The DOI matches its Crossref record; 38 of the 38 references it cites were found in a registry or an index.
Antimicrobial Photodynamic Therapy: Study of Bacterial Recovery Viability and Potential Development of Resistance after Treatment
Open accessAbstract
Antimicrobial photodynamic therapy (aPDT) has emerged in the clinical field as a potential alternative to antibiotics to treat microbial infections. No cases of microbial viability recovery or any resistance mechanisms against it are yet known. 5,10,15-tris(1-Methylpyridinium-4-yl)-20-(pentafluorophenyl)-porphyrin triiodide (Tri-Py+-Me-PF) was used as photosensitizer. Vibrio fischeri and recombinant Escherichia coli were the studied bacteria. To determine the bacterial recovery after treatment, Tri-Py+-Me-PF (5.0 µM) was added to bacterial suspensions and the samples were irradiated with white light (40 W m-2) for 270 minutes. Then, the samples were protected from light, aliquots collected at different intervals and the bioluminescence measured. To assess the development of resistance after treatment, bacterial suspensions were exposed to white light (25 minutes), in presence of 5.0 μM of Tri-Py+-Me-PF (99.99% of inactivation) and plated. After the first irradiation period, surviving colonies were collected from the plate and resuspended in PBS. Then, an identical protocol was used and repeated ten times for each bacterium. The results suggest that aPDT using Tri-Py+-Me-PF represents a promising approach to efficiently destroy bacteria since after a single treatment these microorganisms do not recover their viability and after ten generations of partially photosensitized cells neither of the bacteria develop resistance to the photodynamic process.
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Cites
Photosensitized singlet oxygen and its applications
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Photodynamic therapy: a new antimicrobial approach to infectious disease?
Hamblin, M. R., & Hasan, T. (2004) · Photochemical & Photobiological Sciences · doi:10.1039/b311900a · Cited by 2,035
Photodynamic antimicrobial chemotherapy (PACT)
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Antifungal photodynamic therapy
Donnelly, R. F., McCarron, P. A., & Tunney, M. M. (2008) · Microbiological Research · doi:10.1016/j.micres.2007.08.001 · Cited by 453
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Antibacterial photodynamic therapy in dermatology
Maisch, T., Szeimies, R.-M., Jori, G., & Abels, C. (2004) · Photochemical & Photobiological Sciences · doi:10.1039/b407622b · Cited by 322
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Alves, E., Costa, L., Carvalho, C. M., Tomé, J. P., Faustino, M. A., Neves, M. G., Tomé, A. C., Cavaleiro, J. A., Cunha, Â., & Almeida, A. (2009) · BMC Microbiology · doi:10.1186/1471-2180-9-70 · Cited by 227
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Pseudomonas aeruginosa Biofilms
Thi, M. T. T., Wibowo, D., & Rehm, B. H. A. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21228671 · Cited by 911
Antimicrobial photodynamic therapy – what we know and what we don’t
Cieplik, F., Deng, D., Crielaard, W., Buchalla, W., Hellwig, E., Al-Ahmad, A., & Maisch, T. (2018) · Critical Reviews in Microbiology · doi:10.1080/1040841x.2018.1467876 · Cited by 902
Progress in Alternative Strategies to Combat Antimicrobial Resistance: Focus on Antibiotics
Murugaiyan, J., Kumar, P. A., Rao, G. S., Iskandar, K., Hawser, S., Hays, J. P., Mohsen, Y., Adukkadukkam, S., Awuah, W. A., Jose, R. A. M., et al. (2022) · Antibiotics · doi:10.3390/antibiotics11020200 · Cited by 567
Li, H., Zhou, X., Huang, Y., Liao, B., Cheng, L., & Ren, B. (2021) · Frontiers in Microbiology · doi:10.3389/fmicb.2020.622534 · Cited by 284
Metadata
- Authors
- Tavares, A., Carvalho, C. M. B., Faustino, M. A., Neves, M. G. P. M. S., Tomé, J. P. C., Tomé, A. C., Cavaleiro, J. A. S., Cunha, Â., Gomes, N. C. M., Alves, E., & Almeida, A.
- Venue
- Marine Drugs
- Publisher
- MDPI AG
- Published
- 2010-01-20
- Volume
- 8
- Issue
- 1
- Pages
- 91-105
- ISSN
- 1660-3397 (ISSN-L)
- OpenAlex
- W1992568214
- Cited by
- 419
- References
- 38
- FWCI
- 13.04
- Type
- journal article
- Language
- en
- Open access
- gold
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- Tavares, A., Carvalho, C. M. B., Faustino, M. A., Neves, M. G. P. M. S., Tomé, J. P. C., Tomé, A. C., Cavaleiro, J. A. S., Cunha, Â., Gomes, N. C. M., Alves, E., & Almeida, A. (2010). Antimicrobial Photodynamic Therapy: Study of Bacterial Recovery Viability and Potential Development of Resistance after Treatment. Marine Drugs. https://doi.org/10.3390/md8010091
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