Cited by 57Mesenchymal stem cell researchCancer Cells and MetastasisImmune cells in cancer

The DOI matches its Crossref record; 355 of the 356 references it cites were found in a registry or an index.

The Dual Role of Mesenchymal Stem Cells in Cancer Pathophysiology: Pro-Tumorigenic Effects versus Therapeutic Potential

Open access

Slama, Youssef, Ah-Pine, Franck, Khettab, Mohamed, Arcambal, Angelique, Begue, Mickael, Dutheil, Fabien, Gasque, Philippe·2023·International Journal of Molecular Sciences

DOI 10.3390/ijms241713511PMC PMC10488262

Open this paper in CoChat — free account Open PDF

Abstract

Mesenchymal stem/stromal cells (MSCs) are multipotent cells involved in numerous physiological events, including organogenesis, the maintenance of tissue homeostasis, regeneration, or tissue repair. MSCs are increasingly recognized as playing a major, dual, and complex role in cancer pathophysiology through their ability to limit or promote tumor progression. Indeed, these cells are known to interact with the tumor microenvironment, modulate the behavior of tumor cells, influence their functions, and promote distant metastasis formation through the secretion of mediators, the regulation of cell–cell interactions, and the modulation of the immune response. This dynamic network can lead to the establishment of immunoprivileged tissue niches or the formation of new tumors through the proliferation/differentiation of MSCs into cancer-associated fibroblasts as well as cancer stem cells. However, MSCs exhibit also therapeutic effects including anti-tumor, anti-proliferative, anti-inflammatory, or anti-oxidative effects. The therapeutic interest in MSCs is currently growing, mainly due to their ability to selectively migrate and penetrate tumor sites, which would make them relevant as vectors for advanced therapies. Therefore, this review aims to provide an overview of the double-edged sword implications of MSCs in tumor processes. The therapeutic potential of MSCs will be reviewed in melanoma and lung cancers.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.3390/ijms241713511

Cites

355 of 355 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

1 retracted

RETRACTED: The Oncolytic Virus in Cancer Diagnosis and Treatment
Cao, G., He, X., Sun, Q., Chen, S., Wan, K. M., Xu, X., Feng, X., Li, P., Chen, B., & Xiong, M. (2020) · Frontiers in Oncology · doi:10.3389/fonc.2020.01786 · Cited by 109
Retracted
Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries
Sung, H., Ferlay, J., Siegel, R. L., Laversanne, M., Soerjomataram, I., Jemal, A., & Bray, F. (2021) · CA: A Cancer Journal for Clinicians · doi:10.3322/caac.21660 · Cited by 108,699
Hallmarks of Cancer: The Next Generation
Hanahan, D., & Weinberg, R. A. (2011) · Cell · doi:10.1016/j.cell.2011.02.013 · Cited by 66,590
Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement
Dominici, M., Le Blanc, K., Mueller, I., Slaper-Cortenbach, I., Marini, F. C., Krause, D. S., Deans, R. J., Keating, A., Prockop, D. J., & Horwitz, E. M. (2006) · Cytotherapy · doi:10.1080/14653240600855905 · Cited by 17,766
Cancer statistics, 2022
Siegel, R. L., Miller, K. D., Fuchs, H. E., & Jemal, A. (2022) · CA: A Cancer Journal for Clinicians · doi:10.3322/caac.21708 · Cited by 17,196
The Epithelial-Mesenchymal Transition Generates Cells with Properties of Stem Cells
Mani, S. A., Guo, W., Liao, M.-J., Eaton, E. N., Ayyanan, A., Zhou, A. Y., Brooks, M. W., Reinhard, F., Zhang, C. C., Shipitsin, M. V., et al. (2008) · Cell · doi:10.1016/j.cell.2008.03.027 · Cited by 8,839
Molecular mechanisms of epithelial–mesenchymal transition
Lamouille, S., Xu, J., & Derynck, R. (2014) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3758 · Cited by 8,091
Multilineage Cells from Human Adipose Tissue: Implications for Cell-Based Therapies
Zuk, P. A., Zhu, M., Mizuno, H., Huang, J., Futrell, J. W., Katz, A. J., Benhaim, P., Lorenz, H. P., & Hedrick, M. H. (2001) · Tissue Engineering · doi:10.1089/107632701300062859 · Cited by 7,956
Human Adipose Tissue Is a Source of Multipotent Stem Cells
Zuk, P. A., Zhu, M., Ashjian, P. H., Ugarte, D. A. D., Huang, J. I., Mizuno, H., Alfonso, Z. C., Fraser, J. K., Benhaim, P., & Hedrick, M. H. (2002) · Molecular Biology of the Cell · doi:10.1091/mbc.e02-02-0105 · Cited by 6,762
Mesenchymal stem cells
Caplan, A. I. (1991) · Journal of Orthopaedic Research® · doi:10.1002/jor.1100090504 · Cited by 6,559
TGFβ attenuates tumour response to PD-L1 blockade by contributing to exclusion of T cells
Mariathasan, S., Turley, S. J., Nickles, D., Castiglioni, A., Yuen, K., Wang, Y., Kadel III, E. E., Koeppen, H., Astarita, J. L., Cubas, R., et al. (2018) · Nature · doi:10.1038/nature25501 · Cited by 5,400
The immune contexture in human tumours: impact on clinical outcome
Fridman, W. H., Pagès, F., Sautès-Fridman, C., & Galon, J. (2012) · Nature reviews. Cancer · doi:10.1038/nrc3245 · Cited by 4,981
A Perspective on Cancer Cell Metastasis
Chaffer, C. L., & Weinberg, R. A. (2011) · Science · doi:10.1126/science.1203543 · Cited by 4,905
Sox9 Modulates Proliferation and Expression of Osteogenic Markers of Adipose-Derived Stem Cells (ASC)
Stöckl, S., Göttl, C., Grifka, J. K., & Grässel, S. (2013) · Cellular Physiology and Biochemistry · doi:10.1159/000350089 · Cited by 4,670
Fibroblasts in cancer
Kalluri, R., & Zeisberg, M. (2006) · Nature Reviews Cancer · doi:10.1038/nrc1877 · Cited by 4,538
EMT: 2016
Nieto, M. A., Huang, R. Y.-J., Jackson, R. A., & Thiery, J. P. (2016) · Cell · doi:10.1016/j.cell.2016.06.028 · Cited by 4,492
The biology and function of fibroblasts in cancer
Kalluri, R. (2016) · Nature Reviews Cancer · doi:10.1038/nrc.2016.73 · Cited by 4,366
A perivascular origin for mesenchymal stem cells in multiple human organs
Crisan, M., Yap, S., Casteilla, L., Chen, C.-W., Corselli, M., Park, T. S., Andriolo, G., Sun, B., Zheng, B., Zhang, L., et al. (2008) · Cell Stem Cell · doi:10.1016/j.stem.2008.07.003 · Cited by 3,991 · cited 1×
“During embryogenesis, MSCs can migrate along vessels and then reside in perivascular (p) niches to give rise to pMSCs in adult tissues, adopting almost similar features and cell surface markers to those of PCs (Figure 1) [21,58,59].”
Background
A framework for advancing our understanding of cancer-associated fibroblasts
Sahai, E., Astsaturov, I., Cukierman, E., DeNardo, D. G., Egeblad, M., Evans, R. M., Fearon, D., Greten, F. R., Hingorani, S. R., Hunter, T., et al. (2020) · Nature Reviews Cancer · doi:10.1038/s41568-019-0238-1 · Cited by 3,863 · cited 1×
“The exact composition of the TME varies depending on the type of tumors considered, but it notably comprises immune cells such as tumor-associated macrophages (TAMs), pericytes (PCs)/vascular smooth muscle cells (vSMCs), endothelial cells, myofibroblasts, sometimes adipocytes, MSCs, and fibroblasts, which are the most…”
Background
Mesenchymal stem cells in health and disease
Uccelli, A., Moretta, L., & Pistoia, V. (2008) · Nature reviews. Immunology · doi:10.1038/nri2395 · Cited by 3,838
Mutations Associated with Acquired Resistance to PD-1 Blockade in Melanoma
Zaretsky, J. M., Garcia-Diaz, A., Shin, D. S., Escuin-Ordinas, H., Hugo, W., Hu-Lieskovan, S., Torrejon, D. Y., Abril-Rodriguez, G., Sandoval, S., Barthly, L., et al. (2016) · New England Journal of Medicine · doi:10.1056/nejmoa1604958 · Cited by 3,237
Mesenchymal stem cells as trophic mediators
Caplan, A. I., & Dennis, J. E. (2006) · Journal of Cellular Biochemistry · doi:10.1002/jcb.20886 · Cited by 2,992
Notch Signaling Augments BMP9-Induced Bone Formation by Promoting the Osteogenesis-Angiogenesis Coupling Process in Mesenchymal Stem Cells (MSCs)
Liao, J., Wei, Q., Zou, Y., Fan, J., Song, D., Cui, J., Zhang, W., Zhu, Y., Ma, C., Hu, X. Y., et al. (2017) · Cellular Physiology and Biochemistry · doi:10.1159/000471945 · Cited by 2,742
THE DEVELOPMENT OF FIBROBLAST COLONIES IN MONOLAYER CULTURES OF GUINEA‐PIG BONE MARROW AND SPLEEN CELLS
Friedenstein, A. J., Chailakhjan, R. K., & Lalykina, K. S. (1970) · Cell Proliferation · doi:10.1111/j.1365-2184.1970.tb00347.x · Cited by 2,724
Macrophages: Obligate Partners for Tumor Cell Migration, Invasion, and Metastasis
Condeelis, J. S., & Pollard, J. W. (2006) · Cell · doi:10.1016/j.cell.2006.01.007 · Cited by 2,677
Pericytes: Developmental, Physiological, and Pathological Perspectives, Problems, and Promises
Armulik, A., Genové, G., & Betsholtz, C. (2011) · Developmental Cell · doi:10.1016/j.devcel.2011.07.001 · Cited by 2,653
EMT, CSCs, and drug resistance: the mechanistic link and clinical implications
Shibue, T., & Weinberg, R. A. (2017) · Nature Reviews Clinical Oncology · doi:10.1038/nrclinonc.2017.44 · Cited by 2,539
Tumour heterogeneity and cancer cell plasticity
Meacham, C. E., & Morrison, S. J. (2013) · Nature · doi:10.1038/nature12624 · Cited by 2,526
Mesenchymal stem cells reside in virtually all post-natal organs and tissues
Meirelles, L. D. S., Chagastelles, P. C., & Nardi, N. B. (2006) · Journal of Cell Science · doi:10.1242/jcs.02932 · Cited by 2,472
Concise Review: Mesenchymal Stem Cells: Their Phenotype, Differentiation Capacity, Immunological Features, and Potential for Homing
Chamberlain, G., Fox, J. M., Ashton, B. A., & Middleton, J. (2007) · Stem Cells · doi:10.1634/stemcells.2007-0197 · Cited by 2,432
Evolution of the Cancer Stem Cell Model
Kreso, A., & Dick, J. E. (2014) · Cell stem cell · doi:10.1016/j.stem.2014.02.006 · Cited by 2,304
Mesenchymal stem cell-mediated immunosuppression occurs via concerted action of chemokines and nitric oxide
Ren, G., Zhang, L., Zhao, X., Xu, G., Zhang, Y., Roberts, A. I., Zhao, R. C., & Shi, Y. (2008) · Cell Stem Cell · doi:10.1016/j.stem.2007.11.014 · Cited by 2,101
Clarification of the nomenclature for MSC: The International Society for Cellular Therapy position statement
Horwitz, E. M., Blanc, K. L., Dominici, M., Mueller, I., Slaper‐Cortenbach, I., Marini, F. C., Deans, R. J., Krause, D. S., & Keating, A. (2005) · Cytotherapy · doi:10.1080/14653240500319234 · Cited by 2,071
A molecular atlas of cell types and zonation in the brain vasculature
Vanlandewijck, M., He, L., Mäe, M. A., Andrae, J., Ando, K., Del Gaudio, F., Nahar, K., Lebouvier, T., Laviña, B., Gouveia, L., et al. (2018) · Nature · doi:10.1038/nature25739 · Cited by 1,892 · cited 4×
“[59,60] Desmin [59] CD13 Alanyl Aminopeptidase N [59] CD248 Endosialin (TEM-1), highly expressed in tumor tissues (PCs > pMSCs) [59,61,75] KCNJ8 Kir6.”
BackgroundInfluential
The tumor microenvironment at a glance
Balkwill, F. R., Capasso, M., & Hagemann, T. (2012) · Journal of Cell Science · doi:10.1242/jcs.116392 · Cited by 1,857
Microenvironmental regulation of tumour angiogenesis
De Palma, M., Biziato, D., & Petrova, T. V. (2017) · Nature Reviews Cancer · doi:10.1038/nrc.2017.51 · Cited by 1,847
DHAM-BMSC Matrix Promotes Axonal Regeneration and Functional Recovery After Spinal Cord Injury in Adult Rats
Liang, H., Liang, P., Xu, Y., Wu, J., Liang, T., & Xu, X. (2009) · Journal of Neurotrauma · doi:10.1089/neu.2008.0850 · Cited by 1,749
A molecular cell atlas of the human lung from single-cell RNA sequencing
Travaglini, K. J., Nabhan, A. N., Penland, L., Sinha, R., Gillich, A., Sit, R. V., Chang, S., Conley, S. D., Mori, Y., Seita, J., et al. (2020) · Nature · doi:10.1038/s41586-020-2922-4 · Cited by 1,730
Cells of the adult human heart
Litviňuková, M., Talavera-López, C., Maatz, H., Reichart, D., Worth, C. L., Lindberg, E. L., Kanda, M., Polanski, K., Heinig, M., Lee, M., et al. (2020) · Nature · doi:10.1038/s41586-020-2797-4 · Cited by 1,729
Oncolytic viruses: a new class of immunotherapy drugs
Kaufman, H. L., Kohlhapp, F. J., & Zloza, A. (2015) · Nature Reviews Drug Discovery · doi:10.1038/nrd4663 · Cited by 1,724
Osteogenesis in transplants of bone marrow cells
Friedenstein, A. J., Piatetzky-Shapiro, I. I., & Kv, P. (1966) · Development · doi:10.1242/dev.16.3.381 · Cited by 1,675
Mesenchymal Stem Cells: Revisiting History, Concepts, and Assays
Bianco, P., Robey, P. G., & Simmons, P. J. (2008) · Cell stem cell · doi:10.1016/j.stem.2008.03.002 · Cited by 1,618
The role of pericytes in blood-vessel formation and maintenance
Bergers, G., & Song, S. (2005) · Neuro-Oncology · doi:10.1215/s1152851705000232 · Cited by 1,584
Molecular diversity and specializations among the cells of the adult mouse brain
Saunders, A., Macosko, E. Z., Wysoker, A., Goldman, M., Krienen, F. M., de Rivera, H., Bien, E., Baum, M., Bortolin, L., Wang, S., et al. (2018) · Cell · doi:10.1016/j.cell.2018.07.028 · Cited by 1,531 · cited 2×
“1, Potassium inwardly rectifying channel, associates with Abcc9 [59,60,76]”
Background
Oncolytic virotherapy
Russell, S. J., Peng, K.-W., & Bell, J. C. (2012) · Nature Biotechnology · doi:10.1038/nbt.2287 · Cited by 1,428
Role of tumor microenvironment in tumorigenesis
Wang, M., Zhao, J., Zhang, L., Wei, F., Lian, Y., Wu, Y., Gong, Z., Zhang, S., Zhou, J., Cao, K., et al. (2017) · Journal of Cancer · doi:10.7150/jca.17648 · Cited by 1,404
Collagen density promotes mammary tumor initiation and progression
Provenzano, P. P., Inman, D. R., Eliceiri, K. W., Knittel, J. G., Yan, L., Rueden, C., White, J. G., & Keely, P. J. (2008) · BMC Medicine · doi:10.1186/1741-7015-6-11 · Cited by 1,394
Extracellular matrix: A dynamic microenvironment for stem cell niche
Gattazzo, F., Urciuolo, A., & Bonaldo, P. (2014) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2014.01.010 · Cited by 1,365
The Response of CD24 −/low /CD44 + Breast Cancer–Initiating Cells to Radiation
Phillips, T. M., McBride, W. H., & Pajonk, F. (2006) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djj495 · Cited by 1,304
A New Mesenchymal Stem Cell (MSC) Paradigm: Polarization into a Pro-Inflammatory MSC1 or an Immunosuppressive MSC2 Phenotype
Waterman, R. S., Tomchuck, S. L., Henkle, S. L., & Betancourt, A. M. (2010) · PLoS ONE · doi:10.1371/journal.pone.0010088 · Cited by 1,238
Epithelial–mesenchymal plasticity in carcinoma metastasisPreprint
Tsai, J. H., & Yang, J. (2013) · Genes & Development · doi:10.1101/gad.225334.113 · Cited by 1,162
In Search of the In Vivo Identity of Mesenchymal Stem Cells
da Silva Meirelles, L., Caplan, A. I., & Nardi, N. B. (2008) · Stem Cells · doi:10.1634/stemcells.2007-1122 · Cited by 1,077
A single-cell atlas of mouse brain macrophages reveals unique transcriptional identities shaped by ontogeny and tissue environment
Van Hove, H., Martens, L., Scheyltjens, I., De Vlaminck, K., Pombo Antunes, A. R., De Prijck, S., Vandamme, N., De Schepper, S., Van Isterdael, G., Scott, C. L., et al. (2019) · Nature Neuroscience · doi:10.1038/s41593-019-0393-4 · Cited by 1,074
Bone Marrow-Derived Myofibroblasts Contribute to the Mesenchymal Stem Cell Niche and Promote Tumor Growth
Quante, M., Tu, S. P., Tomita, H., Gonda, T. A., Wang, S. S. W., Takashi, S., Baik, G. H., Shibata, W., DiPrete, B. L., Betz, K. S., et al. (2011) · Cancer Cell · doi:10.1016/j.ccr.2011.01.020 · Cited by 1,041
Prognostic Significance of Tumor-Associated Macrophages in Solid Tumor: A Meta-Analysis of the Literature
Zhang, Q., Liu, L., Gong, C., Shi, H., Zeng, Y., Wang, X., Zhao, Y., & Wei, Y.-Q. (2012) · PLoS ONE · doi:10.1371/journal.pone.0050946 · Cited by 1,041
Human Bone Marrow–Derived Mesenchymal Stem Cells in the Treatment of Gliomas
Nakamizo, A., Marini, F. C., Amano, T., Khan, A., Studeny, M., Gumin, J., Chen, J. J., Hentschel, S. J., Vecil, G. G., Dembinski, J. L., et al. (2005) · Cancer Research · doi:10.1158/0008-5472.can-04-1874 · Cited by 1,029
Concise Review: The Surface Markers and Identity of Human Mesenchymal Stem Cells
Lv, F., Tuan, R. S., Cheung, K., & Leung, V. (2014) · Stem Cells · doi:10.1002/stem.1681 · Cited by 980
The In Vitro Migration Capacity of Human Bone Marrow Mesenchymal Stem Cells: Comparison of Chemokine and Growth Factor Chemotactic Activities
Ponte, A. L., Marais, E., Gallay, N., Langonné, A., Delorme, B., Hérault, O., Charbord, P., & Domenech, J. (2007) · Stem Cells · doi:10.1634/stemcells.2007-0054 · Cited by 943
Periostin secreted by glioblastoma stem cells recruits M2 tumour-associated macrophages and promotes malignant growth
Zhou, W., Ke, S. Q., Huang, Z., Flavahan, W., Fang, X., Paul, J., Wu, L., Sloan, A. E., McLendon, R. E., Li, X., et al. (2015) · Nature Cell Biology · doi:10.1038/ncb3090 · Cited by 940
Identification of a subpopulation of rapidly self-renewing and multipotential adult stem cells in colonies of human marrow stromal cells
Colter, D. C., Sekiya, I., & Prockop, D. J. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.141221698 · Cited by 933
Infiltrating neutrophils mediate the initial angiogenic switch in a mouse model of multistage carcinogenesis
Nozawa, H., Chiu, C. W., & Hanahan, D. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0601807103 · Cited by 926
Carcinoma-associated fibroblast-like differentiation of human mesenchymal stem cells
Mishra, P. J., Mishra, P. J., Humeniuk, R., Medina, D. J., Alexe, G., Mesirov, J. P., Ganesan, S., Glod, J. W., & Banerjee, D. (2008) · Cancer Research · doi:10.1158/0008-5472.can-08-0943 · Cited by 912
Untitled work
(2002) · PubMed · Cited by 903
Mesenchymal Stem Cells
Williams, A. R., & Hare, J. M. (2011) · Circulation Research · doi:10.1161/circresaha.111.243147 · Cited by 899
Environment-mediated drug resistance: A major contributor to minimal residual disease
Meads, M. B., Gatenby, R. A., & Dalton, W. S. (2009) · Nature Reviews Cancer · doi:10.1038/nrc2714 · Cited by 892
A Pericyte Origin of Spinal Cord Scar Tissue
Göritz, C., Dias, D. O., Tomilin, N., Barbacid, M., Shupliakov, O., & Frisén, J. (2011) · Science · doi:10.1126/science.1203165 · Cited by 858
Mesenchymal Stem Cells: Potential Precursors for Tumor Stroma and Targeted-Delivery Vehicles for Anticancer Agents
Studeny, M., Marini, F. C., Dembinski, J. L., Zompetta, C., Cabreira-Hansen, M. D. G., Bekele, B. N., Champlin, R. E., & Andreeff, M. (2004) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djh299 · Cited by 841
Mesenchymal stem cell transition to tumor-associated fibroblasts contributes to fibrovascular network expansion and tumor progression
Spaeth, E. L., Dembinski, J. L., Sasser, A. K., Watson, K., Klopp, A., Hall, B., Andreeff, M., & Marini, F. (2009) · PLoS ONE · doi:10.1371/journal.pone.0004992 · Cited by 807
Mesenchymal stromal cells: new directions
Keating, A. (2012) · Cell Stem Cell · doi:10.1016/j.stem.2012.05.015 · Cited by 778
Blood-derived nurse-like cells protect chronic lymphocytic leukemia B cells from spontaneous apoptosis through stromal cell–derived factor-1
Burger, J. A., Tsukada, N., Burger, M., Zvaifler, N. J., Dell’Aquila, M. L., & Kipps, T. J. (2000) · Blood · doi:10.1182/blood.v96.8.2655 · Cited by 752
Human mesenchymal stem cells exert potent antitumorigenic effects in a model of Kaposi's sarcoma
Khakoo, A. Y., Pati, S., Anderson, S. A., Reid, W., Elshal, M. F., Rovira, I. I., Nguyen, A. T., Malide, D., Combs, C. A., Hall, G., et al. (2006) · The Journal of Experimental Medicine · doi:10.1084/jem.20051921 · Cited by 747
Developmental Basis of Vascular Smooth Muscle Diversity
Majesky, M. W. (2007) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.107.141069 · Cited by 729
Stromal myofibroblasts are drivers of invasive cancer growth
De Wever, O., Demetter, P., Mareel, M., & Bracke, M. (2008) · International Journal of Cancer · doi:10.1002/ijc.23925 · Cited by 722
Single-Colony Derived Strains of Human Marrow Stromal Fibroblasts Form Bone After Transplantation In Vivo
Kuznetsov, S. A., Krebsbach, P. H., Satomura, K., Kerr, J. M., Riminucci, M., Benayahu, D., & Robey, P. G. (1997) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.1997.12.9.1335 · Cited by 721
The Dark Side of Fibroblasts: Cancer-Associated Fibroblasts as Mediators of Immunosuppression in the Tumor Microenvironment
Monteran, L., & Erez, N. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.01835 · Cited by 675
Transforming Growth Factor β-1 Induces Snail Transcription Factor in Epithelial Cell Lines
Peinado, H., Quintanilla, M., & Cano, A. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m211304200 · Cited by 642
PDGF-C Mediates the Angiogenic and Tumorigenic Properties of Fibroblasts Associated with Tumors Refractory to Anti-VEGF Treatment
Crawford, Y., Kasman, I. M., Yu, L., Zhong, C., Wu, X., Modrusan, Z. D., Kaminker, J. S., & Ferrara, N. (2009) · Cancer Cell · doi:10.1016/j.ccr.2008.12.004 · Cited by 635
Tumors: Wounds That Do Not Heal—Redux
Dvorak, H. F. (2015) · Cancer Immunology Research · doi:10.1158/2326-6066.cir-14-0209 · Cited by 618
WNT/β-catenin mediates radiation resistance of mouse mammary progenitor cells
Woodward, W. A., Chen, M. S., Behbod, F., Alfaro, M. P., Buchholz, T. A., & Rosen, J. M. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0606599104 · Cited by 609
Induction of metastasis, cancer stem cell phenotype, and oncogenic metabolism in cancer cells by ionizing radiation
Lee, S. Y., Jeong, E. K., Ju, M. K., Jeon, H. M., Kim, M. Y., Kim, C. H., Park, H. G., Han, S. I., & Kang, H. S. (2017) · Molecular Cancer · doi:10.1186/s12943-016-0577-4 · Cited by 592
The biology of myeloid‐derived suppressor cells: The blessing and the curse of morphological and functional heterogeneity
Youn, J., & Gabrilovich, D. I. (2010) · European Journal of Immunology · doi:10.1002/eji.201040895 · Cited by 568
Neural crest cell plasticity and its limits
Douarin, N. M. L., Creuzet, S., Couly, G. F., & Dupin, É. (2004) · Development · doi:10.1242/dev.01350 · Cited by 561
Recent progress in the battle between oncolytic viruses and tumours
Parato, K. A., Senger, D. L., Forsyth, P. A., & Bell, J. C. (2005) · Nature reviews. Cancer · doi:10.1038/nrc1750 · Cited by 555
Indirect angiogenic cytokines upregulate VEGF and bFGF gene expression in vascular smooth muscle cells, whereas hypoxia upregulates VEGF expression only.
Brogi, E., Wu, T., Namiki, A., & Isner, J. M. (1994) · Circulation · doi:10.1161/01.cir.90.2.649 · Cited by 553
Mechanisms underlying the protective effects of mesenchymal stem cell-based therapy
Fan, X., Zhang, Y., Li, X., & Fu, Q. (2020) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-020-03454-6 · Cited by 551
Mesenchymal stem cells: key players in cancer progression
Ridge, S. M., Sullivan, F. J., & Glynn, S. A. (2017) · Molecular Cancer · doi:10.1186/s12943-017-0597-8 · Cited by 526
Neuroepithelial Cells Supply an Initial Transient Wave of MSC Differentiation
Takashima, Y., Era, T., Nakao, K., Kondo, S., Kasuga, M., Smith, A. G., & Nishikawa, S.-I. (2007) · Cell · doi:10.1016/j.cell.2007.04.028 · Cited by 521
Differentiation, cell fusion, and nuclear fusion during ex vivo repair of epithelium by human adult stem cells from bone marrow stroma
Spees, J. L., Olson, S. D., Ylöstalo, J., Lynch, P. J., Smith, J. R., Perry, A. S., Peister, A., Wang, M. Y., & Prockop, D. J. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0437997100 · Cited by 508
Cancer-associated adipocytes: key players in breast cancer progression
Wu, Q., Li, B., Li, Z., Li, J., Sun, S., & Sun, S. (2019) · Journal of Hematology & Oncology · doi:10.1186/s13045-019-0778-6 · Cited by 462
Homing and migration of mesenchymal stromal cells: How to improve the efficacy of cell therapy?
Becker, A. D., & Riet, I. V. (2016) · World Journal of Stem Cells · doi:10.4252/wjsc.v8.i3.73 · Cited by 460
Angiogenic effects of human multipotent stromal cell conditioned medium activate the PI3K-Akt pathway in hypoxic endothelial cells to inhibit apoptosis, increase survival, and stimulate angiogenesis
Hung, S.-C., Pochampally, R. R., Chen, S.-C., Hsu, S.-C., & Prockop, D. J. (2007) · Stem Cells · doi:10.1634/stemcells.2006-0686 · Cited by 457
Clinical cancer nanomedicine
Wolfram, J., & Mauro Ferrari, B. (2019) · Nano Today · doi:10.1016/j.nantod.2019.02.005 · Cited by 447
Monocyte Chemotactic Protein-1 Secreted by Primary Breast Tumors Stimulates Migration of Mesenchymal Stem Cells
Dwyer, R. M., Potter-Beirne, S. M., Harrington, K. A., Lowery, A., Hennessy, E., Murphy, M. J., Barry, F., O’Brien, T., & Kerin, M. J. (2007) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-07-0731 · Cited by 442
Targeting fibroblast activation protein inhibits tumor stromagenesis and growth in mice
Santos, A., Jung, J. J., Aziz, N., Kissil, J. L., & Puré, E. (2009) · Journal of Clinical Investigation · doi:10.1172/jci38988 · Cited by 436
Adipose Tissue–Derived Human Mesenchymal Stem Cells Mediated Prodrug Cancer Gene Therapy
Kucerova, L., Altanerova, V., Matuskova, M., Tyciakova, S., & Altaner, C. (2007) · Cancer Research · doi:10.1158/0008-5472.can-06-4024 · Cited by 431
DNA Damage-Mediated Induction of a Chemoresistant Niche
Gilbert, L. A., & Hemann, M. T. (2010) · Cell · doi:10.1016/j.cell.2010.09.043 · Cited by 428
B cells inhibit induction of T cell-dependent tumor immunity
Qin, Z., Richter, G. H. S., Schüler, T., Ibe, S., Cao, X., & Blankenstein, T. J. F. (1998) · Nature Medicine · doi:10.1038/nm0598-627 · Cited by 418
Mesenchymal Stem Cell Delivery of TRAIL Can Eliminate Metastatic Cancer
Loebinger, M. R., Eddaoudi, A., Davies, D., & Janes, S. M. (2009) · Cancer Research · doi:10.1158/0008-5472.can-08-4698 · Cited by 417
VEGF expression by mesenchymal stem cells contributes to angiogenesis in pancreatic carcinoma
Beckermann, B. M., Kallifatidis, G., Groth, A., Frommhold, D., Apel, A., Mattern, J., Salnikov, A. V., Moldenhauer, G., Wagner, W., Diehlmann, A., et al. (2008) · British Journal of Cancer · doi:10.1038/sj.bjc.6604508 · Cited by 406
Mesenchymal stem cells inhibit proliferation and apoptosis of tumor cells: impact on in vivo tumor growth
Ramasamy, R., Lam, E. W.-F., Soeiro, I., Tisato, V, Bonnet, D., & Dazzi, F. (2007) · Leukemia · doi:10.1038/sj.leu.2404489 · Cited by 404
The dynamic roles of TGF‐β in cancer
Meulmeester, E., & ten Dijke, P. (2010) · The Journal of Pathology · doi:10.1002/path.2785 · Cited by 399
Stromal cells prevent apoptosis of AML cells by up-regulation of anti-apoptotic proteins
Konopleva, M. Y., Konoplev, S. N., Hu, W., Zaritskey, A. Y., Afanasyev, B. V., & Andreeff, M. (2002) · Leukemia · doi:10.1038/sj.leu.2402608 · Cited by 386
Human ovarian carcinoma-associated mesenchymal stem cells regulate cancer stem cells and tumorigenesis via altered BMP production
McLean, K., Gong, Y., Choi, Y., Deng, N., Yang, K., Bai, S., Cabrera, L., Keller, E., McCauley, L., Cho, K. R., et al. (2011) · Journal of Clinical Investigation · doi:10.1172/jci45273 · Cited by 380
Concise Review: Hitting the Right Spot with Mesenchymal Stromal Cells
Tolar, J., Blanc, K. L., Keating, A., & Blazar, B. R. (2010) · Stem Cells · doi:10.1002/stem.459 · Cited by 375
Mesenchymal stem/stromal cells in cancer therapy
Lan, T., Luo, M., & Wei, X. (2021) · Journal of Hematology & Oncology · doi:10.1186/s13045-021-01208-w · Cited by 374
CCR2-Dependent Recruitment of Macrophages by Tumor-Educated Mesenchymal Stromal Cells Promotes Tumor Development and Is Mimicked by TNFα
Ren, G., Zhao, X., Wang, Y., Zhang, X., Chen, X., Xu, C., Yuan, Z.-R., Roberts, A. I., Zhang, L., Zheng, H. B., et al. (2012) · Cell stem cell · doi:10.1016/j.stem.2012.08.013 · Cited by 370
Exosomes from breast cancer cells can convert adipose tissue-derived mesenchymal stem cells into myofibroblast-like cells
Lee, K. (2011) · International Journal of Oncology · doi:10.3892/ijo.2011.1193 · Cited by 369
The Osteogenic Potential of Culture-Expanded Rat Marrow Mesenchymal Cells Assayed In Vivo in Calcium Phosphate Ceramic Blocks
GOSHIMA, J., Goldberg, V. M., & Caplan, A. I. (1991) · Clinical Orthopaedics and Related Research · doi:10.1097/00003086-199101000-00038 · Cited by 343
Tumor Necrosis Factor-α Stimulates the Epithelial-to-Mesenchymal Transition of Human Colonic Organoids
Bates, R. C., & Mercurio, A. M. (2003) · Molecular Biology of the Cell · doi:10.1091/mbc.e02-09-0583 · Cited by 341
Cancer-Stimulated Mesenchymal Stem Cells Create a Carcinoma Stem Cell Niche via Prostaglandin E2 Signaling
Li, H., Reinhardt, F., Herschman, H. R., & Weinberg, R. A. (2012) · Cancer Discovery · doi:10.1158/2159-8290.cd-12-0101 · Cited by 341
Single-Cell RNA Sequencing Reveals a Dynamic Stromal Niche That Supports Tumor Growth
Davidson, S., Efremova, M., Riedel, A., Mahata, B., Pramanik, J., Huuhtanen, J., Kar, G., Vento‐Tormo, R., Hagai, T., Chen, X. X., et al. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.107628 · Cited by 330
Gold Nanoparticles as Radiosensitizers in Cancer Radiotherapy
Chen, Y., Yang, J., Fu, S., & Wu, J. (2020) · International Journal of Nanomedicine · doi:10.2147/ijn.s272902 · Cited by 319
Oncorine, the World First Oncolytic Virus Medicine and its Update in China
Liang, M. (2018) · Current Cancer Drug Targets · doi:10.2174/1568009618666171129221503 · Cited by 317
Dkk-1 secreted by mesenchymal stem cells inhibits growth of breast cancer cells via depression of Wnt signalling
Qiao, L., Xu, Z.-L., Zhao, T.-J., Ye, L.-H., & Zhang, X.-D. (2008) · Cancer Letters · doi:10.1016/j.canlet.2008.04.032 · Cited by 313
Single-cell dissection of the human brain vasculature
García, F., Sun, N., Lee, H., Godlewski, B. R., Mathys, H., Galani, K., Zhou, B., Jiang, X., Ng, A. P., Mantero, J. C., et al. (2022) · Nature · doi:10.1038/s41586-022-04521-7 · Cited by 313
Exosomes from human adipose-derived mesenchymal stem cells promote migration through Wnt signaling pathway in a breast cancer cell model
Lin, R., Wang, S., & Zhao, R. C. (2013) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-013-1746-z · Cited by 311
IL-12 Family Cytokines in Cancer and Immunotherapy
Mirlekar, B., & Pylayeva‐Gupta, Y. (2021) · Cancers · doi:10.3390/cancers13020167 · Cited by 307
Mesenchymal stem cells induce resistance to chemotherapy through the release of platinum-induced fatty acids
Roodhart, J. M. L., Daenen, L. G. M., Stigter, E. C. A., Prins, H.-J., Gerrits, J., Houthuijzen, J. M., Gerritsen, M. G., Schipper, H. S., Backer, M. J. G., van Amersfoort, M., et al. (2011) · Cancer Cell · doi:10.1016/j.ccr.2011.08.010 · Cited by 305
Mesenchymal progenitor cells as cellular vehicles for delivery of oncolytic adenoviruses
Komarova, S., Kawakami, Y., Stoff-Khalili, M. A., Curiel, D. T., & Pereboeva, L. (2006) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-05-0334 · Cited by 302
Concise Review: Cancer Cells, Cancer Stem Cells, and Mesenchymal Stem Cells: Influence in Cancer Development
Papaccio, F., Paino, F., Regad, T., Papaccio, G., Desiderio, V., & Tirino, V. (2017) · Stem Cells Translational Medicine · doi:10.1002/sctm.17-0138 · Cited by 299
Human bronchial fibroblasts exhibit a mesenchymal stem cell phenotype and multilineage differentiating potentialities
Sabatini, F., Petecchia, L., Tavian, M., de Villeroché, V. J., Rossi, G. A., & Brouty‐Boyé, D. (2005) · Laboratory Investigation · doi:10.1038/labinvest.3700300 · Cited by 296
Mesenchymal stem cell-based drug delivery strategy: from cells to biomimetic
Wu, H., Zhou, Y., Tabata, Y., & Gao, J. (2018) · Journal of Controlled Release · doi:10.1016/j.jconrel.2018.12.019 · Cited by 296
Developmental Biology of the Vascular Smooth Muscle Cell: Building a Multilayered Vessel Wall
Hungerford, J. E., & Little, C. (1999) · Journal of Vascular Research · doi:10.1159/000025622 · Cited by 291
Potential role of mesenchymal stem cells (MSCs) in the breast tumour microenvironment: stimulation of epithelial to mesenchymal transition (EMT)
Martin, F. T., Dwyer, R. M., Kelly, J., Khan, S., Murphy, J. M., Curran, C., Miller, N., Hennessy, E., Dockery, P., Barry, F. P., et al. (2010) · Breast Cancer Research and Treatment · doi:10.1007/s10549-010-0734-1 · Cited by 290
Cancer-associated fibroblasts in desmoplastic tumors: emerging role of integrins
Zeltz, C., Primac, I., Erusappan, P., Alam, J., Noel, A., & Gullberg, D. (2020) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2019.08.004 · Cited by 290
Targeting mitochondrial biogenesis to overcome drug resistance to MAPK inhibitors
Zhang, G., Frederick, D. T., Wu, L. W., Wei, Z., Krepler, C., Srinivasan, S., Chae, Y. C., Xu, X., Choi, H., Dimwamwa, E., et al. (2016) · Journal of Clinical Investigation · doi:10.1172/jci82661 · Cited by 289
Targeting the Tumor Microenvironment with Interferon-β Bridges Innate and Adaptive Immune Responses
Yang, X., Zhang, X., Fu, M. L., Weichselbaum, R. R., Gajewski, T. F., Guo, Y., & Fu, Y. (2014) · Cancer Cell · doi:10.1016/j.ccr.2013.12.004 · Cited by 274
Perivascular macrophages in health and disease
Lapenna, A., Palma, M. D., & Lewis, C. E. (2018) · Nature reviews. Immunology · doi:10.1038/s41577-018-0056-9 · Cited by 268
Host tissue determinants of tumour immunity
Salmon, H., Remark, R., Gnjatic, S., & Mérad, M. (2019) · Nature reviews. Cancer · doi:10.1038/s41568-019-0125-9 · Cited by 263
Identification, discrimination and heterogeneity of fibroblasts
Lendahl, U., Muhl, L., & Betsholtz, C. (2022) · Nature Communications · doi:10.1038/s41467-022-30633-9 · Cited by 256
Vascular endothelial growth factor (VEGF)–C signaling through FLT-4 (VEGFR-3) mediates leukemic cell proliferation, survival, and resistance to chemotherapy
Dias, S., Choy, M., Alitalo, K. K., & Rafii, S. (2002) · Blood · doi:10.1182/blood.v99.6.2179 · Cited by 251
The roles of mesenchymal stem cells in tumor inflammatory microenvironment
Sun, Z., Wang, S., & Zhao, R. C. (2014) · Journal of Hematology & Oncology · doi:10.1186/1756-8722-7-14 · Cited by 249
Mesenchymal Stromal Cells Promote Tumor Growth through the Enhancement of Neovascularization
Suzuki, K., Sun, R., Origuchi, M., Kanehira, M., Takahata, T., Itoh, J., Umezawa, A., Kijima, H., Fukuda, S., & Saijo, Y. (2011) · Molecular Medicine · doi:10.2119/molmed.2010.00157 · Cited by 244
Bone marrow-derived mesenchymal stem cells promote growth and angiogenesis of breast and prostate tumors
Zhang, T., Lee, W., Rui, Y., Cheng, T.-Y., Jiang, X., & Li, G. (2013) · Stem Cell Research & Therapy · doi:10.1186/scrt221 · Cited by 244
Hypoxia-inducible factor–dependent breast cancer–mesenchymal stem cell bidirectional signaling promotes metastasis
Chaturvedi, P., Gilkes, D. M., Wong, C. C., Gupta, K., Luo, W., Zhang, H., Wei, H., Takano, N., Schito, L., Levchenko, A., et al. (2012) · Journal of Clinical Investigation · doi:10.1172/jci64993 · Cited by 244
Fibroblasts and Mesenchymal Stromal/Stem Cells Are Phenotypically Indistinguishable
Denu, R. A., Nemcek, S., Bloom, D. D., Goodrich, A. D., Kim, J., Mosher, D. F., & Hematti, P. (2016) · Acta Haematologica · doi:10.1159/000445096 · Cited by 241
Basic Fibroblast Growth Factor Controls Migration in Human Mesenchymal Stem Cells
Schmidt, A., Ladage, D., Schinköthe, T., Klausmann, U., Ulrichs, C., Klinz, F., Brixius, K., Arnhold, S., Desai, B., Mehlhorn, U., et al. (2006) · Stem Cells · doi:10.1634/stemcells.2005-0191 · Cited by 237
Mesenchymal Stem Cells are Recruited and Activated into Carcinoma-Associated Fibroblasts by Prostate Cancer Microenvironment-Derived TGF-β1
Barcellos‐de‐Souza, P., Comito, G., Segura, C. P., Taddei, M. L., Gori, V., Becherucci, V., Bambi, F., Margheri, F., Laurenzana, A., Rosso, M. D., et al. (2016) · Stem Cells · doi:10.1002/stem.2412 · Cited by 236
Cancer nanomedicine: is targeting our target?
Lammers, T., Kiessling, F. M., Ashford, M. B., Hennink, W. E., Crommelin, D. J. A., & Storm, G. (2016) · Nature Reviews Materials · doi:10.1038/natrevmats.2016.69 · Cited by 234
Mesenchymal stem cells promote growth and angiogenesis of tumors in mice
Huang, W.-H., Chang, M.-C., Tsai, K.-S., Hung, M., Chen, H.-L., & Hung, S.-C. (2012) · Oncogene · doi:10.1038/onc.2012.458 · Cited by 233
Recent advances of oncolytic virus in cancer therapy
Mondal, M., Guo, J., He, P., & Zhou, D. (2020) · Human Vaccines & Immunotherapeutics · doi:10.1080/21645515.2020.1723363 · Cited by 227
The growth inhibitory effect of mesenchymal stem cells on tumor cells in vitro and in vivo
Lu, Y.-R., Yuan, Y., Wang, X.-J., Wei, L.-L., Chen, Y.-N., Cong, C., Li, S.-F., Long, D., Tan, W.-D., Mao, Y.-Q., et al. (2008) · Cancer Biology & Therapy · doi:10.4161/cbt.7.2.5296 · Cited by 225
Poly(Vinylpyrollidone)‐ and Selenocysteine‐Modified Bi2Se3 Nanoparticles Enhance Radiotherapy Efficacy in Tumors and Promote Radioprotection in Normal Tissues
Du, J., Gu, Z., Yan, L., Yong, Y., Yi, X., Zhang, X., Liu, J., Wu, R., Ge, C., Chen, C., et al. (2017) · Advanced Materials · doi:10.1002/adma.201701268 · Cited by 222
Mesenchymal Stem Cell-Mediated Effects of Tumor Support or Suppression
Rhee, K., Lee, J. E., & Eom, Y. W. (2015) · International Journal of Molecular Sciences · doi:10.3390/ijms161226215 · Cited by 221
Mesenchymal Stem Cells Home to Sites of Injury and Inflammation
Rustad, K. C., & Gurtner, G. C. (2012) · Advances in Wound Care · doi:10.1089/wound.2011.0314 · Cited by 221
Innate Immunity to Adenovirus
Hendrickx, R., Stichling, N., Koelen, J. A., Kuryk, Ł., Lipiec, A., & Greber, U. F. (2014) · Human Gene Therapy · doi:10.1089/hum.2014.001 · Cited by 221
Regulator of G-protein signaling-5 induction in pericytes coincides with active vessel remodeling during neovascularization
Berger, M., Bergers, G., Arnold, B., Hämmerling, G. J., & Ganß, R. (2005) · Blood · doi:10.1182/blood-2004-06-2315 · Cited by 220
Cancer drug pan-resistance: pumps, cancer stem cells, quiescence, epithelial to mesenchymal transition, blocked cell death pathways, persisters or what?
Borst, P. (2012) · Open Biology · doi:10.1098/rsob.120066 · Cited by 219
Magnetic Resonance Imaging of Mesenchymal Stem Cells Homing to Pulmonary Metastases Using Biocompatible Magnetic Nanoparticles
Loebinger, M. R., Kyrtatos, P. G., Turmaine, M., Price, A. N., Pankhurst, Q. A., Lythgoe, M. F., & Janes, S. M. (2009) · Cancer Research · doi:10.1158/0008-5472.can-09-1912 · Cited by 212
Mesenchymal Stem Cell Carriers Protect Oncolytic Measles Viruses from Antibody Neutralization in an Orthotopic Ovarian Cancer Therapy Model
Mader, E. K., Maeyama, Y., Lin, Y., Butler, G. W., Russell, H., Galanis, E., Russell, S. J., Dietz, A. B., & Peng, K.-W. (2009) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-09-1292 · Cited by 206
Mesenchymal stem cells as a vehicle for targeted delivery of CRAds to lung metastases of breast carcinoma
Stoff‐Khalili, M. A., Rivera, Á. A., Mathis, J. M., Banerjee, N. S., Moon, A. S., Hess, A., Rocconi, R. P., Numnum, T. M., Everts, M., Chow, L. T., et al. (2007) · Breast Cancer Research and Treatment · doi:10.1007/s10549-006-9449-8 · Cited by 205
Mesenchymal Stem Cell 1 (MSC1)-Based Therapy Attenuates Tumor Growth Whereas MSC2-Treatment Promotes Tumor Growth and Metastasis
Waterman, R. S., Henkle, S. L., & Betancourt, A. M. (2012) · PLoS ONE · doi:10.1371/journal.pone.0045590 · Cited by 205
Radiosensitizing high-Z metal nanoparticles for enhanced radiotherapy of glioblastoma multiforme
Choi, J., Kim, G., Cho, S. B., & Im, H. (2020) · Journal of Nanobiotechnology · doi:10.1186/s12951-020-00684-5 · Cited by 205
Cancer gene therapy using mesenchymal stem cells expressing interferon-β in a mouse prostate cancer lung metastasis model
Ren, C., Kumar, S., Chanda, D., Kallman, L., Chen, J., Mountz, J. D., & Ponnazhagan, S. (2008) · Gene Therapy · doi:10.1038/gt.2008.101 · Cited by 204
Emerging roles for CNS fibroblasts in health, injury and disease
Dorrier, C., Jones, H. E., Pintarić, L., Siegenthaler, J. A., & Daneman, R. (2021) · Nature reviews. Neuroscience · doi:10.1038/s41583-021-00525-w · Cited by 204
Heterogeneity of proangiogenic features in mesenchymal stem cells derived from bone marrow, adipose tissue, umbilical cord, and placenta
Du, W. J., Chi, Y., Yang, Z. X., Li, Z. J., Cui, J. J., Song, B. Q., Li, X., Yang, S. G., Han, Z. B., & Han, Z. C. (2016) · Stem Cell Research & Therapy · doi:10.1186/s13287-016-0418-9 · Cited by 200
CNS fibroblasts form a fibrotic scar in response to immune cell infiltration.
Dorrier, C. E., Aran, D., Haenelt, E. A., Sheehy, R. N., Hoi, K. K., Pintarić, L., Chen, Y., Lizama, C. O., Cautivo, K. M., Weiner, G. A., et al. (2021) · Nature Neuroscience · doi:10.1038/s41593-020-00770-9 · Cited by 199
Therapeutic Potential of Mesenchymal Stem Cells Producing Interferon-α in a Mouse Melanoma Lung Metastasis Model
Ren, C., Kumar, S., Chanda, D., Chen, J., Mountz, J. D., & Ponnazhagan, S. (2008) · Stem Cells · doi:10.1634/stemcells.2008-0084 · Cited by 198
Chemokine-Directed Tumor Microenvironment Modulation in Cancer Immunotherapy
Bule, P., Aguiar, S. I., Aires‐da‐Silva, F., & Dias, J. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22189804 · Cited by 196
Melanoma survival in the United States, 1992 to 2005
Pollack, L. A., Li, J., Berkowitz, Z., Weir, H. K., Wu, X., Ajani, U. A., Ekwueme, D. U., Li, C., & Pollack, B. P. (2011) · Journal of the American Academy of Dermatology · doi:10.1016/j.jaad.2011.05.030 · Cited by 195
Discovery of the cancer stem cell related determinants of radioresistance
Peitzsch, C., Kurth, I., Kunz‐Schughart, L. A., Baumann, M. A., & Dubrovska, A. (2013) · Radiotherapy and Oncology · doi:10.1016/j.radonc.2013.06.003 · Cited by 195
Isolation and Characterization of Mesenchymal Stromal Cells from Human Umbilical Cord and Fetal Placenta
Beeravolu, N., McKee, C., Alamri, A., Mikhael, S., Brown, C., Perez-Cruet, M. J., & Chaudhry, G. R. (2017) · Journal of Visualized Experiments · doi:10.3791/55224 · Cited by 194
Mesenchymal stem cells as a double-edged sword in tumor growth: focusing on MSC-derived cytokines
Liang, W., Chen, X., Zhang, S., Fang, J., Chen, M., Xu, Y., & Chen, X. (2021) · Cellular & Molecular Biology Letters · doi:10.1186/s11658-020-00246-5 · Cited by 192
Adipose Tissue–derived Mesenchymal Stem Cells Expressing Prodrug-converting Enzyme Inhibit Human Prostate Tumor Growth
Cavarretta, I. T. R., Altanerová, V., Matúšková, M., Kučerová, L., Čulig, Z., & Altaner, Č. (2009) · Molecular Therapy · doi:10.1038/mt.2009.237 · Cited by 189
Interaction of MSC with tumor cells
Melzer, C., Yang, Y., & Hass, R. (2016) · Cell Communication and Signaling · doi:10.1186/s12964-016-0143-0 · Cited by 189
Radiation-enhanced cell migration/invasion process: A review
Moncharmont, C., Lévy, A., Guy, J., Falk, A. T., Guilbert, M., Trone, J., Alphonse, G., Gilormini, M., Ardail, D., Toillon, R., et al. (2014) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2014.05.006 · Cited by 184
Hypoxia-inducible factor-dependent breast cancer-mesenchymal stem cell bidirectional signaling promotes metastasis
Chaturvedi, P., Gilkes, D. M., Wong, C. C. L., Kshitiz, K., Luo, W., Zhang, H., Wei, H., Takano, N., Schito, L., Levchenko, A., et al. (2013) · Journal of Clinical Investigation · doi:10.1172/jci69244 · Cited by 181
Mesenchymal progenitor cell-mediated inhibition of tumor growth in vivo and in vitro in gelatin matrix
Ohlsson, L. B., Varas, L. A., Kjellman, C., Edvardsen, K., & Lindvall, M. L. (2003) · Experimental and Molecular Pathology · doi:10.1016/j.yexmp.2003.06.001 · Cited by 181
Osteopontin promotes CCL5-mesenchymal stromal cell-mediated breast cancer metastasis
Mi, Z., Bhattacharya, S. D., Kim, V. M., Guo, H., Talbot, L. J., & Kuo, P. C. (2011) · Carcinogenesis · doi:10.1093/carcin/bgr009 · Cited by 179
Fetal cell microchimerism in tissue from multiple sites in women with systemic sclerosis
Johnson, K. L., Nelson, J. L., Fürst, D. E., McSweeney, P. A., Roberts, D. J., Zhen, D., & Bianchi, D. W. (2001) · Arthritis & Rheumatism · doi:10.1002/1529-0131(200108)44:8 · Cited by 173
Cytosine deaminase expressing human mesenchymal stem cells mediated tumour regression in melanoma bearing mice
Kucerova, L., Matuskova, M., Pastorakova, A., Tyciakova, S., Jakubikova, J., Bohovic, R., Altanerova, V., & Altaner, C. (2008) · The Journal of Gene Medicine · doi:10.1002/jgm.1239 · Cited by 171
Pericytes in the tumor microenvironment
Jiang, Z., Zhou, J., Li, L., Liao, S., He, J., Zhou, S., & Zhou, Y. (2023) · Cancer Letters · doi:10.1016/j.canlet.2023.216074 · Cited by 168
Identification and characterization of alphavirus M1 as a selective oncolytic virus targeting ZAP-defective human cancers
Lin, Y., Zhang, H., Liang, J., Li, K., Zhu, W., Fu, L., Wang, F., Zheng, X., Shi, H., Wu, S., et al. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1408759111 · Cited by 166
Mesenchymal stromal cells in cancer: A review of their immunomodulatory functions and dual effects on tumor progression
Galland, S., & Stamenkovic, I. (2020) · The Journal of Pathology · doi:10.1002/path.5357 · Cited by 165
Designing and Building Oncolytic Viruses
Maroun, J. W., Muñoz-Alía, M. Á., Ammayappan, A., Schulze, A. J., Peng, K.-W., & Russell, S. J. (2017) · Future Virology · doi:10.2217/fvl-2016-0129 · Cited by 162
Therapeutic potential of human mesenchymal stem cells producing IL-12 in a mouse xenograft model of renal cell carcinoma
Gao, P., Ding, Q., Wu, Z., Jiang, H., & Fang, Z. (2009) · Cancer Letters · doi:10.1016/j.canlet.2009.08.031 · Cited by 161
Stem‐cell plasticity and therapy for injuries of the peripheral nervous system
Tohill, M. P., & Terenghi, G. (2004) · Biotechnology and Applied Biochemistry · doi:10.1042/ba20030173 · Cited by 161
The role of mesenchymal stem cells in anti-cancer drug resistance and tumour progression
Houthuijzen, J. M., Daenen, L. G. M., Roodhart, J. M. L., & Voest, E. E. (2012) · British Journal of Cancer · doi:10.1038/bjc.2012.201 · Cited by 159
Haematopoietic stem cells: past, present and future
Ng, A. P., & Alexander, W. S. (2017) · Cell Death Discovery · doi:10.1038/cddiscovery.2017.2 · Cited by 158
Mechanisms that drive inflammatory tumor microenvironment, tumor heterogeneity, and metastatic progression
Yang, H. H., & Lin, P. C. (2017) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2017.08.001 · Cited by 157
Mesenchymal stem cells regulate epithelial–mesenchymal transition and tumor progression of pancreatic cancer cells
Kabashima‐Niibe, A., Higuchi, H., Takaishi, H., Masugi, Y., Matsuzaki, Y., Mabuchi, Y., Funakoshi, S., Adachi, M., Hamamoto, Y., Kawachi, S., et al. (2012) · Cancer Science · doi:10.1111/cas.12059 · Cited by 155
Cancer stem cell niche models and contribution by mesenchymal stroma/stem cells
Melzer, C., von der Ohe, J., Lehnert, H., Ungefroren, H., & Hass, R. (2017) · Molecular Cancer · doi:10.1186/s12943-017-0595-x · Cited by 152
Macrophage Migration Inhibitory Factor–CXCR4 Is the Dominant Chemotactic Axis in Human Mesenchymal Stem Cell Recruitment to Tumors
Lourenco, S. D. S., TEIXEIRA, V. H., Kalber, T. L., José, R. J. P., Floto, R. A., & Janes, S. M. (2015) · The Journal of Immunology · doi:10.4049/jimmunol.1402097 · Cited by 151
The effects of mesenchymal stem cells injected via different routes on modified IL-12-mediated antitumor activity
Seo, S. H., Kim, K. S., Park, S. H., Suh, Y. S., Kim, S. J., Jeun, S.-S., & Sung, Y. C. (2011) · Gene Therapy · doi:10.1038/gt.2010.170 · Cited by 148
Human Mesenchymal Stem Cells Lack Tumor Tropism but Enhance the Antitumor Activity of Oncolytic Adenoviruses in Orthotopic Lung and Breast Tumors
Hakkarainen, T., Särkioja, M., Lehenkari, P. P., Miettinen, S., Ylikomi, T. J., Suuronen, R., Desmond, R. A., Kanerva, A., & Hemminki, A. (2007) · Human Gene Therapy · doi:10.1089/hum.2007.034 · Cited by 148
Matrix Metalloproteinase 1 Is Necessary for the Migration of Human Bone Marrow-Derived Mesenchymal Stem Cells Toward Human Glioma
Ho, I. A. W., Chan, K. Y. W., Ng, W.-H., Guo, C. M., Hui, K. M., Cheang, P., & Lam, P. Y. P. (2009) · Stem Cells · doi:10.1002/stem.50 · Cited by 147
Potential therapeutic applications of muscle-derived mesenchymal stem and progenitor cells
Jackson, W. M., Nesti, L. J., & Tuan, R. S. (2010) · Expert Opinion on Biological Therapy · doi:10.1517/14712591003610606 · Cited by 146
The cytokine secretion profile of mesenchymal stromal cells is determined by surface structure of the microenvironment
Leuning, D. G., Beijer, N. R. M., du Fossé, N. A., Vermeulen, S., Lievers, E., van Kooten, C., Rabelink, T. J., & de Boer, J. (2018) · Scientific Reports · doi:10.1038/s41598-018-25700-5 · Cited by 143
Clinical Trials with Oncolytic Measles Virus: Current Status and Future Prospects
Msaouel, P., Opyrchal, M., Dispenzieri, A. A., Peng, K. W., Federspiel, M. J., Russell, S. J., & Galanis, E. (2017) · Current Cancer Drug Targets · doi:10.2174/1568009617666170222125035 · Cited by 142
CECR2 drives breast cancer metastasis by promoting NF-κB signaling and macrophage-mediated immune suppression
Zhang, M., Liu, Z. Z., Aoshima, K., Cai, W. L., Sun, H., Xu, T., Zhang, Y., An, Y., Chen, J. F.-Y., Chan, L.-H., et al. (2022) · Science Translational Medicine · doi:10.1126/scitranslmed.abf5473 · Cited by 142
Macrophage-Associated Mesenchymal Stem Cells Assume an Activated, Migratory, Pro-Inflammatory Phenotype with Increased IL-6 and CXCL10 Secretion
Anton, K., Banerjee, D., & Glod, J. W. (2012) · PLoS ONE · doi:10.1371/journal.pone.0035036 · Cited by 140
Anti-EMT properties of CoQ0 attributed to PI3K/AKT/NFKB/MMP-9 signaling pathway through ROS-mediated apoptosis
Yang, H., Thiyagarajan, V., Shen, P.-C., Mathew, D. C., Lin, K., Liao, J., & Hseu, Y. (2019) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-019-1196-x · Cited by 138
Mesenchymal Stem Cell-Induced DDR2 Mediates Stromal-Breast Cancer Interactions and Metastasis Growth
González, M. E., Martin, E. E., Anwar, T., Arellano-Garcia, C., Medhora, N., Lama, A., Chen, Y., Tanager, K. S., Yoon, E., Kidwell, K., et al. (2017) · Cell Reports · doi:10.1016/j.celrep.2016.12.079 · Cited by 134
PEX-Producing Human Neural Stem Cells Inhibit Tumor Growth in a Mouse Glioma Model
Kim, S., Cargioli, T. G., Machluf, M., Yang, W., Sun, Y., Al-Hashem, R., Kim, S. U., Black, P. M., & Carroll, R. S. (2005) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-05-0371 · Cited by 134
Gap junctions and connexins as therapeutic targets in cancer
Kandouz, M., & Batist, G. (2010) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728222.2010.487866 · Cited by 133
Acquisition of new tumor cell properties by MSC-derived exosomes
Yang, Y., Bucan, V., Baehre, H., von der Ohe, J., Otte, A., & Hass, R. (2015) · International Journal of Oncology · doi:10.3892/ijo.2015.3001 · Cited by 129
Mesenchymal Stem Cells in the Tumor Microenvironment
Atiya, H. I., Frisbie, L. G., Pressimone, C. A., & Coffman, L. G. (2020) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-37184-5_3 · Cited by 129
Vascular mimicry formation is promoted by paracrine TGF-β and SDF1 of cancer-associated fibroblasts and inhibited by miR-101 in hepatocellular carcinoma
Yang, J., Yang, L., Lin, Y., Zheng, Z., Fang, J., He, S., & Zhuang, S. (2016) · Cancer Letters · doi:10.1016/j.canlet.2016.09.012 · Cited by 128
Neural stem cells target intracranial glioma to deliver an oncolytic adenovirus in vivo
Tyler, M. A., Ulasov, I. V., Sonabend, A. M., Nandi, S., Han, Y., Marler, S., Roth, J. C., & Lesniak, M. S. (2008) · Gene Therapy · doi:10.1038/gt.2008.165 · Cited by 128
Human carcinoma-associated mesenchymal stem cells promote ovarian cancer chemotherapy resistanceviaa BMP4/HH signaling loop
Coffman, L. G., Choi, Y., McLean, K., Allen, B. L., di Magliano, M. P., & Buckanovich, R. J. (2016) · Oncotarget · doi:10.18632/oncotarget.6870 · Cited by 128

Flagged first, then by citations

1 of the 356 references couldn’t be matched to a known paper.

Research works printed but not linked: 1

Birbrair, A. (2020). Tumor Microenvironment: Non-Hematopoietic Cells, Springer International Publishing. Advances in Experimental Medicine and Biology. · DOI

Sorted by citations

Mesenchymal stem cells - the secret agents of cancer immunotherapy: Promises, challenges, and surprising twists
Minev, T., Balbuena, S., Gill, J. M., Marincola, F. M., Kesari, S., & Lin, F. (2024) · Oncotarget · doi:10.18632/oncotarget.28672 · Cited by 34
Fate and long-lasting therapeutic effects of mesenchymal stromal/stem-like cells: mechanistic insights
Hoseinzadeh, A., Esmaeili, S., Sahebi, R., Melak, A. M., Mahmoudi, M., Hasannia, M., & Baharlou, R. (2025) · Stem Cell Research & Therapy · doi:10.1186/s13287-025-04158-z · Cited by 36
The Tumor Stroma of Squamous Cell Carcinoma: A Complex Environment That Fuels Cancer Progression
Buruiană, A., Gheban, B., Gheban-Roşca, I. A., Georgiu, C., Crișan, D., & Crişan, M. (2024) · Cancers · doi:10.3390/cancers16091727 · Cited by 32
Mesenchymal stromal cells in bone marrow niche of patients with multiple myeloma: a double-edged sword
Kamrani, S., Naseramini, R., Khani, P., Razavi, Z. S., Afkhami, H., Atashzar, M. R., Nasri, F., Alavimanesh, S., Saeidi, F., & Ronaghi, H. (2025) · Cancer Cell International · doi:10.1186/s12935-025-03741-x · Cited by 27
“…of MSC to the TME is regulated by numerous factors, including adhesion molecules (VCAM), chemokines (CCL2, CCL5, CCL22, CXCL8, and SDF-1/CXCL12), cytokines (IL-1, IL-6, TGF-β, and TNF-α), insulin GF (IGF-1), PDGF, hypoxia-inducible factor (HIF-1), reactive oxygen species (ROS), and many more [77].”
In-depth insight into tumor-infiltrating stromal cells linked to tertiary lymphoid structures and their prospective function in cancer immunotherapy
Radandish, M., Mashhadi, N., Aghayan, A. H., Taghizadeh, M., Salehianfard, S., Yahyazadeh, S., Vakili, O., & Igder, S. (2025) · Experimental Hematology and Oncology · doi:10.1186/s40164-025-00695-8 · Cited by 27

See all 57

Authors: Slama, Y., Ah-Pine, F., Khettab, M., Arcambal, A., Begue, M., Dutheil, F., & Gasque, P.
Affiliations: University of Reunion Island (RE)
Laboratoire Interdisciplinaire de Recherche en Santé (LIRS), RunResearch, Clinique Sainte-Clotilde, 127 Route de Bois de Nèfles, 97400 Saint-Denis, La Réunion, France
Clinifutur (RE)
Corresponding author: Slama, Youssef
ORCID: Slama, Youssef
Ah-Pine, Franck
Khettab, Mohamed
Begue, Mickael
Gasque, Philippe
Venue: International Journal of Molecular Sciences
Publisher: MDPI AG
Published: 2023-08-31
Volume: 24
Issue: 17
Pages: 13511
ISSN: 1422-0067 (ISSN-L)
DOI: 10.3390/ijms241713511
PMC: PMC10488262
OpenAlex: W4386331467
Cited by: 57
References: 356
Citations by year: 2026: 13 · 2025: 22 · 2024: 21 · 2023: 1
FWCI: 2.67
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
creativecommons.org/licenses/by/4.0/ (vor)
Locations: International Journal of Molecular Sciences (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
Funders: EPIGEN project research (CPER FEDER 2019221-0022768)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Mesenchymal stem cell research
Health Sciences › Medicine › Oncology › Cancer Cells and Metastasis
Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
Keywords: mesenchymal stem cells, tumor microenvironment, tumor progression, metastasis, cancer-associated fibroblasts, cancer stem cells, tumor immunomodulation, melanoma, lung cancer, cell-cell interactions
MeSH terms: Humans, Lung Neoplasms, Melanoma, Multipotent Stem Cells, Tumor Microenvironment, Mesenchymal Stem Cells, Carcinogenesis

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

The Dual Role of Mesenchymal Stem Cells in Cancer Pathophysiology: Pro-Tumorigenic Effects versus Therapeutic Potential

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks