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Long-Term Outcome of Potential Celiac Disease in Genetically at-Risk Children: The Prospective CELIPREV Cohort Study
Open accessAbstract
Background: The long-term outcome of potential celiac disease (CD) is still a debated issue. We aimed to evaluate the progression of potential CD versus overt CD after 10-years of follow-up in a cohort of children genetically predisposed to CD. Methods: The CELIPREV study is prospectively following from birth 553 children with CD-predisposing HLA genes. Children with a diagnosis of potential CD continued to receive a normal diet and repeated the serological screening for CD every year. An intestinal biopsy was taken in presence of persistent positive serology. Results: Overall, 26 (4.7%) children received a diagnosis of potential CD (50% females, median age 24 months). All children were symptom-free. Twenty-three children continued a gluten-containing diet; at 10 years from the first biopsy, three children developed overt CD (13%), 19 (83%) became antibodies negative at 1 year from the first biopsy and remained negative up to 10 years of follow-up and one subject (4%) had fluctuating antibody course with transiently negative values and persistently negative biopsy. Conclusions: In children genetically predisposed to CD with a diagnosis of potential CD the risk of progression to overt CD while on a gluten-containing diet is very low in the long-term.
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The first two issues in the management of potential CD find some evidence in the literature.
“The first two issues find some evidence in the literature (133-140).”
From ESPGHAN Position Paper on Management and Follow-up of Children and Adolescents With Celiac Disease. (2022) · cites this paper as [140]
The majority of patients with potential CD remain as 'potential CD,' with a significant percentage normalizing their CD antibodies, frequently observed in younger children.
“The majority remain as 'potential CD,' with a significant percentage of those normalizing their CD antibodies , which is frequently observed in younger children.”
From ESPGHAN Position Paper on Management and Follow-up of Children and Adolescents With Celiac Disease. (2022) · cites this paper as [140]
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Research works printed but not linked: 22
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Cited by
Sorted by citations
ESPGHAN Position Paper on Management and Follow-up of Children and Adolescents With Celiac Disease.
Mearin, M. L., Agardh, D., Antunes, H., Al‐toma, A., Auricchio, R., Castillejo, G., Catassi, C., Ciacci, C., Discepolo, V., Dolinsek, J., et al. (2022) · Journal of pediatric gastroenterology and nutrition · doi:10.1097/mpg.0000000000003540 · Cited by 186
Self-citation
Metadata
- Authors
- Lionetti, E., Castellaneta, S., Francavilla, R., Pulvirenti, A., Naspi Catassi, G., Catassi, C., & The SIGENP Working Group of Weaning and CD Risk
- Affiliations
- Marche Polytechnic University (IT)
- Ospedale San Paolo (IT)
- University of Bari Aldo Moro (IT)
- University of Catania (IT)
- Department of Pediatrics, Marche Polytechnic University, 60123 Ancona, Italy
- Corresponding author
- Lionetti, Elena
- Venue
- Journal of Clinical Medicine
- Publisher
- MDPI AG
- Published
- 2019-02-05
- Volume
- 8
- Issue
- 2
- Pages
- 186
- ISSN
- 2077-0383 (ISSN-L)
- PMC
- PMC6406363
- OpenAlex
- W2914306443
- Cited by
- 35
- References
- 0
- Citations by year
- 2026: 6 · 2025: 3 · 2024: 3 · 2023: 5 · 2022: 4 · 2021: 8 · 2020: 1 · 2019: 5
- FWCI
- 4.10
- Type
- journal article
- Language
- en
- Open access
- gold
- dx.doi.org
- Licence
- Locations
- Journal of Clinical Medicine (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- IRIS Research product catalog (Sapienza University of Rome) (submittedVersion, other-oa)
- Università Politecnica delle Marche (Università Politecnica delle Marche) (submittedVersion, cc-by)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- CINECA IRIS Institutional Research Information System (University of Bari Aldo Moro) (submittedVersion, cc-by)
- Funders
- Fondazione celiachia of the Italian Society for Celiac Disease (no grant number)
- Topics
- Health Sciences › Medicine › Gastroenterology › Celiac Disease Research and Management
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Wheat and Barley Genetics and Pathology
- Health Sciences › Medicine › Gastroenterology › Eosinophilic Esophagitis
- Keywords
- children, gluten-containing diet, serological screening, intestinal biopsy, anti-tissue transglutaminase antibodies, long-term outcomes
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