Metabolomic Profiling of Bile Acids in an Experimental Model of Prodromal Parkinson’s Disease
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For people with Parkinson’s disease (PD), considered the most common neurodegenerative disease behind Alzheimer’s disease, accurate diagnosis is dependent on many factors; however, misdiagnosis is extremely common in the prodromal phases of the disease, when treatment is thought to be most effective. Currently, there are no robust biomarkers that aid in the early diagnosis of PD. Following previously reported work by our group, we accurately measured the concentrations of 18 bile acids in the serum of a prodromal mouse model of PD. We identified three bile acids at significantly different concentrations (p < 0.05) when mice representing a prodromal PD model were compared with controls. These include ω-murichoclic acid (MCAo), tauroursodeoxycholic acid (TUDCA) and ursodeoxycholic acid (UDCA). All were down-regulated in prodromal PD mice with TUDCA and UDCA at significantly lower levels (17-fold and 14-fold decrease, respectively). Using the concentration of three bile acids combined with logistic regression, we can discriminate between prodromal PD mice from control mice with high accuracy (AUC (95% CI) = 0.906 (0.777–1.000)) following cross validation. Our study highlights the need to investigate bile acids as potential biomarkers that predict PD and possibly reflect the progression of manifest PD.
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The observation of reduced plasma UDCA and TUDCA in PD patients aligns with findings obtained in prodromal PD mice.
“This observation aligns with the findings obtained in prodromal PD mice.382”
From Microbiota–gut–brain axis and its therapeutic applications in neurodegenerative diseases (2024) · cites this paper as [382]
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Metabolomic Biomarkers in Parkinson’s Disease
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- Authors
- Graham, S. F., Rey, N. L., Ugur, Z., Yilmaz, A., Sherman, E., Maddens, M., Bahado-Singh, R. O., Becker, K., Schulz, E., Meyerdirk, L. K., Steiner, J. A., Ma, J., & Brundin, P.
- Affiliations
- Oakland University (US)
- Van Andel Institute (US)
- Beaumont Health (US)
- Beaumont Health, 3811 W. 13 Mile Road, Royal Oak, MI 48073, USA
- University of Michigan (US)
- Corresponding author
- Graham, Stewart F.
- ORCID
- Venue
- Metabolites
- Publisher
- MDPI AG
- Published
- 2018-10-31
- Volume
- 8
- Issue
- 4
- Pages
- 71
- ISSN
- 2218-1989 (ISSN-L)
- PMC
- PMC6316593
- OpenAlex
- W2899229871
- Cited by
- 60
- References
- 44
- Citations by year
- 2026: 5 · 2025: 9 · 2024: 11 · 2023: 8 · 2022: 7 · 2021: 9 · 2020: 9 · 2019: 1
- FWCI
- 3.23
- Type
- journal article
- Language
- en
- Open access
- gold
- dx.doi.org
- Licence
- Locations
- Metabolites (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, other-oa)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- HAL (submittedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- National Institutes of Health (1R01DC016519-01, 5R21NS093993-02)
- Office of the Assistant Secretary of Defense for Health Affairs (W81XWH-17-1-0534)
- Topics
- Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolomics and Mass Spectrometry Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Metabolism and Genetic Disorders
- Keywords
- Parkinson's disease, prodromal Parkinson's disease, bile acids, serum metabolomics, biomarkers, early diagnosis, tauroursodeoxycholic acid, ursodeoxycholic acid, muricholic acids, mouse model
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