The DOI matches its Crossref record; 115 of the 115 references it cites were found in a registry or an index.
Aptamers: A Review of Their Chemical Properties and Modifications for Therapeutic Application
Open accessAbstract
Aptamers are short, single-stranded oligonucleotides that bind to specific target molecules. The shape-forming feature of single-stranded oligonucleotides provides high affinity and excellent specificity toward targets. Hence, aptamers can be used as analogs of antibodies. In December 2004, the US Food and Drug Administration approved the first aptamer-based therapeutic, pegaptanib (Macugen), targeting vascular endothelial growth factor, for the treatment of age-related macular degeneration. Since then, however, no aptamer medication for public health has appeared. During these relatively silent years, many trials and improvements of aptamer therapeutics have been performed, opening multiple novel directions for the therapeutic application of aptamers. This review summarizes the basic characteristics of aptamers and the chemical modifications available for aptamer therapeutics.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Figures
![Figure 1 Overall structure of known aptamer–protein complexes with electrostatic surface potential [5]. The RNA aptamer is represented by a yellow ball-and-stick model. (A) Aptamer–thrombin complex at 1.8 Å resolution [13]. (B) Aptamer–nuclear factor-κB complex at 2.45 Å resolution [11]. (C) Aptamer–MS2 coat protein complex at 2.8 Å resolution [12]. (D) Aptamer–Fc region of human IgG1 (hFc1) complex at 2.15 Å resolution [16]. Blue areas: positively charged; red areas: negatively charged.](/paper-figures/326433949fe441b395fc323372023226/aptamers-a-review-of-their-chemical-properties-and-modifications-for-therapeutic-figure-1.jpg)
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“With the increasing recognition of the vital role played by RNA in transferring cellular information and regulating genes, targeting RNAs has become an exciting opportunity to therapeutically modulate cellular processes linked to previously “undruggable” protein targets.550–552”
From Recent advances in targeting the “undruggable” proteins: from drug discovery to clinical trials (2023) · cites this paper as [552]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Mfold web server for nucleic acid folding and hybridization prediction
Zuker, M. (2003) · Nucleic Acids Research · doi:10.1093/nar/gkg595 · Cited by 13,404
Tuerk, C., & Gold, L. (1990) · Science · doi:10.1126/science.2200121 · Cited by 10,421
In vitro selection of RNA molecules that bind specific ligands
Ellington, A. D., & Szostak, J. W. (1990) · Nature · doi:10.1038/346818a0 · Cited by 9,845
Genome-scale transcriptional activation by an engineered CRISPR-Cas9 complex
Konermann, S., Brigham, M. D., Trevino, A. E., Joung, J., Abudayyeh, O. O., Barcena, C., Hsu, P. D., Habib, N., Gootenberg, J. S., Nishimasu, H., et al. (2015) · Nature · doi:10.1038/nature14136 · Cited by 2,825 · cited 2×
“reported that sgRNA has loop regions outside of Cas9, and a natural RNA aptamer could be integrated [92].”
BackgroundTherapeutic silencing of an endogenous gene by systemic administration of modified siRNAs
Soutschek, J., Akinc, A., Bramlage, B., Charissé, K., Constien, R., Donoghue, M., Elbashir, S. M., Geick, A., Hadwiger, P., Harborth, J., et al. (2004) · Nature · doi:10.1038/nature03121 · Cited by 2,206
Aptamer-Based Multiplexed Proteomic Technology for Biomarker Discovery
Gold, L., Ayers, D., Bertino, J., Bock, C., Bock, A., Brody, E. N., Carter, J., Dalby, A. B., Eaton, B. E., Fitzwater, T., et al. (2010) · PLoS ONE · doi:10.1371/journal.pone.0015004 · Cited by 1,754
Pegaptanib, a targeted anti-VEGF aptamer for ocular vascular disease
Ng, E. W. M., Shima, D. T., Calias, P., Cunningham, E. T., Guyer, D. R., & Adamis, A. P. (2006) · Nature Reviews Drug Discovery · doi:10.1038/nrd1955 · Cited by 1,629
Deisenhofer, J. (1981) · Biochemistry · doi:10.1021/bi00512a001 · Cited by 1,539
Deisenhofer, J. (1981) · PubMed · Cited by 1,422
Ruckman, J., Green, L. S., Beeson, J., Waugh, S. M., Gillette, W. L., Henninger, D. D., Claesson, L., & Janjić, N. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.32.20556 · Cited by 759
Cited by
Sorted by citations
Directed Evolution: Methodologies and Applications
Wang, Y., Xue, P., Cao, M., Yu, T., Lane, S., & Zhao, H. (2021) · Chemical Reviews · doi:10.1021/acs.chemrev.1c00260 · Cited by 745
RNA-based therapeutics: an overview and prospectus
Zhu, Y., Zhu, L., Wang, X., & Jin, H. (2022) · Cell Death and Disease · doi:10.1038/s41419-022-05075-2 · Cited by 683
Lipids and Lipid Derivatives for RNA Delivery
Zhang, Y., Sun, C., Wang, C., Jankovic, K. E., & Dong, Y. (2021) · Chemical Reviews · doi:10.1021/acs.chemrev.1c00244 · Cited by 649
Recent advances in targeting the “undruggable” proteins: from drug discovery to clinical trials
Xie, X., Yu, T., Li, X., Zhang, N., Foster, L. J., Peng, C., Huang, W., & He, G. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01589-z · Cited by 396
Nonspecific Binding—Fundamental Concepts and Consequences for Biosensing Applications
Frutiger, A., Tanno, A., Hwu, S., Tiefenauer, R. F., Vörös, J., & Nakatsuka, N. (2021) · Chemical Reviews · doi:10.1021/acs.chemrev.1c00044 · Cited by 287
Aptamer–Protein Interactions: From Regulation to Biomolecular Detection
Ji, C., Wei, J., Zhang, L., Hou, X., Tan, J., Yuan, Q., & Tan, W. (2023) · Chemical Reviews · doi:10.1021/acs.chemrev.3c00377 · Cited by 221
Boo, Y. C. (2022) · Antioxidants · doi:10.3390/antiox11091663 · Cited by 229
Self-Assembling Nucleic Acid Nanostructures Functionalized with Aptamers
Krissanaprasit, A., Key, C. M., Pontula, S., & LaBean, T. H. (2021) · Chemical Reviews · doi:10.1021/acs.chemrev.0c01332 · Cited by 187
Pandey, P., Khan, F., Upadhyay, T. K., Moon, S., Park, M. N., & Kim, B. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.114491 · Cited by 171
Recent advances in quantum dots-based biosensors for antibiotics detection
Ding, R., Chen, Y., Wang, Q., Wu, Z., Zhang, X., Li, B., & Lin, L. (2021) · Journal of Pharmaceutical Analysis · doi:10.1016/j.jpha.2021.08.002 · Cited by 159
Parihar, A., Singhal, A., Kumar, N., Khan, R., Khan, M. A., & Srivastava, A. K. (2022) · Nano-Micro Letters · doi:10.1007/s40820-022-00845-1 · Cited by 151
New developments in the biology of fibroblast growth factors
Ornitz, D. M., & Itoh, N. (2022) · WIREs Mechanisms of Disease · doi:10.1002/wsbm.1549 · Cited by 147
Nucleic Acid Therapeutics: Successes, Milestones, and Upcoming Innovation
Belgrad, J., Fakih, H. H., & Khvorova, A. (2024) · Nucleic Acid Therapeutics · doi:10.1089/nat.2023.0068 · Cited by 130
Generative aptamer discovery using RaptGen
Iwano, N., Adachi, T., Aoki, K., Nakamura, Y., & Hamada, M. (2022) · Nature Computational Science · doi:10.1038/s43588-022-00249-6 · Cited by 128
Self-citationCurrent State of Human Gene Therapy: Approved Products and Vectors
Shchaslyvyi, A. Y., Antonenko, S. V., Tesliuk, M. G., & Телегеев, Г. Д. (2023) · Pharmaceuticals · doi:10.3390/ph16101416 · Cited by 127
Sanadgol, N., Abedi, M., Hashemzaei, M., Kamran, Z., Khalseh, R., Beyer, C., & Voelz, C. (2025) · Journal of Nanobiotechnology · doi:10.1186/s12951-025-03528-2 · Cited by 112
Non-canonical DNA structures: Diversity and disease association
Bansal, A., Kaushik, S., & Kukreti, S. (2022) · Frontiers in Genetics · doi:10.3389/fgene.2022.959258 · Cited by 111
Aptamer-Targeted Photodynamic Platforms for Tumor Therapy
Yan, J., Gao, T., Lu, Z., Yin, J., Zhang, Y., & Pei, R. (2021) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.1c06818 · Cited by 107
Takakusa, H., Iwazaki, N., Nishikawa, M., Yoshida, T., Obika, S., & Inoué, T. (2023) · Nucleic Acid Therapeutics · doi:10.1089/nat.2022.0054 · Cited by 102
Chemistry of Peptide-Oligonucleotide Conjugates: A Review
Klabenkova, K., Фокина, А. А., & Stetsenko, D. A. (2021) · Molecules · doi:10.3390/molecules26175420 · Cited by 105
Riccardi, C., Napolitano, E., Platella, C., Musumeci, D., & Montesarchio, D. (2020) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2020.107649 · Cited by 94
The Application of Nanomaterials for the Electrochemical Detection of Antibiotics: A Review
Alsaiari, N. S., Katubi, K. M., Alzahrani, F. M. A., Siddeeg, S. M., & Tahoon, M. A. (2021) · Micromachines · doi:10.3390/mi12030308 · Cited by 87
Biomedical Applications of Metal–Organic Frameworks Revisited
Sezgin, P., Gulcay-Ozcan, E., Vučkovski, M., Bondžić, A. M., Eruçar, İ., & Keskın, S. (2025) · Industrial & Engineering Chemistry Research · doi:10.1021/acs.iecr.4c03698 · Cited by 88
Oliva, N., & Almquist, B. D. (2020) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2020.07.021 · Cited by 81
Photoresponsive Drug Delivery Systems: Challenges and Progress
Yang, Y., Long, K., Chu, Y., Lu, H., Wang, W., & Zhan, C. (2024) · Advanced Functional Materials · doi:10.1002/adfm.202402975 · Cited by 77
RNA Therapeutics - Research and Clinical Advancements
Feng, R., Patil, S., Zhao, X., Miao, Z., & Qian, A. (2021) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2021.710738 · Cited by 75
Aptamer targeted therapy potentiates immune checkpoint blockade in triple-negative breast cancer
Camorani, S., Passariello, M., Agnello, L., Esposito, S., Collina, F., Cantile, M., Bonito, M. D., Ulasov, I. V., Fedele, M., Zannetti, A., et al. (2020) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-020-01694-9 · Cited by 72
Ali, G. K., & Omer, K. M. (2022) · ACS Omega · doi:10.1021/acsomega.2c05232 · Cited by 66
Cell Surface Engineering Tools for Programming Living Assemblies
Almeida-Pinto, J., Lagarto, M. R., Lavrador, P., Mano, J. F., & Gaspar, V. M. (2023) · Advanced Science · doi:10.1002/advs.202304040 · Cited by 66
Electrochemical aptasensors for clinical diagnosis. A review of the last five years
Villalonga, A., Mayol, B., Villalonga, R., & Vilela, D. (2022) · Sensors and Actuators B Chemical · doi:10.1016/j.snb.2022.132318 · Cited by 62
Razlansari, M., Jafarinejad, S., Rahdar, A., Shirvaliloo, M., Arshad, R., Fathi‐karkan, S., Mirinejad, S., Sargazi, S., Sheervalilou, R., Ajalli, N., et al. (2022) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-022-04614-x · Cited by 61
Chinnappan, R., Mir, T. A., Alsalameh, S., Makhzoum, T., Adeeb, S., AlKattan, K. M., & Yaqinuddin, A. (2023) · Life · doi:10.3390/life13061273 · Cited by 61
Aptamer-Based Point-of-Care Devices: Emerging Technologies and Integration of Computational Methods
Aslan, Y., Atabay, M., Chowdhury, H. K., Göktürk, I., Saylan, Y., & İnci, F. (2023) · Biosensors · doi:10.3390/bios13050569 · Cited by 58
Dimeric and Multimeric DNA Aptamers for Highly Effective Protein Recognition
Riccardi, C., Napolitano, E., Musumeci, D., & Montesarchio, D. (2020) · Molecules · doi:10.3390/molecules25225227 · Cited by 57
Aptamers and nanobodies as alternatives to antibodies for ligand-targeted drug delivery in cancer
Sanjanwala, D., & Patravale, V. B. (2023) · Drug Discovery Today · doi:10.1016/j.drudis.2023.103550 · Cited by 58
Kumar, S., Mohan, A., Sharma, N. R., Kumar, A., Girdhar, M., Malik, T., & Verma, A. K. (2024) · ACS Omega · doi:10.1021/acsomega.4c02466 · Cited by 56
Overcoming Challenges in Electrochemical Sensing: Toward Continuous Monitoring
Rivera, P., Pelle, F. D., Stonyte, J., Melo, W., Abouhagger, A., & Pauliukaitė, R. (2025) · ACS Sensors · doi:10.1021/acssensors.5c02717 · Cited by 55
Organic Electrochemical Transistor Aptasensor for Interleukin-6 Detection
Diacci, C., Burtscher, B., Berto, M., Ruoko, T., Lienemann, S., Greco, P., Magnus Berggren, A., Borsari, M., Simon, D. T., Bortolotti, C. A., et al. (2023) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.3c12397 · Cited by 56
Overview of the Therapeutic Potential of Aptamers Targeting Coagulation Factors
Liu, M., Zaman, K., & Fortenberry, Y. M. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22083897 · Cited by 54
Oligonucleotide aptamers for pathogen detection and infectious disease control
Wan, Q., Liu, X., & Zu, Y. (2021) · Theranostics · doi:10.7150/thno.61804 · Cited by 52
DNA‐Based Dissipative Assembly toward Nanoarchitectonics
Liu, Q., Li, H., Yu, B., Meng, Z., Zhang, X., Li, J., & Zheng, L. (2022) · Advanced Functional Materials · doi:10.1002/adfm.202201196 · Cited by 50
Advances in Design Strategies of Multiplex Electrochemical Aptasensors
Grabowska, I., Hepel, M., & Kurzątkowska, K. (2021) · Sensors · doi:10.3390/s22010161 · Cited by 49
Aptamer-Mediated Nanotheranostics for Cancer Treatment: A Review
Ravichandran, G., & Rengan, A. K. (2020) · ACS Applied Nano Materials · doi:10.1021/acsanm.0c01785 · Cited by 47
Novel formulations and drug delivery systems to administer biological solids
Zhang, Y., Davis, D. A., AboulFotouh, K., Wang, J., Williams, D., Bhambhani, A., Zakrewsky, M., Maniruzzaman, M., Cui, Z., & Williams, R. O. (2021) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2021.02.011 · Cited by 50
Recent progress in the early detection of cancer based on CD44 biomarker; nano-biosensing approaches
Kazemi, Y., Dehghani, S., Nosrati, R., Taghdisi, S. M., Abnous, K., Alibolandi, M., & Ramezani, M. (2022) · Life Sciences · doi:10.1016/j.lfs.2022.120593 · Cited by 47
Homobivalent, Trivalent, and Covalent PROTACs: Emerging Strategies for Protein Degradation
Yan, J., Li, T., Miao, Z., Wang, P., Sheng, C., & Zhuang, C. (2022) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.2c00728 · Cited by 46
RNA-binding proteins as therapeutic targets in cancer
Jungfleisch, J., & Gebauer, F. (2025) · RNA Biology · doi:10.1080/15476286.2025.2470511 · Cited by 47
Sforzi, J., Palagi, L., & Aime, S. (2020) · Biology · doi:10.3390/biology9080202 · Cited by 42
Synthetic and Biogenic Materials for Oral Delivery of Biologics: From Bench to Bedside
Ding, S., Alexander, E., Liang, H., Kulchar, R. J., SINGH, R. K., Herzog, R. W., Daniell, H., & Leong, K. W. (2025) · Chemical Reviews · doi:10.1021/acs.chemrev.4c00482 · Cited by 43
Cornea‐SELEX for aptamers targeting the surface of eyes and liposomal drug delivery
Wong, K., Liu, Y., Wong, M., & Liu, J. (2024) · Exploration · doi:10.1002/exp.20230008 · Cited by 40
Roushani, M., & Zalpour, N. (2021) · Microchemical Journal · doi:10.1016/j.microc.2021.106955 · Cited by 39
Bege, M., Kattoub, R. G., & Borbás, A. (2025) · Pharmaceutics · doi:10.3390/pharmaceutics17030394 · Cited by 39
Aptamer-based targeted drug delivery and disease therapy in preclinical and clinical applications
Yang, W., Ran, C., Lian, X., Wang, Z., Du, Z., Bing, T., Zhang, Y., & Tan, W. (2025) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2025.115680 · Cited by 38
Jahangiri–Dehaghani, F., Zare, H. R., & Shekari, Z. (2021) · Food Analytical Methods · doi:10.1007/s12161-021-02109-x · Cited by 37
Hosseini-Kharat, M., Bremmell, K. E., Grubor‐Bauk, B., & Prestidge, C. A. (2024) · Journal of Controlled Release · doi:10.1016/j.jconrel.2024.12.002 · Cited by 37
Electrochemical Aptasensors Based on Hybrid Metal-Organic Frameworks
Evtugyn, G. A., Belyakova, S. V., Porfireva, A. V., & Hianik, T. (2020) · Sensors · doi:10.3390/s20236963 · Cited by 36
Inam, A. K. M. S., Angeli, M. A. C., Douaki, A., Shkodra, B., Lugli, P., & Petti, L. (2022) · Sensors · doi:10.3390/s22072754 · Cited by 36
Recent advances in aptamer-based platforms for cortisol hormone monitoring
Mohammadi, F., Zahraee, H., Kazemi, M., Habibi, Z. S., Taghdisi, S. M., Abnous, K., Khoshbin, Z., & Chen, C. (2023) · Talanta · doi:10.1016/j.talanta.2023.125010 · Cited by 35
Aptamers: Novel Therapeutics and Potential Role in Neuro-Oncology
Amero, P., Khatua, S., Rodriguez‐Aguayo, C., & Lopez‐Berestein, G. (2020) · Cancers · doi:10.3390/cancers12102889 · Cited by 36
Aptamer-based Theranostics in Oncology: Design Strategies and Limitations
Trivedi, J., Yasir, M., Maurya, R. K., & Tripathi, A. S. (2024) · BIO Integration · doi:10.15212/bioi-2024-0002 · Cited by 34
Truncations and in silico docking to enhance the analytical response of aptamer-based biosensors
Nguyen, M., Osborne, M., Prevot, G. T., Churcher, Z. R., Johnson, P. E., Simine, L., & Dauphin‐Ducharme, P. (2024) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2024.116680 · Cited by 34
Harnessing synthetic biology for advancing RNA therapeutics and vaccine design
Pfeifer, B. A., Beitelshees, M., Hill, A. B., Bassett, J., & Jones, C. H. (2023) · npj Systems Biology and Applications · doi:10.1038/s41540-023-00323-3 · Cited by 33
Decoding aptamer-protein binding kinetics for continuous biosensing using single-molecule techniques
Filius, M., Fasching, L., van Wee, R., Rwei, A. Y., & Joo, C. (2025) · Science Advances · doi:10.1126/sciadv.ads9687 · Cited by 34
Cortisol sensing by optical sensors
Santonocito, R., Puglisi, R., Cavallaro, A., Pappalardo, A., & Sfrazzetto, G. T. (2023) · The Analyst · doi:10.1039/d3an01801f · Cited by 34
Advances in Screening and Development of Therapeutic Aptamers Against Cancer Cells
Li, Z., Fu, X., Huang, J., Zeng, P., Huang, Y., Chen, X., & Liang, C. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.662791 · Cited by 32
Recent advances of cell surface modification based on aptamers
Jia, H., Zhang, Z., Fang, X., Jiang, M., Chen, M., Chen, S., Gu, K., Luo, Z., Wu, F., & Tan, W. (2022) · Materials Today Nano · doi:10.1016/j.mtnano.2022.100188 · Cited by 32
Growth hormone-releasing hormone and its analogues in health and disease
Granata, R., Leone, S., Zhang, X., Gesmundo, I., Steenblock, C., Cai, R., Sha, W., Ghigo, E., Hare, J. M., Bornstein, S. R., et al. (2024) · Nature Reviews Endocrinology · doi:10.1038/s41574-024-01052-1 · Cited by 31
Chimeric antigen receptor Treg therapy in transplantation
Eskandari, S. K., Daccache, A., & Azzi, J. R. (2023) · Trends in Immunology · doi:10.1016/j.it.2023.11.005 · Cited by 30
Methods to study circRNA-protein interactions
Ulshöfer, C. J., Pfafenrot, C., Bindereif, A., & Schneider, T. P. (2021) · Methods · doi:10.1016/j.ymeth.2021.04.014 · Cited by 31
Aptamer-based approaches in leukemia: a paradigm shift in targeted therapy
Bayani, A., Abosaoda, M. K., Rizaev, J. A., Nazari, M., Jafari, Z., & Samarkhazan, H. S. (2025) · Clinical and Experimental Medicine · doi:10.1007/s10238-025-01724-w · Cited by 29
Aptamer-Based Antibacterial and Antiviral Therapy against Infectious Diseases
Chen, X., Zhao, X., & Yang, Z. (2021) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.1c01567 · Cited by 30
Aptamers: precision tools for diagnosing and treating infectious diseases
Sujith, S., Naresh, R., Srivisanth, B. U., Sajeevan, A., Rajaramon, S., David, H., & Solomon, A. P. (2024) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2024.1402932 · Cited by 28
Tabuchi, Y., Yang, J., & Taki, M. (2021) · Chemical Communications · doi:10.1039/d0cc08109d · Cited by 31
Oligonucleotide-Based Therapies for Renal Diseases
Cartón‐García, F., Saande, C. J., Meraviglia-Crivelli, D., Aldabe, R., & Pastor, F. (2021) · Biomedicines · doi:10.3390/biomedicines9030303 · Cited by 28
Cui, J., Zhang, Y., Kan, L., Wu, B., He, L., Wang, M., Fang, S., Zhang, Z., & Zhou, L. (2023) · Microchimica Acta · doi:10.1007/s00604-023-05978-7 · Cited by 28
Hu, Y., Wang, Z., Liu, L., Zhu, J., Zhang, D., Xu, M., Zhang, Y., Xu, F., & Chen, Y. (2021) · Chemical Science · doi:10.1039/d1sc00271f · Cited by 27
Jang, S. J., & Kim, T. H. (2024) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2024.116039 · Cited by 26
Effects of Experimental Conditions on the Signaling Fidelity of Impedance-Based Nucleic Acid Sensors
Vogiazi, V., de la Cruz, A., Heineman, W. R., White, R. J., & Dionysiou, D. D. (2021) · Analytical Chemistry · doi:10.1021/acs.analchem.0c03269 · Cited by 26
Zhang, W., Wang, J., & Shan, C. (2024) · Pharmacological Research · doi:10.1016/j.phrs.2024.107195 · Cited by 25
Aptamer and Oligonucleotide-Based Biosensors for Health Applications
Mayol, B., Qubbaj, I. Z., Nava-Granados, J., Vasquez, K., Keene, S. T., & Sempionatto, J. R. (2025) · Biosensors · doi:10.3390/bios15050277 · Cited by 29
Diagnostics and Therapeutics in Targeting HER2 Breast Cancer: A Novel Approach
Vi, C., Mandarano, G., & Shigdar, S. L. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22116163 · Cited by 25
Alamudi, S. H., Kimoto, M., & Hirao, I. (2021) · RSC Medicinal Chemistry · doi:10.1039/d1md00199j · Cited by 26
Aptamer-Based Strategies to Boost Immunotherapy in TNBC
Agnello, L., d’Argenio, A., Nilo, R., Fedele, M., Camorani, S., & Cerchia, L. (2023) · Cancers · doi:10.3390/cancers15072010 · Cited by 25
Repurposing CRISPR/Cas to Discover SARS‐CoV‐2 Detecting and Neutralizing Aptamers
Zhang, J., Zhu, A., Mei, M., Qu, J. T., Huang, Y., Shi, Y., Xue, M., Zhang, J., Zhang, R., Zhou, B., et al. (2023) · Advanced Science · doi:10.1002/advs.202300656 · Cited by 27
Switchable DNA Catalysts for Proximity Labeling at Sites of Protein–Protein Interactions
Ogorek, A. N., Zhou, X., & Martell, J. D. (2023) · Journal of the American Chemical Society · doi:10.1021/jacs.3c05578 · Cited by 26
Multidimensional applications of prussian blue-based nanoparticles in cancer immunotherapy
Zhang, J., Wang, F., Sun, Z., Ye, J., & Chu, H. (2025) · Journal of Nanobiotechnology · doi:10.1186/s12951-025-03236-x · Cited by 25
Recent Progress on Highly Selective and Sensitive Electrochemical Aptamer-based Sensors
Tang, T., Liu, Y., & Jiang, Y. Y. (2022) · Chemical Research in Chinese Universities · doi:10.1007/s40242-022-2084-z · Cited by 25
Exosome-mediated aptamer S58 reduces fibrosis in a rat glaucoma filtration surgery model
Lin, Q., Leng, Y., Zhu, X., Tang, M., Lin, Y., Luo, W., Jiang, B., Chen, X., & Xie, L. (2022) · International Journal of Ophthalmology · doi:10.18240/ijo.2022.05.02 · Cited by 25
Kukushkin, V. I., Kristavchuk, O. V., Andreev, E. V., Meshcheryakova, N. F., Zaborova, O. V., Gambaryan, A. S., Nechaev, A. N., & Zavyalova, E. G. (2023) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2022.1076749 · Cited by 24
Aptamers as target-specific recognition elements in drug delivery
Vydaline, A. O. E., Rozhkov, S., Sosa, G., & Mallikaratchy, P. R. (2025) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2025.115685 · Cited by 23
Ayupova, T., Shaimerdenova, M., Sypabekova, M., Vangelista, L., & Tosi, D. (2021) · Optik · doi:10.1016/j.ijleo.2021.166969 · Cited by 23
Recent Advances in DNA Nanotechnology for Plasmonic Biosensor Construction
Park, J. A., Amri, C., Kwon, Y., Lee, J., & Lee, T. (2022) · Biosensors · doi:10.3390/bios12060418 · Cited by 23
Murray, M. T., & Wetmore, S. D. (2024) · Nucleic Acids Research · doi:10.1093/nar/gkae729 · Cited by 23
Designing a new dimerized anti human TNF‐α aptamer with blocking activity
Mashayekhi, K., Ganji, A., & Sankian, M. (2020) · Biotechnology Progress · doi:10.1002/btpr.2969 · Cited by 24
Rezapoor-Fashtali, Z., Ganjali, M. R., & Faridbod, F. (2022) · Biosensors · doi:10.3390/bios12090720 · Cited by 22
Guzman, N. A., & Guzman, D. E. (2020) · Biomedicines · doi:10.3390/biomedicines8080255 · Cited by 22
Relative Nuclease Resistance of a DNA Aptamer Covalently Conjugated to a Target Protein
Tabuchi, Y., Yang, J., & Taki, M. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23147778 · Cited by 21
Advances in RNA cancer therapeutics: New insight into exosomes as miRNA delivery
Volpini, L., Monaco, F., Santarelli, L., Neužil, J., & Tomasetti, M. (2023) · Aspects of Molecular Medicine · doi:10.1016/j.amolm.2023.100005 · Cited by 21
A capacitive laser-induced graphene based aptasensor for SARS-CoV-2 detection in human saliva
Moreira, G. A. M., Qian, H., Datta, S., Bliznyuk, N., Carpenter, J., Dean, D. M. D., McLamore, E. S., & Vanegas, D. C. (2023) · PLoS ONE · doi:10.1371/journal.pone.0290256 · Cited by 21
Advancements in magnetic aptasensors: Recent progress and future trends in biosensor technology
Behyar, M. B., Nilghaz, A., Ebrahimi, R., Hasanzadeh, M., & Shadjou, N. (2024) · TrAC Trends in Analytical Chemistry · doi:10.1016/j.trac.2024.117549 · Cited by 21
Metadata
- Authors
- Adachi, T., & Nakamura, Y.
- Affiliations
- RIBOMIC Inc., Minato-ku, Tokyo 108-0071, Japan
- Institute of Medical Science, The University of Tokyo (JP)
- Corresponding author
- Adachi, Tatsuo
- Venue
- Molecules
- Publisher
- MDPI AG
- Published
- 2019-11-21
- Volume
- 24
- Issue
- 23
- Pages
- 4229
- ISSN
- 1420-3049 (ISSN-L)
- PMC
- PMC6930564
- OpenAlex
- W2989998401
- Cited by
- 300
- References
- 115
- Citations by year
- 2026: 33 · 2025: 50 · 2024: 59 · 2023: 53 · 2022: 44 · 2021: 42 · 2020: 19
- FWCI
- 2.32
- Type
- journal article
- Language
- en
- Open access
- gold
- dx.doi.org
- Licence
- Locations
- Molecules (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- University of Tokyo
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Advanced biosensing and bioanalysis techniques
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Interference and Gene Delivery
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA and Nucleic Acid Chemistry
- Keywords
- aptamers, aptamer therapeutics, chemical modification, oligonucleotide chemistry, pegaptanib, vascular endothelial growth factor, age-related macular degeneration, drug delivery
- MeSH terms
- Animals, Humans, Infections, Neoplasms, Aptamers, Nucleotide, Drug Discovery
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
