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Cited by 36

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Cardiac and Vascular Sympathetic Baroreflex Control during Orthostatic Pre-Syncope

Furlan, Raffaello, Heusser, Karsten, Minonzio, Maura, Shiffer, Dana, Cairo, Beatrice, Tank, Jens, Jordan, Jens, Diedrich, André, Gauger, Peter, Zamuner, Antonio Roberto, Dipaola, Franca, Porta, Alberto, Barbic, Franca·2019·Journal of Clinical Medicine
DOI 10.3390/jcm8091434
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Abstract

We hypothesized that sympathetic baroreflex mediated uncoupling between neural sympathetic discharge pattern and arterial pressure (AP) fluctuations at 0.1 Hz during baroreceptor unloading might promote orthostatic pre-syncope. Ten volunteers (32 ± 6 years) underwent electrocardiogram, beat-to-beat AP, respiratory activity and muscle sympathetic nerve activity (MSNA) recordings while supine (REST) and during 80° head-up tilt (HUT) followed by −10 mmHg stepwise increase of lower body negative pressure until pre-syncope. Cardiac and sympathetic baroreflex sensitivity were quantified. Spectrum analysis of systolic and diastolic AP (SAP and DAP) and calibrated MSNA (cMSNA) variability assessed the low frequency fluctuations (LF, ~0.1 Hz) of SAP, DAP and cMSNA variability. The squared coherence function (K2) quantified the coupling between cMSNA and DAP in the LF band. Analyses were performed while supine, during asymptomatic HUT (T1) and at pre-syncope onset (T2). During T2 we found that: (1) sympathetic baroreceptor modulation was virtually abolished compared to T1; (2) a progressive decrease in AP was accompanied by a persistent but chaotic sympathetic firing; (3) coupling between cMSNA and AP series at 0.1 Hz was reduced compared to T1. A negligible sympathetic baroreceptor modulation during pre-syncope might disrupt sympathetic discharge pattern impairing the capability of vessels to constrict and promote pre-syncope.

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Research works printed but not linked: 44

  1. Alboni, 2015, Pathophysiology of Vasovagal Syncope: Conclusive Remarks, Vasovagal Syncope, Volume 11, 95
  2. Furlan, 1997, Sympathetic and baroreceptor reflex function in neurally mediated syncope evoked by tilt, J. Clin. Investig., 99, 2736, 10.1172/JCI119463 · DOI · Paper page
  3. Diedrich, 2007, Plasma and Blood Volume in Space, Am. J. Med. Sci., 334, 80, 10.1097/MAJ.0b013e318065b89b · DOI
  4. Robertson, 2012, Editorial on arterial baroreflex issue, Auton. Neurosci., 172, 1, 10.1016/j.autneu.2012.10.010 · DOI
  5. Furlan, 2000, Oscillatory Patterns in Sympathetic Neural Discharge and Cardiovascular Variables During Orthostatic Stimulus, Circulation, 101, 886, 10.1161/01.CIR.101.8.886 · DOI
  6. Diedrich, 2009, Lateralization of expression of neural sympathetic activity to the vessels and effects of carotid baroreceptor stimulation, Am. J. Physiol. Heart Circ. Physiol., 296, H1758, 10.1152/ajpheart.01045.2008 · DOI
  7. Kamiya, 2005, Low-frequency oscillation of sympathetic nerve activity decreases during development of tilt-induced syncope preceding sympathetic withdrawal and bradycardia, Am. J. Physiol. Heart Circ. Physiol., 289, H1758, 10.1152/ajpheart.01027.2004 · DOI
  8. Schwartz, 2013, Disruption of phase synchronization between blood pressure and muscle sympathetic nerve activity in postural vasovagal syncope, Am. J. Physiol. Heart Circ. Physiol., 305, H1238, 10.1152/ajpheart.00415.2013 · DOI
  9. Robertson, 1993, The Diagnosis and Treatment of Baroreflex Failure, N. Engl. J. Med., 329, 1449, 10.1056/NEJM199311113292003 · DOI · Paper page
  10. Furlan, 2001, Orthostatic intolerance: different abnormalities in the neural sympathetic response to a gravitational stimulus, Auton. Neurosci., 90, 83, 10.1016/S1566-0702(01)00271-5 · DOI
  11. Jordan, 1997, Malignant Vagotonia Due to Selective Baroreflex Failure, Hypertension, 30, 1072, 10.1161/01.HYP.30.5.1072 · DOI
  12. Heusser, 2005, Baroreflex Failure, Hypertension, 45, 834, 10.1161/01.HYP.0000160355.93303.72 · DOI
  13. Ichinose, 2006, Modulation of the control of muscle sympathetic nerve activity during severe orthostatic stress, J. Physiol., 576, 947, 10.1113/jphysiol.2006.117507 · DOI
  14. Barbic, 2015, Cardiovascular parameters and neural sympathetic discharge variability before orthostatic syncope: Role of sympathetic baroreflex control to the vessels, Physiol. Meas., 36, 633, 10.1088/0967-3334/36/4/633 · DOI
  15. Alboni, 2015, Pathophysiology of Vasovagal Syncope: Role of Baroreceptor Mechanisms, Vasovagal Syncope, Volume 11, 67
  16. Cooke, 2009, Muscle sympathetic nerve activity during intense lower body negative pressure to presyncope in humans, J. Physiol., 587, 4987, 10.1113/jphysiol.2009.177352 · DOI
  17. Alboni, 2015, Cardiovascular Rhythms in Vasovagal Syncope, Vasovagal Syncope, Volume 11, 83
  18. Stauss, 1998, Frequency response characteristics of sympathetically mediated vasomotor waves in humans, Am. J. Physiol., 274, H1277
  19. Diedrich, 2013, Baroreflex physiology studied in healthy subjects with very infrequent muscle sympathetic bursts, J. Appl. Physiol. (1985), 114, 203, 10.1152/japplphysiol.00509.2011 · DOI
  20. Buehlmeier, 2014, A combination of whey protein and potassium bicarbonate supplements during head-down-tilt bed rest: Presentation of a multidisciplinary randomized controlled trial (MEP study), Acta Astronaut., 95, 82, 10.1016/j.actaastro.2013.11.001 · DOI
  21. 1996, Microneurography in neurological research, Am. Acad. Neurol., 2, 4
  22. Pagani, 1986, Power spectral analysis of heart rate and arterial pressure variabilities as a marker of sympatho-vagal interaction in man and conscious dog, Circ. Res., 59, 178, 10.1161/01.RES.59.2.178 · DOI · Paper page
  23. Malik, 1996, Heart rate variability: standards of measurement, physiological interpretation and clinical use. Task Force of the European Society of Cardiology and the North American Society of Pacing and Electrophysiology, Circulation, 93, 1043, 10.1161/01.CIR.93.5.1043 · DOI · Paper page
  24. Barbic, 2007, Early Abnormalities of Vascular and Cardiac Autonomic Control in Parkinson’s Disease Without Orthostatic Hypotension, Hypertension, 49, 120, 10.1161/01.HYP.0000250939.71343.7c · DOI
  25. Hamner, 2001, Automated quantification of sympathetic beat-by-beat activity, independent of signal quality, J. Appl. Physiol. (1985), 91, 1199, 10.1152/jappl.2001.91.3.1199 · DOI
  26. Wallin, 1994, Coupling between variations in strength and baroreflex latency of sympathetic discharges in human muscle nerves, J. Physiol., 474, 331, 10.1113/jphysiol.1994.sp020025 · DOI
  27. Marchi, 2016, Calibrated variability of muscle sympathetic nerve activity during graded head-up tilt in humans and its link with noradrenaline data and cardiovascular rhythms, Am. J. Physiol. Regul. Integr. Comp. Physiol., 310, R1134, 10.1152/ajpregu.00541.2015 · DOI
  28. Pagani, 1997, Relationship Between Spectral Components of Cardiovascular Variabilities and Direct Measures of Muscle Sympathetic Nerve Activity in Humans, Circulation, 95, 1441, 10.1161/01.CIR.95.6.1441 · DOI
  29. Porta, 2013, Model-based causal closed-loop approach to the estimate of baroreflex sensitivity during propofol anesthesia in patients undergoing coronary artery bypass graft, J. Appl. Physiol. (1985), 115, 1032, 10.1152/japplphysiol.00537.2013 · DOI
  30. Magagnin, 2011, Non-stationarities significantly distort short-term spectral, symbolic and entropy heart rate variability indices, Physiol. Meas., 32, 1775, 10.1088/0967-3334/32/11/S05 · DOI
  31. Bertinieri, 1988, Evaluation of baroreceptor reflex by blood pressure monitoring in unanesthetized cats, Am. J. Physiol., 254, H377
  32. Parati, 1988, Evaluation of the baroreceptor-heart rate reflex by 24-hour intra-arterial blood pressure monitoring in humans, Hypertension, 12, 214, 10.1161/01.HYP.12.2.214 · DOI
  33. Hart, 2010, Baroreflex control of muscle sympathetic nerve activity: A nonpharmacological measure of baroreflex sensitivity, Am. J. Physiol. Heart Circ. Physiol., 298, H816, 10.1152/ajpheart.00924.2009 · DOI
  34. Marchi, 2016, Simultaneous Characterization of Sympathetic and Cardiac Arms of the Baroreflex through Sequence Techniques during Incremental Head-Up Tilt, Front. Physiol., 7, 438, 10.3389/fphys.2016.00438 · DOI
  35. Hainsworth, 1994, Combined head-up tilt and lower body suction: A test of orthostatic tolerance, Clin. Auton. Res., 4, 41, 10.1007/BF01828837 · DOI
  36. Piccirillo, 2004, Heart rate and blood pressure variability in subjects with vasovagal syncope, Clin. Sci., 107, 55, 10.1042/CS20030327 · DOI
  37. Ogoh, 2004, Carotid baroreflex function ceases during vasovagal syncope, Clin. Auton. Res., 14, 30, 10.1007/s10286-004-0156-4 · DOI
  38. Jardine, 2002, Decrease in cardiac output and muscle sympathetic activity during vasovagal syncope, Am. J. Physiol. Heart Circ. Physiol., 282, H1804, 10.1152/ajpheart.00640.2001 · DOI · Paper page
  39. Jardine, 2013, Vasovagal syncope: new physiologic insights, Cardiol. Clin., 31, 75, 10.1016/j.ccl.2012.10.010 · DOI
  40. Vaddadi, 2010, Persistence of muscle sympathetic nerve activity during vasovagal syncope, Eur. Hear. J., 31, 2027, 10.1093/eurheartj/ehq071 · DOI · Paper page
  41. Fu, 2012, Cardiac output and sympathetic vasoconstrictor responses during upright tilt to presyncope in healthy humans, J. Physiol., 590, 1839, 10.1113/jphysiol.2011.224998 · DOI
  42. Iwase, 2002, Syncopal attack alters the burst properties of muscle sympathetic nerve activity in humans, Auton. Neurosci., 95, 141, 10.1016/S1566-0702(01)00362-9 · DOI
  43. Eckberg, 1985, Respiratory modulation of muscle sympathetic and vagal cardiac outflow in man, J. Physiol., 365, 181, 10.1113/jphysiol.1985.sp015766 · DOI · Paper page
  44. Malliani, 1969, A sympathetic reflex elicited by experimental coronary occlusion, Am. J. Physiol., 217, 703, 10.1152/ajplegacy.1969.217.3.703 · DOI · Paper page

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Metadata

Authors
Furlan, R., Heusser, K., Minonzio, M., Shiffer, D., Cairo, B., Tank, J., Jordan, J., Diedrich, A., Gauger, P., Zamuner, A. R., Dipaola, F., Porta, A., & Barbic, F.
Affiliations
  • Department of Internal Medicine, Humanitas Clinical and Research Center, IRCCS, Humanitas University, 20089 Rozzano, Italy
  • Institute of Aerospace Medicine, German Aerospace Center (DLR), 51147 Cologne, Germany
  • Department of Biomedical Sciences for Health, University of Milan, 20122 Milan, Italy
  • Autonomic Dysfunction Center, Vanderbilt University Medical Center, Nashville, TN 37232, USA
  • Departamento de Kinesiología, Universidad Católica del Maule, 3530000 Talca, Maule, Chile
ORCID
Venue
Journal of Clinical Medicine
Publisher
MDPI AG
Published
2019-09-10
Volume
8
Issue
9
Pages
1434
ISSN
2077-0383
DOI
10.3390/jcm8091434
Cited by
36
References
7
Language
en
Licence
creativecommons.org/licenses/by/4.0/ (vor)

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CoChat. (2026). Citation check: Cardiac and Vascular Sympathetic Baroreflex Control during Orthostatic Pre-Syncope. https://app.cochat.ai/papers/10.3390/jcm8091434
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Furlan, R., Heusser, K., Minonzio, M., Shiffer, D., Cairo, B., Tank, J., Jordan, J., Diedrich, A., Gauger, P., Zamuner, A. R., Dipaola, F., Porta, A., & Barbic, F. (2019). Cardiac and Vascular Sympathetic Baroreflex Control during Orthostatic Pre-Syncope. Journal of Clinical Medicine. https://doi.org/10.3390/jcm8091434

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