040041 · Cited by 64
Cancer Stem Cells: Powerful Targets to Improve Current Anticancer Therapeutics
Bighetti‐Trevisan, R. L., Sousa, L. O., CASTILHO, R. M., & Almeida, L. O. (2019) · Stem Cells International · doi:10.1155/2019/9618065 · Cited by 64
Jia, X.-H., Feng, G.-W., Wang, Z.-L., Du, Y., Shen, C., Hui, H., Peng, D., Li, Z.-J., Kong, D.-L., & Tian, J. (2016) · Oncotarget · doi:10.18632/oncotarget.8064 · Cited by 62
Bone Marrow–Derived Mesenchymal Stromal Cells Promote Survival and Drug Resistance in Tumor Cells
Bergfeld, S. A., Blavier, L., & DeClerck, Y. A. (2014) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-13-0400 · Cited by 62
Li, J., Deng, Z., Wang, Z., Wang, D., Zhang, L., Su, Q., Lai, Y., Ли, Б., Luo, Z., Xu, C., et al. (2015) · Oncotarget · doi:10.18632/oncotarget.3200 · Cited by 62
Engineered Mesenchymal Stem Cells as an Anti-Cancer Trojan Horse
Nowakowski, A., Drela, K., Rozycka, J., Janowski, M., & Łukomska, B. (2016) · Stem Cells and Development · doi:10.1089/scd.2016.0120 · Cited by 61
Gu, H., Yan, C., Wan, H., Wu, L., Liu, J., Zhu, Z., & Gao, D.-Z. (2021) · Human Cell · doi:10.1007/s13577-021-00599-9 · Cited by 60
Beeravolu, N., McKee, C., Alamri, A. S. M., Mikhael, S., Brown, C., Perez-Cruet, M. J., & Chaudhry, G. R. (2017) · Journal of Visualized Experiments · doi:10.3791/55224-v · Cited by 60
Yao, Y., Li, P., He, J., Wang, D., Hu, J., & Yang, X. (2021) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.1c05669 · Cited by 59
Pawitan, J. A., Bùi, T. A., Mubarok, W., Antarianto, R. D., Nurhayati, R. W., Dilogo, I. H., & Oceandy, D. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.587776 · Cited by 59
Petitprez, F., Sun, C., Lacroix, L., Sautès‐Fridman, C., de Reyniès, A., & Fridman, W. H. (2018) · Frontiers in Oncology · doi:10.3389/fonc.2018.00390 · Cited by 58
Oncolytic (replication-competent) adenoviruses as anticancer agents
Tóth, K., Dhar, D., & Wold, W. S. M. (2010) · Expert Opinion on Biological Therapy · doi:10.1517/14712590903559822 · Cited by 57
Kuroda, H., Jamiyan, T., Yamaguchi, R., Kakumoto, A., Abe, A., Harada, O., Enkhbat, B., & Masunaga, A. (2021) · Breast Cancer · doi:10.1007/s12282-021-01227-y · Cited by 57
Xue, Z., Wu, X., Chen, X., Liu, Y., Wang, X., Wu, K., Nie, Y., & Fan, D. (2014) · Journal of Cellular Biochemistry · doi:10.1002/jcb.25013 · Cited by 57
Wu, T., Liu, Y. F., Fan, Z., Xu, J., Jin, L., Gao, Z., Wu, Z., Hu, L., Wang, J., Zhang, C., et al. (2015) · Stem Cells · doi:10.1002/stem.2081 · Cited by 56
Rossignoli, F., Spano, C., Grisendi, G., Foppiani, E. M., Golinelli, G., Mastrolia, I., Bestagno, M., Candini, O., Petrachi, T., Recchia, A., et al. (2019) · Theranostics · doi:10.7150/thno.27576 · Cited by 55
Chen, M.-S., Lin, C., Chiu, Y.-H., Chen, C., Tsai, P., & Wang, H.-S. (2018) · Stem Cells International · doi:10.1155/2018/3524759 · Cited by 54
Mechanisms of measles virus oncolytic immunotherapy
Pidelaserra-Martí, G., & Engeland, C. E. (2020) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2020.07.009 · Cited by 53
Song, D., Jia, X., Liu, X., Hu, L., Lin, K., Xiao, T., Qiao, Y., Zhang, J., Jia, D., Wong, C.-W., et al. (2022) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-022-00921-3 · Cited by 53
Papait, A., Stefani, F. R., Cargnoni, A., Magatti, M., Parolini, O., & Silini, A. R. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.00447 · Cited by 52
Enhanced Invasion of Metastatic Cancer Cells via Extracellular Matrix Interface
Zhu, J., Liang, L., Jiao, Y., Liu, L., & on behalf of the U.S.-China Physical Sciences-Oncology Alliance (2015) · PLoS ONE · doi:10.1371/journal.pone.0118058 · Cited by 52
McGuire, J., Frieling, J. S., Lo, C. H., Li, T., Muhammad, A., Lawrence, H. R., Lawrence, N. J., Cook, L. M., & Lynch, C. C. (2021) · Nature Communications · doi:10.1038/s41467-021-20962-6 · Cited by 52
Harnessing mesenchymal stem cell homing as an anticancer therapy
Hagenhoff, A., Bruns, C. J., Zhao, Y., von Lüttichau, I., Nieß, H., Spitzweg, C., & Nelson, P. J. (2016) · Expert Opinion on Biological Therapy · doi:10.1080/14712598.2016.1196179 · Cited by 51
Hayashi, Y., Tsujii, M., Kodama, T., Akasaka, T., Kondo, J., Hikita, H., Inoue, T., Tsujii, Y., Maekawa, A., Yoshii, S., et al. (2016) · Carcinogenesis · doi:10.1093/carcin/bgw085 · Cited by 51
Guo, V. Y., Chan, K., Lai, W., Siu, C., Kwan, S.-C., Tse, H., Ho, P. W., & Ho, J. W.-M. (2013) · NeuroImmunoModulation · doi:10.1159/000351450 · Cited by 51
Mesenchymal stem cells as delivery vectors for anti-tumor therapy.
Li, Z., Fan, D., & Xiong, D. (2015) · Europe PMC (PubMed Central) · doi:10.3978/j.issn.2306-9759.2015.03.01 · Cited by 51
Recent progress in the research of suicide gene therapy for malignant glioma
Tamura, R., Miyoshi, H., Yoshida, K., Okano, H., & Toda, M. (2019) · Neurosurgical Review · doi:10.1007/s10143-019-01203-3 · Cited by 50
Jothimani, G., Pathak, S., Dutta, S., Duttaroy, A. K., & Banerjee, A. (2022) · Tissue Engineering and Regenerative Medicine · doi:10.1007/s13770-022-00450-8 · Cited by 50
Zhang, J., Ji, C., Li, W., Mao, Z., Shi, Y., Shi, H., Ji, R., Qian, H., Xu, W., & Zhang, X. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.00788 · Cited by 49
Xiao, J., Zeng, L., Ding, S., Chen, Y., Zhang, X., Bian, X., & Tian, G. (2022) · Advanced Healthcare Materials · doi:10.1002/adhm.202200143 · Cited by 48
Host effects contributing to cancer therapy resistance.
Katz, O. B., & Shaked, Y. (2015) · Drug Resistance Updates · doi:10.1016/j.drup.2014.12.002 · Cited by 47
Loussouarn, C., Pers, Y., Bony, C., Jørgensen, C., & Noël, D. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.623973 · Cited by 47
Gu, J., Hoj, J. P., Rouse, C., & Pendergast, A. M. (2020) · PLoS ONE · doi:10.1371/journal.pone.0241423 · Cited by 47
Watt, S. M., Gilmore, D. J., Davis, J. M., Clark, M., & Waldmann, H. (1987) · Molecular and Cellular Probes · doi:10.1016/0890-8508(87)90013-2 · Cited by 46
Huang, R.-Y., Lin, Y.-H., Lin, S.-Y., Li, Y., Chiang, C., & Chang, C. (2019) · Theranostics · doi:10.7150/thno.29326 · Cited by 45
Gazdic, M., Marković, B. S., Jovicic, N. U., Misirkic-Marjanovic, M., Djonov, V., Jakovljevic, V. L., Arsenijević, N., Lukić, M. L., & Volarević, V. (2017) · Stem Cells International · doi:10.1155/2017/6294717 · Cited by 44
Ando, M., Hoyos, V., Yagyu, S., Tao, W., Ramos, C. A., Dotti, G., Brenner, M. K., & Bouchier‐Hayes, L. (2014) · Cancer Gene Therapy · doi:10.1038/cgt.2014.53 · Cited by 44
Griffiths, M., Botto, M., Morgan, B. P., Neal, J., & Gasque, P. (2018) · Immunology · doi:10.1111/imm.12974 · Cited by 43
Self-citationTyčiaková, S., Matúšková, M., Bohovic, R., Poláková, K., Toro, L., Miklikova, S., & Kučerová, L. (2015) · The Journal of Gene Medicine · doi:10.1002/jgm.2823 · Cited by 42
Seo, K., Lee, H. W., Oh, Y., Ahn, J., Koh, Y., Oh, S., Kang, S.-K., & Youn, H. (2011) · Cytotherapy · doi:10.3109/14653249.2011.584864 · Cited by 42
Hu, Y., Jiang, Y., Behnan, J., Ribeiro, M. M., Kalantzi, C., Zhang, M.-D., Lou, D., Häring, M., Sharma, N., Okawa, S., et al. (2022) · Science Advances · doi:10.1126/sciadv.abm6340 · Cited by 40
Programming of the Development of Tumor-Promoting Neutrophils by Mesenchymal Stromal Cells
Hu, X., Zhou, Y., Dong, K., Sun, Z., Zhao, D., Wang, W., Yu, G., Liu, W., Xu, G., Han, Z., et al. (2014) · Cellular Physiology and Biochemistry · doi:10.1159/000362959 · Cited by 40
Heřmánková, B., Zajı́cová, A., Javorková, E., Chudíčková, M., Trošan, P., Hájková, M., Krulová, M., & Holáň, V. (2015) · Immunobiology · doi:10.1016/j.imbio.2015.09.017 · Cited by 39
Keshavarz, M., Miri, S. M., Behboudi, E., Arjeini, Y., Dianat‐Moghadam, H., & Ghaemi, A. (2022) · International Immunopharmacology · doi:10.1016/j.intimp.2022.108882 · Cited by 39
Mesenchymal stem cell-based NK4 gene therapy in nude mice bearing gastric cancer xenografts
Zhu, Cheng, M., Yang, Z., Zeng, C., Chen, J., Xie, Y., Luo, S., Zhang, K., Zhou, S.-F., & Lv, N. (2014) · Drug Design, Development and Therapy · doi:10.2147/dddt.s71466 · Cited by 38
Guiho, R., Biteau, K., Grisendi, G., Taurelle, J., Chatelais, M., Gantier, M., Heymann, D., Dominici, M., & Redini, F. (2016) · International Journal of Cancer · doi:10.1002/ijc.30402 · Cited by 38
Pei, J., Park, I.-H., Ryu, H., Li, S.-Y., Li, C., Lim, S.-H., Wen, M., Jang, W., & Jung, S. (2015) · Radiation Oncology · doi:10.1186/s13014-015-0475-8 · Cited by 37
Yang, P., Hsieh, Y., Du, J.-L., Yen, S.-C., & Hung, C. (2020) · Biomolecules · doi:10.3390/biom10040643 · Cited by 36
Growth‐inhibitory activity of interferon‐beta against human colorectal carcinoma cell lines
Wong, V. L. Y., Rieman, D. J., Aronson, L., Dalton, B. J., GREIG, R. G., & Anzano, M. A. (1989) · International Journal of Cancer · doi:10.1002/ijc.2910430331 · Cited by 35
Zhang, J., Chen, H., Chen, C., Liu, H., He, Y., Zhao, J., Yang, P., Mao, Q., & Xia, H. (2021) · Cancer Letters · doi:10.1016/j.canlet.2021.03.027 · Cited by 35
Wang, W., Wang, Q., Huang, D., Sun, Q.-K., Wu, S., Zhao, Y., Jia, W., Hu, D., & He, Y. (2021) · Cancer Letters · doi:10.1016/j.canlet.2021.01.011 · Cited by 34
Eiró, N., Fraile, M., Fernández-Francos, S., Sánchez, R., Costa, L. A., & Vizoso, F. J. (2021) · Cell & Bioscience · doi:10.1186/s13578-021-00620-6 · Cited by 33
Mesenchymal Stem Cells as Vectors for Lung Cancer Therapy
Kolluri, K. K., Laurent, G. J., & Janes, S. M. (2013) · Respiration · doi:10.1159/000351284 · Cited by 31
Zhou, B., Zhuang, X., Wang, Y., Lin, Z., Zhang, D., Fan, S., Li, J., & Chen, W. (2015) · Oral Oncology · doi:10.1016/j.oraloncology.2015.08.017 · Cited by 31
HIF-1α Promotes A Hypoxia-Independent Cell Migration
Li, L., Madu, C. O., Lu, A., & Lu, Y. W. (2010) · The Open Biology Journal · doi:10.2174/18741967010030100008 · Cited by 31
Taipale, K., Liikanen, I., Juhila, J., Turkki, R., Tähtinen, S., Kankainen, M., Vassilev, L., Ristimaki, A. P., Koski, A., Kanerva, A., et al. (2015) · Molecular Therapy · doi:10.1038/mt.2015.143 · Cited by 29
Guo, S., Huang, C., Han, F., Chen, B., Ding, Y., Zhao, Y., Chen, Z., Wen, S., Wang, M., Shen, B., et al. (2021) · Stem Cells International · doi:10.1155/2021/9989790 · Cited by 28
Perivascular Mesenchymal Stem/Stromal Cells, an Immune Privileged Niche for Viruses?
Lebeau, G., Ah-Pine, F., Daniel, M., Bedoui, Y., Vagner, D., Frumence, É., & Gasque, P. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23148038 · Cited by 25
Self-citationIsolation and Expansion of Mesenchymal Stem/Stromal Cells Derived from Human Placenta Tissue
Pelekanos, R., Sardesai, V. S., Futrega, K., Lott, W. B., Kuhn, M., & Doran, M. R. (2016) · Journal of Visualized Experiments · doi:10.3791/54204-v · Cited by 25
Li, S., Han, Y., Lu, M., Liu, Z., Jin, J., Guo, Q., Wang, Y., & Liu, H. (2022) · Journal of Oral Pathology and Medicine · doi:10.1111/jop.13321 · Cited by 24
Maintaining and Loading Neural Stem Cells for Delivery of Oncolytic Adenovirus to Brain Tumors
Ahmed, A. U., Ulasov, I. V., Mercer, R. W., & Lesniak, M. S. (2011) · Methods in molecular biology · doi:10.1007/978-1-61779-340-0_8 · Cited by 24
Ah-Pine, F., Septembre‐Malaterre, A., Bedoui, Y., Khettab, M., Neal, J., Freppel, S., & Gasque, P. (2023) · Cancers · doi:10.3390/cancers15092647 · Cited by 23
Self-citationSzewc, M., Radzikowska-Büchner, E., Wdowiak, P., Kozak, J., Kuszta, P., Niezabitowska, E., Matysiak, J., Kubiński, K., & Masłyk, M. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23052745 · Cited by 23
Mesenchymal Stem Cells Engineered by Nonviral Vectors: A Powerful Tool in Cancer Gene Therapy
Ding, Y., Wang, C., Sun, Z., Wu, Y., You, W., Mao, Z., & Wang, W. (2021) · Pharmaceutics · doi:10.3390/pharmaceutics13060913 · Cited by 23
Wagner, V. P., Martins, M. A. T., Martins, M. D., Warner, K. A., Webber, L. P., SQUARIZE, C. H., Nor, J. E., & CASTILHO, R. M. (2016) · Oncotarget · doi:10.18632/oncotarget.12195 · Cited by 23
IFNβ Is a Potent Adjuvant for Cancer Vaccination Strategies
Audsley, K. M., Wagner, T., Ta, C., Newnes, H. V., Buzzai, A. C., Barnes, S. A., Wylie, B., Armitage, J. D., Kaisho, T., Bosco, A., et al. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.735133 · Cited by 22
Bagheri‐Mohammadi, S., Tehrani, R. M., Noureddini, M., & Alani, B. (2020) · Biologicals · doi:10.1016/j.biologicals.2020.09.004 · Cited by 20
Kodet, O., Kučera, J., Strnadová, K., Dvořánková, B., Štork, J., Lacina, L., & Smetana, K. (2020) · International Journal of Oncology · doi:10.3892/ijo.2020.5090 · Cited by 20
Isolation and Culture of Mesenchymal Stem Cells from Mouse Compact Bone
Short, B., & Wagey, R. (2012) · Methods in molecular biology · doi:10.1007/978-1-62703-128-8_21 · Cited by 20
Combinatorial targeting of cancer bone metastasis using mRNA engineered stem cells
Ségaliny, A. I., Cheng, J. L., Farhoodi, H. P., Toledano, M., Yu, C. C., Tierra, B. A., Hildebrand, L., Liu, L., Liao, M. J., Cho, J., et al. (2019) · EBioMedicine · doi:10.1016/j.ebiom.2019.06.047 · Cited by 19
Role of macrophages in progression of colorectal cancer: a contrast with the traditional paradigm.
Konstantinov, A., Kovaleva, O. V., Samoilova, D. V., & Shelekhova, K. V. (2022) · PubMed · Cited by 19
(2020) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-37184-5 · Cited by 17
Çakır, U., Hajdara, A., Széky, B., Mayer, B., Kárpáti, S., Mezey, É., Silló, P., Szakács, G., Füredi, A., Pós, Z., et al. (2021) · Cancers · doi:10.3390/cancers13246173 · Cited by 12
Cutaneous Melanoma, 4th Edition
Balch, C. M., Houghton, A. N., Sober, A. J., & Soong, S.-J. (2005) · Dermatologic Surgery · doi:10.2310/6350.2005.31316 · Cited by 8
Петров, В. Н., Isaeva, E. V., Ul’yanenko, S. E., Beketov, E. E., Yatsenko, E. M., Sayapina, E. V., Лепехина, Л. А., Nasedkina, N., Grivtsova, L. Y., & Каприн, А. Д. (2020) · Bulletin of Experimental Biology and Medicine · doi:10.1007/s10517-020-04753-5 · Cited by 6
Nanoparticle-Based Radiosensitizers in Radiotherapy Applications
Cihan, Y. B. (2020) · Cancer Biotherapy and Radiopharmaceuticals · doi:10.1089/cbr.2020.4211 · Cited by 2
Flagged first, then by citations
1 of the 356 references couldn’t be matched to a known paper.
Research works printed but not linked: 1
- Birbrair, A. (2020). Tumor Microenvironment: Non-Hematopoietic Cells, Springer International Publishing. Advances in Experimental Medicine and Biology. · DOI
Cited by
Sorted by citations
Minev, T., Balbuena, S., Gill, J. M., Marincola, F. M., Kesari, S., & Lin, F. (2024) · Oncotarget · doi:10.18632/oncotarget.28672 · Cited by 34
Hoseinzadeh, A., Esmaeili, S., Sahebi, R., Melak, A. M., Mahmoudi, M., Hasannia, M., & Baharlou, R. (2025) · Stem Cell Research & Therapy · doi:10.1186/s13287-025-04158-z · Cited by 36
The Tumor Stroma of Squamous Cell Carcinoma: A Complex Environment That Fuels Cancer Progression
Buruiană, A., Gheban, B., Gheban-Roşca, I. A., Georgiu, C., Crișan, D., & Crişan, M. (2024) · Cancers · doi:10.3390/cancers16091727 · Cited by 32
Kamrani, S., Naseramini, R., Khani, P., Razavi, Z. S., Afkhami, H., Atashzar, M. R., Nasri, F., Alavimanesh, S., Saeidi, F., & Ronaghi, H. (2025) · Cancer Cell International · doi:10.1186/s12935-025-03741-x · Cited by 27
“…of MSC to the TME is regulated by numerous factors, including adhesion molecules (VCAM), chemokines (CCL2, CCL5, CCL22, CXCL8, and SDF-1/CXCL12), cytokines (IL-1, IL-6, TGF-β, and TNF-α), insulin GF (IGF-1), PDGF, hypoxia-inducible factor (HIF-1), reactive oxygen species (ROS), and many more [77].”
Radandish, M., Mashhadi, N., Aghayan, A. H., Taghizadeh, M., Salehianfard, S., Yahyazadeh, S., Vakili, O., & Igder, S. (2025) · Experimental Hematology and Oncology · doi:10.1186/s40164-025-00695-8 · Cited by 27
Metadata
- Authors
- Slama, Y., Ah-Pine, F., Khettab, M., Arcambal, A., Begue, M., Dutheil, F., & Gasque, P.
- Affiliations
- University of Reunion Island (RE)
- Laboratoire Interdisciplinaire de Recherche en Santé (LIRS), RunResearch, Clinique Sainte-Clotilde, 127 Route de Bois de Nèfles, 97400 Saint-Denis, La Réunion, France
- Clinifutur (RE)
- Corresponding author
- Slama, Youssef
- Venue
- International Journal of Molecular Sciences
- Publisher
- MDPI AG
- Published
- 2023-08-31
- Volume
- 24
- Issue
- 17
- Pages
- 13511
- ISSN
- 1422-0067 (ISSN-L)
- PMC
- PMC10488262
- OpenAlex
- W4386331467
- Cited by
- 57
- References
- 356
- Citations by year
- 2026: 13 · 2025: 22 · 2024: 21 · 2023: 1
- FWCI
- 2.67
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- International Journal of Molecular Sciences (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- EPIGEN project research (CPER FEDER 2019221-0022768)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Mesenchymal stem cell research
- Health Sciences › Medicine › Oncology › Cancer Cells and Metastasis
- Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
- Keywords
- mesenchymal stem cells, tumor microenvironment, tumor progression, metastasis, cancer-associated fibroblasts, cancer stem cells, tumor immunomodulation, melanoma, lung cancer, cell-cell interactions
- MeSH terms
- Humans, Lung Neoplasms, Melanoma, Multipotent Stem Cells, Tumor Microenvironment, Mesenchymal Stem Cells, Carcinogenesis
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
