Daily Fluctuation of Facial Pore Area, Roughness and Redness among Young Japanese Women; Beneficial Effects of Galactomyces Ferment Filtrate Containing Antioxidative Skin Care Formula
Open accessAbstract
Young women often complain about the daily fluctuation of their facial skin conditions. However, no objective study has been carried out on such changes. This study is aimed at quantitatively elucidating daily skin fluctuation and evaluating the efficacy of cosmetic skin care treatment. We developed the first portable and self-guided facial skin imaging device (eMR Pro) to reproducibly capture facial images at home. Two 8 week clinical studies were then conducted to analyze daily skin fluctuation of facial pore areas, roughness and redness in young Japanese women (n = 47 in study 1 and n = 57 in study 2) by collecting facial images three times a day, during the morning after wake-up, during the morning after face wash, and during the evening after face wash. After a 4 week baseline measurement period (week -4 to week -1), all subjects applied Galactomyces ferment filtrate (GFF, Pitera®) skin care formula twice a day for 4 weeks (week 1 to week 4). These three skin conditions did exhibit different fluctuation patterns. The pore area and roughness showed the “morning after wake-up”-largest fluctuation pattern, whereas redness showed the “evening after face wash”-largest fluctuation pattern. GFF treatment significantly reduced the net values and delta fluctuation of pore area, roughness, and redness, which were consistently observed in two studies. In conclusion, the daily fluctuation of facial skin conditions is potentially a new target field for investigating healthy skin maintenance.
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Daily application of Pitera increases skin hydration and decreases TEWL of facial skin.
“clinical studies have revealed that the daily application of PiteraTM indeed increases the skin hydration and decreases the TEWL of facial skin [10,11].”
From Significant Reversal of Facial Wrinkle, Pigmented Spot and Roughness by Daily Application of Galactomyces Ferment Filtrate-Containing Skin Products for 12 Months—An 11-Year Longitudinal Skin Aging Rejuvenation Study (2023) · cites this paper as [10]
The Clinical Study Protocol describes twice-daily facial application of GFF (Pitera®), and the Discussion reports increased skin hydration in this study. Our copy does not report a decrease in transepidermal water loss (TEWL); the TEWL search found no such result. (LLM, conf=0.86)
Experimental — accuracy not yet measuredGFF-containing moisturizers increase skin hydration and reduce TEWL.
“GFF-containing moisturizers are capable of increasing skin hydration and reducing TEWL [46,54].”
From Galactomyces Ferment Filtrate Potentiates an Anti-Inflammaging System in Keratinocytes (2022) · cites this paper as [46]
The Discussion reports that the GFF-formulated product increased skin hydration in the study, and the Clinical Study Protocol describes measuring hydration at the cheek. Our copy does not report that the product reduced transepidermal water loss (TEWL); the TEWL mention found is in a reference title, not a finding of this study. (LLM, conf=0.88)
Experimental — accuracy not yet measuredTopical application of GFF PiteraTM improves intraday fluctuations in facial redness, skin roughness, and hair pore size.
“Clinical trials have also shown that the topical application of GFF Pitera™ improves intraday fluctuations in facial redness, skin roughness, and hair pore size [46].”
From Galactomyces Ferment Filtrate Potentiates an Anti-Inflammaging System in Keratinocytes (2022) · cites this paper as [46]
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Cites
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Characteristics of the Aging Skin
Farage, M. A., Miller, K. W., Elsner, P., & Maibach, H. I. (2013) · Advances in Wound Care · doi:10.1089/wound.2011.0356 · Cited by 535 · see citing works
Takei, K., Mitoma, C., Hashimoto‐Hachiya, A., Takahara, M., Tsuji, G., Nakahara, T., & Furue, M. (2015) · Clinical and Experimental Dermatology · doi:10.1111/ced.12635 · Cited by 45 · see citing works
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Research works printed but not linked: 9
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Cited by
Sorted by citations
Galactomyces Ferment Filtrate Potentiates an Anti-Inflammaging System in Keratinocytes
Yan, X., Tsuji, G., Hashimoto-Hachiya, A., & Furue, M. (2022) · Journal of Clinical Medicine · doi:10.3390/jcm11216338 · Cited by 20 · see citing works
Self-citationMiyamoto, K., Inoue, Y., Yan, X., Yagi, S., Suda, S., & Furue, M. (2023) · Journal of Clinical Medicine · doi:10.3390/jcm12031168 · Cited by 9 · see citing works
Self-citation
- Authors
- Miyamoto, K., Dissanayake, B., Omotezako, T., Takemura, M., Tsuji, G., & Furue, M.
- Affiliations
- Procter & Gamble Japan K.K. (Japan) (JP)
- Research and Development, Beauty Care, P&G International Operations (SA) Singapore Branch, Singapore 138547, Singapore
- Kyushu University (JP)
- Corresponding author
- Miyamoto, Kukizo
- ORCID
- Venue
- Journal of Clinical Medicine
- Publisher
- MDPI AG
- Published
- 2021-06-05
- Volume
- 10
- Issue
- 11
- Pages
- 2502
- ISSN
- 2077-0383 (ISSN-L)
- PMC
- PMC8200969
- OpenAlex
- W3171698583
- Cited by
- 28
- References
- 3
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 6 · 2023: 10 · 2022: 6 · 2021: 2
- FWCI
- 5.33
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Journal of Clinical Medicine (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Health Sciences › Medicine › Dermatology › Skin Protection and Aging
- Health Sciences › Medicine › Dermatology › Dermatology and Skin Diseases
- Health Sciences › Medicine › Dermatology › Acne and Rosacea Treatments and Effects
- Keywords
- skin roughness, facial redness, young women
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