Allium sativum Extract Chemical Composition, Antioxidant Activity and Antifungal Effect against Meyerozyma guilliermondii and Rhodotorula mucilaginosa Causing Onychomycosis
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Onychomycosis is a major health problem due to its chronicity and resistance to therapy. Because some cases associate paronychia, any therapy must target the fungus and the inflammation. Medicinal plants represent an alternative for onychomycosis control. In the present work the antifungal and antioxidant activities of Alium sativum extract against Meyerozyma guilliermondii (Wick.) Kurtzman & M. Suzuki and Rhodotorula mucilaginosa (A. Jörg.) F.C. Harrison, isolated for the first time from a toenail onychomycosis case, were investigated. The fungal species were confirmed by DNA molecular analysis. A. sativum minimum inhibitory concentration (MIC) and ultrastructural effects were examined. At the MIC concentration (120 mg/mL) the micrographs indicated severe structural alterations with cell death. The antioxidant properties of the A. sativum extract were evaluated is a rat turpentine oil induced inflammation, and compared to an anti-inflammatory drug, diclofenac, and the main compound from the extract, allicin. A. sativum reduced serum total oxidative status, malondialdehyde and nitric oxide production, and increased total thiols. The effects were comparable to those of allicin and diclofenac. In conclusion, the garlic extract had antifungal effects against M. guilliermondii and R. mucilaginosa, and antioxidant effect in turpentine-induced inflammation. Together, the antifungal and antioxidant activities support that A. sativum is a potential alternative treatment in onychomycosis.
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Garlic extract was found to inhibit Meyerozyma guilliermondii and Rhodotorula mucilaginosa germination and growth.
“Recently, garlic extract was found to inhibit the Meyerozyma guilliermondii and Rhodotorula mucilaginosa germination and growth [55].”
From Chemical Constituents and Pharmacological Activities of Garlic (Allium sativum L.): A Review (2020) · cites this paper as [55]
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- Authors
- Pârvu, M., Moţ, C. A., Pârvu, A. E., Mircea, C., Stoeber, L., Roşca-Casian, O., & Ţigu, A. B.
- Affiliations
- Babeș-Bolyai University (RO)
- Iuliu Hațieganu University of Medicine and Pharmacy (RO)
- Department of Biology, Faculty of Biology and Geology, Babeș-Bolyai University, 42 Republicii Street, 400015 Cluj-Napoca, Romania
- Corresponding author
- Pârvu, Marcel
- Venue
- Molecules
- Publisher
- MDPI AG
- Published
- 2019-10-31
- Volume
- 24
- Issue
- 21
- Pages
- 3958
- ISSN
- 1420-3049 (ISSN-L)
- PMC
- PMC6865177
- OpenAlex
- W2982656479
- Cited by
- 66
- References
- 36
- Citations by year
- 2026: 6 · 2025: 10 · 2024: 8 · 2023: 13 · 2022: 8 · 2021: 13 · 2020: 7 · 2018: 1
- FWCI
- 5.16
- Type
- journal article
- Language
- en
- Open access
- gold
- dx.doi.org
- Licence
- Locations
- Molecules (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- UEFISCDI (PN-II-RU-TE-2014-4-2555)
- FEDR through Competitiveness Operational Programme 2014 – 2020 (UBB-TeMATIC Art P_40_374)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Garlic and Onion Studies
- Health Sciences › Medicine › Epidemiology › Nail Diseases and Treatments
- Life Sciences › Agricultural and Biological Sciences › Food Science › Essential Oils and Antimicrobial Activity
- Keywords
- onychomycosis, garlic extract, garlic, Candida guilliermondii, Rhodotorula mucilaginosa, antifungal activity, antioxidant activity, allicin, diclofenac, minimum inhibitory concentration, fungal ultrastructure, malondialdehyde, nitric oxide, thiols, total oxidant status, paronychia
- MeSH terms
- Animals, Antifungal Agents, Antioxidants, Biphenyl Compounds, Saccharomycetales, Garlic, Humans, Male, Nails, Picrates, Plant Extracts, Rhodotorula, Sulfonic Acids, Onychomycosis, Colony Count, Microbial, Free Radical Scavengers, Rats, Wistar, Benzothiazoles, Phytochemicals
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