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The Role of Ferritin in Health and Disease: Recent Advances and Understandings

Kotla, Nikhil Kumar, Dutta, Priyata, Parimi, Sanjana, Das, Nupur K.·2022·Metabolites
DOI 10.3390/metabo12070609PMC PMC9320524
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Abstract

Systemic iron homeostasis needs to be tightly controlled, as both deficiency and excess iron cause major global health concerns, such as iron deficiency anemia, hemochromatosis, etc. In mammals, sufficient dietary acquisition is critical for fulfilling the systemic iron requirement. New questions are emerging about whether and how cellular iron transport pathways integrate with the iron storage mechanism. Ferritin is the intracellular iron storage protein that stores surplus iron after all the cellular needs are fulfilled and releases it in the face of an acute demand. Currently, there is a surge in interest in ferritin research after the discovery of novel pathways like ferritinophagy and ferroptosis. This review emphasizes the most recent ferritin-related discoveries and their impact on systemic iron regulation.

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Figure 1 Recent advances in understanding the regulation of cellular iron storage mechanism. After cellular uptake, PCBPs act as iron chaperones to deliver iron to ferritin. During conditions of increased demand, NCOA4 acts as a cargo receptor for lysosomal degradation of ferritin, followed by increased labile iron pool (LIP) level. Excess iron contributes to lipid peroxidation-mediated ferroptosis.
Figure 1 Recent advances in understanding the regulation of cellular iron storage mechanism. After cellular uptake, PCBPs act as iron chaperones to deliver iron to ferritin. During conditions of increased demand, NCOA4 acts as a cargo receptor for lysosomal degradation of ferritin, followed by increased labile iron pool (LIP) level. Excess iron contributes to lipid peroxidation-mediated ferroptosis.CC BY · PubMed Central
Figure 2 Gut microbial regulation of host ferritin.
Figure 2 Gut microbial regulation of host ferritin.CC BY · PubMed Central

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Metadata

Authors
Kotla, N. K., Dutta, P., Parimi, S., & Das, N. K.
Affiliations
Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI 48109, USA
ORCID
Dutta, Priyata
Venue
Metabolites
Publisher
MDPI AG
Published
2022-06-30
Volume
12
Issue
7
Pages
609
ISSN
2218-1989
DOI
10.3390/metabo12070609
PMC
PMC9320524
Cited by
132
References
24
Language
en
Licence
creativecommons.org/licenses/by/4.0/ (vor)

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