Antiangiogenic Activity of Brown Algae Fucoxanthin and Its Deacetylated Product, Fucoxanthinol
Abstract
The antiangiogenic effects of fucoxanthin and a deacetylated product, fucoxanthinol, were examined. Fucoxanthin significantly suppressed HUVEC proliferation and tube formation at more than 10 microM, but it had no significant effect on HUVEC chemotaxis. The formation of blood vessel-like structures from CD31-positive cells was evaluated using embryonic stem cell-derived embryoid bodies. Fucoxanthin effectively suppressed the development of these structures at 10-20 microM, suggesting that it could suppress differentiation of endothelial progenitor cells into endothelial cells involving new blood vessel formation. Fucoxanthin and fucoxanthinol suppressed microvessel outgrowth in an ex vivo angiogenesis assay using a rat aortic ring, in a dose-dependent manner. These results imply that fucoxanthin having antiangiogenic activity might be useful in preventing angiogenesis-related diseases.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Fucoxanthin and fucoxanthinol inhibit the angiogenesis process in the aortic ring of rats by suppressing the growth of microvessels.
“Fucoxanthin and fucoxanthinol have been shown to inhibit the angiogenesis process in the aortic ring of rats by suppressing the growth of microvessels [233].”
From The promising future of microalgae: Current status, challenges, and optimization of a sustainable and renewable industry for biofuels, feed, and other products (2018) · cites this paper as [233]
Cites
Isolation of Putative Progenitor Endothelial Cells for Angiogenesis
Asahara, T., Murohara, T., Sullivan, A., Silver, M., van der Zee, R., Li, T., Witzenbichler, B., Schatteman, G., & Isner, J. M. (1997) · Science · doi:10.1126/science.275.5302.964 · Cited by 8,725 · see citing works
Angiogenesis in cancer, vascular, rheumatoid and other disease
Folkman, J. (1995) · Nature Medicine · doi:10.1038/nm0195-27 · Cited by 7,627 · see citing works
Angiogenesis as a therapeutic target
Ferrara, N., & Kerbel, R. S. (2005) · Nature · doi:10.1038/nature04483 · Cited by 2,653 · see citing works
Rampino, N. J., Yamamoto, H., Ionov, Y., Li, Y., Sawai, H., Reed, J. C., & Perucho, M. (1997) · Science · doi:10.1126/science.275.5302.967 · Cited by 1,326 · see citing works
Signal transduction by VEGF receptors in regulation of angiogenesis and lymphangiogenesis
Shibuya, M., & Claesson, L. (2005) · Experimental Cell Research · doi:10.1016/j.yexcr.2005.11.012 · Cited by 1,057 · see citing works
Adipose tissue mass can be regulated through the vasculature
Rupnick, M. A., Panigrahy, D., Zhang, C.-Y., Dallabrida, S. M., Lowell, B. B., Langer, R., & Folkman, M. J. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.162349799 · Cited by 845 · see citing works
Vascular and haematopoietic stem cells: novel targets for anti-angiogenesis therapy?
Rafii, S., Lyden, D. C., Benezra, R., Hattori, K., & Heissig, B. (2002) · Nature reviews. Cancer · doi:10.1038/nrc925 · Cited by 678 · see citing works
Vasculogenesis and angiogenesis in embryonic-stem-cell-derived embryoid bodies
Risau, W., Sariola, H. V., Zerwes, H., Sasse, J., Ekblom, P., Kemler, R., & Doetschman, T. (1988) · Development · doi:10.1242/dev.102.3.471 · Cited by 656 · see citing works
Maeda, H., Hosokawa, M., Sashima, T., Funayama, K., & Miyashita, K. (2005) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2005.05.002 · Cited by 641 · see citing works
Carotenoids Affect Proliferation of Human Prostate Cancer Cells
Kotake‐Nara, E., Miyashita, K., Nagao, A., Kushiro, M., Zhang, H., & Sugawara, T. (2001) · Journal of Nutrition · doi:10.1093/jn/131.12.3303 · Cited by 465 · see citing works
Self-citationShono, T., Ono, M., Izumi, H., Jimi, S., Matsushima, K., Okamoto, T., Kohno, K., & Kuwano, M. (1996) · Molecular and Cellular Biology · doi:10.1128/mcb.16.8.4231 · Cited by 272 · see citing works
Asai, A., Sugawara, T., Ono, H., & Nagao, A. (2004) · Drug Metabolism and Disposition · doi:10.1124/dmd.32.2.205 · Cited by 244 · see citing works
Self-citationSugawara, T., Kushiro, M., Zhang, H., Ono, H., Nagao, A., & Nara, E. (2001) · Journal of Nutrition · doi:10.1093/jn/131.11.2921 · Cited by 240 · see citing works
Self-citationEffects of fucoxanthin on lipopolysaccharide-induced inflammation in vitro and in vivo
Shiratori, K., Ohgami, K., Ilieva, I. B., Jin, X.-H., Koyama, Y., Miyashita, K., Yoshida, K., Kase, S., & Ohno, S. (2005) · Experimental Eye Research · doi:10.1016/j.exer.2005.03.002 · Cited by 218 · see citing works
Sugawara, T., Baskaran, V., Tsuzuki, W., & Nagao, A. (2002) · Journal of Nutrition · doi:10.1093/jn/132.5.946 · Cited by 211 · see citing works
Self-citationNeoxanthin and fucoxanthin induce apoptosis in PC-3 human prostate cancer cells
Kotake‐Nara, E., Asai, A., & Nagao, A. (2004) · Cancer Letters · doi:10.1016/j.canlet.2004.07.048 · Cited by 201 · see citing works
Tumor invasion: molecular shears blunted by green tea
Garbisa, S., Biggin, S., Cavallarin, N., Sartor, L., Benelli, R., & Albini, A. (1999) · Nature Medicine · doi:10.1038/15145 · Cited by 174 · see citing works
Apoptosis-inducing effect of fucoxanthin on human leukemia cell line HL-60
HOSOKAWA, M., WANEZAKI, S., MIYAUCHI, K., KURIHARA, H., KOHNO, H., KAWABATA, J., ODASHIMA, S., & TAKAHASHI, K. (1999) · Food Science and Technology Research · doi:10.3136/fstr.5.243 · Cited by 173 · see citing works
Antiangiogenic Activity of Nasunin, an Antioxidant Anthocyanin, in Eggplant Peels
Matsubara, K., Kaneyuki, T., Miyake, T., & Mori, M. (2005) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf050796r · Cited by 153 · see citing works
Self-citationSeaweed Prevents Breast Cancer?
Funahashi, H., Imai, T., Mase, T., Sekiya, M., YOKOI, K., Hayashi, H., Shibata, A., Hayashi, T., Nishikawa, M., Suda, N., et al. (2001) · Japanese Journal of Cancer Research · doi:10.1111/j.1349-7006.2001.tb01119.x · Cited by 147 · see citing works
Characterization of Apoptosis Induced by Fucoxanthin in Human Promyelocytic Leukemia Cells
Kotake‐Nara, E., Terasaki, M., & Nagao, A. (2005) · Bioscience Biotechnology and Biochemistry · doi:10.1271/bbb.69.224 · Cited by 122 · see citing works
Okuzumi, J., Takahashi, T., Yamane, T., Kitao, Y., Inagake, M., Ohya, K., Nishino, H., & Tanaka, Y. Y. (1993) · Cancer Letters · doi:10.1016/0304-3835(93)90142-v · Cited by 113 · see citing works
Eriksson, K., Magnusson, P. U., Dixelius, J., Claesson, L., & Cross, M. J. (2003) · FEBS Letters · doi:10.1016/s0014-5793(03)00003-6 · Cited by 110 · see citing works
Thalidomide Inhibits Angiogenesis in Embryoid Bodies by the Generation of Hydroxyl Radicals
Sauer, H., Günther, J., Hescheler, J., & Wartenberg, M. (2000) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)64714-1 · Cited by 108 · see citing works
Stewart, J. R., Ward, N. E., Ioannides, C. G., & O’Brian, C. A. (1999) · Biochemistry · doi:10.1021/bi990875u · Cited by 97 · see citing works
Funahashi, H., Imai, T., Tanaka, Y., Tsukamura, K., Hayakawa, Y., Kikumori, T., Mase, T., Itoh, T., Nishikawa, M., Hayashi, H., et al. (1999) · Japanese Journal of Cancer Research · doi:10.1111/j.1349-7006.1999.tb00836.x · Cited by 92 · see citing works
Endostatin Inhibits Microvessel Formation in the ex Vivo Rat Aortic Ring Angiogenesis Assay
Kruger, E. A., Duray, P. H., Tsokos, M., Venzon, D. J., Libutti, S. K., Dixon, S. C., Rudek, M. A., Pluda, J. M., Allegra, C. J., & Figg, W. D. (2000) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1999.2018 · Cited by 91 · see citing works
Wobus, A. M., Rohwedel, J., Maltsev, V. A., & Hescheler, J. (1995) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1995.tb17456.x · Cited by 61 · see citing works
Antiproliferative effect of neoxanthin and fucoxanthin on cultured cells
Kotake‐Nara, E., Sugawara, T., & Nagao, A. (2005) · Fisheries Science · doi:10.1111/j.1444-2906.2005.00986.x · Cited by 54 · see citing works
Self-citationMatsubara, K., Mori, M., Matsumoto, H., Hori, K., & Miyazawa, K. (2003) · Journal of Applied Phycology · doi:10.1023/a:1022958222915 · Cited by 28 · see citing works
Self-citationMicroarray Gene Expression Profiling of Angiogenesis Inhibitors Using the Rat Aortic Ring Assay
Zogakis, T. G., Costouros, N. G., Kruger, E. A., Forbes, S., He, M., Qian, M., Feldman, A. L., Figg, W. D., Alexander, H. R., Liu, E. T., et al. (2002) · BioTechniques · doi:10.2144/02333dd02 · Cited by 17 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Khan, M. I., Shin, J. H., & Kim, J. D. (2018) · Microbial Cell Factories · doi:10.1186/s12934-018-0879-x · Cited by 2,082 · see citing works
Peng, J., Yuan, J.-P., Wu, C.-F., & Wang, J.-H. (2011) · Marine Drugs · doi:10.3390/md9101806 · Cited by 820 · see citing works
Biological activities and health benefit effects of natural pigments derived from marine algae
Pangestuti, R., & Kim, S. (2011) · Journal of Functional Foods · doi:10.1016/j.jff.2011.07.001 · Cited by 577 · see citing works
Sathasivam, R., & Ki, J. (2018) · Marine Drugs · doi:10.3390/md16010026 · Cited by 481 · see citing works
Antioxidants from macroalgae: potential applications in human health and nutrition
Cornish, M. L., & Garbary, D. J. (2010) · ALGAE · doi:10.4490/algae.2010.25.4.155 · Cited by 290 · see citing works
The Potential of Microalgae for the Production of Bioactive Molecules of Pharmaceutical Interest
Mimouni, V., Ulmann, L., Pasquet, V., Mathieu, M., Picot, L., Bougaran, G., Cadoret, J., Morant-Manceau, A., & Schoefs, B. (2012) · Current Pharmaceutical Biotechnology · doi:10.2174/138920112804724828 · Cited by 274 · see citing works
Antioxidant activity of Hawaiian marine algae
Kelman, D., Posner, E. K., McDermid, K. J., Tabandera, N. K., Wright, P. R., & Wright, A. D. (2012) · Marine Drugs · doi:10.3390/md10020403 · Cited by 250 · see citing works
Fucoxanthin: A Marine Carotenoid Exerting Anti-Cancer Effects by Affecting Multiple Mechanisms
Kumar, S., Hosokawa, M., & Miyashita, K. (2013) · Marine Drugs · doi:10.3390/md11125130 · Cited by 247 · see citing works
Heo, S., Ko, S., Kang, S., Kang, H., Kim, J.-P., Kim, S.-H., Lee, K.-W., Cho, M.-G., & Jeon, Y. (2008) · European Food Research and Technology · doi:10.1007/s00217-008-0918-7 · Cited by 210 · see citing works
Bioactive compounds in seaweeds: An overview of their biological properties and safety
Rengasamy, K. R. R., Mahomoodally, M. F., Aumeeruddy, M. Z., Zengin, G., Xiao, J., & Kim, D. H. (2019) · Food and Chemical Toxicology · doi:10.1016/j.fct.2019.111013 · Cited by 194 · see citing works
Moghadamtousi, S. Z., Karimian, H., Khanabdali, R., Razavi, M., Firoozinia, M., Zandi, K., & Kadir, H. A. (2014) · The Scientific World JOURNAL · doi:10.1155/2014/768323 · Cited by 182 · see citing works
Méresse, S., Fodil, M., Fleury, F., & Chénais, B. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21239273 · Cited by 171 · see citing works
Namvar, F., Mohamad, R., Baharara, J., Zafar-Balanejad, S., Fargahi, F., & Rahman, H. S. (2013) · BioMed Research International · doi:10.1155/2013/604787 · Cited by 165 · see citing works
Shimoda, H., Tanaka, J., Shan, S.-J., & Maoka, T. (2010) · Journal of Pharmacy and Pharmacology · doi:10.1111/j.2042-7158.2010.01139.x · Cited by 152 · see citing works
Protective Effect of Fucoxanthin against UVB-Induced Skin Photoaging in Hairless Mice
URIKURA, I., Sugawara, T., & Hirata, T. (2011) · Bioscience Biotechnology and Biochemistry · doi:10.1271/bbb.110040 · Cited by 145 · see citing works
Self-citationLow bioavailability of dietary epoxyxanthophylls in humans
Asai, A., Yonekura, L., & Nagao, A. (2008) · British Journal Of Nutrition · doi:10.1017/s0007114507895468 · Cited by 144 · see citing works
Nutraceutical Effects of Fucoxanthin for Obesity and Diabetes Therapy: A Review
Maeda, H. (2015) · Journal of Oleo Science · doi:10.5650/jos.ess14226 · Cited by 130 · see citing works
Carotenoids modulate the hallmarks of cancer cells
Niranjana, R., Gayathri, R., Stephen, N. M., Sugawara, T., Hirata, T., Miyashita, K., & Ponesakki, G. (2014) · Journal of Functional Foods · doi:10.1016/j.jff.2014.10.017 · Cited by 128 · see citing works
Self-citationKanazawa, K., Ozaki, Y., Hashimoto, T., DAS, S. K., Matsushita, S., HIRANO, M., OKADA, T., Komoto, A., Nobuki, M. O. R. I., & Nakatsuka, M. (2008) · Food Science and Technology Research · doi:10.3136/fstr.14.573 · Cited by 125 · see citing works
Le Goff, M., Le Ferrec, E., Mayer, C., Mimouni, V., Lagadic-Gossmann, D., Schoefs, B., & Ulmann, L. (2019) · Biochimie · doi:10.1016/j.biochi.2019.09.012 · Cited by 123 · see citing works
Marine natural pigments as potential sources for therapeutic applications
Manivasagan, P., Bharathiraja, S., Santhamoorthy, M., Mondal, S., Seo, H., Lee, K. D., & Oh, J. (2017) · Critical Reviews in Biotechnology · doi:10.1080/07388551.2017.1398713 · Cited by 122 · see citing works
Anti-angiogenic effect of siphonaxanthin from green alga, Codium fragile
Ganesan, P., Matsubara, K., Ohkubo, T., Tanaka, Y., Noda, K., Sugawara, T., & Hirata, T. (2010) · Phytomedicine · doi:10.1016/j.phymed.2010.05.005 · Cited by 112 · see citing works
Self-citationFucoxanthin: A Promising Phytochemical on Diverse Pharmacological Targets
Mumu, M., Das, A., Emran, T. B., Mitra, S., Islam, F., Roy, A., Karim, M. M., Das, R. C., Park, M. N., Chandran, D., et al. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.929442 · Cited by 108 · see citing works
Sakai, S., Sugawara, T., Matsubara, K., & Hirata, T. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.001099 · Cited by 100 · see citing works
Self-citationZarekarizi, A., Hoffmann, L. J., & Burritt, D. J. (2018) · Journal of Applied Phycology · doi:10.1007/s10811-018-1558-3 · Cited by 97 · see citing works
Siphonaxanthin, a Green Algal Carotenoid, as a Novel Functional Compound
Sugawara, T., Ponesakki, G., Li, Z., Manabe, Y., & Hirata, T. (2014) · Marine Drugs · doi:10.3390/md12063660 · Cited by 92 · see citing works
Self-citationCancer Preventive Efficacy of Marine Carotenoid Fucoxanthin: Cell Cycle Arrest and Apoptosis
Rengarajan, T., Rajendran, P., Nandakumar, N., Balasubramanian, M. P., & Nishigaki, I. (2013) · Nutrients · doi:10.3390/nu5124978 · Cited by 91 · see citing works
The potential of seaweed as a source of drugs for use in cancer chemotherapy
Murphy, C., Hotchkiss, S., Worthington, J., & McKEOWN, S. R. (2014) · Journal of Applied Phycology · doi:10.1007/s10811-014-0245-2 · Cited by 92 · see citing works
Keto-Carotenoids Are the Major Metabolites of Dietary Lutein and Fucoxanthin in Mouse Tissues1–3
Yonekura, L., Kobayashi, M., Terasaki, M., & Nagao, A. (2010) · Journal of Nutrition · doi:10.3945/jn.110.126466 · Cited by 90 · see citing works
Sappati, P. K., Nayak, B., van Walsum, G. P., & Mulrey, O. T. (2018) · Journal of Applied Phycology · doi:10.1007/s10811-018-1596-x · Cited by 89 · see citing works
Gastineau, R., Pouvreau, J., Hellio, C., Morançais, M., Fleurence, J., Gaudin, P., Bourgougnon, N., & Mouget, J. (2012) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf205004x · Cited by 85 · see citing works
Marine algal fucoxanthin inhibits the metastatic potential of cancer cells
Chung, T., Choi, H., Lee, J.-Y., Jeong, H.-S., Kim, C., Joo, M., Choi, J., Han, C., Kim, S., Choi, J., et al. (2013) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2013.09.019 · Cited by 82 · see citing works
Ahmed, S. A., Mendonca, P., Elhag, R. I., & Soliman, K. F. A. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232416091 · Cited by 84 · see citing works
Production of fucoxanthin by the microalga Tisochrysis lutea: A review of recent developments
Mohamadnia, S., Tavakoli, O., Faramarzi, M. A., & Shamsollahi, Z. (2020) · Aquaculture · doi:10.1016/j.aquaculture.2019.734637 · Cited by 78 · see citing works
Ponesakki, G., Matsubara, K., Sugawara, T., & Hirata, T. (2013) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-013-1651-5 · Cited by 78 · see citing works
Self-citationWang, C., Chen, X., Nakamura, Y., Yu, C., & Qi, H. (2020) · Food & Function · doi:10.1039/d0fo02176h · Cited by 76 · see citing works
Biological Activities and Potential Health Benefits of Fucoxanthin Derived from Marine Brown Algae
Kim, S., & Pangestuti, R. (2011) · Advances in food and nutrition research · doi:10.1016/b978-0-12-387669-0.00009-0 · Cited by 74 · see citing works
Déléris, P., Nazih, H., & Bard, J. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-802772-1.00010-5 · Cited by 73 · see citing works
Kawee‐ai, A., Kuntiya, A., & Kim, S. M. (2013) · Natural Product Communications · doi:10.1177/1934578x1300801010 · Cited by 68 · see citing works
Afolayan, A. F., Bolton, J. J., Lategan, C. A., Smith, P. J., & Beukes, D. R. (2008) · Zeitschrift für Naturforschung C · doi:10.1515/znc-2008-11-1211 · Cited by 64 · see citing works
Bioaccessibility, Bioavailability and Bioactivities of Carotenoids in Microalgae: A Review
Duan, X., Xie, C., Hill, D. R., Barrow, C. J., Dunshea, F. R., Martin, G. J. O., & Suleria, H. A. R. (2023) · Food Reviews International · doi:10.1080/87559129.2023.2165095 · Cited by 64 · see citing works
Cystoseira algae (Fucaceae): update on their chemical entities and biological activities
de Sousa, C. B., Gangadhar, K. N., Macridachis, J., Pavão, M., Morais, T. R., Campino, L., Varela, J. C. S., & Lago, J. H. G. (2017) · Tetrahedron Asymmetry · doi:10.1016/j.tetasy.2017.10.014 · Cited by 64 · see citing works
Taniguchi, M., Kameda, M., Namae, T., Ochiai, A., Saitoh, E., & Tanaka, T. (2017) · Journal of Functional Foods · doi:10.1016/j.jff.2017.04.046 · Cited by 56 · see citing works
Progress in Carotenoid Research
Zepka, L. Q., Lopes, E. J., & de Rosso, V. V. (2018) · InTech eBooks · doi:10.5772/intechopen.73775 · Cited by 56 · see citing works
Umigai, N., Tanaka, J., Tsuruma, K., Shimazawa, M., & Hara, H. (2012) · Current Neurovascular Research · doi:10.2174/156720212800410830 · Cited by 53 · see citing works
Guo, B., Oliviero, T., Fogliano, V., Ma, Y., Chen, F., & Capuano, E. (2019) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.9b02496 · Cited by 53 · see citing works
Kanamoto, A., Kato, Y., Yoshida, E., Hasunuma, T., & Kondo, A. (2021) · Marine Biotechnology · doi:10.1007/s10126-021-10028-5 · Cited by 47 · see citing works
Production of Fucoxanthin-Rich Powder from Cladosiphon okamuranus
Mise, T., Ueda, M., & Yasumoto, T. (2011) · Advance Journal of Food Science and Technology · Cited by 47 · see citing works
Fucoxanthin and Colorectal Cancer Prevention
Terasaki, M., Kubota, A., Kojima, H., Maeda, H., Miyashita, K., Kawagoe, C., Mutoh, M., & Tanaka, T. (2021) · Cancers · doi:10.3390/cancers13102379 · Cited by 46 · see citing works
A review of the components of brown seaweeds as potential candidates in cancer therapy
Hussain, E., Wang, L., Jiang, B., Riaz, S., Butt, G. Y., & Shi, D. (2016) · RSC Advances · doi:10.1039/c5ra23995h · Cited by 44 · see citing works
Juin, C., Júnior, R. G. D. O., Fleury, A., Oudinet, C., Pytowski, L., Bérard, J., Nicolau, É., Thiéry, V., Lanneluc, I., Beaugeard, L., et al. (2018) · Revista Brasileira de Farmacognosia · doi:10.1016/j.bjp.2018.05.009 · Cited by 43 · see citing works
Kang, M., Lee, S., Lee, W., Kang, N., Kim, E.-A. L., Kim, S. C., Lee, D. H., Kim, D., & Jeon, Y. (2014) · Journal of Functional Foods · doi:10.1016/j.jff.2014.09.007 · Cited by 42 · see citing works
Fernando, K. H. N., Yang, H.-W., Jiang, Y., Jeon, Y., & Ryu, B. (2018) · Marine Drugs · doi:10.3390/md16100375 · Cited by 42 · see citing works
Chen, S., Lee, C.-J., Lin, T.-B., Peng, H., Liu, H.-J., Chen, Y.-S., & Tseng, K. (2019) · Marine Drugs · doi:10.3390/md17030152 · Cited by 43 · see citing works
Agatonović-Kuštrin, S., & Morton, D. W. (2017) · Journal of Chromatography A · doi:10.1016/j.chroma.2017.11.024 · Cited by 38 · see citing works
Bioprospecting microalgae and cyanobacteria for biopharmaceutical applications
Saeed, M. U., Hussain, N., Shahbaz, A., Hameed, T., Iqbal, H. M. N., & Bilal, M. (2021) · Journal of Basic Microbiology · doi:10.1002/jobm.202100445 · Cited by 38 · see citing works
Fucoxanthin Is a Potential Therapeutic Agent for the Treatment of Breast Cancer
Lau, T.-Y., & Kwan, H. Y. (2022) · Marine Drugs · doi:10.3390/md20060370 · Cited by 37 · see citing works
Manabe, Y., Hirata, T., & Sugawara, T. (2014) · Journal of Oleo Science · doi:10.5650/jos.ess13169 · Cited by 36 · see citing works
Self-citationSelected Phyto and Marine Bioactive Compounds: Alternatives for the Treatment of Type 2 Diabetes
Reyes, B. A. S., Dufourt, E. C., Ross, J. A., Warner, M. J., Tanquilut, N., & Leung, A. B. (2017) · Studies in natural products chemistry · doi:10.1016/b978-0-444-64068-0.00004-8 · Cited by 35 · see citing works
Zhu, J., Sun, X., Chen, X., Wang, S., & Wang, D. (2016) · Food Chemistry · doi:10.1016/j.foodchem.2016.05.064 · Cited by 33 · see citing works
Chen, S., Lee, C.-J., Lin, T.-B., Liu, H.-J., Huang, S.-Y., Chen, J.-Z., & Tseng, K. (2016) · Marine Drugs · doi:10.3390/md14010013 · Cited by 32 · see citing works
Wu, Z., Tang, Y., Liu, Y., Chen, Z., Feng, Y., Hu, H., Liu, H., Chen, G., Lu, Y., Hu, Y., et al. (2024) · Journal of Advanced Research · doi:10.1016/j.jare.2024.04.017 · Cited by 31 · see citing works
Wu, S., Xie, X., Li, H., Zheng, Z., Zhao, P., Kuang, J., Liu, X., & Wang, G. (2015) · Journal of Applied Phycology · doi:10.1007/s10811-015-0716-0 · Cited by 31 · see citing works
Komba, S., Kotake‐Nara, E., & Tsuzuki, W. (2018) · Marine Drugs · doi:10.3390/md16080275 · Cited by 30 · see citing works
Taniguchi, M., Saito, K., Aida, R., Ochiai, A., Saitoh, E., & Tanaka, T. (2019) · Journal of Bioscience and Bioengineering · doi:10.1016/j.jbiosc.2019.02.002 · Cited by 29 · see citing works
Almeida, T., Ramos, A. A., Ferreira, J. S. P. D. M., Azqueta, A., & Rocha, E. (2019) · Mini-Reviews in Medicinal Chemistry · doi:10.2174/1389557519666190311095655 · Cited by 28 · see citing works
Nutraceutical and Pharmaceutical Applications of Carotenoids
Honda, M. (2020) · Springer eBooks · doi:10.1007/978-3-030-50971-2_18 · Cited by 23 · see citing works
Shaikh, R., Rizvi, A., Pandit, S., Desai, N., & Patil, R. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-823499-0.00004-3 · Cited by 24 · see citing works
Algae-Based Biologically Active Compounds
Ibrahim, M., Salman, M., Kamal, S., Rehman, S., Razzaq, A., & Akash, M. S. H. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-812360-7.00006-9 · Cited by 23 · see citing works
Application of photosensitive microalgae in targeted tumor therapy
Wang, R., Wang, Z., Zhang, M., Zhong, D., & Zhou, M. (2025) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2025.115519 · Cited by 24 · see citing works
Solvent Extraction of Fucoxanthin fromPhaeodactylum tricornutum
Kim, J. C. (2013) · Separation Science and Technology · doi:10.1080/01496395.2013.839703 · Cited by 20 · see citing works
Yang, Z., Lu, W., Ma, X., & Song, D. (2012) · Phytomedicine · doi:10.1016/j.phymed.2011.11.009 · Cited by 20 · see citing works
Terasaki, M., Ono, S., Hashimoto, S., Kubota, A., Kojima, H., Ohta, T., Tanaka, T., Maeda, H., Miyashita, K., & Mutoh, M. (2021) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2021.108871 · Cited by 19 · see citing works
Calabrone, L., Carlini, V., Noonan, D. M., Festa, M., Ferrario, C., Morelli, D., Macis, D., Fontana, A., Pistelli, L., Brunet, C., et al. (2023) · Cells · doi:10.3390/cells12071053 · Cited by 20 · see citing works
Gentscheva, G., Milkova-Tomova, I., Pehlivanov, I., Gugleva, V., Nikolova, K., Petkova, N., Andonova, V., Buhalova, D., & Pisanova, E. (2022) · Applied Sciences · doi:10.3390/app12199935 · Cited by 19 · see citing works
Taniguchi, M., Ochiai, A., Namae, T., Saito, K., Kato, T., Saitoh, E., & Tanaka, T. (2018) · Peptides · doi:10.1016/j.peptides.2018.04.017 · Cited by 18 · see citing works
Taniguchi, M., Saito, K., Nomoto, T., Namae, T., Ochiai, A., Saitoh, E., & Tanaka, T. (2017) · Biopolymers · doi:10.1002/bip.23023 · Cited by 18 · see citing works
Krueger, K., Boehme, E., Klettner, A., & Zille, M. (2021) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2021.1915242 · Cited by 18 · see citing works
ECT as a therapeutic option in severe brain injury.
Kant, R., Bogyi, A. M., Carosella, N. W., Fishman, E., Kane, V., & Coffey, C. E. (1995) · PubMed · Cited by 18 · see citing works
Algae as Functional Foods for the Elderly
Figueiredo, F., Encarnação, T., & Campos, M. G. (2016) · Food and Nutrition Sciences · doi:10.4236/fns.2016.712107 · Cited by 17 · see citing works
Acylated catechin derivatives inhibitors of DNA polymerase and angiogenesis
Mizushina, Y. (2011) · Frontiers in Bioscience-Elite · doi:10.2741/e337 · Cited by 16 · see citing works
Effects of Z-Isomerization on the Bioavailability and Functionality of Carotenoids: A Review
Honda, M., Maeda, H., Fukaya, T., & Goto, M. (2018) · InTech eBooks · doi:10.5772/intechopen.78309 · Cited by 15 · see citing works
Angiomodulators in cancer therapy: New perspectives
Varinská, L., Kubatka, P., Mojžíš, J., Zulli, A., Gazdíková, K., Žúbor, P., Büsselberg, D., Čaprnda, M., Opatřilová, R., Gašparová, I., et al. (2017) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2017.02.071 · Cited by 14 · see citing works
Koch, W., Kukula-Koch, W. A., Wawruszak, A., Okoń, E., Stępnik, K. E., Gaweł‐Bęben, K., Setzer, W. N., Dini, I., Sharifi‐Rad, J., & Călina, D. C. (2024) · Current Research in Biotechnology · doi:10.1016/j.crbiot.2024.100203 · Cited by 13 · see citing works
Canoy, J. L., & Bitacura, J. G. (2018) · Analytical Cellular Pathology · doi:10.1155/2018/3709491 · Cited by 13 · see citing works
Nursid, M., Wikanta, T., & Susilowati, R. (2014) · Jurnal Pascapanen dan Bioteknologi Kelautan dan Perikanan · doi:10.15578/jpbkp.v8i1.55 · Cited by 12 · see citing works
Fucoxanthin from brown seaweed Sargassum cristaefolium tea in acid pH
Kartikaningsih, H., Mufti, E. D., & Nurhanief, A. E. (2017) · AIP conference proceedings · doi:10.1063/1.4983436 · Cited by 13 · see citing works
Angiosuppressive properties of marine-derived compounds—a mini review
Yue, P. Y., Leung, H. M., Li, A. J., Chan, T. N. C., Lum, J. T.-S., Chung, Y.-T., Sung, Y., Wong, M. H., Leung, K. S., & Zeng, E. Y. (2015) · Environmental Science and Pollution Research · doi:10.1007/s11356-015-5536-x · Cited by 12 · see citing works
Synthesis and biological evaluation of vitamin K derivatives as angiogenesis inhibitor
Kayashima, T., Mori, M., Mizutani, R., Nishio, K., Kuramochi, K., Tsubaki, K., Yoshida, H., Mizushina, Y., & Matsubara, K. (2010) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2010.07.022 · Cited by 12 · see citing works
Self-citationPhull, A. R., & Kim, S. J. (2018) · Nutrition and Cancer · doi:10.1080/01635581.2018.1490449 · Cited by 13 · see citing works
Health benefits of bioactive compounds from microalgae
Singh, D. V., Upadhyay, A. K., Singh, R. P., & Singh, D. P. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-824109-7.00015-7 · Cited by 12 · see citing works
Rui, X., Amenorfenyo, D. K., Peng, K., Li, H., Wang, L., Huang, X., Li, C., & Li, F. (2023) · Marine Drugs · doi:10.3390/md21020106 · Cited by 11 · see citing works
Harnessing seaweed's potential for blue bioeconomy and sustainable future
Divakar, S., Beji, D. S., Santosh, A. B. R., Sekaran, M., Thaigarajan, K., Nachiappan, K., & Chandrasekaran, R. (2025) · South African Journal of Botany · doi:10.1016/j.sajb.2025.10.034 · Cited by 10 · see citing works
Mise, T., & Yasumoto, T. (2011) · Cited by 10 · see citing works
Medicinal and Pharmaceutical Applications of Seaweeds
El-Sheekh, M. M., Fathy, A. A., Saber, H., & Saber, A. A. (2022) · Egyptian Journal of Botany · doi:10.21608/ejbo.2022.145631.2022 · Cited by 13 · see citing works
Bioactive Metabolites and Value-Added Products from Marine Macroalgae
Rengasamy, K. R. R., Kulkarni, M. G., Stirk, W. A., & Staden, J. V. (2013) · Springer eBooks · doi:10.1007/978-1-4614-9590-1_21 · Cited by 10 · see citing works
İnam, A., Öner, T. Ö., & Deniz, İ. (2024) · Advances in experimental medicine and biology · doi:10.1007/5584_2024_795 · Cited by 9 · see citing works
Sarmiento-Padilla, A. L., Moreira, S. M. G., Rocha, H. A. O., Araújo, R. G., Govea‐Salas, M., Pinales‐Márquez, C. D., Ruíz, H. A., & Rodríguez‐Jasso, R. M. (2021) · Journal of Chemical Technology & Biotechnology · doi:10.1002/jctb.6930 · Cited by 9 · see citing works
Nishimura, M., Sugawara, M., Kudo, M., Kinoshita, Y., Yoshino, H. K. H., & Nishihira, J. (2019) · Functional Foods in Health and Disease · doi:10.31989/ffhd.v9i4.594 · Cited by 9 · see citing works
Microalgae as Nutraceutical for Achieving Sustainable Food Solution in Future
Kaur, P. (2020) · Environmental and microbial biotechnology · doi:10.1007/978-981-15-2817-0_5 · Cited by 10 · see citing works
- Authors
- Sugawara, T., Matsubara, K., Akagi, R., Mori, M., & Hirata, T.
- Affiliations
- Okayama Prefectural University (JP)
- Corresponding author
- Hirata, Takashi
- Venue
- Journal of Agricultural and Food Chemistry
- Publisher
- American Chemical Society (ACS)
- Published
- 2006-12-01
- Volume
- 54
- Issue
- 26
- Pages
- 9805-9810
- ISSN
- 0021-8561 (ISSN-L)
- 1520-5118
- OpenAlex
- W2012477218
- Cited by
- 148
- References
- 31
- Citations by year
- 2026: 4 · 2025: 6 · 2024: 4 · 2023: 8 · 2022: 11 · 2021: 11 · 2020: 8 · 2019: 10 · 2018: 14 · 2017: 11 · 2016: 10 · 2015: 6 · 2014: 9 · 2013: 10 · 2012: 6
- FWCI
- 2.55
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Agricultural and Food Chemistry (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Seaweed-derived Bioactive Compounds
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Angiogenesis and VEGF in Cancer
- Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
- Keywords
- fucoxanthin, fucoxanthinol, antiangiogenic activity, brown algae, HUVEC proliferation, tube formation, endothelial progenitor cells, embryoid bodies, aortic ring assay, angiogenesis, chemotaxis
- MeSH terms
- Phaeophyceae, Animals, Aorta, Cell Division, Humans, Male, Umbilical Veins, Rats, Wistar, Neovascularization, Physiologic, beta Carotene, Angiogenesis Inhibitors, Xanthophylls, Endothelial Cells, Rats, Embryonic Stem Cells
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review