Extraction of Glycyrrhizic Acid and Glabridin from Licorice
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The extraction and separation conditions of glycyrrhizic acid and glabridin from licorice were investigated. By changing the different extraction solvents, procedures, times and temperature, the optimum extraction condition was established: the used of ethanol/water (30:70, v/v) as an extraction solvent, and 60 min dipping time under 50°C. The extracts of licorice were separated and determined by reversed-phase high performance liquid chromatography with a methanol/water (70:30, v/v, containing 1% acetic acid) as the mobile phase. Under the optimum extraction condition, 2.39 mg/g of glycyrrhizic acid and 0.92 mg/g of glabridin were extracted from Chinese licorice and the recoveries were 89.7% and 72.5% respectively.
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A mixture of ethanol/water (30:70, v/v) used for an extraction time of 60 min under 50°C of licorice gave a high recovery of glabridin (72.5%).
“Indeed a mixture of ethanol/water (30:70, v/v) used for an extraction time of 60 min under 50 • C of licorice gave a high recovery of glabridin (72.5%) [28].”
From Licorice (Glycyrrhiza glabra, G. uralensis, and G. inflata) and Their Constituents as Active Cosmeceutical Ingredients (2022) · cites this paper as [28]
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- Authors
- Tian, M., Yan, H., & Row, K. H.
- Affiliations
- Inha University (KR)
- Corresponding author
- Row, Kyung Ho
- Venue
- International Journal of Molecular Sciences
- Publisher
- MDPI AG
- Published
- 2008-04-16
- Volume
- 9
- Issue
- 4
- Pages
- 571-577
- ISSN
- 1422-0067 (ISSN-L)
- PMC
- PMC2635700
- OpenAlex
- W2098013424
- Cited by
- 133
- References
- 11
- Citations by year
- 2026: 8 · 2025: 8 · 2024: 11 · 2023: 10 · 2022: 15 · 2021: 14 · 2020: 9 · 2019: 11 · 2018: 5 · 2017: 9 · 2016: 5 · 2015: 3 · 2014: 5 · 2013: 5 · 2012: 3
- FWCI
- 3.64
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- International Journal of Molecular Sciences (publishedVersion, cc-by)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Inha University
- Topics
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Pharmacological Effects of Natural Compounds
- Health Sciences › Medicine › Complementary and alternative medicine › Traditional Chinese Medicine Analysis
- Physical Sciences › Chemistry › Analytical Chemistry › Chromatography in Natural Products
- Keywords
- glycyrrhizin, glabridin, licorice, extraction optimization, ethanol-water solvent, reversed-phase HPLC, saponins, triterpenoids
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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