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Stability of Chitosan—A Challenge for Pharmaceutical and Biomedical Applications
Open accessAbstract
Chitosan—one of the natural multifunctional polymers—due to its unique and versatile biological properties is regarded as a useful compound in medical and pharmaceutical technology. Recently, considerable research effort has been made in order to develop safe and efficient chitosan products. However, the problem of poor stability of chitosan-based systems restricts its practical applicability; thus, it has become a great challenge to establish sufficient shelf-life for chitosan formulations. Improved stability can be assessed by controlling the environmental factors, manipulating processing conditions (e.g., temperature), introducing a proper stabilizing compound, developing chitosan blends with another polymer, or modifying the chitosan structure using chemical or ionic agents. This review covers the influence of internal, environmental, and processing factors on the long-term stability of chitosan products. The aim of this paper is also to highlight the latest developments which enable the physicochemical properties of chitosan-based applications to be preserved upon storage.
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Cites
Freeze-drying of nanoparticles: Formulation, process and storage considerations
ABDELWAHED, W., DEGOBERT, G., STAINMESSE, S., & FESSI, H. (2006) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2006.09.017 · Cited by 1,611
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Cited by
Chitosan based nanocomposite films and coatings: Emerging antimicrobial food packaging alternatives
Kumar, S., Mukherjee, A., & Dutta, J. (2020) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2020.01.002 · Cited by 850
Chitosan modifications for adsorption of pollutants – A review
Saheed, I. O., Oh, W. D., & Suah, F. B. M. (2021) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2020.124889 · Cited by 616
Sharifi-Rad, J., Quispe, C., Butnariu, M., Rotariu, L. S., Sytar, O., Sestito, S., Rapposelli, S., Akram, M., Iqbal, M., Krishna, A., et al. (2021) · Cancer Cell International · doi:10.1186/s12935-021-02025-4 · Cited by 290
Recent advances in colon drug delivery systems
Arévalo-Pérez, R., Maderuelo, C., & Lanao, J. M. (2020) · Journal of Controlled Release · doi:10.1016/j.jconrel.2020.09.026 · Cited by 179
The use of chitosan-based metal catalysts in organic transformations
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Metadata
- Authors
- Szymańska, E., & Winnicka, K.
- Venue
- Marine Drugs
- Publisher
- MDPI AG
- Published
- 2015-04-01
- Volume
- 13
- Issue
- 4
- Pages
- 1819-1846
- ISSN
- 1660-3397 (ISSN-L)
- OpenAlex
- W2086775219
- Cited by
- 942
- References
- 3
- FWCI
- 24.38
- Type
- journal article
- Language
- en
- Open access
- gold
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