Systematic Study of Resveratrol Nanoliposomes Transdermal Delivery System for Enhancing Anti-Aging and Skin-Brightening Efficacy
Open accessAbstract
Due to the stratum corneum barrier, resveratrol is difficult to be absorbed transdermally, limiting its anti-aging and skin-brightening effects. Furthermore, there is a lack of systematic studies on the efficacy of resveratrol in human skin, especially in three-dimensional skin models and clinical trials. To overcome the low transdermal delivery issue, we encapsulated resveratrol into nanoliposomes using the high-pressure homogenization method to develop an efficient transdermal drug delivery system, and systematically evaluated its anti-aging and skin-brightening efficacy via cell line models, a three-dimensional skin model and human skin. The resveratrol nanoliposomes effectively improved the transdermal penetration and retention of resveratrol and enhanced cellular uptake. In addition, compared to free resveratrol, resveratrol nanoliposomes remarkably enhanced the skin-care effects by promoting the antioxidant capacity and collagen synthesis, inhibiting the secretion of matrix metalloproteinases, tyrosine activity and melanin synthesis. Notably, human clinical trials proved the anti-wrinkle and skin-brightening effectiveness of resveratrol nanoliposomes. Three levels of systematic studies indicated that resveratrol nanoliposomes could be a promising transdermal drug delivery system to enhance the anti-aging and skin-brightening effects of resveratrol.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Zhang et al. study on resveratrol nanoliposomes was limited by small sample size, lack of control group, and short-term duration.
“The sample size was relatively small, and the study did not include a control group for comparison. Additionally, the duration of the study was short‐term, so the long‐term effects of the treatment remain unclear.”
From Cosmeceuticals in photoaging: A review. (2024) · cites this paper as [24]
Materials and Methods §3.12 (page unavailable) reports 33 volunteers and measurements through day 28, supporting the small-sample and short-duration concerns. But it explicitly describes three groups, including a blank-cream placebo group, so the claim that there was no control group is incorrect. (LLM, conf=0.90)
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Insight into Cellular Uptake and Intracellular Trafficking of Nanoparticles
Foroozandeh, P., & Aziz, A. A. (2018) · Nanoscale Research Letters · doi:10.1186/s11671-018-2728-6 · Cited by 1,395 · see citing works
Skin whitening agents: medicinal chemistry perspective of tyrosinase inhibitors
Pillaiyar, T., Manickam, M., & Namasivayam, V. (2017) · Journal of Enzyme Inhibition and Medicinal Chemistry · doi:10.1080/14756366.2016.1256882 · Cited by 932 · see citing works
Health benefits of resveratrol: Evidence from clinical studies
Singh, A. P., Singh, R., Verma, S. S., Rai, V., Kaschula, C. H., Maiti, P., & Gupta, S. C. (2019) · Medicinal Research Reviews · doi:10.1002/med.21565 · Cited by 523 · see citing works
Antibacterial and antifungal properties of resveratrol
Vestergaard, M., & Ingmer, H. (2019) · International Journal of Antimicrobial Agents · doi:10.1016/j.ijantimicag.2019.02.015 · Cited by 482 · see citing works
Yu, Y., Yang, X., Wu, X., & Fan, Y. (2021) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2021.646554 · Cited by 447 · see citing works
van Smeden, J., & Bouwstra, J. A. (2016) · Current Problems in Dermatology · doi:10.1159/000441540 · Cited by 366 · see citing works
Extracellular matrix regulation of fibroblast function: redefining our perspective on skin aging
Cole, M. A., Quan, T., Voorhees, J. J., & Fisher, G. J. (2018) · Journal of Cell Communication and Signaling · doi:10.1007/s12079-018-0459-1 · Cited by 365 · see citing works
The use of skin models in drug development
Mathes, S. H., Ruffner, H., & Graf‐Hausner, U. (2014) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2013.12.006 · Cited by 321 · see citing works
Transport, stability, and biological activity of resveratrol
Delmas, D., Aires, V., Limagne, E., Dutartre, P., Mazué, F., Ghiringhelli, F., & Latruffe, N. (2011) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2010.05871.x · Cited by 252 · see citing works
Liposomes and Niosomes as Topical Drug Delivery Systems
Choi, M., & Maïbach, H. I. (2005) · Skin Pharmacology and Physiology · doi:10.1159/000086666 · Cited by 239 · see citing works
Wang, Y., Wang, L., Wen, X., Hao, D., Zhang, N., He, G., & Jiang, X. L. (2019) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2019.111160 · Cited by 231 · see citing works
Resveratrol as an active ingredient for cosmetic and dermatological applications: a review
Ratz-Łyko, A., & Arct, J. (2019) · Journal of Cosmetic and Laser Therapy · doi:10.1080/14764172.2018.1469767 · Cited by 216 · see citing works
Niehues, H., Bouwstra, J. A., El Ghalbzouri, A., Brandner, J. M., Zeeuwen, P. L. J. M., & van den Bogaard, E. H. (2018) · Experimental Dermatology · doi:10.1111/exd.13531 · Cited by 210 · see citing works
Advances in the Biofabrication of 3D Skin in vitro: Healthy and Pathological Models
Randall, M. J., Jüngel, A., Rimann, M., & Wuertz‐Kozak, K. (2018) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2018.00154 · Cited by 193 · see citing works
Invasome: A Novel Nanocarrier for Transdermal Drug Delivery
Babaie, S., Bakhshayesh, A. R. D., Ha, J. W., Hamishehkar, H., & Kim, K. H. (2020) · Nanomaterials · doi:10.3390/nano10020341 · Cited by 154 · see citing works
Updates on Responsive Drug Delivery Based on Liposome Vehicles for Cancer Treatment
Nikolova, M. P., Kumar, E. M., & Chavali, M. S. (2022) · Pharmaceutics · doi:10.3390/pharmaceutics14102195 · Cited by 133 · see citing works
Paolino, D., Celia, C., Trapasso, E., Cilurzo, F., & Fresta, M. (2012) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2012.02.008 · Cited by 121 · see citing works
Park, S., Byun, E. J., Lee, J. D., Kim, S., & Kim, H. S. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19092727 · Cited by 120 · see citing works
Zarrabi, A., Abadi, M. A. A., Khorasani, S., Mohammadabadi, M., Jamshidi, A., Torkaman, S., Taghavi, E., Mozafari, M. R., & Rasti, B. (2020) · Molecules · doi:10.3390/molecules25030638 · Cited by 119 · see citing works
Anti-tumor effects and cellular mechanisms of resveratrol
Han, G., Xia, J., Gao, J., Inagaki, Y., Tang, W., & Kokudo, N. (2015) · Drug Discoveries & Therapeutics · doi:10.5582/ddt.2015.01007 · Cited by 107 · see citing works
Current Advances of Nanocarrier Technology-Based Active Cosmetic Ingredients for Beauty Applications
Zhou, H. W., Luo, D., Chen, D., Tan, X., Bai, X., Liu, Z., Yang, X., & Liu, W. (2021) · Clinical Cosmetic and Investigational Dermatology · doi:10.2147/ccid.s313429 · Cited by 98 · see citing works
Self-citationThe Bioactivities of Resveratrol and Its Naturally Occurring Derivatives on Skin
Lin, M.-H., Hung, C., Sung, H., Yang, S.-C., Yu, H., & Fang, J. (2021) · Journal of Food and Drug Analysis · doi:10.38212/2224-6614.1151 · Cited by 76 · see citing works
Resveratrol as a kcat type inhibitor for tyrosinase: Potentiated melanogenesis inhibitor
Satooka, H., & Kubo, I. (2011) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2011.11.030 · Cited by 73 · see citing works
Bose, T., Latawiec, D., Mondal, P. P., & Mandal, S. (2014) · Journal of Nanoparticle Research · doi:10.1007/s11051-014-2527-7 · Cited by 71 · see citing works
Resveratrol as a Multifunctional Topical Hypopigmenting Agent
Na, J., Shin, J. W., Choi, H.-R., Kwon, S., & Park, K.-C. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20040956 · Cited by 70 · see citing works
Eberlin, S., da Silva, M. S., Facchini, G., da Silva, G. H., Pinheiro, A. L. T. A., Eberlin, S., & Pinheiro, A. D. S. (2020) · Alternatives to Laboratory Animals · doi:10.1177/0261192920914193 · Cited by 69 · see citing works
Nanoliposomes: Synthesis methods and applications in cosmetics
Fakhravar, Z., Ebrahimnejad, P., Daraee, H., & Akbarzadeh, A. (2015) · Journal of Cosmetic and Laser Therapy · doi:10.3109/14764172.2015.1039040 · Cited by 67 · see citing works
Skin hyperpigmentation treatment using herbs: A review of clinical evidences
Kanlayavattanakul, M., & Lourith, N. (2017) · Journal of Cosmetic and Laser Therapy · doi:10.1080/14764172.2017.1368666 · Cited by 64 · see citing works
Resveratrol: a unique antioxidant offering a multi-mechanistic approach for treating aging skin.
Farris, P. K., Krutmann, J., Li, Y., McDaniel, D. H., & Krol, Y. (2013) · PubMed · Cited by 61 · see citing works
Xu, J., Jiang, S., Liu, L., Zhao, Y., & Zeng, M. (2021) · Journal of Food Science · doi:10.1111/1750-3841.15606 · Cited by 50 · see citing works
Nanoliposomes codelivering bioactive peptides produce enhanced anti-aging effect in human skin
Han, F., Luo, D., Qu, W., Chen, D., Hong, Y., Sheng, J., Yang, X., & Liu, W. (2020) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2020.101693 · Cited by 49 · see citing works
Self-citationThe Improvement of Skin Whitening of Phenylethyl Resorcinol by Nanostructured Lipid Carriers
Kim, B.-S., Na, Y., Choi, J., Kim, I., Lee, E. J., Kim, S.-Y., Lee, J., & Cho, C. (2017) · Nanomaterials · doi:10.3390/nano7090241 · Cited by 47 · see citing works
Lane, M. E., Hadgraft, J., de Oliveira, G. B., Vieira, R., Mohammed, D., & Hirata, K. (2012) · International Journal of Cosmetic Science · doi:10.1111/j.1468-2494.2012.00747.x · Cited by 45 · see citing works
Nanoliposomes, from food industry to nutraceuticals: Interests and uses
Bondu, C., & Yen, F. T. (2022) · Innovative Food Science & Emerging Technologies · doi:10.1016/j.ifset.2022.103140 · Cited by 45 · see citing works
Yang, C., Wang, Y., Xie, Y., Liu, G., Lü, Y., Wu, W., & Chen, L. (2019) · Nanomedicine · doi:10.2217/nnm-2019-0244 · Cited by 44 · see citing works
Yang, Q., Liu, S., Gu, Y., Tang, X., Wang, T., Wu, J., & Liu, J. (2019) · International Journal of Nanomedicine · doi:10.2147/ijn.s206657 · Cited by 42 · see citing works
Emerging Effects of Resveratrol on Wound Healing: A Comprehensive Review
Jia, Y., Shao, J.-H., Zhang, K., Zou, M., Teng, Y., Fan, T., Chen, M.-N., Chen, W., Yuan, Z., Wu, J., et al. (2022) · Molecules · doi:10.3390/molecules27196736 · Cited by 40 · see citing works
Zuccari, G., Alfei, S., Zorzoli, A., Marimpietri, D., Turrini, F., Baldassari, S., Marchitto, L., & Caviglioli, G. (2021) · Pharmaceutics · doi:10.3390/pharmaceutics13081128 · Cited by 37 · see citing works
Advances in cosmeceutical nanotechnology for hyperpigmentation treatment
Tangau, M. J., Chong, Y. K., & Yeong, K. Y. (2022) · Journal of Nanoparticle Research · doi:10.1007/s11051-022-05534-z · Cited by 36 · see citing works
Xiao, Z., Yu, X., Zhang, S., & Liang, A. (2022) · BioMed Research International · doi:10.1155/2022/6916179 · Cited by 33 · see citing works
Self-citationLi, J., Nan, J., Wu, H., Park, H. J., Zhao, Q., & Yang, L. (2022) · Food Chemistry · doi:10.1016/j.foodchem.2022.132931 · Cited by 28 · see citing works
Co-delivery of bioactive peptides by nanoliposomes for promotion of hair growth
Tian, L.-W., Luo, D., Chen, D., Zhou, H. W., Zhang, X., Yang, X., Wang, Y., & Liu, W. (2022) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2022.103381 · Cited by 27 · see citing works
Self-citationRecent Advances in Studies of Skin Color and Skin Cancer.
LaBerge, G. S., Duvall, E., Grasmick, Z., Haedicke, K., Galan, A., Leverett, J. C., Baswan, S. M., Yim, S., & Pawelek, J. M. (2020) · PubMed Central · Cited by 21 · see citing works
Xia, H., Tang, Y., Huang, R., Liang, J., Ma, S., Chen, D., Feng, Y., Lei, Y., Zhang, Q., Yang, Y., et al. (2022) · Coatings · doi:10.3390/coatings12030362 · Cited by 21 · see citing works
Self-citationChen, S., Tamaki, N., Kudo, Y., Tsunematsu, T., Miki, K., Ishimaru, N., & Ito, H.-O. (2021) · Journal of clinical biochemistry and nutrition · doi:10.3164/jcbn.21-23 · Cited by 16 · see citing works
Self-citationWu, Y., Cao, K., Zhang, W., Zhang, G., & Zhou, M. (2021) · Skin Pharmacology and Physiology · doi:10.1159/000514496 · Cited by 15 · see citing works
Diabetic retinopathy treatments based on nanotechnologyPreprint
Montoya-Álvarez, M., Gonzalez-Perez, J., & Londoño, M. E. (2022) · doi:10.14293/s2199-1006.1.sor-.ppqoq83.v2 · Cited by 4 · see citing works
Wei, T., Chen, D., Mei, H., Zheng, Z., Sheng, J., & Liu, W. (2020) · Nano LIFE · doi:10.1142/s1793984420400097 · Cited by 3 · see citing works
Self-citationWhitening Effects of Anthricin on B16F10 Cells
Shim, J. H. (2021) · doi:10.22889/kjp.2021.52.1.13 · Cited by 1 · see citing works
Flagged first, then by citations
1 of the 50 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Recent advances in encapsulation of resveratrol for enhanced delivery
Dikmetaş, D. N., Yenipazar, H., & Karaça, A. C. (2024) · Food Chemistry · doi:10.1016/j.foodchem.2024.140475 · Cited by 55 · see citing works
Photoaging: Current Concepts on Molecular Mechanisms, Prevention, and Treatment
Kaltchenko, M. V., & Chien, A. L.-L. (2025) · American Journal of Clinical Dermatology · doi:10.1007/s40257-025-00933-z · Cited by 53 · see citing works
Resveratrol-loaded invasome gel: A promising nanoformulation for treatment of skin cancer
Samir, B., El-Kamel, A. H., Zahran, N. M., & Heikal, L. (2024) · Drug Delivery and Translational Research · doi:10.1007/s13346-024-01534-9 · Cited by 48 · see citing works
Zhang, S. M., Zhou, H. W., Chen, X., Zhu, S., Chen, D., Luo, D., Chen, S., & Liu, W. (2024) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.3c16608 · Cited by 43 · see citing works
Self-citationKalita, P., Chakrabarti, S., Bhattacharjee, B., Paul, S., Dutta, P. P., & Pachuau, L. (2025) · Food Chemistry · doi:10.1016/j.foodchem.2025.145087 · Cited by 42 · see citing works
Nanocarriers for natural polyphenol senotherapeutics
Joma, N., Bielawski, P., Saini, A., Kakkar, A. K., & Maysinger, D. (2024) · Aging Cell · doi:10.1111/acel.14178 · Cited by 33 · see citing works
Lombardi, F., Augello, F. R., Ciafarone, A., Ciummo, V., Altamura, S., Cinque, B., & Palumbo, P. (2024) · Biomolecules · doi:10.3390/biom14091066 · Cited by 33 · see citing works
Cosmeceuticals in photoaging: A review.
Chan, L. K. W., Lee, K. W. A., Lee, C. H., Lam, K. W. P., Lee, K. F. V., Wu, R., Wan, J., Shivananjappa, S., Sky, W. T. H., Choi, H., et al. (2024) · Skin Research and Technology · doi:10.1111/srt.13730 · Cited by 23 · see citing works
Cui, Q., & Wang, H. (2025) · Clinical Cosmetic and Investigational Dermatology · doi:10.2147/ccid.s543849 · Cited by 21 · see citing works
Innovative Plant Exosome Delivery System for Enhancing Antiaging Potency on Skin
Wei, W., Ren, X., Fan, Y., Zhang, X., Hou, J., Zhang, Z., Yuan, L., Li, L., & Gao, Q. (2025) · ACS Applied Bio Materials · doi:10.1021/acsabm.4c01691 · Cited by 19 · see citing works
Self-citationApplication of nanotechnology in anti-aging cosmetics: advantages, challenges, and prospects
Pan, X., Zhong, Z., Hu, X., Wu, J., Huang, W., Li, W., Zhao, Y., Xie, Y., Huang, Y., Liang, J., et al. (2025) · Polymer Bulletin · doi:10.1007/s00289-025-05903-3 · Cited by 13 · see citing works
Azeredo, P. D. S., Fan, D., Murphy, E. A., & Carver, W. E. (2024) · Cells · doi:10.3390/cells13050421 · Cited by 10 · see citing works
Liang, X. H., Lü, C., Zheng, F., Lan, Z., Wang, H., Shafiq, M., Pan, X., Chen, H., & Ma, M. (2025) · Biomedicines · doi:10.3390/biomedicines13020322 · Cited by 10 · see citing works
Glabridin-encapsulated liposomes targeting melanocytes through the melanocortin 1 receptor
Cheng, L., Xu, J., Wang, A., Hou, S., & Li, A. (2025) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2025.114979 · Cited by 10 · see citing works
Hidden Links Between Skin Microbiome and Skin Imaging Phenome
Cheng, M., Zhou, H. W., Zhang, H., Zhang, X., Zhang, S. M., Bai, H. W., Zha, Y., Luo, D., Chen, D., Chen, S., et al. (2024) · Genomics Proteomics & Bioinformatics · doi:10.1093/gpbjnl/qzae040 · Cited by 9 · see citing works
Self-citationYang, F., Wang, H., Luo, D., Deng, J., Hu, Y., Liu, Z., & Liu, W. (2025) · Pharmaceutics · doi:10.3390/pharmaceutics17080956 · Cited by 9 · see citing works
Self-citationTu, Y., Li, N., Liu, H., Sun, D., He, L., & Gu, H. (2025) · Scientific Reports · doi:10.1038/s41598-025-01960-w · Cited by 8 · see citing works
Nanostructured Lipid Carriers: A Revolutionary Approach in Antifungal Drug Delivery
Mahapatra, M., Mohapatra, S., & Jena, G. K. (2025) · Biomedical Materials & Devices · doi:10.1007/s44174-025-00277-6 · Cited by 7 · see citing works
Wang, Y., Deng, J., Wang, X., Luo, D., Ren, S., Guo, X., Chen, D., Liu, R. R., Chen, S., & Liu, W. (2025) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2025.107648 · Cited by 6 · see citing works
Self-citationPolyphenol-Mediated Nanoparticle Synthesis: Insights Into Their Role in Size and Shape Control
Abdulmumin, A. G., Garba, D., Adamu, H. I., & Akinpelu, Z. M. (2026) · Chemistry Africa · doi:10.1007/s42250-026-01614-y · Cited by 6 · see citing works
Shang, G., Niu, X., Tong, Q., Zhao, Y., Yin, J., Zhou, X., Xu, J., Cao, Y., Cheng, F.-F., Bao, B., et al. (2023) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2023.117482 · Cited by 6 · see citing works
Yu, X., Liu, S., Li, Y., & Yuan, S. (2025) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2025.114725 · Cited by 6 · see citing works
Phytochemical nanoliposomes: next-generation therapeutics in precision oncology
Sowmiya, S., Suseela, V., & Jeyaramraja, P. R. (2025) · Nano Express · doi:10.1088/2632-959x/ae2041 · Cited by 5 · see citing works
Wang, Y., Wang, M., He, X., Wei, Y., Liang, Z., Ma, S., Wu, Y., Liu, Q., Wang, J., Wang, J., et al. (2023) · Journal of the mechanical behavior of biomedical materials/Journal of mechanical behavior of biomedical materials · doi:10.1016/j.jmbbm.2023.106342 · Cited by 5 · see citing works
Zhang, Z., Wang, P., Liu, H., Wang, H., Zhen, M., He, X., Gao, S., Xie, J., & Xie, J. (2025) · Bioengineering & Translational Medicine · doi:10.1002/btm2.70016 · Cited by 4 · see citing works
Liu, C., Yan, Z., Chen, X., Mandal, S., Das, U., Singh, S. K., & Olatunji, O. J. (2025) · Fitoterapia · doi:10.1016/j.fitote.2025.107034 · Cited by 4 · see citing works
Self-citationTherapeutic potential of r esveratrol: n ovel b iological and p harmacological p erspectives
Ashrafizadeh, M. (2025) · Journal of Basic and Clinical Physiology and Pharmacology · doi:10.1515/jbcpp-2024-0211 · Cited by 4 · see citing works
Nikmehr, M. M., Mohammadi, M., Mirzaei, F., & Vafaei, S. Y. (2025) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2025.126389 · Cited by 3 · see citing works
Herbal Nanocosmeceuticals: The Ultimate Fusion of Science and Nature
Konaparthi, S. B., Guduru, M. R., Anumalasetti, A., Kakad, K. S., & Nawale, S. (2024) · Pharmacophore · doi:10.51847/9bmyopsrjn · Cited by 2 · see citing works
Transdermal delivery materials for polyphenols in whitening and anti-aging applications
Liu, H., Feng, W., Chen, R., Wang, X., Hua, P., & Chen, M. (2025) · Biomaterials Science · doi:10.1039/d5bm01144b · Cited by 2 · see citing works
Barik, B., Taj, T., Fatima, R., Dey, S., Rahaman, S. A., Pal, R., Ashique, S., Hussain, M. S., Yasmin, S., Khalid, M., et al. (2026) · Journal of Liposome Research · doi:10.1080/08982104.2026.2664876 · Cited by 2 · see citing works
Beheshtkhoo, N., Kouhbanani, M. A. J., Daghighi, S. M., Shakouri-Nikjeh, M., Esmaeili, Z., Khosravani, M., & Adabi, M. (2025) · Journal of Liposome Research · doi:10.1080/08982104.2025.2476529 · Cited by 2 · see citing works
Lee, E., Wang, Y., Lee, K., & Lee, K. (2025) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2025.107783 · Cited by 1 · see citing works
Wang, H., Jiang, J., Kang, W., Zhao, B., & Ma, Y. (2025) · Journal of Natural Medicines · doi:10.1007/s11418-025-01969-5 · Cited by 1 · see citing works
Vaiss, D. P., Dias, D. C. C., Yurgel, V. C., Araujo, F. B. V., Porto, L. C., Burkert, J. F. D. M., Marinho, M. A. G., Filgueira, D. D. M. V. B., & Dora, C. L. (2026) · Pharmaceutics · doi:10.3390/pharmaceutics18010109 · Cited by 1 · see citing works
He, F., Qi, Y., Xu, Y., & Shan, J. (2026) · Food Research International · doi:10.1016/j.foodres.2026.119547 · Cited by 1 · see citing works
Zoweil, M., Aboushady, D., Kamel, A. S. E. D., Tadros, M. I., Mansour, S., & Rady, M. (2026) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2026.115206 · Cited by 1 · see citing works
Novel Delivery Approaches and Therapeutic Potential of Resveratrol – A Review
Nooreen, Z., Rai, A. K., Wal, P., Bhise, M. R., Balaji, J., & Gasmi, A. (2025) · Current Chemical Biology · doi:10.2174/0122127968347682250110051811 · Cited by 1 · see citing works
Zhang, X., Wang, J., Kang, J., Li, J., Li, J., Guo, C., Hao, Z., & Liu, D. (2026) · Chemical Research in Chinese Universities · doi:10.1007/s40242-026-6027-y · Cited by 1 · see citing works
Self-citationZhang, D., Chittasupho, C., & Jiranusornkul, S. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27083451 · Cited by 1 · see citing works
Unveiling the therapeutic properties of resveratrol: Health benefits and clinical data
Garg, Y., Sharma, N., Narang, R. K., & Singh, A. (2026) · PharmaNutrition · doi:10.1016/j.phanu.2026.100521 · Cited by 1 · see citing works
Bălăceanu-Gurău, B., Sotiri, I., Girštautė, P., Șmocot-Stănescu, A. P., Voinea, I.-A., Bărbulescu, A.-L., & Cortese, A. (2026) · Molecules · doi:10.3390/molecules31152563 · Cited by 1 · see citing works
Nanoliposomes in skincare products
Simões, S., Jovanović, A., Ali, N., Ribeiro, A. R., Pereira‐Leite, C., Aruci, E., Colley, H. E., & Lima, S. A. C. (2025) · Elsevier eBooks · doi:10.1016/b978-0-443-30184-1.00022-3
The Role of Phospholipids in Skin Health and Organism Aging
任, 雪. (2026) · Advances in Clinical Medicine · doi:10.12677/acm.2026.163892
Hou, B., Ma, D., Yang, K., Peng, M., Liu, Q., Heng, Z., Chen, S., & Liu, W. (2026) · Journal of Pharmaceutical Innovation · doi:10.1007/s12247-026-10594-y
Self-citationAntineoplastic, longevity, and antimutagenic effect of resveratrol
Acar, A., Aydemir, E., & Kaya, B. (2026) · Aging Medicine and Healthcare · doi:10.4103/amah.amh-2025-04-037
Li, J., Luo, D., Deng, J., Junpeng, Y., Han, R., Wang, S., Zhou, J., Liu, W., & Cui, B. (2026) · Current Drug Delivery · doi:10.2174/0115672018426483251223115253
Self-citationProcess, Evaluation, and New Trends of Skin Antioxidant Strategies
唐, 榕. (2026) · Hans Journal of Biomedicine · doi:10.12677/hjbm.2026.163045
Transdermal drug delivery systems in cancer therapy: advances, challenges, and future perspectives
Arghidash, F., Judaki, A. A., Nejad, M. M. S., Nazari, E. L. H. A. M., & Rezaei–Tavirani, M. (2026) · European Journal of Clinical Pharmacology · doi:10.1007/s00228-026-04086-8
Precise assessment of facial skin based on multimodal data fusion of the microbiome
Meng, F., Zhang, J., Yuan, C., Li, R., Sun, Y., Jiang, H., Yang, S., Li, Y., & Su, X. (2026) · Quantitative Biology · doi:10.1002/qub2.70046
Cutaneous Photoaging: A Review of Melasma and Nanotechnological Approaches to Its Control
Figueiredo, D. M. D. O., & Leite, M. V. (2026) · Dermatologic Therapy · doi:10.1155/dth/1927016
Layered lipid-protein nanoemulsions for the delivery of poorly water-soluble resveratrol
Ghosal, A., Labouta, H. I., & Bandara, N. (2026) · Food Chemistry · doi:10.1016/j.foodchem.2026.150055
Ma, Z., Huang, B., Chen, K., Yuan, R., Li, L., & Shen, Y. (2026) · Foods · doi:10.3390/foods15152646
A Review of Preparation Methods, Mechanisms, and Applications of Bio-Based Phenolic Nanoparticles
Ma, Y., Deng, W., Sun, M., Jiang, X., & Hong, J. (2026) · Foods · doi:10.3390/foods15172970
Catarino, R. I. L., Sobral, B., Pimenta, A. M., Souto, M. R. S., & Silva, F. A. M. (2026) · Applied Sciences · doi:10.3390/app16178855
Babaali, A., Majdrezaei, Z., Javad-Khayat, Y., Fereidooni, S., & Mirzapoor, A. (2026) · Next Nanotechnology · doi:10.1016/j.nxnano.2026.100742
O-methylation of phenolic natural products: translational insights from resveratrol
Habtemariam, S. (2026) · Medicinal Chemistry Research · doi:10.1007/s00044-026-03614-6
Skin Aging: From Molecular Mechanisms to Therapeutic and Technological Innovations
Chen, S., Yang, Y., Pan, X., Pan, Y., & Cai, S. (2026) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.71357
Self-citationPudžiuvelytė, L., & Paliulian, A. (2026) · Pharmaceutics · doi:10.3390/pharmaceutics18101303
Li, J., Li, S., Wen, J., Fu, J., Yao, J., Mao, S., Sun, Y., Shan, S., Zhao, C., & Liu, X. (2026) · Pharmaceuticals · doi:10.3390/ph19111722
- Authors
- Zhang, X., Chen, S., Luo, D., Chen, D., Zhou, H., Zhang, S., Chen, X., Lu, W., & Liu, W.
- Affiliations
- Huazhong University of Science and Technology (CN)
- Nanjing Tech University (CN)
- Guangzhou Jiyan Cosmetics Technology Co., Ltd., Guangzhou 510275, China
- Corresponding author
- Lu, Wangwang
- Liu, Wei
- Venue
- Molecules
- Publisher
- MDPI AG
- Published
- 2023-03-17
- Volume
- 28
- Issue
- 6
- Pages
- 2738
- ISSN
- 1420-3049 (ISSN-L)
- PMC
- PMC10058087
- OpenAlex
- W4327972600
- Cited by
- 60
- References
- 50
- Citations by year
- 2026: 25 · 2025: 23 · 2024: 10 · 2023: 2
- FWCI
- 6.55
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Molecules (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- National Natural Science Foundation of China (31470968, 32101068, 2020YFA071070)
- National Key R & D Program of Nanotechnology of China (31470968, 32101068, 2020YFA071070)
- Nanjing Overseas Students Merit-Based Program Funding (31470968, 32101068, 2020YFA071070)
- Topics
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advancements in Transdermal Drug Delivery
- Health Sciences › Medicine › Dermatology › Skin Protection and Aging
- Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
- Keywords
- resveratrol, nanoliposomes, transdermal drug delivery, anti-aging, skin lightening, high-pressure homogenization, 3D skin model, collagen synthesis, matrix metalloproteinases, melanogenesis, antioxidant capacity, stratum corneum barrier, topical formulation
- MeSH terms
- Resveratrol, Administration, Cutaneous, Aging, Humans, Skin, Skin Absorption, Drug Delivery Systems
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
