Cited by 148Seaweed-derived Bioactive CompoundsAngiogenesis and VEGF in CancerFatty Acid Research and Health

Antiangiogenic Activity of Brown Algae Fucoxanthin and Its Deacetylated Product, Fucoxanthinol

Sugawara, Tatsuya, Matsubara, Kiminori, Akagi, Reiko, Mori, Masaharu, Hirata, Takashi·2006·Journal of Agricultural and Food Chemistry

Abstract

The antiangiogenic effects of fucoxanthin and a deacetylated product, fucoxanthinol, were examined. Fucoxanthin significantly suppressed HUVEC proliferation and tube formation at more than 10 microM, but it had no significant effect on HUVEC chemotaxis. The formation of blood vessel-like structures from CD31-positive cells was evaluated using embryonic stem cell-derived embryoid bodies. Fucoxanthin effectively suppressed the development of these structures at 10-20 microM, suggesting that it could suppress differentiation of endothelial progenitor cells into endothelial cells involving new blood vessel formation. Fucoxanthin and fucoxanthinol suppressed microvessel outgrowth in an ex vivo angiogenesis assay using a rat aortic ring, in a dose-dependent manner. These results imply that fucoxanthin having antiangiogenic activity might be useful in preventing angiogenesis-related diseases.

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Crossref · 10.1021/jf062204q

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Authors
Sugawara, T., Matsubara, K., Akagi, R., Mori, M., & Hirata, T.
Affiliations
Okayama Prefectural University (JP)
Corresponding author
Hirata, Takashi
Venue
Journal of Agricultural and Food Chemistry
Published
2006-12-01
Volume
54
Issue
26
Pages
9805-9810
ISSN
  • 0021-8561 (ISSN-L)
  • 1520-5118
OpenAlex
W2012477218
Cited by
148
References
31
Citations by year
2026: 4 · 2025: 6 · 2024: 4 · 2023: 8 · 2022: 11 · 2021: 11 · 2020: 8 · 2019: 10 · 2018: 14 · 2017: 11 · 2016: 10 · 2015: 6 · 2014: 9 · 2013: 10 · 2012: 6
FWCI
2.55
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of Agricultural and Food Chemistry (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Seaweed-derived Bioactive Compounds
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Angiogenesis and VEGF in Cancer
  • Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
Keywords
fucoxanthin, fucoxanthinol, antiangiogenic activity, brown algae, HUVEC proliferation, tube formation, endothelial progenitor cells, embryoid bodies, aortic ring assay, angiogenesis, chemotaxis
MeSH terms
Phaeophyceae, Animals, Aorta, Cell Division, Humans, Male, Umbilical Veins, Rats, Wistar, Neovascularization, Physiologic, beta Carotene, Angiogenesis Inhibitors, Xanthophylls, Endothelial Cells, Rats, Embryonic Stem Cells

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