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Cited by 1Extracellular vesicles in diseaseGlioma Diagnosis and TreatmentNanoparticle-Based Drug Delivery

Emerging Frontiers in Neuro-Oncology: Insights into Extracellular Vesicle-Driven Tumor Mechanisms and Nanotherapeutic Strategies

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Colangelo, Tommaso, Saponaro, Anna Alessia, Mazzoccoli, Gianluigi, Serviddio, Gaetano, Villani, Rosanna·2025·International Journal of Molecular Sciences
DOI 10.3390/ijms262411826PMC PMC12733313
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Abstract

Brain tumors encompass a heterogeneous group of neoplasms, including primary and secondary metastatic lesions, with glioblastoma multiforme (GBM) representing the most aggressive primary malignancy. Despite advancements in surgical resection, radiotherapy, and chemotherapy, the prognosis for GBM remains poor due to its infiltrative nature, tumor heterogeneity and resistance mechanisms. Emerging diagnostic tools, such as liquid biopsies, and therapeutic strategies leveraging extracellular vesicles (EVs) are reshaping the field of neuro-oncology. EVs, lipid bilayer-enclosed particles secreted by cells, carry oncogenic cargo such as microRNAs and molecular chaperones, influencing tumor progression, immune evasion, and therapy resistance. Recent research highlights their potential as biomarkers for early diagnosis and vehicles for targeted drug delivery across the blood–brain barrier (BBB). EV-based nanotherapeutics show promise in improving treatment precision, reducing systemic toxicity, and advancing precision medicine in brain tumor management. However, challenges related to EV heterogeneity, cargo-loading efficiency, and large-scale production must be addressed to fully realize their therapeutic potential. This review explores the multifaceted roles of EVs in brain tumors, emphasizing their diagnostic, prognostic, and therapeutic applications.

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  • Extracellular vesicles regulate cell migration in several cancer types, including glioblastoma.

    “In this context, extracellular vesicles (EVs) have emerged as important mediators, regulating cell migration in several cancer types, including GB.”

    From Optimized Wound Healing Assay to Study Extracellular Vesicle-Driven Glioblastoma Cell Migration (2026) · cites this paper as [31]

    Section 4.1 (page unavailable) says GBM-derived EVs enhance invasiveness, supporting a role in glioblastoma cell migration. The passages found do not establish that EVs regulate cell migration in several cancer types; that broader part of the claim is unsupported by our copy. (LLM, conf=0.82)

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Authors
Colangelo, T., Saponaro, A. A., Mazzoccoli, G., Serviddio, G., & Villani, R.
Affiliations
  • University of Foggia (IT)
  • Casa Sollievo della Sofferenza (IT)
Corresponding author
Serviddio, Gaetano
ORCID
Venue
International Journal of Molecular Sciences
Publisher
MDPI AG
Published
2025-12-07
Volume
26
Issue
24
Pages
11826
ISSN
1422-0067 (ISSN-L)
DOI
10.3390/ijms262411826
PMC
PMC12733313
OpenAlex
W4417106642
Cited by
1
References
164
Citations by year
2026: 1
FWCI
0.09
Type
journal article
Language
en
Open access
Licence
Locations
  • International Journal of Molecular Sciences (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • PubMed Central (publishedVersion, cc-by)
Funders
  • European Commission
  • Fondazione Umberto Veronesi
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Extracellular vesicles in disease
  • Health Sciences › Medicine › Genetics › Glioma Diagnosis and Treatment
  • Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
Keywords
extracellular vesicles, glioblastoma, brain tumors, liquid biopsy, microRNA, blood-brain barrier drug delivery, nanotherapeutics, tumor heterogeneity, treatment resistance, immune evasion, biomarkers
MeSH terms
Extracellular Vesicles, Animals, Blood-Brain Barrier, Brain Neoplasms, Glioblastoma, Humans, Biomarkers, Tumor, Drug Delivery Systems

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