The DOI matches its Crossref record; 21 of the 21 references it cites were found in a registry or an index.
Antibiotics and Bacterial Resistance in the 21st Century
Open accessAbstract
Dangerous, antibiotic resistant bacteria have been observed with increasing frequency over the past several decades. In this review the factors that have been linked to this phenomenon are addressed. Profiles of bacterial species that are deemed to be particularly concerning at the present time are illustrated. Factors including economic impact, intrinsic and acquired drug resistance, morbidity and mortality rates, and means of infection are taken into account. Synchronously with the waxing of bacterial resistance there has been waning antibiotic development. The approaches that scientists are employing in the pursuit of new antibacterial agents are briefly described. The standings of established antibiotic classes as well as potentially emerging classes are assessed with an emphasis on molecules that have been clinically approved or are in advanced stages of development. Historical perspectives, mechanisms of action and resistance, spectrum of activity, and preeminent members of each class are discussed.
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Cites
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BackgroundAntibiotic resistance is ancient
D’Costa, V. M., King, C. E., Kalan, L., Morar, M., Sung, W. W. L., Schwarz, C., Froese, D., Zazula, G., Calmels, F., Debruyne, R., et al. (2011) · Nature · doi:10.1038/nature10388 · Cited by 2,720
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Drugs for bad bugs: confronting the challenges of antibacterial discovery
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A Diarylquinoline Drug Active on the ATP Synthase of Mycobacterium tuberculosis
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Sampling the Antibiotic Resistome
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Cited by
Singh, J., Dutta, T., Kim, K.-H., Rawat, M., Samddar, P., & Kumar, P. (2018) · Journal of Nanobiotechnology · doi:10.1186/s12951-018-0408-4 · Cited by 2,700
Li, B., & Webster, T. J. (2018) · Journal of Orthopaedic Research · doi:10.1002/jor.23656 · Cited by 907
The Genus Enterococcus: Between Probiotic Potential and Safety Concerns—An Update
Hanchi, H., Mottawea, W., Sebei, K., & Hammami, R. (2018) · Frontiers in Microbiology · doi:10.3389/fmicb.2018.01791 · Cited by 569
A New Era of Antibiotics: The Clinical Potential of Antimicrobial Peptides
Browne, K., Chakraborty, S., Chen, R., Willcox, M. D., Black, D. S., Walsh, W. R., & Kumar, N. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21197047 · Cited by 482
Osorio, L. L. D. R., Flórez-López, E., & Grande-Tovar, C. D. (2021) · Molecules · doi:10.3390/molecules26020515 · Cited by 367
Metadata
- Authors
- Fair, R. J., & Tor, Y.
- Venue
- Perspectives in Medicinal Chemistry
- Publisher
- SAGE Publications
- Published
- 2014-01
- Volume
- 6
- Pages
- 25-64
- ISSN
- 1177-391X (ISSN-L)
- OpenAlex
- W2009933778
- Cited by
- 1,955
- References
- 21
- FWCI
- 24.27
- Type
- journal article
- Language
- en
- Open access
- bronze
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Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
