The consumption of seaweed as a protective factor in the etiology of breast cancer: proof of principle
Open accessAbstract
Daily consumption of seaweed has been proposed as a factor in explaining lower postmenopausal breast cancer (BC) incidence and mortality rates in Japan. This clinical trial assessed the impact of introducing seaweed- to non-seaweed-consuming American postmenopausal women. Fifteen healthy postmenopausal women were recruited for a 3-month single-blinded placebo controlled clinical trial; five had no history of BC (controls) and ten were BC survivors. Participants ingested ten capsules daily (5 g day −1 ) of placebo for 4 weeks, seaweed ( Undaria ) for 4 weeks, then placebo for another 4 weeks. Blood and urine samples were collected after each treatment period. Urinary human urokinase-type plasminogen activator receptor concentrations (uPAR) were analyzed by ELISA, and urine and serum were analyzed for protein expression using surface-enhanced laser desorption/ionization–time-of-flight mass spectrometry (SELDI-TOF-MS). Urinary creatinine standardized uPAR (in pg mL μg −1 creatinine) changed significantly between groups, decreasing by about half following seaweed supplementation (placebo 1, 1.5 (95 % CI, 0.9–2.1) and seaweed, 0.9 (95 % CI, 0.6–1.1) while placebo 2 returned to pre-seaweed concentration (1.7 (95 % CI, 1.2-2.2); p = 0.01, ANOVA). One SELDI-TOF-MS-identified urinary protein ( m / z 9,776) showed a similar reversible decrease with seaweed and is reported to be associated with cell attachment. One serum protein ( m / z 8,928) reversibly increased with seaweed and may be the immunostimulatory complement activation C3a des-arginine. uPAR is higher among postmenopausal women generally, and for BC patients, it is associated with unfavorable BC prognosis. By lowering uPAR, dietary seaweed may help explain lower BC incidence and mortality among postmenopausal women in Japan.
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Urinary human urokinase-type plasminogen activator receptor concentration is higher among postmenopausal women breast cancer patients.
“Urinary human urokinase-type plasminogen activator receptor concentration is higher among postmenopausal women breast cancer patients.”
From Anticancer and Cancer Preventive Properties of Marine Polysaccharides: Some Results and Prospects (2013) · cites this paper as [77]
This concentration was decreased by about 50% after seaweed supplementation.
“It was shown that this concentration was decreased by about 50% after seaweed supplementation [77].”
From Anticancer and Cancer Preventive Properties of Marine Polysaccharides: Some Results and Prospects (2013) · cites this paper as [77]
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- Authors
- Teas, J., Vena, S., Cone, D. L., & Irhimeh, M.
- Affiliations
- University of South Carolina (US)
- The University of Sydney (AU)
- Corresponding author
- Teas, Jane
- Venue
- Journal of Applied Phycology
- Published
- 2012-11-10
- Volume
- 25
- Issue
- 3
- Pages
- 771-779
- ISSN
- 0921-8971 (ISSN-L)
- 1573-5176
- PMC
- PMC3651528
- OpenAlex
- W1977658960
- Cited by
- 77
- References
- 49
- Citations by year
- 2026: 2 · 2025: 4 · 2024: 7 · 2023: 7 · 2022: 9 · 2021: 4 · 2020: 4 · 2019: 10 · 2018: 7 · 2017: 6 · 2016: 3 · 2015: 6 · 2014: 5 · 2013: 3
- FWCI
- 6.56
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Applied Phycology (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- University of Sydney
- Medical Research and Materiel Command
- Topics
- Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Seaweed-derived Bioactive Compounds
- Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Echinoderm biology and ecology
- Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
- Keywords
- seaweed consumption, Undaria, breast cancer, postmenopausal women, urokinase-type plasminogen activator receptor, uPAR, dietary supplementation, urinary biomarkers, cancer etiology, Japanese diet
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