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Nonalcoholic fatty liver disease: a challenge from mechanisms to therapy.
Open accessAbstract
Focusing on previously published mechanisms of non-alcoholic fatty liver disease (NAFLD), their uncertainty does not always permit a clear elucidation of the grassroot alterations that are at the basis of the wide-spread illness, and thus curing it is still a challenge. There is somehow exceptional progress, but many controversies persist in NAFLD research and clinical investigation. It is likely that hidden mechanisms will be brought to light in the near future. Hereby, the authors present, with some criticism, classical mechanisms that stand at the basis of NAFLD, and consider contextually different emerging processes. Without ascertaining these complex interactions, investigators have a long way left ahead before finding an effective therapy for NAFLD beyond diet and exercise.
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“its development is associated with the insulin receptor, low-grade inflammation, and ectopic lipid deposition”
From Effect of Exercise Training on Fat Loss—Energetic Perspectives and the Role of Improved Adipose Tissue Function and Body Fat Distribution (2021) · cites this paper as Tarantino et al., 2019
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“Consequently, NAFLD is exacerbated with AT dysfunction”
From Effect of Exercise Training on Fat Loss—Energetic Perspectives and the Role of Improved Adipose Tissue Function and Body Fat Distribution (2021) · cites this paper as Tarantino et al., 2019
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Metadata
- Authors
- Tarantino, G., Citro, V., & Capone, D.
- Affiliations
- Federico II University Hospital (IT)
- Department of General Medicine, “Umberto I” Hospital, 84014 Nocera Inferiore (Sa), Italy
- Care Department of Public Health and Drug-Use, Section of Medical Pharmacology and Toxicology, “Federico II” University, 80131 Naples, Italy
- Corresponding author
- Tarantino, Giovanni
- ORCID
- Tarantino, Giovanni
- Venue
- Journal of Clinical Medicine
- Publisher
- MDPI AG
- Published
- 2019-12-19
- Volume
- 9
- Issue
- 1
- Pages
- 15
- ISSN
- 2077-0383 (ISSN-L)
- PMC
- PMC7019297
- OpenAlex
- W2995566743
- Cited by
- 134
- References
- 123
- Citations by year
- 2026: 3 · 2025: 6 · 2024: 8 · 2023: 8 · 2022: 27 · 2021: 68 · 2020: 11 · 2019: 2
- FWCI
- 3.94
- Type
- journal article
- Language
- en
- Open access
- gold
- dx.doi.org
- Licence
- Locations
- Journal of Clinical Medicine (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Hepatology › Liver Disease Diagnosis and Treatment
- Health Sciences › Medicine › Hepatology › Liver physiology and pathology
- Health Sciences › Medicine › Pathology and Forensic Medicine › Alcohol Consumption and Health Effects
- Keywords
- non-alcoholic fatty liver disease, pathogenesis, disease mechanisms, NAFLD therapy, diet and exercise
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