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Cited by 71Microbial Metabolic Engineering and BioproductionEvolutionary Game Theory and CooperationBacterial biofilms and quorum sensing

Bottom-Up Approaches to Synthetic Cooperation in Microbial Communities

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Rodríguez Amor, Daniel, Dal Bello, Martina·2019·Life
DOI 10.3390/life9010022PMC PMC6462982
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Abstract

Microbial cooperation pervades ecological scales, from single-species populations to host-associated microbiomes. Understanding the mechanisms promoting the stability of cooperation against potential threats by cheaters is a major question that only recently has been approached experimentally. Synthetic biology has helped to uncover some of these basic mechanisms, which were to some extent anticipated by theoretical predictions. Moreover, synthetic cooperation is a promising lead towards the engineering of novel functions and enhanced productivity of microbial communities. Here, we review recent progress on engineered cooperation in microbial ecosystems. We focus on bottom-up approaches that help to better understand cooperation at the population level, progressively addressing the challenges of tackling higher degrees of complexity: spatial structure, multispecies communities, and host-associated microbiomes. We envisage cooperation as a key ingredient in engineering complex microbial ecosystems.

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Cited by

Sorted by citations

Authors
Rodríguez Amor, D., & Dal Bello, M.
Affiliations
Physics of Living Systems, Department of Physics, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
ORCID
Venue
Life
Publisher
MDPI AG
Published
2019-02-26
Volume
9
Issue
1
Pages
22
ISSN
2075-1729 (ISSN-L)
DOI
10.3390/life9010022
PMC
PMC6462982
OpenAlex
W2916899223
Cited by
71
References
5
Citations by year
2026: 5 · 2025: 7 · 2024: 13 · 2023: 8 · 2022: 14 · 2021: 12 · 2020: 9 · 2019: 2 · 2018: 1
FWCI
0.85
Type
journal article
Language
en
Open access
Licence
Locations
  • Life (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
  • DSpace@MIT (Massachusetts Institute of Technology) (submittedVersion, cc-by)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Microbial Metabolic Engineering and Bioproduction
  • Social Sciences › Sociology and Political Science › Evolutionary Game Theory and Cooperation
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bacterial biofilms and quorum sensing
Keywords
microbial cooperation, cheaters, cooperation stability, synthetic biology, multispecies microbial communities, spatial structure, host-associated microbiome, bottom-up approach

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