The Potential of Phytomelatonin as a Nutraceutical

B. Arnao, Marino; Hernández-Ruiz, Josefa

doi:10.3390/molecules23010238

Cited by 102Circadian rhythm and melatoninPhytochemicals and Antioxidant Activitiesmelanin and skin pigmentation

The Potential of Phytomelatonin as a Nutraceutical

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B. Arnao, Marino, Hernández-Ruiz, Josefa·2018·Molecules

DOI 10.3390/molecules23010238PMC PMC6017233

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Abstract

Phytomelatonin (plant melatonin) is chemically related to the amino acid tryptophan and has many diverse properties. Phytomelatonin is an interesting compound due to its outstanding actions at the cellular and physiological level, especially its protective effect in plants exposed to diverse stress situations, while its vegetable origin offers many opportunities because it is a natural compound. We present an overview of its origin, its action in plants in general (particularly in plant species with high levels of phytomelatonin), and its possibilities for use as a nutraceutical with particular attention paid to the beneficial effects that it may have in human health. The differences between synthetic melatonin and phytomelatonin, according to its origin and purity, are presented. Finally, the current market for phytomelatonin and its limits and potentials are discussed.

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Synthetically produced melatonin can contain common contaminants, which may or may not be in the final product, including 1,2,3,4-tetrahydro-beta-carboline-3-carboxylic acid, 3-(phenylamino)-alanine, 1,1′-ethylidene bis-(tryptophan) ('peak E'), 2-(3-indolylmethyl)-tryptophan, formaldehyde-melatonin, formaldehyde-melatonin condensation products, hydroxymelatonin isomers, 5-hydroxy-tryptamine and 5-
“Common contaminants of synthetically produced melatonin, which may or may not be in the final product, include the following compounds [210]:”
From Is Melatonin the “Next Vitamin D”?: A Review of Emerging Science, Clinical Uses, Safety, and Dietary Supplements (2022) · cites this paper as [210]

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Is Melatonin the “Next Vitamin D”?: A Review of Emerging Science, Clinical Uses, Safety, and Dietary Supplements
Minich, D. M., Henning, M., Darley, C., Fahoum, M., Schuler, C. B., & Frame, J. (2022) · Nutrients · doi:10.3390/nu14193934 · Cited by 176 · see citing works
“There may also be methodological issues that result in variability in outcomes [211].”
Background

Authors: B. Arnao, M., & Hernández-Ruiz, J.
Affiliations: Department of Plant Biology (Plant Physiology), Faculty of Biology, University of Murcia, 30100 Murcia, Spain
ORCID: B. Arnao, Marino
Venue: Molecules
Publisher: MDPI AG
Published: 2018-01-22
Volume: 23
Issue: 1
Pages: 238
ISSN: 1420-3049 (ISSN-L)
DOI: 10.3390/molecules23010238
PMC: PMC6017233
OpenAlex: W2788308603
Cited by: 102
References: 118
Citations by year: 2026: 8 · 2025: 8 · 2024: 12 · 2023: 17 · 2022: 16 · 2021: 14 · 2020: 13 · 2019: 6 · 2018: 7 · 2017: 1
FWCI: 1.40
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
creativecommons.org/licenses/by/4.0/ (vor)
Locations: Molecules (publishedVersion, cc-by)
Europe PMC (PubMed Central) (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Topics: Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
Health Sciences › Medicine › Biochemistry › Phytochemicals and Antioxidant Activities
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › melanin and skin pigmentation
Keywords: phytomelatonin, nutraceuticals, tryptophan, plant stress protection, human health benefits, natural compounds
MeSH terms: Humans, Melatonin, Plant Growth Regulators, Plants, Dietary Supplements, Metabolic Networks and Pathways

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The Potential of Phytomelatonin as a Nutraceutical

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