The DOI matches its Crossref record; 75 of the 75 references it cites were found in a registry or an index.
A Comprehensive Review on Medicinal Plants as Antimicrobial Therapeutics: Potential Avenues of Biocompatible Drug Discovery
Open accessAbstract
The war on multidrug resistance (MDR) has resulted in the greatest loss to the world’s economy. Antibiotics, the bedrock, and wonder drug of the 20th century have played a central role in treating infectious diseases. However, the inappropriate, irregular, and irrational uses of antibiotics have resulted in the emergence of antimicrobial resistance. This has resulted in an increased interest in medicinal plants since 30–50% of current pharmaceuticals and nutraceuticals are plant-derived. The question we address in this review is whether plants, which produce a rich diversity of secondary metabolites, may provide novel antibiotics to tackle MDR microbes and novel chemosensitizers to reclaim currently used antibiotics that have been rendered ineffective by the MDR microbes. Plants synthesize secondary metabolites and phytochemicals and have great potential to act as therapeutics. The main focus of this mini-review is to highlight the potential benefits of plant derived multiple compounds and the importance of phytochemicals for the development of biocompatible therapeutics. In addition, this review focuses on the diverse effects and efficacy of herbal compounds in controlling the development of MDR in microbes and hopes to inspire research into unexplored plants with a view to identify novel antibiotics for global health benefits.
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Cites
Natural products as sources of new drugs from 1981 to 2014
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Discovery and resupply of pharmacologically active plant-derived natural products: A review
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Antibacterial drug discovery in the resistance era
Brown, E. D., & Wright, G. D. (2016) · Nature · doi:10.1038/nature17042 · Cited by 2,247
Phytochemicals: extraction, isolation, and identification of bioactive compounds from plant extracts
Altemimi, A., Lakhssassi, N., Baharlouei, A., Watson, D., & Lightfoot, D. (2017) · Plants · doi:10.3390/plants6040042 · Cited by 1,965
Self-citationThe Essential Medicinal Chemistry of Curcumin
Nelson, K. M., Dahlin, J. L., Bisson, J., Graham, J., Pauli, G. F., & Walters, M. A. (2017) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.6b00975 · Cited by 1,956
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Will 10 Million People Die a Year due to Antimicrobial Resistance by 2050?
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Cited by
Chandran, H., Meena, M., Barupal, T., & Sharma, K. (2020) · Biotechnology Reports · doi:10.1016/j.btre.2020.e00450 · Cited by 462
Plant-derived exosome-like nanoparticles and their therapeutic activities
Kim, J., Li, S., Zhang, S., & Wang, J. (2022) · Asian Journal of Pharmaceutical Sciences · doi:10.1016/j.ajps.2021.05.006 · Cited by 396
Paul, S., Chakraborty, S., Anand, U., Dey, S., Nandy, S., Ghorai, M., Saha, S. C., Patil, M. T., Kandimalla, R., Proćków, J., et al. (2021) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2021.112175 · Cited by 306
Self-citationExploring phytochemicals for combating antibiotic resistance in microbial pathogens
Khare, T., Anand, U., Dey, A., Assaraf, Y. G., Chen, Z.-S., Liu, Z., & Kumar, V. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.720726 · Cited by 281
Gorlenko, C. L., Kiselev, H. Y., Budanova, E. V., Zamyatnin, A. A., & Ikryannikova, L. N. (2020) · Antibiotics · doi:10.3390/antibiotics9040170 · Cited by 264
Metadata
- Authors
- Anand, U., Jacobo-Herrera, N., Altemimi, A., & Lakhssassi, N.
- Venue
- Metabolites
- Publisher
- MDPI AG
- Published
- 2019-11-01
- Volume
- 9
- Issue
- 11
- Pages
- 258
- ISSN
- 2218-1989 (ISSN-L)
- OpenAlex
- W2987783202
- Cited by
- 867
- References
- 75
- FWCI
- 57.38
- Type
- journal article
- Language
- en
- Open access
- gold
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- Anand, U., Jacobo-Herrera, N., Altemimi, A., & Lakhssassi, N. (2019). A Comprehensive Review on Medicinal Plants as Antimicrobial Therapeutics: Potential Avenues of Biocompatible Drug Discovery. Metabolites. https://doi.org/10.3390/metabo9110258
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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