Freeze-drying of nanoparticles: Formulation, process and storage considerations
Abstract
Freeze-drying has been considered as a good technique to improve the long-term stability of colloidal nanoparticles. The poor stability in an aqueous medium of these systems forms a real barrier against the clinical use of nanoparticles. This article reviews the state of the art of freeze-drying nanoparticles. It discusses the most important parameters that influence the success of freeze-drying of these fragile systems, and provides an overview of nanoparticles freeze-drying process and formulation strategies with a focus on the impact of formulation and process on particle stability.
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Sucrose or trehalose are used as lyoprotectants to stabilize colloidal particles during freeze-drying.
“Sucrose or trehalose are used for that purpose (Abdelwahed et al., 2006).”
From mRNA-lipid nanoparticle COVID-19 vaccines: structure and stability (2021) · cites this paper as Abdelwahed et al., 2006
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- Authors
- ABDELWAHED, W., DEGOBERT, G., STAINMESSE, S., & FESSI, H.
- Affiliations
- Lyon 1 Université (FR)
- Conservatoire National des Arts et Métiers (FR)
- Corresponding author
- DEGOBERT, G
- Venue
- Advanced Drug Delivery Reviews
- Publisher
- Elsevier BV
- Published
- 2006-12-30
- Volume
- 58
- Issue
- 15
- Pages
- 1688-1713
- ISSN
- 0169-409X (ISSN-L)
- OpenAlex
- W2120826143
- Cited by
- 1,611
- References
- 93
- Citations by year
- 2026: 78 · 2025: 95 · 2024: 81 · 2023: 95 · 2022: 96 · 2021: 114 · 2020: 132 · 2019: 106 · 2018: 125 · 2017: 131 · 2016: 85 · 2015: 88 · 2014: 87 · 2013: 88 · 2012: 79
- FWCI
- 8.26
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Advanced Drug Delivery Reviews (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion)
- Topics
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Life Sciences › Agricultural and Biological Sciences › Food Science › Microencapsulation and Drying Processes
- Physical Sciences › Materials Science › Materials Chemistry › Pickering emulsions and particle stabilization
- Keywords
- freeze-drying, nanoparticles, colloidal stability, nanoparticle formulation, storage stability, aqueous nanoparticle suspensions
- MeSH terms
- Chemistry, Pharmaceutical, Chemistry, Physical, Drug Storage, Freeze Drying, Nanoparticles, Chemical Phenomena
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