The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Chemosensitization of tumors by resveratrol
Open accessAbstract
Because tumors develop resistance to chemotherapeutic agents, the cancer research community continues to search for effective chemosensitizers. One promising possibility is to use dietary agents that sensitize tumors to the chemotherapeutics. In this review, we discuss that the use of resveratrol can sensitize tumor cells to chemotherapeutic agents. The tumors shown to be sensitized by resveratrol include lung carcinoma, acute myeloid leukemia, promyelocytic leukemia, multiple myeloma, prostate cancer, oral epidermoid carcinoma, and pancreatic cancer. The chemotherapeutic agents include vincristine, adriamycin, paclitaxel, doxorubicin, cisplatin, gefitinib, 5‐fluorouracil, velcade, and gemcitabine. The chemosensitization of tumor cells by resveratrol appears to be mediated through its ability to modulate multiple cell‐signaling molecules, including drug transporters, cell survival proteins, cell proliferative proteins, and members of the NF‐κB and STAT3 signaling pathways. Interestingly, this nutraceutical has also been reported to suppress apoptosis induced by paclitaxel, vincristine, and daunorubicin in some tumor cells. The potential mechanisms underlying this dual effect are discussed. Overall, studies suggest that resveratrol can be used to sensitize tumors to standard cancer chemotherapeutics.
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Cites
Cancer chemopreventive activity of resveratrol, a natural product derived from grapes
Jang, M., Cai, L., Udeani, G. O., Slowing, K. V., Thomas, C. F., Beecher, C. W. W., Fong, H. H. S., Farnsworth, N. R., Kinghorn, A. D., Mehta, R. G., et al. (1997) · Science · doi:10.1126/science.275.5297.218 · Cited by 4,935
STATs: transcriptional control and biological impact
Levy, D. E., & Darnell, J. E. (2002) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm909 · Cited by 3,201
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Newman, D. J., Cragg, G. M., & Snader, K. M. (2003) · Journal of Natural Products · doi:10.1021/np030096l · Cited by 3,082
IAP proteins: blocking the road to death's door
Salvesen, G. S., & Duckett, C. S. (2002) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm830 · Cited by 1,756
Inhibiting NF-κB activation by small molecules as a therapeutic strategy
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Self-citationReal, P. J., Sierra, A., de Juan, A., Segovia, J. C., Lopez-Vega, J. M., & Fernandez-Luna, J. L. (2002) · Oncogene · doi:10.1038/sj.onc.1206004 · Cited by 321
Cited by
Gupta, S. C., Hevia, D., Patchva, S., Park, B., Koh, W., & Aggarwal, B. B. (2012) · Antioxidants & Redox Signaling · doi:10.1089/ars.2011.4414 · Cited by 732
Self-citationResveratrol and health—A comprehensive review of human clinical trials
Smoliga, J. M., Baur, J. A., & Hausenblas, H. A. (2011) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201100143 · Cited by 594
Plant-Derived Anticancer Compounds as New Perspectives in Drug Discovery and Alternative Therapy
Dehelean, C. A., Marcovici, I., Soica, C., Mioc, M., Coricovac, D., Iurciuc, S., Cretu, O. M., & Pinzaru, I. (2021) · Molecules · doi:10.3390/molecules26041109 · Cited by 502
Curcumin mediates anticancer effects by modulating multiple cell signaling pathways
Kunnumakkara, A. B., Bordoloi, D., Harsha, C., Banik, K., Gupta, S. C., & Aggarwal, B. B. (2017) · Clinical Science · doi:10.1042/cs20160935 · Cited by 332
Self-citationUnsal, V., Dalkiran, T., Çiçek, M., & Kölükçü, E. (2020) · Advanced Pharmaceutical Bulletin · doi:10.34172/apb.2020.023 · Cited by 305
Metadata
- Authors
- Gupta, S. C., Kannappan, R., Reuter, S., Kim, J. H., & Aggarwal, B. B.
- Venue
- Annals of the New York Academy of Sciences
- Publisher
- Wiley
- Published
- 2011-01
- Volume
- 1215
- Issue
- 1
- Pages
- 150-160
- ISSN
- 0077-8923 (ISSN-L)
- 1749-6632
- OpenAlex
- W1885503255
- Cited by
- 305
- References
- 6
- FWCI
- 11.80
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Gupta, S. C., Kannappan, R., Reuter, S., Kim, J. H., & Aggarwal, B. B. (2011). Chemosensitization of tumors by resveratrol. Annals of the New York Academy of Sciences. https://doi.org/10.1111/j.1749-6632.2010.05852.x
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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