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Cited by 15Inflammatory Bowel DiseasePhytochemistry and biological activity of medicinal plantsNatural Compounds in Disease Treatment

Beneficial Effects of Hordenine on a Model of Ulcerative Colitis

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Xu, Zhengguang, Zhang, Qilian, Ding, Ce, Wen, Feifei, Sun, Fang, Liu, Yanzhan, Tao, Chunxue, Yao, Jing·2023·Molecules
DOI 10.3390/molecules28062834PMC PMC10054341
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Abstract

Hordenine, a phenethylamine alkaloid, is found in a variety of plants and exhibits a broad array of biological activities and pharmacological properties, including anti-inflammatory and anti-fibrotic effects. However, the efficacy and underlying mechanisms of hordenine in treating ulcerative colitis (UC) remain unclear. To address this, we examined the therapeutic effects of hordenine on dextran sodium sulphate (DSS)-induced UC by comparing disease activity index (DAI), colon length, secretion of inflammatory factors, and degree of colonic histological lesions across diseased mice that were and were not treated with hordenine. We found that hordenine significantly reduced DAI and levels of pro-inflammatory factors, including interleukin (IL)-6, IL-1β, and tumor necrosis factor alpha (TNF-α), and also alleviated colon tissue oedema, colonic lesions, inflammatory cells infiltration and decreased the number of goblet cells. Moreover, in vitro experiments showed that hordenine protected intestinal epithelial barrier function by increasing the expression of tight junction proteins including ZO-1 and occludin, while also promoting the healing of intestinal mucosa. Using immunohistochemistry and western blotting, we demonstrated that hordenine reduced the expression of sphingosine kinase 1 (SPHK1), sphingosine-1-phosphate receptor 1 (S1PR1), and ras-related C3 botulinum toxin substrate 1 (Rac1), and it inhibited the expression of phosphorylated signal transducer and activator of transcription 3 (p-STAT3) in colon tissues. Thus, hordenine appears to be effective in UC treatment owing to pharmacological mechanisms that favor mucosal healing and the inhibition of SPHK-1/S1PR1/STAT3 signaling.

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  1. [1]Chen M. Ding Y. Tong Z. Efficacy and Safety of Sophora flavescens (Kushen) Based Traditional Chinese Medicine in the Treatment of Ulcerative Colitis: Clinical Evidence and Potential Mechanisms Front. Pharmacol. 2020 11 603476 10.3389/fphar.2020.603476 33362558 PMC7758483 · DOI
  2. [2]He Z. Zhou Q. Wen K. Wu B. Sun X. Wang X. Chen Y. Huangkui Lianchang Decoction Ameliorates DSS-Induced Ulcerative Colitis in Mice by Inhibiting the NF-kappaB Signaling Pathway Evid.-Based Complement. Altern. Med. 2019 2019 1040847 10.1155/2019/1040847 31093294 PMC6481129 · DOI
  3. [3]Kucharzik T. Koletzko S. Kannengiesser K. Dignass A. Ulcerative Colitis-Diagnostic and Therapeutic Algorithms Dtsch. Ärzteblatt Int. 2020 117 564 574 10.3238/arztebl.2020.0564 33148393 PMC8171548 · DOI
  4. [4]Choi Y.A. Kang O.H. Park H.J. Tae J. Kim D.K. Kang C.S. Choi S.C. Yun K.J. Choi S.J. Nah Y.H. Effect of processed Scutellaria baicalensis on dextran sulfate sodium-induced colitis in mice Int. J. Mol. Med. 2005 16 667 672 10.3892/ijmm.16.4.667 16142402 · DOI
  5. [5]Panés J. Gisbert J.P. Efficacy of tofacitinib treatment in ulcerative colitis Gastroenterol. Hepatol. 2019 42 403 412 10.1016/j.gastrohep.2019.03.002 31101342 · DOI
  6. [6]Kaur A. Goggolidou P. Ulcerative colitis: Understanding its cellular pathology could provide insights into novel therapies J. Inflamm. 2020 17 15 10.1186/s12950-020-00246-4 PMC7175540 32336953 · DOI
  7. [7]Wang W. Xu C. Li X. Wang Z. Yang J. Shen Y. Shi M. Chen L. Zhang L. Guo Y. Exploration of the potential mechanism of Banxia Xiexin Decoction for the effects on TNBS-induced ulcerative colitis rats with the assistance of network pharmacology analysis J. Ethnopharmacol. 2021 277 114197 10.1016/j.jep.2021.114197 34004261 · DOI
  8. [8]Wehkamp J. Stange E.F. Recent advances and emerging therapies in the non-surgical management of ulcerative colitis F1000Research 2018 7 1207 10.12688/f1000research.15159.1 PMC6081982 30135722 · DOI
  9. [9]Ye Q. Hu Z. Yang M. Qin K. Zhou Y. Effects and mechanisms of Chinese herbal medicine for ulcerative colitis: Protocol for a systematic review and meta-analysis Medicine 2020 99 e19768 10.1097/MD.0000000000019768 32311981 PMC7220501 · DOI
  10. [10]Park S.B. Choi B.I. Lee B.J. Kim N.J. Jeong Y.A. Joo M.K. Kim H.J. Park J.J. Kim J.S. Noh Y.S. Intestinal Epithelial Deletion of Sphk1 Prevents Colitis-Associated Cancer Development by Inhibition of Epithelial STAT3 Activation Dig. Dis. Sci. 2020 65 2284 2293 10.1007/s10620-019-05971-2 31776862 · DOI
  11. [11]Zimmer J. Takahashi T. Duess J.W. Hofmann A.D. Puri P. Upregulation of S1P1 and Rac1 receptors in the pulmonary vasculature of nitrofen-induced congenital diaphragmatic hernia Pediatr. Surg. Int. 2016 32 147 154 10.1007/s00383-015-3825-6 26543024 · DOI
  12. [12]Wu X. Xu J. Li X. Dai J. Wang L. Inhibition of SphK1/S1P Signaling Pathway Alleviates Fibrosis and Inflammation of Rat Myocardium after Myocardial Infarction Comput. Math. Methods Med. 2022 2022 5985375 10.1155/2022/5985375 35872958 PMC9300330 · DOI
  13. [13]Jin Z. Li H. Hong X. Ying G. Lu X. Zhuang L. Wu S. TRIM14 promotes colorectal cancer cell migration and invasion through the SPHK1/STAT3 pathway Cancer Cell Int. 2018 18 202 10.1186/s12935-018-0701-1 30555277 PMC6288942 · DOI
  14. [14]Hart P.C. Chiyoda T. Liu X. Weigert M. Curtis M. Chiang C.Y. Loth R. Lastra R. McGregor S.M. Locasale J.W. SPHK1 Is a Novel Target of Metformin in Ovarian Cancer Mol. Cancer Res. 2019 17 870 881 10.1158/1541-7786.MCR-18-0409 30655321 PMC6445689 · DOI
  15. [15]Chen L. Li L. Song Y. Lv T. Blocking SphK1/S1P/S1PR1 Signaling Pathway Alleviates Lung Injury Caused by Sepsis in Acute Ethanol Intoxication Mice Inflammation 2021 44 2170 2179 10.1007/s10753-021-01490-3 34109517 PMC8189277 · DOI
  16. [16]Mao Y. Kleinjan M.L. Jilishitz I. Swaminathan B. Obinata H. Komarova Y.A. Bayless K.J. Hla T. Kitajewski J.K. CLIC1 and CLIC4 mediate endothelial S1P receptor signaling to facilitate Rac1 and RhoA activity and function Sci. Signal. 2021 14 eabc0425 10.1126/scisignal.abc0425 33879602 PMC8722429 · DOI
  17. [17]Yao J. Liu T. Chen R.J. Liang J. Li J. Wang C.G. Sphingosine-1-phosphate signal transducer and activator of transcription 3 signaling pathway contributes to baicalein-mediated inhibition of dextran sulfate sodium-induced experimental colitis in mice Chin. Med. J. (Engl.) 2020 133 292 300 10.1097/CM9.0000000000000627 31904729 PMC7004614 · DOI
  18. [18]Suh J.H. Degagné É. Gleghorn E.E. Setty M. Rodriguez A. Park K.T. Verstraete S.G. Heyman M.B. Patel A.S. Irek M. Sphingosine-1-Phosphate Signaling and Metabolism Gene Signature in Pediatric Inflammatory Bowel Disease: A Matched-case Control Pilot Study Inflamm. Bowel Dis. 2018 24 1321 1334 10.1093/ibd/izy007 29788359 PMC5986285 · DOI
  19. [19]Song S. Min H. Niu M. Wang L. Wu Y. Zhang B. Chen X. Liang Q. Wen Y. Wang Y. S1PR1 predicts patient survival and promotes chemotherapy drug resistance in gastric cancer cells through STAT3 constitutive activation EBioMedicine 2018 37 168 176 10.1016/j.ebiom.2018.10.005 30316864 PMC6284371 · DOI
  20. [20]Deng S. Zhou X. Ge Z. Song Y. Wang H. Liu X. Zhang D. Exosomes from adipose-derived mesenchymal stem cells ameliorate cardiac damage after myocardial infarction by activating S1P/SK1/S1PR1 signaling and promoting macrophage M2 polarization Int. J. Biochem. Cell. Biol. 2019 114 105564 10.1016/j.biocel.2019.105564 31276786 · DOI
  21. [21]Sugimoto K. Role of STAT3 in inflammatory bowel disease World J. Gastroenterol. 2008 14 5110 5114 10.3748/wjg.14.5110 18777586 PMC2743999 · DOI
  22. [22]Pang L. Huynh J. Alorro M.G. Li X. Ernst M. Chand A.L. STAT3 Signalling via the IL-6ST/gp130 Cytokine Receptor Promotes Epithelial Integrity and Intestinal Barrier Function during DSS-Induced Colitis Biomedicines 2021 9 187 10.3390/biomedicines9020187 33673239 PMC7918037 · DOI
  23. [23]Nguyen P.M. Putoczki T.L. Ernst M. STAT3-Activating Cytokines: A Therapeutic Opportunity for Inflammatory Bowel Disease? J. Interf. Cytok. Res. 2015 35 340 350 10.1089/jir.2014.0225 PMC4426323 25760898 · DOI
  24. [24]Mitsuyama K. Matsumoto S. Masuda J. Yamasakii H. Kuwaki K. Takedatsu H. Sata M. Therapeutic strategies for targeting the IL-6/STAT3 cytokine signaling pathway in inflammatory bowel disease Anticancer Res. 2007 27 3749 3756 17970038
  25. [26]Kim S.C. Lee J.H. Kim M.H. Lee J.A. Kim Y.B. Jung E. Kim Y.S. Lee J. Park D. Hordenine, a single compound produced during barley germination, inhibits melanogenesis in human melanocytes Food Chem. 2013 141 174 181 10.1016/j.foodchem.2013.03.017 23768344 · DOI
  26. [28]Anwar S. Mohammad T. Shamsi A. Queen A. Parveen S. Luqman S. Hasan G.M. Alamry K.A. Azum N. Asiri A.M. Discovery of Hordenine as a Potential Inhibitor of Pyruvate Dehydrogenase Kinase 3: Implication in Lung Cancer Therapy Biomedicines 2020 8 119 10.3390/biomedicines8050119 32422877 PMC7277448 · DOI
  27. [29]Hahn M. Lindemann V. Behrens M. Mulac D. Langer K. Esselen M. Humpf H.U. Permeability of dopamine D2 receptor agonist hordenine across the intestinal and blood-brain barrier in vitro PLoS ONE 2022 17 e0269486 10.1371/journal.pone.0269486 35709159 PMC9202863 · DOI
  28. [30]Su S. Cao M. Wu G. Long Z. Cheng X. Fan J. Xu Z. Su H. Hao Y. Li G. Hordenine protects against hyperglycemia-associated renal complications in streptozotocin-induced diabetic mice Biomed. Pharmacother. 2018 104 315 324 10.1016/j.biopha.2018.05.036 29775900 · DOI
  29. [31]Hassan S.T.S. Shedding Light on the Effect of Natural Anti-Herpesvirus Alkaloids on SARS-CoV-2: A Treatment Option for COVID-19 Viruses 2020 12 476 10.3390/v12040476 32340120 PMC7232216 · DOI
  30. [32]Rao G.S. Identity of peyocactin, an antibiotic from peyote (Lophophora williamsii), and hordenine J. Pharm. Pharmacol. 1970 22 544 545 10.1111/j.2042-7158.1970.tb10566.x 4395066 · DOI
  31. [33]Zhang Q. Wen F. Sun F. Xu Z. Liu Y. Tao C. Sun F. Jiang M. Yang M. Yao J. Efficacy and Mechanism of Quercetin in the Treatment of Experimental Colitis Using Network Pharmacology Analysis Molecules 2022 28 146 10.3390/molecules28010146 36615338 PMC9822290 · DOI
  32. [34]Chassaing B. Aitken J.D. Malleshappa M. Vijay-Kumar M. Dextran sulfate sodium (DSS)-induced colitis in mice Curr. Protoc. Immunol. 2014 104 15.25.11 15.25.14 10.1002/0471142735.im1525s104 24510619 PMC3980572 · DOI
  33. [35]Cardiff R.D. Miller C.H. Munn R.J. Manual hematoxylin and eosin staining of mouse tissue sections Cold Spring Harb. Protoc. 2014 2014 655 658 10.1101/pdb.prot073411 24890205 · DOI
  34. [36]Ding F. Wu J. Liu C. Bian Q. Qiu W. Ma Q. Li X. Long M. Zou X. Chen J. Effect of Xiaoyaosan on Colon Morphology and Intestinal Permeability in Rats with Chronic Unpredictable Mild Stress Front. Pharmacol. 2020 11 1069 10.3389/fphar.2020.01069 32765272 PMC7378849 · DOI
  35. [37]Yao J. Pan D. Zhao Y. Zhao L. Sun J. Wang Y. You Q.D. Xi T. Guo Q.L. Lu N. Wogonin prevents lipopolysaccharide-induced acute lung injury and inflammation in mice via peroxisome proliferator-activated receptor gamma-mediated attenuation of the nuclear factor-kappaB pathway Immunology 2014 143 241 257 10.1111/imm.12305 24766487 PMC4172140 · DOI
  36. [38]Yao J. Zhao L. Zhao Q. Zhao Y. Sun Y. Zhang Y. Miao H. You Q.D. Hu R. Guo Q.L. NF-κB and Nrf2 signaling pathways contribute to wogonin-mediated inhibition of inflammation-associated colorectal carcinogenesis Cell Death Dis. 2014 5 e1283 10.1038/cddis.2014.221 24901054 PMC4611709 · DOI
  37. [39]Yu M. Wang Q. Ma Y. Li L. Yu K. Zhang Z. Chen G. Li X. Xiao W. Xu P. Aryl Hydrocarbon Receptor Activation Modulates Intestinal Epithelial Barrier Function by Maintaining Tight Junction Integrity Int. J. Biol. Sci. 2018 14 69 77 10.7150/ijbs.22259 29483826 PMC5821050 · DOI · Paper page
  38. [40]Patel A. Vanecha R. Patel J. Patel D. Shah U. Bambharoliya T. Development of Natural Bioactive Alkaloids: Anticancer Perspective Mini-Rev. Med. Chem. 2022 22 200 212 10.2174/1389557521666210712111331 34254913 · DOI
  39. [41]Peng J. Zheng T.T. Li X. Liang Y. Wang L.J. Huang Y.C. Xiao H.T. Plant-Derived Alkaloids: The Promising Disease-Modifying Agents for Inflammatory Bowel Disease Front. Pharmacol. 2019 10 351 10.3389/fphar.2019.00351 31031622 PMC6473079 · DOI
  40. [42]Souza C.R.M. Bezerra W.P. Souto J.T. Marine Alkaloids with Anti-Inflammatory Activity: Current Knowledge and Future Perspectives Mar Drugs 2020 18 147 10.3390/md18030147 32121638 PMC7142576 · DOI
  41. [43]Eichele D.D. Kharbanda K.K. Dextran sodium sulfate colitis murine model: An indispensable tool for advancing our understanding of inflammatory bowel diseases pathogenesis World. J. Gastroenterol. 2017 23 6016 6029 10.3748/wjg.v23.i33.6016 28970718 PMC5597494 · DOI
  42. [44]Tang P. Zha L. Ye C. Zhou L. Research progress on the carcinogenesis mechanism of inflammation in ulcerative colitis: A narrative review Ann. Palliat. Med. 2021 10 11994 12002 10.21037/apm-21-3138 34872322 · DOI
  43. [45]Yu W. Cheng H. Zhu B. Yan J. Network Pharmacology-Based Validation of the Efficacy of Huiyangjiuji Decoction in the Treatment of Experimental Colitis Front. Pharmacol. 2021 12 666432 10.3389/fphar.2021.666432 34122086 PMC8193934 · DOI
  44. [46]Sun J. Zhao P. Ding X. Li F. Jiang J. Huang H. Ji L. Cayratia japonica Prevents Ulcerative Colitis by Promoting M2 Macrophage Polarization through Blocking the TLR4/MAPK/NF-kappaB Pathway Mediators Inflamm. 2022 2022 1108569 10.1155/2022/1108569 36619207 PMC9822765 · DOI
  45. [47]He R. Li Y. Han C. Lin R. Qian W. Hou X. L-Fucose ameliorates DSS-induced acute colitis via inhibiting macrophage M1 polarization and inhibiting NLRP3 inflammasome and NF-kB activation Int. Immunopharmacol. 2019 73 379 388 10.1016/j.intimp.2019.05.013 31132733 · DOI
  46. [48]Wu M.M. Wang Q.M. Huang B.Y. Mai C.T. Wang C.L. Wang T.T. Zhang X.J. Dioscin ameliorates murine ulcerative colitis by regulating macrophage polarization Pharmacol. Res. 2021 172 105796 10.1016/j.phrs.2021.105796 34343656 · DOI
  47. [49]Chen L. Li L. Han Y. Lv B. Zou S. Yu Q. Tong-fu-li-fei decoction exerts a protective effect on intestinal barrier of sepsis in rats through upregulating ZO-1/occludin/claudin-1 expression J. Pharmacol. Sci. 2020 143 89 96 10.1016/j.jphs.2020.02.009 32173265 · DOI
  48. [50]Liu X. Zhu H. Curcumin Improved Intestinal Epithelial Barrier Integrity by Up-Regulating ZO-1/Occludin/Claudin-1 in Septic Rats Evid.-Based Complement. Altern. Med. 2022 2022 2884522 10.1155/2022/2884522 PMC9197639 35711494 · DOI
  49. [51]Suh J.H. Saba J.D. Sphingosine-1-phosphate in inflammatory bowel disease and colitis-associated colon cancer: The fat’s in the fire Transl. Cancer Res. 2015 4 469 483 10.3978/j.issn.2218-676X.2015.10.06 27011900 PMC4800486 · DOI
  50. [52]Snider A.J. Ali W.H. Sticca J.A. Coant N. Ghaleb A.M. Kawamori T. Yang V.W. Hannun Y.A. Obeid L.M. Distinct roles for hematopoietic and extra-hematopoietic sphingosine kinase-1 in inflammatory bowel disease PLoS ONE 2014 9 e113998 10.1371/journal.pone.0113998 25460165 PMC4252067 · DOI
  51. [53]Yuza K. Nagahashi M. Shimada Y. Nakano M. Tajima Y. Kameyama H. Nakajima M. Takabe K. Wakai T. Upregulation of phosphorylated sphingosine kinase 1 expression in colitis-associated cancer J. Surg. Res. 2018 231 323 330 10.1016/j.jss.2018.05.085 30278948 · DOI
  52. [54]Zhang Y.G. Zhu X. Lu R. Messer J.S. Xia Y. Chang E.B. Sun J. Intestinal epithelial HMGB1 inhibits bacterial infection via STAT3 regulation of autophagy Autophagy 2019 15 1935 1953 10.1080/15548627.2019.1596485 30894054 PMC6844505 · DOI
  53. [55]Bao Y. Li K. Guo Y. Wang Q. Li Z. Yang Y. Chen Z. Wang J. Zhao W. Zhang H. Tumor suppressor PRSS8 targets Sphk1/S1P/Stat3/Akt signaling in colorectal cancer Oncotarget 2016 7 26780 26792 10.18632/oncotarget.8511 27050145 PMC5042014 · DOI
  54. [57]Degagné E. Pandurangan A. Bandhuvula P. Kumar A. Eltanawy A. Zhang M. Yoshinaga Y. Nefedov M. de Jong P.J. Fong L.G. Sphingosine-1-phosphate lyase downregulation promotes colon carcinogenesis through STAT3-activated microRNAs J. Clin. Investig. 2014 124 5368 5384 10.1172/JCI74188 25347472 PMC4348973 · DOI
  55. [58]Nguyen A.V. Wu Y.Y. Lin E.Y. STAT3 and sphingosine-1-phosphate in inflammation-associated colorectal cancer World J. Gastroenterol. 2014 20 10279 10287 10.3748/wjg.v20.i30.10279 25132744 PMC4130835 · DOI
  56. [59]Yu C. Zhang S. Song L. Wang Y. Hwaiz R. Luo L. Thorlacius H. Rac1 signaling regulates neutrophil-dependent tissue damage in experimental colitis Eur. J. Pharmacol. 2014 741 90 96 10.1016/j.ejphar.2014.07.039 25084221 · DOI
  57. [60]Mouawad F. Tsui H. Takano T. Role of Rho-GTPases and their regulatory proteins in glomerular podocyte function Can. J. Physiol. Pharmacol. 2013 91 773 782 10.1139/cjpp-2013-0135 24144047 · DOI
  58. [61]Jiang J.X. Zhang S.J. Shen H.J. Guan Y. Liu Q. Zhao W. Jia Y.L. Shen J. Yan X.F. Xie Q.M. Rac1 signaling regulates cigarette smoke-induced inflammation in the lung via the Erk1/2 MAPK and STAT3 pathways BBA-Mol. Basis Dis. 2017 1863 1778 1788 10.1016/j.bbadis.2017.04.013 28428003 · DOI

Cited by

Sorted by citations

Authors
Xu, Z., Zhang, Q., Ding, C., Wen, F., Sun, F., Liu, Y., Tao, C., & Yao, J.
Affiliations
  • Jining Medical University (CN)
  • Weifang Medical University (CN)
Corresponding author
Yao, Jing
ORCID
Venue
Molecules
Publisher
MDPI AG
Published
2023-03-21
Volume
28
Issue
6
Pages
2834
ISSN
1420-3049 (ISSN-L)
DOI
10.3390/molecules28062834
PMC
PMC10054341
OpenAlex
W4353072654
Cited by
15
References
3
Citations by year
2026: 5 · 2025: 9 · 2024: 1
FWCI
2.46
Type
journal article
Language
en
Update notices
correction (2023-03-21)
Open access
Licence
Locations
  • Molecules (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
  • National Natural Science Foundation of China (81603143, 2020Q060, M-2022247, JYHL2021MS30, JYHL2021FMS13, cx2022006z, s202210443013, JYSJ2022B44)
  • Shandong Traditional Chinese Medicine Science and Technology Project (81603143, 2020Q060, M-2022247, JYHL2021MS30, JYHL2021FMS13, cx2022006z, s202210443013, JYSJ2022B44)
  • Research Fund for Lin He’s Academician Workstation of New Medicine and Clinical Translation in Jining Medical University (81603143, 2020Q060, M-2022247, JYHL2021MS30, JYHL2021FMS13, cx2022006z, s202210443013, JYSJ2022B44)
  • Training Program of Innovation and Entrepreneurship for Undergraduates (81603143, 2020Q060, M-2022247, JYHL2021MS30, JYHL2021FMS13, cx2022006z, s202210443013, JYSJ2022B44)
  • Scientific Research and Innovation Team of Jining Medical University (Cultivation): Digestive System Inflammation and Tumour Molecular Pharmacology Research Innovation Team (81603143, 2020Q060, M-2022247, JYHL2021MS30, JYHL2021FMS13, cx2022006z, s202210443013, JYSJ2022B44)
  • Practical Teaching Education Research Project of Jining Medical University (81603143, 2020Q060, M-2022247, JYHL2021MS30, JYHL2021FMS13, cx2022006z, s202210443013, JYSJ2022B44)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Inflammatory Bowel Disease
  • Life Sciences › Agricultural and Biological Sciences › Plant Science › Phytochemistry and biological activity of medicinal plants
  • Health Sciences › Medicine › Complementary and alternative medicine › Natural Compounds in Disease Treatment
Keywords
hordenine, ulcerative colitis, DSS-induced colitis, anti-inflammatory activity, intestinal epithelial barrier, tight junction proteins, sphingosine kinase 1, S1PR1, Rac1, STAT3 signaling, mucosal healing, goblet cells, inflammatory cytokines
MeSH terms
Animals, Anti-Inflammatory Agents, Colitis, Colitis, Ulcerative, Colon, Disease Models, Animal, Mice, Inbred C57BL, Tyramine, Interleukin-6, Dextran Sulfate, Mice

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