Cited by 134Liver Disease Diagnosis and TreatmentLiver physiology and pathologyAlcohol Consumption and Health Effects

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Nonalcoholic fatty liver disease: a challenge from mechanisms to therapy.

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Tarantino, Giovanni, Citro, Vincenzo, Capone, Domenico·2019·Journal of Clinical Medicine

DOI 10.3390/jcm9010015PMC PMC7019297

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Abstract

Focusing on previously published mechanisms of non-alcoholic fatty liver disease (NAFLD), their uncertainty does not always permit a clear elucidation of the grassroot alterations that are at the basis of the wide-spread illness, and thus curing it is still a challenge. There is somehow exceptional progress, but many controversies persist in NAFLD research and clinical investigation. It is likely that hidden mechanisms will be brought to light in the near future. Hereby, the authors present, with some criticism, classical mechanisms that stand at the basis of NAFLD, and consider contextually different emerging processes. Without ascertaining these complex interactions, investigators have a long way left ahead before finding an effective therapy for NAFLD beyond diet and exercise.

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Authors: Tarantino, G., Citro, V., & Capone, D.
Affiliations: Federico II University Hospital (IT)
Department of General Medicine, “Umberto I” Hospital, 84014 Nocera Inferiore (Sa), Italy
Care Department of Public Health and Drug-Use, Section of Medical Pharmacology and Toxicology, “Federico II” University, 80131 Naples, Italy
Corresponding author: Tarantino, Giovanni
ORCID: Tarantino, Giovanni
Venue: Journal of Clinical Medicine
Publisher: MDPI AG
Published: 2019-12-19
Volume: 9
Issue: 1
Pages: 15
ISSN: 2077-0383 (ISSN-L)
DOI: 10.3390/jcm9010015
PMC: PMC7019297
OpenAlex: W2995566743
Cited by: 134
References: 123
Citations by year: 2026: 3 · 2025: 6 · 2024: 8 · 2023: 8 · 2022: 27 · 2021: 68 · 2020: 11 · 2019: 2
FWCI: 3.94
Type: journal article
Language: en
Open access: gold
dx.doi.org
Licence: cc-by
creativecommons.org/licenses/by/4.0/ (vor)
Locations: Journal of Clinical Medicine (publishedVersion, cc-by)
Europe PMC (PubMed Central) (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Hepatology › Liver Disease Diagnosis and Treatment
Health Sciences › Medicine › Hepatology › Liver physiology and pathology
Health Sciences › Medicine › Pathology and Forensic Medicine › Alcohol Consumption and Health Effects
Keywords: non-alcoholic fatty liver disease, pathogenesis, disease mechanisms, NAFLD therapy, diet and exercise

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Nonalcoholic fatty liver disease: a challenge from mechanisms to therapy.

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