Antiviral activity of exopolysaccharides produced by lactic acid bacteria of the genera Pediococcus, Leuconostoc and Lactobacillus against human adenovirus type 5
Open accessAbstract
Background and objectives: The use of antagonistic probiotic microorganisms and their byproducts represents a promising approach for the treatment of viral diseases. In the current work, the effect of exopolysaccharides (EPSs) produced by lactic acid bacteria from different genera on the structural and functional characteristics of cells and the development of adenoviral infection in vitro was studied. Materials and Methods: Cytotoxicity of six EPSs of lactic acid bacteria of the genera Lactobacillus, Leuconostoc and Pediococcus was determined by MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide) assay. The influence of the EPSs on the infectivity of human adenovirus type 5 (HAdV-5) and on the cell cycle under a condition of adenovirus infection was studied using plaque reduction assay and flow cytometric analysis, respectively. Results: It was shown that exopolysaccharides were non-toxic to Madin-Darby bovine kidney cells (MDBK) as they reduced their viability by 3–17%. A change in the distribution of the cell cycle phases in the non-infected cell population treated with EPSs was observed. The analysis demonstrated an increase in the number of cells in the S phase by 47% when using EPSs 15a and a decrease in the number of cells in the G1 phase by 20–27% when treated with the EPSs 15a, 33a, and 19s. The use of EPSs did not led to the normalization of the life cycle of HAdV-5 infected cells to the level of non-infected cells. The EPSs showed low virucidal activity and reduced the HAdV-5 infectivity to 85%. Among the studied exopolysaccharides, anti-adenovirus activity was found for EPS 26a that is produced by Lactobacillus spp. strain. The treatment of cells with the EPS following virus adsorption completely (100%) suppressed the formation and release of HAdV-5 infectious. Conclusions: EPS 26a possessed distinct anti-HAdV-5 activity and the obtained data demonstrate the potential of using exopolysaccharides as anti-adenoviral agents.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Exopolysaccharides produced by lactic acid bacteria have been shown to effectively interfere with virus adhesion, e.g., adenovirus.
“Exopolysaccharides produced by lactic acid bacteria have been shown to effectively interfere with this step of, e.g., adenovirus (Biliavska et al., 2019).”
From Viral Infections, the Microbiome, and Probiotics (2021) · cites this paper as Biliavska et al., 2019
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Mosmann, T. (1983) · Journal of Immunological Methods · doi:10.1016/0022-1759(83)90303-4 · Cited by 56,104 · see citing works
Approved Antiviral Drugs over the Past 50 Years
Clercq, E. D., & Li, G. (2016) · Clinical Microbiology Reviews · doi:10.1128/cmr.00102-15 · Cited by 1,443 · see citing works
Human adenovirus: Viral pathogen with increasing importance
Ghebremedhin, B. (2014) · European Journal of Microbiology and Immunology · doi:10.1556/eujmi.4.2014.1.2 · Cited by 329 · see citing works
Assaying Cell Cycle Status Using Flow Cytometry
Kim, K. H., & Sederstrom, J. M. (2015) · Current Protocols in Molecular Biology · doi:10.1002/0471142727.mb2806s111 · Cited by 311 · see citing works
Molecular evolution of human adenoviruses
Robinson, C. M., Singh, G., Lee, J. Y., Dehghan, S., Rajaiya, J., Liu, E. B., Yousuf, M. A., Betensky, R. A., Jones, M. S., Dyer, D. W., et al. (2013) · Scientific Reports · doi:10.1038/srep01812 · Cited by 282 · see citing works
Inhibition of adenovirus infection and adenain by green tea catechins
WEBER, J. M., Ruzindana-Umunyana, A., Imbeault, L., & Sircar, S. (2003) · Antiviral Research · doi:10.1016/s0166-3542(02)00212-7 · Cited by 225 · see citing works
Ryan, P. M., Ross, R. P., Fitzgerald, G. F., Caplice, N. M., & Stanton, C. (2015) · Food & Function · doi:10.1039/c4fo00529e · Cited by 221 · see citing works
Antiviral Potential of Lactic Acid Bacteria and Their Bacteriocins
Al Kassaa, I., Hober, D., Hamze, M., Chihib, N. E., & Drider, D. (2014) · Probiotics and Antimicrobial Proteins · doi:10.1007/s12602-014-9162-6 · Cited by 217 · see citing works
Jung, Y., Lee, Y., Ngo, V. L., Cho, Y.-H., Ko, E.-J., Hong, S.-M., Kim, K., Jang, J.-H., Oh, J. S., Park, M.-K., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-17487-8 · Cited by 118 · see citing works
Development of plaque assays for adenoviruses 40 and 41
Cromeans, T. L., Lu, X., Erdman, D. D., Humphrey, C. D., & Hill, V. R. (2008) · Journal of Virological Methods · doi:10.1016/j.jviromet.2008.03.007 · Cited by 74 · see citing works
Morfin, F., Dupuis‐Girod, S., Frobert, É., Mundweiler, S., Carrington, D., Sedláček, P., Bierings, M., Cetkovský, P., Kroes, A. C. M., van Tol, M. J. D., et al. (2009) · Antiviral Therapy · doi:10.1177/135965350901400110 · Cited by 65 · see citing works
Inhibition of human immunodeficiency virus type 1 by lactic acid bacteria from human breastmilk
Martín, V., Maldonado, A., Fernández, L., Rodríguez, J. M., & Connor, R. I. (2010) · Breastfeeding Medicine · doi:10.1089/bfm.2010.0001 · Cited by 64 · see citing works
Anti-Viral Drugs for Human Adenoviruses
Waye, M. M. Y., & Sing, C. (2010) · Pharmaceuticals · doi:10.3390/ph3103343 · Cited by 62 · see citing works
Das, A., Trousdale, M. D., Ren, S., & Lien, E. J. C. (1999) · Antiviral Research · doi:10.1016/s0166-3542(99)00070-4 · Cited by 60 · see citing works
Ying, B., Tollefson, A. E., Spencer, J. F., Balakrishnan, L., Dewhurst, S., Capella, C., Buller, R. M. L., Tóth, K., & Wold, W. S. M. (2014) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.03860-14 · Cited by 52 · see citing works
Safrin, S., Cherrington, J. M., & Jaffe, H. S. (1999) · Advances in experimental medicine and biology · doi:10.1007/978-1-4615-4743-3_10 · Cited by 49 · see citing works
Kohn, L. K., Foglio, M., Rodrigues, R. A. F., Sousa, I. D. O., Martini, M., Padilla, M., Neto, D. F. D. L., & Arns, C. W. (2015) · Brazilian Journal of Poultry Science · doi:10.1590/1516-635x1703275-280 · Cited by 48 · see citing works
Cidofovir. Review of current and potential clinical uses.
Safrin, S., Cherrington, J. M., & Jaffe, H. (1999) · PubMed · Cited by 46 · see citing works
Gugliandolo, C., Spanò, A., Maugeri, T. L., Poli, A., Arena, A., & Nicolaus, B. (2015) · Microorganisms · doi:10.3390/microorganisms3030464 · Cited by 42 · see citing works
Trapp-Fragnet, L., Bencherit, D., Chabanne-Vautherot, D., Vern, Y. L., Remy, S., Boutet-Robinet, E. A., Mirey, G., Vautherot, J.-F., & Denesvre, C. (2014) · PLoS ONE · doi:10.1371/journal.pone.0100004 · Cited by 38 · see citing works
Yang, Y., Song, H. S., Wang, L., Dong, W., Yang, Z., Yuan, P., Wang, K., & Song, Z. (2017) · Journal of Probiotics & Health · doi:10.4172/2329-8901.1000184 · Cited by 37 · see citing works
Curious (Old and New) Antiviral Nucleoside Analogues with Intriguing Therapeutic Potential
Clercq, E. D. (2015) · Current Medicinal Chemistry · doi:10.2174/0929867322666150625094705 · Cited by 35 · see citing works
Human Cells Arrest in S Phase in Response to Adenovirus 12 E1A
Grand, R. J. A., Ibrahim, A. P., Taylor, A. M. R., Milner, A. E., Gregory, C. D., Gallimore, P. H., & Turnell, A. S. (1998) · Virology · doi:10.1006/viro.1998.9102 · Cited by 34 · see citing works
Human Adenoviruses: Propagation, Purification, Quantification, and Storage
Green, M., & Loewenstein, P. M. (2006) · Current Protocols in Microbiology · doi:10.1002/9780471729259.mc14c01s00 · Cited by 22 · see citing works
Adenovirus inhibition of cellular protein synthesis and the specific translation of late viral mRNAs
Zhang, Y., & Schneider, R. J. (1993) · Seminars in Virology · doi:10.1006/smvy.1993.1019 · Cited by 20 · see citing works
Monitoring of the Adenovirus Production Process by Flow Cytometry
Sandhu, K. S., & Al‐Rubeai, M. (2007) · Biotechnology Progress · doi:10.1021/bp070198s · Cited by 18 · see citing works
Isolation and characterization of lactic acid bacteria from Ukrainiantraditional dairy products
Garmasheva, I. L. (2016) · AIMS Microbiology · doi:10.3934/microbiol.2016.3.372 · Cited by 11 · see citing works
[Experimental study of Ingavirin antiviral activity against human adenovirus].
Zarubaev, V. V., Slita, A. V., Sirotkin, A. K., Nebol'sin, V. E., & Oi, K. (2010) · PubMed · Cited by 3 · see citing works
EXOPOLYSACCHARIDES PRODUCTION BY LACTIC ACID BACTERIA STRAINS ISOLATED FROM FERNMENTED PRODUCTS
Garmasheva, I. L., Коваленко, Н. К., Василюк, О. М., & Oleshchenko, L. T. (2017) · Microbiology&Biotechnology · doi:10.18524/2307-4663.2017.4(40).118933 · Cited by 2 · see citing works
Bencherit, D., Vern, Y. L., Rémy, S., Boutet-Robinet, E., Mirey, G., & Denesvre, C. (2016) · Cited by 1 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Exopolysaccharides from Probiotic Bacteria and Their Health Potential
Angelin, J., & Kavitha, M. (2020) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2020.06.190 · Cited by 617 · see citing works
Exopolysaccharides as Antimicrobial Agents: Mechanism and Spectrum of Activity
Abdalla, A. K., Ayyash, M. M., Olaimat, A. N., Osaili, T. M., Al-Nabulsi, A. A., Shah, N. P., & Holley, R. (2021) · Frontiers in Microbiology · doi:10.3389/fmicb.2021.664395 · Cited by 268 · see citing works
Bacterial exopolysaccharides as emerging bioactive macromolecules: from fundamentals to applications
Kaur, N., & Dey, P. (2022) · Research in Microbiology · doi:10.1016/j.resmic.2022.104024 · Cited by 270 · see citing works
Diet Supplementation, Probiotics, and Nutraceuticals in SARS-CoV-2 Infection: A Scoping Review
Infusino, F., Marazzato, M., Mancone, M., Fedele, F., Mastroianni, C. M., Severino, P., Ceccarelli, G., Santinelli, L., Cavarretta, E., Marullo, A. G. M., et al. (2020) · Nutrients · doi:10.3390/nu12061718 · Cited by 202 · see citing works
Viral Infections, the Microbiome, and Probiotics
Harper, A., Vijayakumar, V., Ouwehand, A. C., ter Haar, J., Obis, D., Espadaler, J., Binda, S., Desiraju, S., & Day, R. (2021) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2020.596166 · Cited by 177 · see citing works
Dietary Supplements and Nutraceuticals under Investigation for COVID-19 Prevention and Treatment
Lordan, R., Rando, H. M., & Greene, C. S. (2021) · mSystems · doi:10.1128/msystems.00122-21 · Cited by 130 · see citing works
Werning, M. L., Hernández-Alcántara, A. M., Ruiz, M. J., Soto, L. P., Dueñas, M. T., López, P., & Frizzo, L. S. (2022) · Foods · doi:10.3390/foods11091284 · Cited by 126 · see citing works
Recent advances in the biological activities of microbial exopolysaccharides
Salimi, F., & Farrokh, P. (2023) · World Journal of Microbiology and Biotechnology · doi:10.1007/s11274-023-03660-x · Cited by 116 · see citing works
Variation in oral microbiome is associated with future risk of lung cancer among never-smokers
Hosgood, H. D., Cai, Q., Hua, X., Long, J., Shi, J., Wan, Y., Yang, Y., Abnet, C. C., Bassig, B. A., Hu, W., et al. (2020) · Thorax · doi:10.1136/thoraxjnl-2020-215542 · Cited by 100 · see citing works
Pourjafar, H., Ansari, F., Sadeghi, A., Samakkhah, S. A., & Jafari, S. M. (2022) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2022.2047883 · Cited by 103 · see citing works
Bacterial polysaccharides—A big source for prebiotics and therapeutics
Khan, R., Shah, M. D., Shah, L., Lee, P.-C., & Khan, I. (2022) · Frontiers in Nutrition · doi:10.3389/fnut.2022.1031935 · Cited by 88 · see citing works
KHALIL, M. A. E. F., Sonbol, F., Al-Madboly, L. A., Aboshady, T. A., Alqurashi, A. S., & Ali, S. S. (2022) · Frontiers in Microbiology · doi:10.3389/fmicb.2022.803688 · Cited by 86 · see citing works
Chaisuwan, W., Phimolsiripol, Y., Chaiyaso, T., Techapun, C., Leksawasdi, N., Jantanasakulwong, K., Rachtanapun, P., Wangtueai, S., Sommano, S. R., You, S., et al. (2021) · Frontiers in Nutrition · doi:10.3389/fnut.2021.772033 · Cited by 81 · see citing works
Emerging paradigms of viral diseases and paramount role of natural resources as antiviral agents
Jansi, R. S., Khusro, A., Agastian, P., Alfarhan, A., Al-Dhabi, N. A., Arasu, M. V., Rajagopal, R., Barceló, ., & Al-Tamimi, A. (2020) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2020.143539 · Cited by 54 · see citing works
Biopharmaceutical applications of microbial polysaccharides as materials: A Review
Song, Y., Li, S., Hao, G., Yip, R. C. S., & Chen, H. (2023) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2023.124259 · Cited by 51 · see citing works
Foolchand, A., Ghazi, T., & Chuturgoon, A. A. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23052654 · Cited by 45 · see citing works
Kavitake, D., Tiwari, S., Shah, I. A., Devi, P. B., Delattre, C., Reddy, G. B., & Shetty, P. H. (2023) · Food Control · doi:10.1016/j.foodcont.2023.109850 · Cited by 41 · see citing works
Exopolysaccharides from vaginal lactobacilli modulate microbial biofilms
Giordani, B., Naldi, M., Croatti, V., Parolin, C., Uzunoğlu, Ü. E., Bartolini, M., & Vitali, B. (2023) · Microbial Cell Factories · doi:10.1186/s12934-023-02053-x · Cited by 40 · see citing works
Postbiotics as potential promising tools for SARS-CoV-2 disease adjuvant therapy
Khani, N., Soleimani, R. A., Noorkhajavi, G., Soleimani, A. A., Abbasi, A., & Rad, A. H. (2022) · Journal of Applied Microbiology · doi:10.1111/jam.15457 · Cited by 39 · see citing works
Alharbi, K. S., Singh, Y. P., Almalki, W. H., Rawat, S., Afzal, O., Altamimi, A. S. A., Kazmi, I. A., Al-Abbasi, F. A., Alzarea, S. I., Singh, S. K., et al. (2022) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2022.109898 · Cited by 37 · see citing works
Zayed, A., Mansour, M. K., Sedeek, M. S., Habib, M. H., Ulber, R., & Farag, M. A. (2021) · Critical Reviews in Biotechnology · doi:10.1080/07388551.2021.1942779 · Cited by 32 · see citing works
Demirhan, H. K., Arslan, Y. E., Ceylan, A., Karaca, B., Halisçelik, O., & Kıran, F. (2020) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2020.10.106 · Cited by 31 · see citing works
Microbial exopolysaccharides: role in functional food engineering and gut‐health management
Muninathan, C., Guruchandran, S., Kalyan, A. J. V., & Ganesan, N. D. (2021) · International Journal of Food Science & Technology · doi:10.1111/ijfs.15334 · Cited by 28 · see citing works
Marimuthu, S., & Rajendran, K. (2023) · Applied Biochemistry and Biotechnology · doi:10.1007/s12010-023-04368-2 · Cited by 27 · see citing works
Anti-Herpes Virus Activity Of Lactobacillus’ Postbiotics
Vilhelmova-Ilieva, N., Atanasov, G. R., Simeonova, L. S., Dobreva, L. I., Mancheva, K., Trepechova, M., & Danova, S. T. (2022) · Biomedicine · doi:10.37796/2211-8039.1277 · Cited by 26 · see citing works
The Role of Lactic Acid in the Management of Bacterial Vaginosis: A Systematic Literature Review
Mendling, W., Shazly, M. A. E., & Zhang, L. (2022) · Future Pharmacology · doi:10.3390/futurepharmacol2030014 · Cited by 25 · see citing works
Jia, K., Wei, M., He, Y., Wang, Y., Hua, W., & Tao, X. (2022) · Foods · doi:10.3390/foods11213538 · Cited by 25 · see citing works
Screening of Lactic Acid Bacterial Strains with Antiviral Activity Against Porcine Epidemic Diarrhea
Chen, Y.-M., Limaye, A., Chang, H., & Liu, J. (2021) · Probiotics and Antimicrobial Proteins · doi:10.1007/s12602-021-09829-w · Cited by 24 · see citing works
N., A., El-Gammal, E. W., Atwa, N. A., Eldiwany Ahmed, I., Dawoud, I. E., & Rashad, F. M. (2021) · Journal of Applied Pharmaceutical Science · doi:10.7324/japs.2021.110504 · Cited by 22 · see citing works
Chang-Liao, W.-P., Lee, A., Chiu, Y.-H., Chang, H., & Liu, J. (2020) · Frontiers in Microbiology · doi:10.3389/fmicb.2020.01578 · Cited by 19 · see citing works
Ghanaim, A. M., Mohamed, H. I., & El-Ansary, A. E. (2025) · Microbial Cell Factories · doi:10.1186/s12934-025-02730-z · Cited by 18 · see citing works
Gastrointestinal disorders in post-COVID syndrome. Clinical guidelines
Grinevich, V., Lazebnik, L., Kravchuk, Y., Radchenko, V., Tkachenko, E., Pershko, A., Seliverstov, P., Salikova, C. P., Zhdanov, K., Kozlov, K., et al. (2023) · Experimental and Clinical Gastroenterology · doi:10.31146/1682-8658-ecg-208-12-4-68 · Cited by 14 · see citing works
Bacterial Exopolysaccharides: From Production to Functional Features
Talbi, C., Elmarrkechy, S., Youssfi, M. E., Bouzroud, S., Belfquih, M., Sifou, A., Bouhaddou, N., Badaoui, B., Balahbib, A., Bouyahya, A., et al. (2023) · Progress In Microbes & Molecular Biology · doi:10.36877/pmmb.a0000384 · Cited by 17 · see citing works
Probiotic supplementation: A prospective approach in the treatment of COVID-19
Nayebi, A., Navashenaq, J. G., Soleimani, D., & Nachvak, S. M. (2021) · Nutrition and Health · doi:10.1177/02601060211049631 · Cited by 17 · see citing works
Dekham, K., Jones, S. M., Jitrakorn, S., Charoonnart, P., Thadtapong, N., Intuy, R., Dubbs, P., Siripattanapipong, S., Saksmerprome, V., & Chaturongakul, S. (2023) · Scientific Reports · doi:10.1038/s41598-023-47897-w · Cited by 15 · see citing works
Salman, J. A. S., Mahmood, N. N., Abdulsattar, B. O., & Abid, H. A. (2020) · Open Access Macedonian Journal of Medical Sciences · doi:10.3889/oamjms.2020.5483 · Cited by 15 · see citing works
Saad, M. H., Sidkey, N. M., & El‐Fakharany, E. M. (2024) · Microbial Cell Factories · doi:10.1186/s12934-024-02383-4 · Cited by 14 · see citing works
Chouchane, H., Boutiti, S., Ouertani, A., Hassen, W., Guesmi, S., Neifar, M., Jelassi, H., Sghaier, H., Masmoudi, A. S., & Cherif, A. (2021) · Polymers · doi:10.3390/polym13213798 · Cited by 13 · see citing works
Aullybux, A. A., Puchooa, D., Bahorun, T., Jeewon, R., Wen, X., & Matin, P. (2021) · Journal of Polymers and the Environment · doi:10.1007/s10924-021-02290-4 · Cited by 12 · see citing works
Hoxha, R., Todorov, D. G., Hinkov, A. V., Shishkova, K., Evstatieva, Y., & Nikolova, D. (2023) · Microbiology Research · doi:10.3390/microbiolres14010026 · Cited by 9 · see citing works
Implications and Mechanisms of Antiviral Effects of Lactic Acid Bacteria: A Systematic Review
Farahmandi, F., Parhizgar, P., Tape, P. M. K., Bizhannia, F., rohani, F. S., Bizhanzadeh, M., Alhosseini, Z. S. M., hosseinzade, M., Farsi, Y., & Nasiri, M. J. (2023) · International Journal of Microbiology · doi:10.1155/2023/9298363 · Cited by 8 · see citing works
Can postbiotics show antiviral effects against Sars-CoV-2?
de Brito, L. P., Júnior, J. N. D. S., de Barros, P. D. S., da Silva, E. C., Calaça, P. R. D. A., Cavalcanti, M. T. H., & Porto, A. L. F. (2021) · Research Society and Development · doi:10.33448/rsd-v10i8.17259 · Cited by 9 · see citing works
Tang, S., Liu, J., Xu, C., Shang, D., Chen, H., & Zhang, G. (2021) · International Journal of Functional Nutrition · doi:10.3892/ijfn.2021.22 · Cited by 8 · see citing works
Alpural, A., Gebologlu, I. K., Parekh, M., İmamoğlu, E., Ali, Z., & Yeşil-Çeliktaş, Ö. (2025) · Engineering in Life Sciences · doi:10.1002/elsc.70034 · Cited by 7 · see citing works
Probiotics Based on Lactic Acid Bacteria for Aquaculture
Vasyliuk, O. M., Skrotskyi, S., La, K., & Tv, B. (2023) · Mikrobiolohichnyi Zhurnal · doi:10.15407/microbiolj85.02.075 · Cited by 7 · see citing works
Kim, H., Park, J., Moon, K.-S., Jung, S., Kwon, Y. M., Kang, N. S., Kim, J.-H., Nam, S., Choi, G., Baek, Y., et al. (2024) · Archives of Virology · doi:10.1007/s00705-024-05979-8 · Cited by 7 · see citing works
Spangler, J. R., Caruana, J. C., Medintz, I. L., & Walper, S. A. (2021) · Future Science OA · doi:10.2144/fsoa-2020-0153 · Cited by 7 · see citing works
Rossi, R. E., Chen, J., & Caplin, M. E. (2022) · Preventive Nutrition and Food Science · doi:10.3746/pnf.2022.27.2.137 · Cited by 7 · see citing works
Akhtach, S., Tabia, Z., Bricha, M., Belkhou, R., & Mabrouk, K. E. (2021) · Journal of Food Science · doi:10.1111/1750-3841.15941 · Cited by 7 · see citing works
García-Vicente, E. J., Rey-Casero, I., Martín, M., Pérez, A., Benito-Murcia, M., & Risco, D. (2024) · Vaccine · doi:10.1016/j.vaccine.2024.05.026 · Cited by 6 · see citing works
Microbial exopolysaccharides: Unveiling the pharmacological aspects for therapeutic advancements
Akhtar, N., Wani, A. K., Sharma, N. R., Sanami, S., Kaleem, S., MACHFUD, M., Purbiati, T., Sugiono, S., Djumali, D., Prahardini, P. E. R., et al. (2024) · Carbohydrate Research · doi:10.1016/j.carres.2024.109118 · Cited by 5 · see citing works
Scope of bacterial surface effector molecules beyond probiotics
Bhawal, S., Kumari, A., Rana, S., Kapila, S., & Kapila, R. (2023) · Food Bioscience · doi:10.1016/j.fbio.2023.103180 · Cited by 5 · see citing works
Microbial extracellular polymeric substance: function and role against environmental stress
Santra, H. K., & Banerjee, D. (2023) · Elsevier eBooks · doi:10.1016/b978-0-323-95251-4.00018-1 · Cited by 5 · see citing works
Lactobacillus - A Multifunctional Genus
Laranjo, M. (2022) · IntechOpen eBooks · doi:10.5772/intechopen.98170 · Cited by 4 · see citing works
Avitabile, E., Menotti, L., Giordani, B., Croatti, V., Parolin, C., & Vitali, B. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25052492 · Cited by 4 · see citing works
The application of exopolysaccharides (EPS) can prevent viral disease of fish
Bergmann, S. M., Reichert, M., Hwang, J. Y., Becker, A. M., Lenk, M., Kotterba, G., Buchholz, R., Jung, S., Gebler, A., Todte, M., et al. (2022) · Bulletin of the European Association of Fish Pathologists · doi:10.48045/001c.38087 · Cited by 4 · see citing works
Postbiotics as promising tools for controlling foodborne viruses infections
Soleimani, R. A., Abdoli, A., Milani, P. G., Khani, N., & Rad, A. H. (2025) · Microbial Pathogenesis · doi:10.1016/j.micpath.2025.107835 · Cited by 3 · see citing works
Virus Association with Bacteria and Bacterial Cell Components Enhance Virus Infectivity
Deng, W., Almeida, G., & Gibson, K. E. (2025) · Food and Environmental Virology · doi:10.1007/s12560-025-09633-7 · Cited by 3 · see citing works
Panicz, R., Eljasik, P., Troszok, A., Sobczak, M., Lisiecki, S., Nędzarek, A., & Sadowski, J. (2022) · Aquaculture Reports · doi:10.1016/j.aqrep.2022.101116 · Cited by 3 · see citing works
Recommendations and guidelines of integrative medicine for COVID-19 care: The APEC project outcome
Jia, L., Beidelschies, M. A., Evans, J. M., Niemtzow, R. C., Niemtzow, S. Z., Dusek, J. A., Lin, Y., Wu, C. G., Wang, C.-H. J., Su, Y., et al. (2024) · Integrative Medicine Research · doi:10.1016/j.imr.2024.101022 · Cited by 2 · see citing works
Potensi Antivirus dari Bakteri Asam Laktat
Muharram, L. H. (2020) · Cited by 2 · see citing works
Antiviral effects of Lactic Acid Bacteria; a systematic reviewPreprint
Farahmnandi, F., Parhizgar, P., Tape, P. M. K., Bizhannia, F., rohani, F. S., Bizhanzadeh, M., Alhosseini, Z. S. M., hosseinzade, M., Farsi, Y., & Nasiri, M. J. (2023) · Research Square · doi:10.21203/rs.3.rs-2519608/v1 · Cited by 2 · see citing works
Rai, A., Lama, S., Das, S., Thatal, B., & Tamang, J. P. (2024) · Current Probiotics · doi:10.2174/0126666499321746240809073632 · Cited by 1 · see citing works
Lactobacillus exopolysaccharide: An Untapped Biopolymer
Eze, O. C., Berebon, D. P., Gugu, T. H., Anazodo, F. I., & Okorie, J. E. (2022) · IntechOpen eBooks · doi:10.5772/intechopen.104954 · Cited by 1 · see citing works
Pezzino, G., Calabrò, A., Drommi, F., Campana, S., Cavaliere, R., Bonaccorsi, I., Carrega, P., Zammuto, V., Rizzo, M. G., Gugliandolo, C., et al. (2024) · ImmunoTargets and Therapy · doi:10.2147/itt.s470319 · Cited by 1 · see citing works
Probiotics, Prebiotics, and Synbiotics: Advanced Nutraceuticals
Singh, B., Mal, G., Kalra, R. S., & Marotta, F. (2024) · Springer eBooks · doi:10.1007/978-3-031-65455-8_4 · Cited by 1 · see citing works
Recent Trends in the Valorization of Value-Added Biomass from Microbes for Sustainable Development
Sakshi, S., Singh, P., Mishra, A. P., Mishra, P., Nigam, M., & Singh, S. K. (2025) · Environmental science and engineering · doi:10.1007/978-3-031-62660-9_15 · Cited by 1 · see citing works
Les probiotiques jouent-ils un rôle dans les infections virales, notamment le SRAS-CoV-2 ?
Simone, C. D., & Marazzato, M. (2020) · HEGEL - HEpato-GastroEntérologie Libérale · doi:10.3917/heg.103.0237
Mohammed, S., Özdemir, N., & Çon, A. H. (2021) · Food and Health · doi:10.3153/fh21030
Bioactivities of Bacterial Polysaccharides
Cruz‐Aldaco, K., Govea‐Salas, M., Araújo, R. G., Medina, M. D. D., & Loredo‐Treviño, A. (2022) · Springer eBooks · doi:10.1007/978-3-030-42215-8_30
Dietary Supplements and Nutraceuticals Under Investigation for COVID-19 Prevention and Treatment.Preprint
Lordan, R., Rando, H. M., & Greene, C. S. (2021) · PubMed
Antiviral history and viral targets for antiviral therapy
Hegazy, A., Mahmoud, S. H., Khalil, A. M., Martínez‐Sobrido, L., & Mostafa, A. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-18866-4.00009-2
Human Microbiome, Virome, and Microbial Therapies Against COVID-19
Singh, B., Mal, G., Kalra, R. S., & Marotta, F. (2024) · Springer eBooks · doi:10.1007/978-3-031-65459-6_20
Evaluation Anti-porcine Reproductive and Respiratory Syndrome Virus Activity of Bacillus StrainsPreprint
Zheng, Y., Chang, H., & Liu, J. (2024) · Research Square · doi:10.21203/rs.3.rs-5366186/v1
Postbiotics in Antimicrobial Food Packaging
Kutlu, G., Pirouzian, H. R., Pourjafar, H., & Törnük, F. (2025) · Elsevier eBooks · doi:10.1016/b978-0-323-90747-7.00051-x
Awady, M. E. E., Hamed, A. A., Selim, M. S., Selim, H. M. R. M., Gomaa, F. A. M., Moustafa, N. M., El-Wakil, E. S., Mohamed, S. S., & Ghareeb, M. A. (2025) · Elsevier eBooks · doi:10.1016/b978-0-443-26771-0.00034-5
Additional file 1 of Exopolysaccharides from vaginal lactobacilli modulate microbial biofilms
Giordani, B., Naldi, M., Croatti, V., Parolin, C., Erdoğan, Ü., Bartolini, M., & Vitali, B. (2023) · Figshare · doi:10.6084/m9.figshare.22622066
Suman, K., & Bandi, A. (2025) · Research Journal of Pharmacy and Technology · doi:10.52711/0974-360x.2025.00835
Mejía-Avellaneda, L. F., Céspedes‐Gutiérrez, E., Cortés-Rojas, D. F., & Mesa, L. (2026) · Sustainable Food Technology · doi:10.1039/d5fb00684h
Soleimani, R. A., Abdoli, A., Milani, P. G., Khani, N., & Rad, A. H. (2026) · Enzyme and Microbial Technology · doi:10.1016/j.enzmictec.2026.110899
Xing, Y., Hu, Y., Ma, Y., Yao, P., Jiang, J., Guo, J., & Liu, S. (2026) · Food Frontiers · doi:10.1002/fft2.70336
- Authors
- Biliavska, L., Pankivska, Y., Povnitsa, O., & Zagorodnya, S.
- Affiliations
- National Academy of Sciences of Ukraine (UA)
- Zabolotny Institute of Microbiology and Virology, National Academy of Sciences of Ukraine, 03143 Kyiv, Ukraine
- Corresponding author
- Biliavska, Liubov
- Venue
- Medicina
- Publisher
- MDPI AG
- Published
- 2019-08-22
- Volume
- 55
- Issue
- 9
- Pages
- 519
- ISSN
- 1010-660X (ISSN-L)
- 1648-9144
- PMC
- PMC6780409
- OpenAlex
- W2969845124
- Cited by
- 81
- References
- 30
- Citations by year
- 2026: 3 · 2025: 8 · 2024: 12 · 2023: 15 · 2022: 17 · 2021: 17 · 2020: 9
- FWCI
- 8.29
- Type
- journal article
- Language
- en
- Open access
- gold
- dx.doi.org
- Licence
- Locations
- Medicina (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- National Academy of Sciences of Ukraine
- State Fund for Fundamental Research of Ukraine
- Topics
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Life Sciences › Agricultural and Biological Sciences › Food Science › Polysaccharides Composition and Applications
- Physical Sciences › Environmental Science › Ecology › Bacteriophages and microbial interactions
- Keywords
- exopolysaccharides, lactic acid bacteria, Pediococcus, Leuconostoc, Lactobacillus, adenovirus type 5, antiviral activity, virucidal activity, cell cycle, MDBK cells, probiotics, viral infection
- MeSH terms
- Adenovirus Infections, Human, Adenoviruses, Human, Animals, Cell Cycle, Cell Line, Dogs, Humans, Lactobacillus, Leuconostoc, Pediococcus, Polysaccharides, Bacterial, G1 Phase, S Phase, Lactobacillales
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
