The DOI matches its Crossref record; 36 of the 36 references it cites were found in a registry or an index.
Gut Microbiota and Immune System Interactions
Open accessAbstract
Dynamic interactions between gut microbiota and a host’s innate and adaptive immune systems are essential in maintaining intestinal homeostasis and inhibiting inflammation. Gut microbiota metabolizes proteins and complex carbohydrates, synthesizes vitamins, and produces an enormous number of metabolic products that can mediate cross-talk between gut epithelium and immune cells. As a defense mechanism, gut epithelial cells produce a mucosal barrier to segregate microbiota from host immune cells and reduce intestinal permeability. An impaired interaction between gut bacteria and the mucosal immune system can lead to an increased abundance of potentially pathogenic gram-negative bacteria and their associated metabolic changes, disrupting the epithelial barrier and increasing susceptibility to infections. Gut dysbiosis, or negative alterations in gut microbial composition, can also dysregulate immune responses, causing inflammation, oxidative stress, and insulin resistance. Over time, chronic dysbiosis and the leakage of microbiota and their metabolic products across the mucosal barrier may increase prevalence of type 2 diabetes, cardiovascular disease, autoimmune disease, inflammatory bowel disease, and a variety of cancers. In this paper, we highlight the pivotal role gut bacteria and their metabolic products (short-chain fatty acids (SCFAs)) which play in mucosal immunity.
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Cites
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Cited by
Probiotics Regulate Gut Microbiota: An Effective Method to Improve Immunity
Wang, X., Zhang, P., & Zhang, X. (2021) · Molecules · doi:10.3390/molecules26196076 · Cited by 529
The Spread of Antibiotic Resistance Genes In Vivo Model
Tao, S., Chen, H., Li, N., Wang, T., & Liang, W. (2022) · Canadian Journal of Infectious Diseases and Medical Microbiology · doi:10.1155/2022/3348695 · Cited by 189
Understanding the Gut–Brain Axis and Its Therapeutic Implications for Neurodegenerative Disorders
Zheng, Y., Bonfili, L., Wei, T., & Eleuteri, A. M. (2023) · Nutrients · doi:10.3390/nu15214631 · Cited by 175
Gut microbiota in multiple sclerosis and animal models
Schumacher, S. M., Doyle, W. J., Hill, K., & Ochoa‐Repáraz, J. (2025) · The FEBS Journal · doi:10.1111/febs.17161 · Cited by 21
The holobiont mind: A bridge between 4E-cognition and the microbiome
Palacios-Garcia, I., & Parada, F. J. (2021) · doi:10.31234/osf.io/thuvc · Cited by 21
Metadata
- Authors
- Yoo, J., Groer, M., Dutra, S., Sarkar, A., & McSkimming, D.
- Venue
- Microorganisms
- Publisher
- MDPI AG
- Published
- 2020-10-15
- Volume
- 8
- Issue
- 10
- Pages
- 1587
- ISSN
- 2076-2607 (ISSN-L)
- OpenAlex
- W3093234803
- Cited by
- 1,032
- References
- 36
- FWCI
- 22.68
- Type
- journal article
- Language
- en
- Open access
- gold
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- Yoo, J., Groer, M., Dutra, S., Sarkar, A., & McSkimming, D. (2020). Gut Microbiota and Immune System Interactions. Microorganisms. https://doi.org/10.3390/microorganisms8101587
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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