LC-MS-Based metabolomics study of marine bacterial secondary metabolite and antibiotic production in Salinispora arenicola
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An LC-MS-based metabolomics approach was used to characterise the variation in secondary metabolite production due to changes in the salt content of the growth media as well as across different growth periods (incubation times). We used metabolomics as a tool to investigate the production of rifamycins (antibiotics) and other secondary metabolites in the obligate marine actinobacterial species Salinispora arenicola, isolated from Great Barrier Reef (GBR) sponges, at two defined salt concentrations and over three different incubation periods. The results indicated that a 14 day incubation period is optimal for the maximum production of rifamycin B, whereas rifamycin S and W achieve their maximum concentration at 29 days. A “chemical profile” link between the days of incubation and the salt concentration of the growth medium was shown to exist and reliably represents a critical point for selection of growth medium and harvest time.
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- Authors
- Bose, U., Hewavitharana, A., Ng, Y., Shaw, P., Fuerst, J., & Hodson, M.
- Affiliations
- The University of Queensland (AU)
- Corresponding author
- Hodson, Mark
- Venue
- Marine Drugs
- Publisher
- MDPI AG
- Published
- 2015-01-07
- Volume
- 13
- Issue
- 1
- Pages
- 249-266
- ISSN
- 1660-3397 (ISSN-L)
- PMC
- PMC4306935
- OpenAlex
- W2015490812
- Cited by
- 64
- References
- 67
- Citations by year
- 2026: 4 · 2025: 4 · 2024: 7 · 2023: 5 · 2022: 9 · 2021: 3 · 2020: 8 · 2019: 7 · 2018: 5 · 2017: 8 · 2016: 3 · 2015: 1
- FWCI
- 4.07
- Type
- journal article
- Language
- en
- Open access
- gold
- dx.doi.org
- Licence
- Locations
- Marine Drugs (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- University of Queensland
- Topics
- Health Sciences › Medicine › Pharmacology › Microbial Natural Products and Biosynthesis
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biotechnology › Marine Sponges and Natural Products
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biotechnology › Microbial Metabolism and Applications
- Keywords
- Salinispora arenicola, marine actinomycetes, secondary metabolites, antibiotic production, rifamycin B, rifamycin S, salt concentration, incubation time, sponge-associated bacteria, metabolite profiling, growth medium optimization
- MeSH terms
- Animals, Anti-Bacterial Agents, Chromatography, Liquid, Micromonosporaceae, Porifera, Rifamycins, Seawater, Mass Spectrometry, Metabolomics
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