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Plant-Derived Anticancer Compounds as New Perspectives in Drug Discovery and Alternative Therapy
Open accessAbstract
Despite the recent advances in the field of chemically synthetized pharmaceutical agents, nature remains the main supplier of bioactive molecules. The research of natural products is a valuable approach for the discovery and development of novel biologically active compounds possessing unique structures and mechanisms of action. Although their use belongs to the traditional treatment regimes, plant-derived compounds still cover a large portion of the current-day pharmaceutical agents. Their medical importance is well recognized in the field of oncology, especially as an alternative to the limitations of conventional chemotherapy (severe side effects and inefficacy due to the occurrence of multi-drug resistance). This review offers a comprehensive perspective of the first blockbuster chemotherapeutic agents of natural origin’s (e.g. taxol, vincristine, doxorubicin) mechanism of action using 3D representation. In addition is portrayed the step-by-step evolution from preclinical to clinical evaluation of the most recently studied natural compounds with potent antitumor activity (e.g. resveratrol, curcumin, betulinic acid, etc.) in terms of anticancer mechanisms of action and the possible indications as chemotherapeutic or chemopreventive agents and sensitizers. Finally, this review describes several efficient platforms for the encapsulation and targeted delivery of natural compounds in cancer treatment
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1 retracted
RETRACTED: Resveratrol eliminates cancer stem cells of osteosarcoma by STAT3 pathway inhibition
Peng, L., & Jiang, D. (2018) · PLoS ONE · doi:10.1371/journal.pone.0205918 · Cited by 92
RetractedNatural Products as Sources of New Drugs over the Nearly Four Decades from 01/1981 to 09/2019
Newman, D. J., & Cragg, G. M. (2020) · Journal of Natural Products · doi:10.1021/acs.jnatprod.9b01285 · Cited by 7,015
Discovery and resupply of pharmacologically active plant-derived natural products: A review
Atanasov, A. G., Waltenberger, B., Pferschy-Wenzig, E.-M., Linder, T., Wawrosch, C., Uhrin, P., Temml, V., Wang, L., Schwaiger, S., Heiss, E. H., et al. (2015) · Biotechnology Advances · doi:10.1016/j.biotechadv.2015.08.001 · Cited by 2,904
A view on drug resistance in cancer
Vasan, N., Baselga, J., & Hyman, D. M. (2019) · Nature · doi:10.1038/s41586-019-1730-1 · Cited by 2,770
The Traditional Medicine and Modern Medicine from Natural Products
Yuan, H., Ma, Q., Ye, L., & Piao, G. (2016) · Molecules · doi:10.3390/molecules21050559 · Cited by 2,434
Natural Products for Drug Discovery in the 21st Century: Innovations for Novel Drug Discovery
Thomford, N. E., Senthebane, D. A., Rowe, A., Munro, D., Seele, P., Maroyi, A., & Dzobo, K. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19061578 · Cited by 1,241
Anthracycline Chemotherapy and Cardiotoxicity
McGowan, J. V., Chung, R., Maulik, A., Piotrowska, I., Walker, J. M., & Yellon, D. M. (2017) · Cardiovascular Drugs and Therapy · doi:10.1007/s10557-016-6711-0 · Cited by 956
Natural products derived from plants as a source of drugs
Veeresham, C. (2012) · Journal of Advanced Pharmaceutical Technology & Research · doi:10.4103/2231-4040.104709 · Cited by 858
Beneficial Properties of Green Tea Catechins
Musial, C., Kuban-Jankowska, A., & Gorska-Ponikowska, M. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21051744 · Cited by 805
Cragg, G. M., & Pezzuto, J. M. (2016) · Medical Principles and Practice · doi:10.1159/000443404 · Cited by 798
Anti-Inflammatory Action and Mechanisms of Resveratrol
Meng, T., Xiao, D., Muhammed, A., Deng, J., Chen, L., & He, J. (2021) · Molecules · doi:10.3390/molecules26010229 · Cited by 698
The anti-cancer effect of quercetin: molecular implications in cancer metabolism
Reyes-Farias, M., & Carrasco-Pozo, C. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20133177 · Cited by 689 · cited 3×
“Quercetin, a major representative of the flavonoid subclass of flavonols, is abundantly present in fruits and vegetables [36].”
BackgroundSeca, A., & Pinto, D. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19010263 · Cited by 686
Pharmacological basis and new insights of quercetin action in respect to its anti-cancer effects
Tang, S.-M., Deng, X.-T., Zhou, J., Li, Q.-P., Ge, X.-X., & Miao, L. (2020) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2019.109604 · Cited by 654
Clinical Pharmacology of Resveratrol and Its Metabolites in Colorectal Cancer Patients
Patel, K. R., Brown, V. A., Jones, D. J. L., Britton, R. G., Hemingway, D., Miller, A. S., West, K. P., Booth, T. D., Perloff, M., Crowell, J. A., et al. (2010) · Cancer Research · doi:10.1158/0008-5472.can-10-2027 · Cited by 624
Natural product and natural product derived drugs in clinical trials
Butler, M. S., Robertson, A. A. B., & Cooper, M. A. (2014) · Nat. Prod. Rep. · doi:10.1039/c4np00064a · Cited by 602
Antioxidant effects of resveratrol in the cardiovascular system
Xia, N., Daiber, A., Förstermann, U., & Li, H. (2017) · British Journal of Pharmacology · doi:10.1111/bph.13492 · Cited by 574
Health benefits of resveratrol: Evidence from clinical studies
Singh, A. P., Singh, R., Verma, S. S., Rai, V., Kaschula, C. H., Maiti, P., & Gupta, S. C. (2019) · Medicinal Research Reviews · doi:10.1002/med.21565 · Cited by 523
Cancer Prevention With Natural Compounds
Gullett, N. P., Ruhul Amin, A. R. M., Bayraktar, S., Pezzuto, J. M., Shin, D. M., Khuri, F. R., Aggarwal, B. B., Surh, Y.-J., & Kucuk, O. (2010) · Seminars in Oncology · doi:10.1053/j.seminoncol.2010.06.014 · Cited by 485
The role of natural products in modern drug discovery.
CALIXTO, J. B. (2019) · Anais da Academia Brasileira de Ciências · doi:10.1590/0001-3765201920190105 · Cited by 472
Natural compounds as potential adjuvants to cancer therapy: Preclinical evidence
Lin, S., Chang, C., Hsu, C., Tsai, M., Cheng, H., Leong, M. K., Sung, P., Chen, J., & Weng, C. (2020) · British Journal of Pharmacology · doi:10.1111/bph.14816 · Cited by 425
Chow, H.-H. S., Hakim, I. A., Vining, D. R., Crowell, J. A., Ranger-Moore, J., Chew, W. M., Celaya, C. A., Rodney, S. R., Hara, Y., & Alberts, D. S. (2005) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-04-2549 · Cited by 400
Dietary phytochemicals and cancer chemoprevention: a review of the clinical evidence
Kotecha, R., Takami, A., & Espinoza, J. L. (2016) · Oncotarget · doi:10.18632/oncotarget.9593 · Cited by 396
Plant flavonoids in cancer chemoprevention: role in genome stability
George, V. C., Dellaire, G., & Rupasinghe, H. P. V. (2017) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2016.11.007 · Cited by 362
Resveratrol induces apoptosis and inhibits angiogenesis in human breast cancer xenografts in vivo
Garvin, S., Öllinger, K., & Dabrosin, C. (2006) · Cancer Letters · doi:10.1016/j.canlet.2005.01.031 · Cited by 351
Li, L., Ahmed, B., Mehta, K., & Kurzrock, R. (2007) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-06-0556 · Cited by 332
Aung, T., Qu, Z., Kortschak, R., & Adelson, D. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18030656 · Cited by 319
Chemosensitization of tumors by resveratrol
Gupta, S. C., Kannappan, R., Reuter, S., Kim, J. H., & Aggarwal, B. B. (2011) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2010.05852.x · Cited by 305
History of Antibiotics Research
Mohr, K. I. (2016) · Current Topics in Microbiology and Immunology · doi:10.1007/82_2016_499 · Cited by 287
Desai, S. J., Prickril, B., & Rasooly, A. (2018) · Nutrition and Cancer · doi:10.1080/01635581.2018.1446091 · Cited by 274
Curcumin Nanoformulations for Colorectal Cancer: A Review
Wong, K. E., Ngai, S. C., Chan, K.-G., Lee, L.-H., Goh, B.-H., & Chuah, L.-H. (2019) · Frontiers in Pharmacology · doi:10.3389/fphar.2019.00152 · Cited by 262
Ward, A. B., Mir, H., Kapur, N., Gales, D. N., Carriere, P. P., & Singh, S. (2018) · World Journal of Surgical Oncology · doi:10.1186/s12957-018-1400-z · Cited by 245
Artemisinin as an anticancer drug: Recent advances in target profiling and mechanisms of action
Wong, Y. K., Xu, C., Kalesh, K. A., He, Y., Lin, Q., Wong, W. S. F., Shen, H., & Wang, J. (2017) · Medicinal Research Reviews · doi:10.1002/med.21446 · Cited by 240
Targeting Multiple Signaling Pathways in Cancer: The Rutin Therapeutic Approach
Nouri, Z., Fakhri, S., Nouri, K., Wallace, C. E., Farzaei, M. H., & Bishayee, A. (2020) · Cancers · doi:10.3390/cancers12082276 · Cited by 236
Kellogg, E. H., Hejab, N. M. A., Howes, S., Northcote, P., Miller, J. H., Díaz, J. F., Downing, K. H., & Nogales, E. (2017) · Journal of Molecular Biology · doi:10.1016/j.jmb.2017.01.001 · Cited by 234
Comprehensive Review on Betulin as a Potent Anticancer Agent
Król, S. K., Kiełbus, M., Rivero-Müller, A., & Stepulak, A. (2015) · BioMed Research International · doi:10.1155/2015/584189 · Cited by 220
Is curcumin bioavailability a problem in humans: lessons from clinical trials
Kunnumakkara, A. B., Harsha, C., Banik, K., Vikkurthi, R., Sailo, B. L., Bordoloi, D., Gupta, S. C., & Aggarwal, B. B. (2019) · Expert Opinion on Drug Metabolism & Toxicology · doi:10.1080/17425255.2019.1650914 · Cited by 208
Curcumin Synergizes With Resveratrol to Inhibit Colon Cancer
Majumdar, A. P. N., Banerjee, S., Nautiyal, J., Patel, B. B., Patel, V., Du, J., Yu, Y., Elliott, A. A., Levi, E., & Sarkar, F. H. (2009) · Nutrition and Cancer · doi:10.1080/01635580902752262 · Cited by 201
Liu, H., Yang, Y., Liu, Y., Pan, J., Wang, J., Man, F., Zhang, W., & Liu, G. (2020) · Advanced Science · doi:10.1002/advs.201903129 · Cited by 196
Wu, H., Chen, L., Zhu, F., Han, X., Sun, L., & Chen, K. (2019) · Toxins · doi:10.3390/toxins11120731 · Cited by 192
In vitro and in vivo anticancer efficacy potential of Quercetin loaded polymeric nanoparticles
Baksi, R., Singh, D. P., Borse, S. P., Rana, R., Sharma, V., & Nivsarkar, M. (2018) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2018.07.106 · Cited by 185
Zan, L., Chen, Q., Zhang, L., & Li, X. (2019) · Bioengineered · doi:10.1080/21655979.2019.1657327 · Cited by 184
Melanin nanoparticles as a promising tool for biomedical applications – a review
Caldas, M., Santos, A. C., Veiga, F., Rebelo, R., Reis, R. L., & Correlo, V. M. (2020) · Acta Biomaterialia · doi:10.1016/j.actbio.2020.01.044 · Cited by 179
Banerjee, S., Ji, C., Mayfield, J. E., Goel, A., Xiao, J., Dixon, J. E., & Guo, X. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1806797115 · Cited by 174
Hong, C., Wang, D., Liang, J., Guo, Y., Zhu, Y., Xia, J., Qin, J., Zhan, H., & Wang, J. (2019) · Theranostics · doi:10.7150/thno.34953 · Cited by 168
ZHAO, G., HAN, X., ZHENG, S., LI, Z., SHA, Y., NI, J., SUN, Z., QIAO, S., & SONG, Z. (2016) · Oncology Reports · doi:10.3892/or.2015.4413 · Cited by 163
ben Sghaier, M., Pagano, A., Mousslim, M., Ammari, Y., Kovacic, H., & Luis, J. (2016) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2016.11.001 · Cited by 162
Sreekanth, C. N., Bava, S. V., Sreekumar, E., & Anto, R. J. (2011) · Oncogene · doi:10.1038/onc.2011.23 · Cited by 160
Moudi, M., Go, R., Yien, C. Y. S., et al. (2013) · PubMed · Cited by 159
Zhang, X.-A., Zhang, S., Yin, Q., & Zhang, J. (2015) · Pharmacognosy Magazine · doi:10.4103/0973-1296.153096 · Cited by 158
Quercetin modulates signaling pathways and induces apoptosis in cervical cancer cells
Sundaram, M. K., Raina, R., Afroze, N., Bajbouj, K., Hamad, M. A., Haque, S., & Hussain, A. (2019) · Bioscience Reports · doi:10.1042/bsr20190720 · Cited by 156
Rutin Exerts Antitumor Effects on Nude Mice Bearing SW480 Tumor
Alonso‐Castro, Á. J., Domínguez, F., & García-Carrancá, A. M. (2013) · Archives of Medical Research · doi:10.1016/j.arcmed.2013.06.002 · Cited by 145
The Flavonoid Quercetin Inhibits Pancreatic Cancer Growth In Vitro and In Vivo
Angst, E., Park, J. L., Moro, A., Lu, Q., Lu, X., Li, G., King, J. C., Chen, M. F., Reber, H. A., Go, V. L. W., et al. (2012) · Pancreas · doi:10.1097/mpa.0b013e318264ccae · Cited by 142
Chen, Y., Wang, X., Zhang, Q., Zhu, J., Li, Y., Xie, C., Li, X., Wu, J., Geng, S., Zhong, C., et al. (2017) · Nutrients · doi:10.3390/nu9060572 · Cited by 139
Thipe, V. C., Amiri, K. P., Bloebaum, P., Raphael, A. K., Khoobchandani, M., Katti, K. K., Jurisson, S. S., & Katti, K. V. (2019) · International Journal of Nanomedicine · doi:10.2147/ijn.s204443 · Cited by 138
Tong, W., Wang, Q., Sun, D., & Suo, J. (2016) · Oncology Letters · doi:10.3892/ol.2016.5148 · Cited by 136
Wang, Y.-R., Chen, S.-F., Wu, C.-C., Liao, Y.-W., Lin, T.-S., Liu, K.-T., Chen, Y.-S., Li, T., Chien, T., & Chan, N. (2017) · Nucleic Acids Research · doi:10.1093/nar/gkx742 · Cited by 129
Ghante, M. H., & Jamkhande, P. G. (2019) · Journal of pharmacopuncture · doi:10.3831/kpi.201.22.007 · Cited by 127
Cote, B., Carlson, L. J., Rao, D. A., & Alani, A. W. G. (2015) · Journal of Controlled Release · doi:10.1016/j.jconrel.2015.06.040 · Cited by 125
Artemisinin enhances the anti-tumor immune response in 4T1 breast cancer cells in vitro and in vivo
Cao, Y. Q., Feng, Y., Gao, L., Li, X.-Y., Jin, Q., Wang, Y., Xu, Y., Jin, F., Lu, S., & Wei, M. (2019) · International Immunopharmacology · doi:10.1016/j.intimp.2019.01.041 · Cited by 125
Sanna, V., Singh, C. K., Jashari, R., Adhami, V. M., Chamcheu, J. C., Rady, I., Sechi, M., Mukhtar, H., & Siddiqui, I. A. (2017) · Scientific Reports · doi:10.1038/srep41573 · Cited by 123
Recent advances in cancer chemoprevention with phytochemicals
Koh, Y., Ho, C., & Pan, M. (2019) · Journal of Food and Drug Analysis · doi:10.1016/j.jfda.2019.11.001 · Cited by 121
Li, L., Zhang, H., Yuan, S., Tian, Z., Wang, L., & Sun, Z. (2007) · International Journal of Cancer · doi:10.1002/ijc.22804 · Cited by 119
Curcumin-cyclodextrin complexes enhanced the anti-cancer effects of curcumin
Zhang, L., Man, S., Qiu, H., Liu, Z., Zhang, M., Ma, L., & Gao, W. (2016) · Environmental Toxicology and Pharmacology · doi:10.1016/j.etap.2016.09.021 · Cited by 115
Delivering Natural Products and Biotherapeutics to Improve Drug Efficacy
Obeid, M. A., Qaraghuli, M. M. A., Alsaadi, M., Alzahrani, A. R., Niwasabutra, K., & Ferro, V. A. (2017) · Therapeutic Delivery · doi:10.4155/tde-2017-0060 · Cited by 112
Ranjan, A. P., Mukerjee, A., Helson, L., Gupta, R. V., & Vishwanatha, J. K. (2013) · PubMed · Cited by 111
Rodríguez‐Enríquez, S., Pacheco-Velázquez, S. C., Marín‐Hernández, Á., Gallardo‐Pérez, J. C., Robledo‐Cadena, D. X., Hernández‐Reséndiz, I., García-García, J. D., Belmont-Díaz, J., López‐Marure, R., Hernández‐Esquivel, L., et al. (2019) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2019.03.008 · Cited by 109
Adverse drug reactions of anticancer drugs derived from natural sources
Tewari, D., Rawat, P., & Singh, P. K. (2018) · Food and Chemical Toxicology · doi:10.1016/j.fct.2018.11.041 · Cited by 108
Carlson, L. J., Cote, B., Alani, A. W. G., & Rao, D. A. (2014) · Journal of Pharmaceutical Sciences · doi:10.1002/jps.24042 · Cited by 105
Effect of Natural Food Antioxidants against LDL and DNA Oxidative Changes
Kiokias, S. N., Proestos, C., & Oreopoulou, V. (2018) · Antioxidants · doi:10.3390/antiox7100133 · Cited by 98
Şoica, C., Danciu, C., Savoiu-Balint, G., Borcan, F., Ambrus, R., Zupkó, I., Bojin, F. M., Coricovac, D. E., Ciurlea, S. A., Avram, Ș., et al. (2014) · International Journal of Molecular Sciences · doi:10.3390/ijms15058235 · Cited by 97
Self-citationArtemisinin loaded chitosan magnetic nanoparticles for the efficient targeting to the breast cancer
Natesan, S., Ponnusamy, C., Sugumaran, A., Chelladurai, S., Sharavanan, P., & Rajaguru, P. (2017) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2017.03.137 · Cited by 96
Júnior, R. G. D. O., Adrielly, A. F. C., Almeida, J. R. G. D. S., Grougnet, R., Thiéry, V., & Picot, L. (2018) · Fitoterapia · doi:10.1016/j.fitote.2018.02.025 · Cited by 96
Perspectives on In Vitro to In Vivo Extrapolations
Härtung, T. (2017) · Applied In Vitro Toxicology · doi:10.1089/aivt.2016.0026 · Cited by 90
Jiang, F., Zhou, J., Zhang, D., Liu, M., & Chen, Y. (2018) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2018.3712 · Cited by 90
Zeng, L., Yan, J., Luo, L., Ma, M., & Zhu, H. (2017) · Scientific Reports · doi:10.1038/srep45521 · Cited by 89
Anti-breast cancer activity of resveratrol encapsulated in liposomes
Zhao, Y., Cao, Y. N., Sun, J., Liang, Z., Wu, Q., Cui, S. H., Zhi, D., Guo, S., Zhen, Y., & Zhang, S. (2019) · Journal of Materials Chemistry B · doi:10.1039/c9tb02051a · Cited by 88
Hong, O., Noh, E., Jang, H., Lee, Y., Lee, B. K., Jung, S. H., Kim, J., & Youn, H. J. (2017) · Oncology Letters · doi:10.3892/ol.2017.6108 · Cited by 86
Ma, L., Li, W., Wang, R., Nan, Y., Wang, Q., Liu, W., & Jin, F. (2015) · International Journal of Oncology · doi:10.3892/ijo.2015.3124 · Cited by 85
Lai, H., Chien, S., Kuo, S., Tseng, L., Lin, H., Chi, C., & Chen, D. (2011) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2012/486568 · Cited by 84
Betulinic Acid as a Potent and Complex Antitumor Phytochemical: A Minireview
Gheorgheosu, D., Duicu, O., Dehelean, C. A., Şoica, C., & Muntean, D. M. (2014) · Anti-Cancer Agents in Medicinal Chemistry · doi:10.2174/1871520614666140223192148 · Cited by 84
Self-citationResveratrol Regulates Colorectal Cancer Cell Invasion by Modulation of Focal Adhesion Molecules
Buhrmann, C., Shayan, P., Goel, A., & Shakibaei, M. (2017) · Nutrients · doi:10.3390/nu9101073 · Cited by 84
Guon, T. E., & Chung, H. S. (2016) · Oncology Letters · doi:10.3892/ol.2016.4247 · Cited by 79
Zeng, A., Hua, H., Liu, L., & Zhao, J. (2019) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2019.03.033 · Cited by 78
Suzuki, R., Kang, Y., Li, X., Roife, D., Zhang, R., & Fleming, J. B. (2014) · PubMed · Cited by 77
A Presurgical Study of Lecithin Formulation of Green Tea Extract in Women with Early Breast Cancer
Lazzeroni, M., Guerrieri‐Gonzaga, A., Gandini, S., Johansson, H. A., Serrano, D., Cazzaniga, M., Aristarco, V., Macis, D., Mora, S., Caldarella, P., et al. (2017) · Cancer Prevention Research · doi:10.1158/1940-6207.capr-16-0298 · Cited by 76
Apigenin-induced lysosomal degradation of β-catenin in Wnt/β-catenin signaling
Lin, C.-M., Chen, H., Lin, C.-A., Wu, H., Sheu, J. J., & Chen, H. (2017) · Scientific Reports · doi:10.1038/s41598-017-00409-z · Cited by 72
Modern drug delivery strategies applied to natural active compounds
Puglia, C., Lauro, M. R., Tirendi, G. G., Fassari, G. E., Carbone, C., Bonina, F. P., & Puglisi, G. (2016) · Expert Opinion on Drug Delivery · doi:10.1080/17425247.2017.1234452 · Cited by 71
Ginseng on Cancer: Potential Role in Modulating Inflammation-Mediated Angiogenesis
Dai, D., Zhang, C.-F., Williams, S., Yuan, C., & Wang, C. (2017) · The American Journal of Chinese Medicine · doi:10.1142/s0192415x17500021 · Cited by 70
Checkley, S., MacCallum, L., Yates, J. W. T., Jasper, P., Luo, H., Tolsma, J., & Bendtsen, C. (2015) · Scientific Reports · doi:10.1038/srep13545 · Cited by 68
Watz, C. G., Dehelean, C. A., Pînzaru, I., Mioc, M., Socoliuc, V., Moacă, E.-A., Avram, Ș., Ghiulai, R. M., Coricovac, D. E., Pavel, I., et al. (2020) · International Journal of Nanomedicine · doi:10.2147/ijn.s269630 · Cited by 68
Self-citationSong, Y., Cai, L., Tian, Z., Wu, Y., & Chen, J. (2020) · ACS Omega · doi:10.1021/acsomega.0c00912 · Cited by 65
Meier, B. P., & Lappas, C. M. (2015) · Medical Decision Making · doi:10.1177/0272989x15621877 · Cited by 64
Betulinic Acid Suppresses Ovarian Cancer Cell Proliferation through Induction of Apoptosis
Lee, D., Lee, S. R., Kang, K. S., Ko, Y., Pang, C., Yamabe, N., & Kim, K. H. (2019) · Biomolecules · doi:10.3390/biom9070257 · Cited by 62
In vivo Anti-Cancer Effects of Resveratrol Mediated by NK Cell Activation
Lee, Y., Shin, H.-W., & Kim, J. (2020) · Journal of Innate Immunity · doi:10.1159/000510315 · Cited by 62
Screening and Structural Analysis of Flavones Inhibiting Tankyrases
Narwal, M., Haikarainen, T., Fallarero, A., Vuorela, P. M., & Lehtiö, L. (2013) · Journal of Medicinal Chemistry · doi:10.1021/jm3018783 · Cited by 61
Mondal, A., & Chatterji, U. (2015) · Journal of Cellular Biochemistry · doi:10.1002/jcb.25152 · Cited by 60
Effects of Epigallocatechin-3-gallate (EGCG) on A549 Lung Cancer Tumor Growth and Angiogenesis
Sakamoto, Y., TERASHITA, N., Muraguchi, T., Fukusato, T., & Kubota, S. (2013) · Bioscience Biotechnology and Biochemistry · doi:10.1271/bbb.120882 · Cited by 59
Jin, H., Gong, Zhang, & Wang (2013) · OncoTargets and Therapy · doi:10.2147/ott.s40914 · Cited by 59
Kumar, P., Bhadauria, A. S., Singh, A. K., & Saha, S. (2018) · Life Sciences · doi:10.1016/j.lfs.2018.07.056 · Cited by 59
The Multitarget Activity of Natural Extracts on Cancer: Synergy and Xenohormesis
Herranz‐López, M., Losada-Echeberría, M., & Barrajón‐Catalán, E. (2018) · Medicines · doi:10.3390/medicines6010006 · Cited by 59
Betulin and betulinic acid in cancer research
Hordyjewska, A., Ostapiuk, A., & Horecka, A. (2018) · Journal of Pre-Clinical and Clinical Research · doi:10.26444/jpccr/92743 · Cited by 57
SONODA, J.-I., Ikeda, R., Baba, Y., Narumi, K., KAWACHI, A., Tomishige, E., Nishihara, K., TAKEDA, Y., Yamada, K., Sato, K., et al. (2014) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2014.1719 · Cited by 56
Shang, H., Chang, C.-H., Chou, Y.-R., Yeh, M., Au, M.-K., Lu, H.-F., Chu, Y., Chou, H.-M., Chou, H.-C., Shih, Y., et al. (2016) · Oncology Reports · doi:10.3892/or.2016.5002 · Cited by 56
Luo, J., Zhu, W., Tang, Y., Cao, H., Zhou, Y., Ji, R., Zhou, X., Lu, Z., Yang, H., Zhang, S., et al. (2014) · Radiation Oncology · doi:10.1186/1748-717x-9-84 · Cited by 54
Challenges of conducting clinical trials of natural products to combat cancer.
Paller, C. J., Denmeade, S. R., & Carducci, M. A. (2016) · PubMed · Cited by 54
Rastegar, R., Javar, H. A., Khoobi, M., Dehghankelishadi, P., Yousefi, G. H., Doosti, M., Ghahremani, M. H., Shariftabrizi, A., Imanparast, F., Gholibeglu, E., et al. (2018) · Artificial Cells Nanomedicine and Biotechnology · doi:10.1080/21691401.2018.1453829 · Cited by 54
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Marwah, M. K., Perrie, Y., Badhan, R. K. S., & Lowry, D. (2019) · Journal of Liposome Research · doi:10.1080/08982104.2019.1604746 · Cited by 52
Zhang, Y. J., Gallis, B. M., Taya, M. D., Wang, S., Ho, R. J. Y., & Sasaki, T. (2013) · PLoS ONE · doi:10.1371/journal.pone.0059086 · Cited by 51
Intranasal administration of resveratrol successfully prevents lung cancer in A/J mice
Monteillier, A., Voisin, A., Furrer, P., Allémann, É., & Cuendet, M. (2018) · Scientific Reports · doi:10.1038/s41598-018-32423-0 · Cited by 51
Wang, X., Parvathaneni, V., Shukla, S. K., Kanabar, D. D., Muth, A., & Gupta, V. (2020) · AAPS PharmSciTech · doi:10.1208/s12249-020-01724-x · Cited by 51
Pan, M., Chiou, Y., Chen, L., & Ho, C. (2014) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201400515 · Cited by 46
Özlü, B., Kabay, G., Bocek, I., Yılmaz, M., Pişkin, A. K., Shim, B. S., & Mutlu, M. (2019) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2019.118613 · Cited by 46
de Melo, F. H. M., Oliveira, J. S., Bressani, V. O., & Montor, W. R. (2018) · Frontiers in Oncology · doi:10.3389/fonc.2018.00644 · Cited by 44
Chen, H., Han, X., & Pang, J. (2020) · Plants · doi:10.3390/plants9030392 · Cited by 44
Pînzaru, I., Tanase, A., ENĂTESCU, V. R., Coricovac, D. E., Bociort, F., Marcovici, I., Watz, C. G., Vlaia, L. L., Şoica, C., & Dehelean, C. A. (2021) · Antioxidants · doi:10.3390/antiox10010085 · Cited by 40
Self-citationKang, Y., Hu, W., Bai, E., Zheng, H., Liu, Z., Wu, J., Jin, R., Zhao, C., & Liang, G. (2016) · OncoTargets and Therapy · doi:10.2147/ott.s118272 · Cited by 39
Sturza, A., Pavel, I. Z., Ancușa, S., Danciu, C., Dehelean, C. A., Duicu, O., & Muntean, D. M. (2018) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-018-3296-x · Cited by 38
Self-citationDanciu, C., Pînzaru, I., Coricovac, D. E., Andrica, F., Sizemore, I. E. P., Dehelean, C. A., Baderca, F., Lăzureanu, V. E., Şoica, C., Mioc, M., et al. (2018) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2018.11.006 · Cited by 34
Self-citationModified Panax ginseng extract regulates autophagy by AMPK signaling in A549 human lung cancer cells
Yoo, H., Kim, J. M., Jo, E., Cho, C.-K., Lee, S.-Y., Kang, H. S., Lee, M. G., Yang, P.-Y., & Jang, I. (2017) · Oncology Reports · doi:10.3892/or.2017.5590 · Cited by 32
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Pfarr, K., Danciu, C., Arlt, O., Neske, C., Dehelean, C. A., Pfeilschifter, J. M., & Radeke, H. H. (2015) · PLoS ONE · doi:10.1371/journal.pone.0118802 · Cited by 31
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Dai, L., Zhu, W., Si, C., & Lei, J. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19020627 · Cited by 31
Kim, J., Yoo, J., Kim, J. S., Kim, S.-G., Park, J. E., Seok, Y. M., Son, J., & Kim, H. J. (2020) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2020/2584783 · Cited by 26
Liu, A., Zheng, R., Yang, F., Huang, L., Zhang, L., & Zhang, J. (2017) · Food Science and Technology · doi:10.1590/1678-457x.02817 · Cited by 16
Pînzaru, I., Sarău, C. A., Coricovac, D. E., Marcovici, I., Utescu, C., Tofan, S., Popovici, R. A., Manea, H. C., Pavel, I., Şoica, C., et al. (2021) · Nanomaterials · doi:10.3390/nano11010152 · Cited by 14
Self-citationWang, K., Wang, S., Chen, K., Zhao, Y., Ma, X., & Wang, L. (2018) · Journal of Nanomaterials · doi:10.1155/2018/2603712 · Cited by 13
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Metadata
- Authors
- Dehelean, C. A., Marcovici, I., Soica, C., Mioc, M., Coricovac, D., Iurciuc, S., Cretu, O. M., & Pinzaru, I.
- Venue
- Molecules
- Publisher
- MDPI AG
- Published
- 2021-02-19
- Volume
- 26
- Issue
- 4
- Pages
- 1109
- ISSN
- 1420-3049 (ISSN-L)
- OpenAlex
- W3130954936
- Cited by
- 502
- References
- 126
- FWCI
- 36.57
- Type
- journal article
- Language
- en
- Open access
- gold
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.