The DOI matches its Crossref record; 26 of the 26 references it cites were found in a registry or an index.
Antimicrobial and Cytotoxic Assessment of Marine Cyanobacteria - Synechocystis and Synechococcus
Open accessAbstract
Aqueous extracts and organic solvent extracts of isolated marine cyanobacteria strains were tested for antimicrobial activity against a fungus, Gram-positive and Gram-negative bacteria and for cytotoxic activity against primary rat hepatocytes and HL-60 cells. Antimicrobial activity was based on the agar diffusion assay. Cytotoxic activity was measured by apoptotic cell death scored by cell surface evaluation and nuclear morphology. A high percentage of apoptotic cells were observed for HL-60 cells when treated with cyanobacterial organic extracts. Slight apoptotic effects were observed in primary rat hepatocytes when exposed to aqueous cyanobacterial extracts. Nine cyanobacteria strains were found to have antibiotic activity against two Gram-positive bacteria, Clavibacter michiganensis subsp. insidiosum and Cellulomonas uda. No inhibitory effects were found against the fungus Candida albicans and Gram-negative bacteria. Marine Synechocystis and Synechococcus extracts induce apoptosis in eukaryotic cells and cause inhibition of Gram-positive bacteria. The different activity in different extracts suggests different compounds with different polarities.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“After treatment with extracts, cells express apoptotic markers, such as fragmentation of nucleus, shrinkage of cells, and release of apoptotic substances [240].”
From The promising future of microalgae: Current status, challenges, and optimization of a sustainable and renewable industry for biofuels, feed, and other products (2018) · cites this paper as [240]
In the citing paper
“Extracts of Synechocystis sp. and Synechococcus sp. have been shown to drive HL-60 cells into apoptotic conditions.”
From The promising future of microalgae: Current status, challenges, and optimization of a sustainable and renewable industry for biofuels, feed, and other products (2018) · cites this paper as [240]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Antibiotic Susceptibility Testing by a Standardized Single Disk Method
Bauer, A. W., Kirby, W. M. M., Sherris, J. C., & Turck, M. (1966) · American Journal of Clinical Pathology · doi:10.1093/ajcp/45.4_ts.493 · Cited by 18,523
Exocellular polysaccharides from cyanobacteria and their possible applications
Philippis, R. D., & Vincenzini, M. (1998) · FEMS Microbiology Reviews · doi:10.1111/j.1574-6976.1998.tb00365.x · Cited by 661
Natural products in anticancer therapy
Ab, D. R. (2001) · Current Opinion in Pharmacology · doi:10.1016/s1471-4892(01)00063-7 · Cited by 618
Falconer, I. R. (1999) · Environmental Toxicology · doi:10.1002/(sici)1522-7278(199902)14:1 · Cited by 410
Gerwick, W. H., Proteau, P. J., Nagle, D. G., Hamel, E., Blokhin, A., & Slate, D. L. (1994) · The Journal of Organic Chemistry · doi:10.1021/jo00085a006 · Cited by 365
Anti-HIV Activity of Extracts and Compounds from Algae and Cyanobacteria
Schaeffer, D. J., & Krylov, V. S. (2000) · Ecotoxicology and Environmental Safety · doi:10.1006/eesa.1999.1862 · Cited by 326
Suikkanen, S., Fistarol, G. O., & Granéli, E. (2004) · Journal of Experimental Marine Biology and Ecology · doi:10.1016/j.jembe.2004.02.012 · Cited by 226
Marine pharmacology in 2000: Antitumor and cytotoxic compounds
Mayer, A. M. S., & Gustafson, K. R. (2003) · International Journal of Cancer · doi:10.1002/ijc.11080 · Cited by 168
The cyanobacterial toxin, microcystin-LR, can induce apoptosis in a variety of cell types
McDermott, C. M., Nho, C. W., Howard, W., & Holton, B. (1998) · Toxicon · doi:10.1016/s0041-0101(98)00128-7 · Cited by 164
Shimizu, Y. (2003) · Current Opinion in Microbiology · doi:10.1016/s1369-5274(03)00064-x · Cited by 157
Flagged first, then by citations
Research works printed but not linked: 1
- Moore, R.E.; Patterson, G.M.L.; Carmichael, W.W. New pharmaceuticals from cultured blue-green algae. In Biomedical importance of marine organisms; Fautin, D.G., Ed.; Mem. Cal. Acad. Sci., 1988; Volume 13, pp. 143-150.
Cited by
Sorted by citations
Items 101–117 of 117
Schallenberg, L., Wood, S. A., Puddick, J., Cabello‐Yeves, P. J., & Burns, C. W. (2022) · Inland Waters · doi:10.1080/20442041.2022.2053455 · Cited by 3
Queiroga, F. R., Marques‐Santos, L. F., Hégaret, H., Sassi, R., Farias, N. D., Santana, L. N., & da Silva, P. M. (2017) · Aquatic Toxicology · doi:10.1016/j.aquatox.2017.03.019 · Cited by 3
Marine Photosynthetic Microorganisms
Singh, S. P., & Sinha, R. P. (2020) · Wiley eBooks · doi:10.1002/9781119143802.ch101 · Cited by 3
Sigamani, S., Balasubramani, G., Panneerselvam, B., Kannupaiyan, J., Sivanandam, M., Ramamurthy, D., & Hemalatha, N. (2025) · Applied Biochemistry and Biotechnology · doi:10.1007/s12010-025-05246-9 · Cited by 2
do Amaral, S. C., Xavier, L. P., Reis, M. A., Médice, R. V., Morone, J., da Silva, R. S., Morais, J., Vasconcelos, V. M., & Santos, A. V. (2025) · Chemistry & Biodiversity · doi:10.1002/cbdv.202501582 · Cited by 2
Self-citationBrazilian Coast: A Significant Gap in the Knowledge of Cyanobacteria and Their Applications
Caires, T. A., & Affe, H. M. D. J. (2021) · IntechOpen eBooks · doi:10.5772/intechopen.97151 · Cited by 4
Biocompatibility of Synechococcus sp. PCC 7002 with Human Dermal Cells In Vitro
Fuchs, B., Mert, S., Kuhlmann, C., Taha, S., Birt, A., Nickelsen, J., Schenck, T. L., Giunta, R. E., Wiggenhauser, P. S., & Moellhoff, N. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25073922 · Cited by 2
Antimicrobial Agents from Marine Cyanobacteria and Actinomycetes
Pramanik, A., Saha, M., & Sana, B. (2013) · Wiley eBooks · doi:10.1002/9783527665259.ch11 · Cited by 2
Enríquez-Espinoza, T. L., Mendoza-Cano, F., Encinas-García, T., Olguín-León, P., Luna, J. D., Muhlia‐Almazán, A., & Sánchez‐Paz, A. (2026) · Journal of Virological Methods · doi:10.1016/j.jviromet.2026.115430 · Cited by 1
THERMOPHILIC CYANOBACTERIA: AN UNTAPPED RESERVOIR OF PHARMACOLOGICAL LEADS
Tyagi, S., Suyal, S., Tewari, A., Awasthi, S., Singh, R. K., Kumar, A., Sharma, N., & Uniyal, A. (2023) · European Chemical Bulletin · doi:10.53555/ecb/2023.12.si5a.0161 · Cited by 1
(2022) · Journal of Chemical Biological and Physical Sciences · doi:10.24214/jcbps.b.12.3.21728 · Cited by 1
Allelopathic activity of the Baltic picocyanobacterium Synechocystis sp.
Śliwińska‐Wilczewska, S., Knitter, A., Cisło, D., & Latała, A. (2017) · Annales Universitatis Paedagogicae Cracoviensis Studia Naturae · doi:10.24917/25438832.2.10
Molinski, T. F. (2010) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.5811956.5793054
ANTIBACTERIAL ACTIVITY OF DIFFERENT EXTRACTS OF CYANOBACTERIA.
Mehasen, H., Arafa, S., & Samy, A. E. A. (2014) · Journal of Productivity and Development · doi:10.21608/jpd.2014.42667
Vasconcelos, V. M., & Leão, P. N. (2014) · CRC Press eBooks · doi:10.1201/b16662-45
Self-citationGreen Chemicals From Microalgae
Makhlof, M. E. M., Shehata, N., & EL‐Sayed, A. I. M. (2023) · Elsevier eBooks · doi:10.1016/b978-0-443-15738-7.00014-3
Antimicrobial Activities of the Bidens Species
Sadaf, H. M. (2025) · Springer eBooks · doi:10.1007/978-981-96-4257-1_13
Metadata
- Authors
- Martins, R., Ramos, M., Herfindal, L., Sousa, J., Skærven, K., & Vasconcelos, V.
- Affiliations
- Universidade do Porto (PT)
- University of Bergen (NO)
- Department of Biomedicine, University of Bergen, Jonas Lies vei 91, N-5009 Bergen, Norway
- Corresponding author
- Vasconcelos, Vitor
- Venue
- Marine Drugs
- Publisher
- MDPI AG
- Published
- 2008-01-22
- Volume
- 6
- Issue
- 1
- Pages
- 1-11
- ISSN
- 1660-3397 (ISSN-L)
- OpenAlex
- W4297835311
- Cited by
- 117
- References
- 26
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 5 · 2023: 8 · 2022: 12 · 2021: 9 · 2020: 12 · 2019: 6 · 2018: 9 · 2017: 7 · 2016: 7 · 2015: 10 · 2014: 5 · 2013: 9 · 2012: 2
- FWCI
- 2.57
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Marine Drugs (publishedVersion, cc-by)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Life Sciences › Immunology and Microbiology › Applied Microbiology and Biotechnology › Microbial Natural Products and Biosynthesis
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biotechnology › Marine Sponges and Natural Products
- Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Seaweed-derived Bioactive Compounds
- Keywords
- marine cyanobacteria, Synechocystis, Synechococcus, antimicrobial activity, cytotoxicity, apoptosis, HL-60 cells, rat hepatocytes, Cellulomonas uda, Candida albicans, Gram-positive bacteria, organic solvent extracts, aqueous extract, natural products
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
