The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
Fucoxanthin: A Marine Carotenoid Exerting Anti-Cancer Effects by Affecting Multiple Mechanisms
Open accessAbstract
Fucoxanthin is a marine carotenoid exhibiting several health benefits. The anti-cancer effect of fucoxanthin and its deacetylated metabolite, fucoxanthinol, is well documented. In view of its potent anti-carcinogenic activity, the need to understand the underlying mechanisms has gained prominence. Towards achieving this goal, several researchers have carried out studies in various cell lines and in vivo and have deciphered that fucoxanthin exerts its anti-proliferative and cancer preventing influence via different molecules and pathways including the Bcl-2 proteins, MAPK, NFκB, Caspases, GADD45, and several other molecules that are involved in either cell cycle arrest, apoptosis, or metastasis. Thus, in addition to decreasing the frequency of occurrence and growth of tumours, fucoxanthin has a cytotoxic effect on cancer cells. Some studies show that this effect is selective, i.e., fucoxanthin has the capability to target cancer cells only, leaving normal physiological cells unaffected/less affected. Hence, fucoxanthin and its metabolites show great promise as chemotherapeutic agents in cancer.
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Cites
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Apoptosis-inducing effect of fucoxanthin on human leukemia cell line HL-60
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Antiangiogenic Activity of Brown Algae Fucoxanthin and Its Deacetylated Product, Fucoxanthinol
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“[77] have reported the anti-angiogenic activity of fucoxanthin and postulated that this may be another protective effect of fucoxanthin in pathologies such as cancer.”
BackgroundHistory and characteristics of Okinawan longevity food
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Review of Natural Compounds for Potential Skin Cancer Treatment
Chinembiri, T., Du Plessis, L., Gerber, M., Hamman, J., & Du Plessis, J. (2014) · Molecules · doi:10.3390/molecules190811679 · Cited by 270
Sanaeimehr, Z., Javadi, I., & Namvar, F. (2018) · Cancer Nanotechnology · doi:10.1186/s12645-018-0037-5 · Cited by 257
Microalgae in modern cancer therapy: current knowledge
Abd El-Hack, M. E., Abdelnour, S., Alagawany, M., Abdo, M., Sakr, M. A., Khafaga, A. F., Mahgoub, S. A., Elnesr, S. S., & Gebriel, M. G. (2019) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2018.12.069 · Cited by 206
Milledge, J. J., Nielsen, B. V., & Bailey, D. (2016) · Reviews in Environmental Science and Bio/Technology · doi:10.1007/s11157-015-9381-7 · Cited by 193
Neumann, U., Derwenskus, F., Flaiz Flister, V., Schmid-Staiger, U., Hirth, T., & Bischoff, S. (2019) · Antioxidants · doi:10.3390/antiox8060183 · Cited by 154
Metadata
- Authors
- Kumar, S., Hosokawa, M., & Miyashita, K.
- Venue
- Marine Drugs
- Publisher
- MDPI AG
- Published
- 2013-12-16
- Volume
- 11
- Issue
- 12
- Pages
- 5130-5147
- ISSN
- 1660-3397 (ISSN-L)
- OpenAlex
- W2017590409
- Cited by
- 246
- References
- 8
- FWCI
- 16.91
- Type
- journal article
- Language
- en
- Open access
- gold
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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