Cited by 247Peroxisome Proliferator-Activated ReceptorsAdipose Tissue and MetabolismParaoxonase enzyme and polymorphisms

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PPARs as Nuclear Receptors for Nutrient and Energy Metabolism

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Hong, Fan, Pan, Shijia, Guo, Yuan, Xu, Pengfei, Zhai, Yonggong·2019·Molecules

DOI 10.3390/molecules24142545PMC PMC6680900

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Abstract

It has been more than 36 years since peroxisome proliferator-activated receptors (PPARs) were first recognized as enhancers of peroxisome proliferation. Consequently, many studies in different fields have illustrated that PPARs are nuclear receptors that participate in nutrient and energy metabolism and regulate cellular and whole-body energy homeostasis during lipid and carbohydrate metabolism, cell growth, cancer development, and so on. With increasing challenges to human health, PPARs have attracted much attention for their ability to ameliorate metabolic syndromes. In our previous studies, we found that the complex functions of PPARs may be used as future targets in obesity and atherosclerosis treatments. Here, we review three types of PPARs that play overlapping but distinct roles in nutrient and energy metabolism during different metabolic states and in different organs. Furthermore, research has emerged showing that PPARs also play many other roles in inflammation, central nervous system-related diseases, and cancer. Increasingly, drug development has been based on the use of several selective PPARs as modulators to diminish the adverse effects of the PPAR agonists previously used in clinical practice. In conclusion, the complex roles of PPARs in metabolic networks keep these factors in the forefront of research because it is hoped that they will have potential therapeutic effects in future applications.

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BindingDB (2024) · UC San Diego · doi:10.7270/q2862mvk

Authors: Hong, F., Pan, S., Guo, Y., Xu, P., & Zhai, Y.
Affiliations: Beijing Normal University (CN)
University of Pittsburgh (US)
Corresponding author: Xu, Pengfei
Zhai, Yonggong
ORCID: Guo, Yuan
Xu, Pengfei
Zhai, Yonggong
Venue: Molecules
Publisher: MDPI AG
Published: 2019-07-12
Volume: 24
Issue: 14
Pages: 2545
ISSN: 1420-3049 (ISSN-L)
DOI: 10.3390/molecules24142545
PMC: PMC6680900
OpenAlex: W2961328380
Cited by: 233
References: 167
Citations by year: 2026: 20 · 2025: 38 · 2024: 42 · 2023: 33 · 2022: 41 · 2021: 32 · 2020: 21 · 2019: 6
FWCI: 2.22
Type: journal article
Language: en
Open access: gold
dx.doi.org
Licence: cc-by
creativecommons.org/licenses/by/4.0/ (vor)
Locations: Molecules (publishedVersion, cc-by)
Europe PMC (PubMed Central) (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders: National Natural Science Foundation of China (Nos. 31571164, Nos.31271207)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Peroxisome Proliferator-Activated Receptors
Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Paraoxonase enzyme and polymorphisms
Keywords: peroxisome proliferator-activated receptors, nuclear receptors, nutrient metabolism, energy homeostasis, lipid metabolism, carbohydrate metabolism, obesity, atherosclerosis, metabolic syndrome, inflammation, central nervous system disorders, cancer, drug development
MeSH terms: Nutrients, Animals, Energy Metabolism, Humans, Organ Specificity, Signal Transduction, Receptors, Cytoplasmic and Nuclear, Peroxisome Proliferator-Activated Receptors

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PPARs as Nuclear Receptors for Nutrient and Energy Metabolism

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