Cited by 1,611Nanoparticle-Based Drug DeliveryMicroencapsulation and Drying ProcessesPickering emulsions and particle stabilization

Freeze-drying of nanoparticles: Formulation, process and storage considerations

ABDELWAHED, W, DEGOBERT, G, STAINMESSE, S, FESSI, H·2006·Advanced Drug Delivery Reviews

Abstract

Freeze-drying has been considered as a good technique to improve the long-term stability of colloidal nanoparticles. The poor stability in an aqueous medium of these systems forms a real barrier against the clinical use of nanoparticles. This article reviews the state of the art of freeze-drying nanoparticles. It discusses the most important parameters that influence the success of freeze-drying of these fragile systems, and provides an overview of nanoparticles freeze-drying process and formulation strategies with a focus on the impact of formulation and process on particle stability.

Integrity signals

Registry

Crossref · 10.1016/j.addr.2006.09.017

Cites

91 of 91 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Cites

Flagged first, then by citations

2 of the 93 references couldn’t be matched to a known paper.

Cited by

Sorted by citations

Authors
ABDELWAHED, W., DEGOBERT, G., STAINMESSE, S., & FESSI, H.
Affiliations
  • Lyon 1 Université (FR)
  • Conservatoire National des Arts et Métiers (FR)
Corresponding author
DEGOBERT, G
Venue
Advanced Drug Delivery Reviews
Publisher
Elsevier BV
Published
2006-12-30
Volume
58
Issue
15
Pages
1688-1713
ISSN
0169-409X (ISSN-L)
OpenAlex
W2120826143
Cited by
1,611
References
93
Citations by year
2026: 78 · 2025: 95 · 2024: 81 · 2023: 95 · 2022: 96 · 2021: 114 · 2020: 132 · 2019: 106 · 2018: 125 · 2017: 131 · 2016: 85 · 2015: 88 · 2014: 87 · 2013: 88 · 2012: 79
FWCI
8.26
Type
journal article
Language
en
Open access
closed
Locations
  • Advanced Drug Delivery Reviews (publishedVersion)
  • PubMed (publishedVersion)
  • HAL (submittedVersion)
Topics
  • Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
  • Life Sciences › Agricultural and Biological Sciences › Food Science › Microencapsulation and Drying Processes
  • Physical Sciences › Materials Science › Materials Chemistry › Pickering emulsions and particle stabilization
Keywords
freeze-drying, nanoparticles, colloidal stability, nanoparticle formulation, storage stability, aqueous nanoparticle suspensions
MeSH terms
Chemistry, Pharmaceutical, Chemistry, Physical, Drug Storage, Freeze Drying, Nanoparticles, Chemical Phenomena

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review