Cited by 26Neuroinflammation and Neurodegeneration MechanismsParkinson's Disease Mechanisms and TreatmentsNuclear Receptors and Signaling

Hordenine inhibits neuroinflammation and exerts neuroprotective effects via inhibiting NF-κB and MAPK signaling pathways in vivo and in vitro

Su, Yingchun, Liu, Yanting, He, Dewei, Hu, Guiqiu, Wang, Hefei, Ye, Bojian, He, Yuan, Gao, Xiyu +1 more·2022·International Immunopharmacology

Abstract

Parkinson's disease (PD) is a usual disease caused by degeneration of the central nervous system, which features the denaturation and death of dopaminergic neurons in the substantia nigra compact (SNc) of the midbrain. Neuroinflammation casts a consequential role in its pathogenesis, and the excessive activation of microglia as a major part of neuroinflammation cannot be ignored. Studies have indicated that Hordenine (HOR) functioned widely as an anti-oxidant and anti-inflammatory substance, but there are no reports on neuroinflammation effects. Therefore, this study is devoted to exploring the effect of HOR on neuroinflammation and its specific mechanism. In vivo, results revealed that HOR depressed the activation of microglia in SNc and protected dopaminergic neurons in the 6-hydroxydopamine (6-OHDA)-induced PD rat model, which terminally reduced movement disorders and weight loss. In vitro, studies have shown that HOR can inhibit inflammatory responses triggered by lipopolysaccharide (LPS) in BV-2 cells. More profound studies have discovered that the specific anti-inflammatory mechanism is intimately associated with the NF-κB and MAPK signaling pathways. All in it together, HOR acts as a significant role in preserving dopaminergic neurons by restraining neuroinflammation mediated by activation of microglia. This may provide a potential drug for Parkinson's treatment.

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Authors
Su, Y., Liu, Y., He, D., Hu, G., Wang, H., Ye, B., He, Y., Gao, X., & Liu, D.
Affiliations
  • Jilin University (CN)
  • The Catholic University of Korea Seoul St. Mary's Hospital (KR)
Corresponding author
  • Liu, Yanting
  • Liu, Dianfeng
Venue
International Immunopharmacology
Publisher
Elsevier BV
Published
2022-07
Volume
108
Pages
108694
ISSN
1567-5769 (ISSN-L)
OpenAlex
W4220990437
Cited by
26
References
47
Citations by year
2026: 3 · 2025: 6 · 2024: 8 · 2023: 6 · 2022: 3
FWCI
2.03
Type
journal article
Language
en
Open access
closed
Locations
  • International Immunopharmacology (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Natural Science Foundation of China (31772547)
  • Fundamental Research Funds for the Central Universities
  • Jilin Scientific and Technological Development Program (20200703011ZP)
Topics
  • Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
  • Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nuclear Receptors and Signaling
Keywords
hordenine, Parkinson's disease, neuroinflammation, neuroprotection, microglial activation, dopaminergic neurons, substantia nigra pars compacta, NF-κB signaling, MAPK signaling, 6-hydroxydopamine, lipopolysaccharide, BV-2 cells, anti-inflammatory agents
MeSH terms
Neuroinflammatory Diseases, Animals, Anti-Inflammatory Agents, Cell Line, Lipopolysaccharides, Parkinson Disease, Tyramine, NF-kappa B, Microglia, Neuroprotective Agents, MAP Kinase Signaling System, Rats

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