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Cited by 183Seaweed-derived Bioactive CompoundsMedicinal Plants and NeuroprotectionAlzheimer's disease research and treatments

The DOI matches its Crossref record; 176 of the 177 references it cites were found in a registry or an index.

Bioactive Compounds from Macroalgae in the New Millennium: Implications for Neurodegenerative Diseases

Open access
Barbosa, Mariana, Valentão, Patrícia, Andrade, Paula·2014·Marine Drugs
DOI 10.3390/md12094934PMC PMC4178484
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Abstract

Marine environment has proven to be a rich source of structurally diverse and complex compounds exhibiting numerous interesting biological effects. Macroalgae are currently being explored as novel and sustainable sources of bioactive compounds for both pharmaceutical and nutraceutical applications. Given the increasing prevalence of different forms of dementia, researchers have been focusing their attention on the discovery and development of new compounds from macroalgae for potential application in neuroprotection. Neuroprotection involves multiple and complex mechanisms, which are deeply related. Therefore, compounds exerting neuroprotective effects through different pathways could present viable approaches in the management of neurodegenerative diseases, such as Alzheimer's and Parkinson's. In fact, several studies had already provided promising insights into the neuroprotective effects of a series of compounds isolated from different macroalgae species. This review will focus on compounds from macroalgae that exhibit neuroprotective effects and their potential application to treat and/or prevent neurodegenerative diseases.

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Integrity signals

Registry

Crossref · 10.3390/md12094934

Cites

176 of 176 references verified0 citation errors · 0 not checkable

Statistics

Figures

Figure 1 Microglia-mediated neurotoxicity in Alzheimer’s Disease (AD) and Parkinson’s Disease (PD).
Figure 1 Microglia-mediated neurotoxicity in Alzheimer’s Disease (AD) and Parkinson’s Disease (PD).CC BY · PubMed Central
Figure 2 Chemical structures of different types of phlorotannins.
Figure 2 Chemical structures of different types of phlorotannins.CC BY · PubMed Central
Figure 3 Chemical structure of triphlorethol A.
Figure 3 Chemical structure of triphlorethol A.CC BY · PubMed Central
Figure 4 Inhibition of the formation of advanced glycation end products (AGEs) by some phlorotannins through the scavenging of reactive carbonyl intermediates.
Figure 4 Inhibition of the formation of advanced glycation end products (AGEs) by some phlorotannins through the scavenging of reactive carbonyl intermediates.CC BY · PubMed Central
Figure 5 Polyphenols involved in neuroprotection mediated by anti-neuroinflammatory and antioxidant mechanisms.
Figure 5 Polyphenols involved in neuroprotection mediated by anti-neuroinflammatory and antioxidant mechanisms.CC BY · PubMed Central
Figure 6 Polyphenols with ChE inhibitory activity.
Figure 6 Polyphenols with ChE inhibitory activity.CC BY · PubMed Central
Figure 7 Chemical structure of caulerpin.
Figure 7 Chemical structure of caulerpin.CC BY · PubMed Central
Figure 8 Chemical structure of racemosin A (a) and racemosin B (b).
Figure 8 Chemical structure of racemosin A (a) and racemosin B (b).CC BY · PubMed Central
Figure 9 Schematic representation of the biosynthesis of the major subclasses of terpenes. Monoterpenes (C10), sesquiterpenes (C15) and diterpenes (C20) are derived from the corresponding intermediates, by sequential head-to-tail addition of C5 units. Triterpenes (C30) result from two C15 units linked head-to-head and tetraterpenes (C40) are formed from two C20 units, also joined head-to-head.
Figure 9 Schematic representation of the biosynthesis of the major subclasses of terpenes. Monoterpenes (C10), sesquiterpenes (C15) and diterpenes (C20) are derived from the corresponding intermediates, by sequential head-to-tail addition of C5 units. Triterpenes (C30) result from two C15 units linked head-to-head and tetraterpenes (C40) are formed from two C20 units, also joined head-to-head.CC BY · PubMed Central
Figure 10 Chemical structure of sargachromenol.
Figure 10 Chemical structure of sargachromenol.CC BY · PubMed Central
Figure 11 Chemical structure of sargaquinoic acid.
Figure 11 Chemical structure of sargaquinoic acid.CC BY · PubMed Central
Figure 12 Chemical structure of pacifenol (a), epitaondiol (b) and stypotriol triacetate (c).
Figure 12 Chemical structure of pacifenol (a), epitaondiol (b) and stypotriol triacetate (c).CC BY · PubMed Central
Figure 13 Chemical structure of (5E,10Z)-6,10,14-trimethylpentadeca-5,10-dien-2,12-dione (a) and (5E,9E,13E)-6,10,14-trimethylpentadeca-5,9,13-trien-2,12-dione (b).
Figure 13 Chemical structure of (5E,10Z)-6,10,14-trimethylpentadeca-5,10-dien-2,12-dione (a) and (5E,9E,13E)-6,10,14-trimethylpentadeca-5,9,13-trien-2,12-dione (b).CC BY · PubMed Central
Figure 14 Chemical structure of caulerpenyne.
Figure 14 Chemical structure of caulerpenyne.CC BY · PubMed Central
Figure 15 Chemical structure of fucoxanthin.
Figure 15 Chemical structure of fucoxanthin.CC BY · PubMed Central
Figure 16 Chemical structure of astaxanthin (AST).
Figure 16 Chemical structure of astaxanthin (AST).CC BY · PubMed Central
Figure 17 Chemical structure of pheophytin A.
Figure 17 Chemical structure of pheophytin A.CC BY · PubMed Central
Figure 18 Chemical structure of fucosterol (a) and cholesterol (b).
Figure 18 Chemical structure of fucosterol (a) and cholesterol (b).CC BY · PubMed Central
Figure 19 Chemical structure of fucoidan from Fucus evanescens C. Agardh (a) and from F. vesiculosus and Ascophyllum nodosum (Linnaeus) Le Jolis (b).
Figure 19 Chemical structure of fucoidan from Fucus evanescens C. Agardh (a) and from F. vesiculosus and Ascophyllum nodosum (Linnaeus) Le Jolis (b).CC BY · PubMed Central
Figure 20 Chemical structure of κ-carrageenan.
Figure 20 Chemical structure of κ-carrageenan.CC BY · PubMed Central
Figure 21 Chemical structure of EPA (a) and DHA (b).
Figure 21 Chemical structure of EPA (a) and DHA (b).CC BY · PubMed Central
Figure 22 Chemical structure of floridoside.
Figure 22 Chemical structure of floridoside.CC BY · PubMed Central

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Citations

Cites

2 retracted

Show all 177 references

Research works printed but not linked: 4

  1. Kim, S.-K. (2012). Marine Pharmacognosy: Trends and Applications, Taylor & Francis.
  2. Ramawat, K.G., and Mérillon, J.-M. (2013). Natural Products: Phytochemistry, Botany and Metabolism of Alkaloids, Phenolics and Terpenes, Springer Berlin Heidelberg. · DOI
  3. Ramawat, K.G., and Mérillon, J.-M. (2013). Natural Products: Phytochemistry, Botany and Metabolism of Alkaloids, Phenolics and Terpenes, Springer (Berlin Heidelberg). · DOI
  4. Zhang, L., and Demain, A. (2005). Natural Products: Phytochemistry, Botany and Metabolism of Alkaloids, Phenolics and Terpenes, Humana Press.

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Metadata

Authors
Barbosa, M., Valentão, P., & Andrade, P.
Affiliations
  • Universidade do Porto (PT)
  • REQUIMTE/Laboratory of Pharmacognosy, Department of Chemistry, Faculty of Pharmacy, University of Porto, Rua de Jorge Viterbo Ferreira n° 228, 4050-313 Porto, Portugal
Corresponding author
Andrade, Paula
ORCID
Venue
Marine Drugs
Publisher
MDPI AG
Published
2014-09-25
Volume
12
Issue
9
Pages
4934-4972
ISSN
1660-3397 (ISSN-L)
DOI
10.3390/md12094934
PMC
PMC4178484
OpenAlex
W1975237170
Cited by
181
References
177
Citations by year
2026: 15 · 2025: 10 · 2024: 23 · 2023: 14 · 2022: 19 · 2021: 15 · 2020: 21 · 2019: 19 · 2018: 23 · 2017: 6 · 2016: 11 · 2015: 4 · 2014: 1
FWCI
1.11
Type
journal article
Language
en
Open access
Licence
Locations
  • Marine Drugs (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
  • European Commission (Pest-C/EQB/LA0006/2013)
  • Fundação para a Ciência e a Tecnologia (COMPETE, C/EQB/LA0006/2013, PEst-C/EQB/LA0006/2013, SFRH/BD/95861/2013)
Topics
  • Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Seaweed-derived Bioactive Compounds
  • Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plants and Neuroprotection
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Keywords
seaweed, bioactive compounds, neuroprotection, neurodegenerative diseases, Alzheimer's disease, Parkinson's disease, marine natural products, nutraceuticals, pharmaceuticals, dementia
MeSH terms
Animals, Antioxidants, Humans, Seaweed, Water Microbiology, Neuroprotective Agents, Neurodegenerative Diseases

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