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Cited by 88Bone Tissue Engineering MaterialsHydrogels: synthesis, properties, applications3D Printing in Biomedical Research

Fabrication and Biomedical Application of Alginate Composite Hydrogels in Bone Tissue Engineering: A Review

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Chen, Xiuqiong, Wu, Ting, Bu, Yanan, Yan, Huiqiong, Lin, Qiang·2024·International Journal of Molecular Sciences
DOI 10.3390/ijms25147810PMC PMC11277200
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Abstract

Nowadays, as a result of the frequent occurrence of accidental injuries and traumas such as bone damage, the number of people causing bone injuries or fractures is increasing around the world. The design and fabrication of ideal bone tissue engineering (BTE) materials have become a research hotspot in the scientific community, and thus provide a novel path for the treatment of bone diseases. Among the materials used to construct scaffolds in BTE, including metals, bioceramics, bioglasses, biomacromolecules, synthetic organic polymers, etc., natural biopolymers have more advantages against them because they can interact with cells well, causing natural polymers to be widely studied and applied in the field of BTE. In particular, alginate has the advantages of excellent biocompatibility, good biodegradability, non-immunogenicity, non-toxicity, wide sources, low price, and easy gelation, enabling itself to be widely used as a biomaterial. However, pure alginate hydrogel as a BTE scaffold material still has many shortcomings, such as insufficient mechanical properties, easy disintegration of materials in physiological environments, and lack of cell-specific recognition sites, which severely limits its clinical application in BTE. In order to overcome the defects of single alginate hydrogels, researchers prepared alginate composite hydrogels by adding one or more materials to the alginate matrix in a certain proportion to improve their bioapplicability. For this reason, this review will introduce in detail the methods for constructing alginate composite hydrogels, including alginate/polymer composite hydrogels, alginate/bioprotein or polypeptide composite hydrogels, alginate/bioceramic composite hydrogels, alginate/bioceramic composite hydrogels, and alginate/nanoclay composite hydrogels, as well as their biological application trends in BTE scaffold materials, and look forward to their future research direction. These alginate composite hydrogel scaffolds exhibit both unexceptionable mechanical and biochemical properties, which exhibit their high application value in bone tissue repair and regeneration, thus providing a theoretical basis for the development and sustainable application of alginate-based functional biomedical materials.

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  • Autologous and allogeneic bone grafts are the most frequently employed clinical techniques for bone repair but have limitations including donor-site defects, immune rejection, and surgical pain.

    “Autologous and allogeneic bone grafts are the most frequently employed clinical techniques [129,130]. However, there are still some limitations to these treatments, such as the risk of creating new defects at the donor site, potential immune rejection, and the pain associated with surgical procedures [131,132].”

    From Mussel-Inspired Injectable Adhesive Hydrogels for Biomedical Applications (2024) · cites this paper as [130]

    The Introduction identifies autologous and allogeneic grafting as clinical treatments for bone defects and says allogeneic grafts can cause rejection. Section 4 also describes these transplantation methods as usually used. Neither passage establishes that they are the most frequently employed techniques or identifies donor-site defects and surgical pain as limitations. (LLM, conf=0.86)

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Cited by

Sorted by citations

Authors
Chen, X., Wu, T., Bu, Y., Yan, H., & Lin, Q.
Affiliations
Hainan Normal University (CN)
Corresponding author
Yan, Huiqiong
ORCID
Venue
International Journal of Molecular Sciences
Publisher
MDPI AG
Published
2024-07-17
Volume
25
Issue
14
Pages
7810
ISSN
1422-0067 (ISSN-L)
DOI
10.3390/ijms25147810
PMC
PMC11277200
OpenAlex
W4400723281
Cited by
88
References
2
Citations by year
2026: 51 · 2025: 34 · 2024: 3
FWCI
3.15
Type
journal article
Language
en
Open access
Licence
Locations
  • International Journal of Molecular Sciences (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
Funders
  • Key Research and Development Project of Hainan Province (ZDYF2023SHFZ124, 202208460007, 51963009, Qhyb2023-141, Qhys2023-335)
  • China Scholarship Council (ZDYF2023SHFZ124, 202208460007, 51963009, Qhyb2023-141, Qhys2023-335)
  • National Natural Science Foundation of China (ZDYF2023SHFZ124, 202208460007, 51963009, Qhyb2023-141, Qhys2023-335)
  • Innovation and Scientific Research Projects for Graduates of Hainan Province (ZDYF2023SHFZ124, 202208460007, 51963009, Qhyb2023-141, Qhys2023-335)
  • Innovation and Entrepreneurship of College Students of Hainan Province (ZDYF2023SHFZ124, 202208460007, 51963009, Qhyb2023-141, Qhys2023-335)
  • Innovation and Entrepreneurship of College Students of Hainan Normal University (ZDYF2023SHFZ124, 202208460007, 51963009, Qhyb2023-141, Qhys2023-335)
Topics
  • Physical Sciences › Engineering › Biomedical Engineering › Bone Tissue Engineering Materials
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Hydrogels: synthesis, properties, applications
  • Physical Sciences › Engineering › Biomedical Engineering › 3D Printing in Biomedical Research
Keywords
alginate, composite hydrogels, bone tissue engineering, bone scaffolds, mechanical properties, biodegradability, bone regeneration
MeSH terms
Alginates, Animals, Biocompatible Materials, Bone and Bones, Bone Regeneration, Humans, Hydrogels, Tissue Engineering, Tissue Scaffolds

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