Hordenine Protects Against Lipopolysaccharide-Induced Acute Lung Injury by Inhibiting Inflammation
Open accessAbstract
Acute lung injury (ALI) is a respiratory disease that leads to death in severe cases. Hordenine (Hor), a barley-derived natural product, has various biological activities, including anti-inflammatory, and anti-oxidation activities. We investigated the effect of Hor on lipopolysaccharide-induced ALI and its potential mechanism. The anti-inflammatory effects of Hor were detected using in vivo and in vitro models by enzyme-linked immunosorbent assay, real-time polymerase chain reaction, western blotting, and molecular docking simulations. Hor inhibited increases in the levels of inflammatory factors both in vivo and in vitro, and its anti-inflammatory effect inhibited activation of protein kinase B, nuclear factor-κB, and mitogen-activated protein kinase signaling. Hor alleviated lipopolysaccharide-induced ALI by inhibiting inflammatory cytokine increases in vivo and in vitro and shows potential for preventing inflammatory disease.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Hordenine reduced pro-inflammatory cytokine expression (IL-6, IL-1β, TNF-α) in LPS-induced acute lung injury in mice.
“Zhang et al. observed a diminution in pro-inflammatory cytokine expression, such as IL-6, IL-1β, and TNF-α.”
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Origin and physiological roles of inflammation
Medzhitov, R. (2008) · Nature · doi:10.1038/nature07201 · Cited by 6,618 · see citing works
AKT/PKB Signaling: Navigating the Network
Manning, B. D., & Toker, A. (2017) · Cell · doi:10.1016/j.cell.2017.04.001 · Cited by 3,772 · see citing works
The MAPK signalling pathways and colorectal cancer
Fang, J. Y., & Richardson, B. C. (2005) · The Lancet Oncology · doi:10.1016/s1470-2045(05)70168-6 · Cited by 1,185 · see citing works
Myeloperoxidase: Its role for host defense, inflammation, and neutrophil function
Aratani, Y. (2018) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2018.01.004 · Cited by 945 · see citing works
Acute Lung Injury: A Clinical and Molecular Review
Butt, Y. M., Kurdowska, A., & Allen, T. C. (2016) · Archives of Pathology & Laboratory Medicine · doi:10.5858/arpa.2015-0519-ra · Cited by 898 · see citing works
Cyclooxygenase‐2 in cancer: A review
Goradel, N. H., Najafi, M., Salehi, E., Farhood, B., & Mortezaee, K. (2018) · Journal of Cellular Physiology · doi:10.1002/jcp.27411 · Cited by 812 · see citing works
Chen, G., Ran, X., Li, B., Li, Y., He, D., Huang, B., Fu, S., Liu, J., & Wang, W. (2018) · eBioMedicine · doi:10.1016/j.ebiom.2018.03.030 · Cited by 580 · see citing works
Lv, H., Liu, Q., Wen, Z., Feng, H., Deng, X., & Ci, X. (2017) · Redox Biology · doi:10.1016/j.redox.2017.03.001 · Cited by 424 · see citing works
Natural product derived phytochemicals in managing acute lung injury by multiple mechanisms
He, Y.-Q., Zhou, C., Yu, L., Wang, L., Deng, J.-L., Tao, Y., Zhang, F., & Chen, W. (2020) · Pharmacological Research · doi:10.1016/j.phrs.2020.105224 · Cited by 415 · see citing works
Transfusion-related acute lung injury: a clinical review
Vlaar, A. P. J., & Juffermans, N. P. (2013) · The Lancet · doi:10.1016/s0140-6736(12)62197-7 · Cited by 384 · see citing works
Mowery, N. T., Terzian, W. T. H., & Nelson, A. C. (2020) · Current Problems in Surgery · doi:10.1016/j.cpsurg.2020.100777 · Cited by 323 · see citing works
NF-κB Signaling Regulates Physiological and Pathological Chondrogenesis
Jimi, E., Huang, F., & Nakatomi, C. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20246275 · Cited by 322 · see citing works
Lu, M., Li, L., Lu, S., Li, K., Su, Z., Wang, Y., Fan, X., Li, X., & Zhao, G. (2017) · Molecular Immunology · doi:10.1016/j.molimm.2017.12.008 · Cited by 299 · see citing works
Acute respiratory distress syndrome and acute lung injury
Dushianthan, A., Grocott, M. P. W., Postle, A. D., & Cusack, R. (2011) · Postgraduate Medical Journal · doi:10.1136/pgmj.2011.118398 · Cited by 288 · see citing works
Wang, J., Ma, C., & Shumin, W. (2015) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2015.04.004 · Cited by 228 · see citing works
Zhou, J.-W., Luo, H.-Z., Jiang, H., Jian, T.-K., Chen, Z.-Q., & Jia, A.-Q. (2018) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.7b05035 · Cited by 206 · see citing works
Nová, Z., Škovierová, H., & Čalkovská, A. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20040831 · Cited by 164 · see citing works
Huang, B., Liu, J., Meng, T., Li, Y., He, D., Ran, X., Chen, G., Guo, W., Kan, X., Fu, S., et al. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.02527 · Cited by 147 · see citing works
Akt as a target for cancer therapy: more is not always better (lessons from studies in mice)
Wang, Q., Chen, X., & Hay, N. (2017) · British Journal of Cancer · doi:10.1038/bjc.2017.153 · Cited by 143 · see citing works
Ye, J., Piao, H., Jiang, J., Jin, G., Zheng, M., Yang, J., Jin, X., Sun, T., Choi, Y. H., Li, L., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-12252-3 · Cited by 126 · see citing works
Zhong, W., Wu, Y.-C., Xie, X., Zhou, X., Wei, M., Soromou, L. W., Ci, X., & Wang, D.-C. (2013) · Fitoterapia · doi:10.1016/j.fitote.2013.06.003 · Cited by 122 · see citing works
Molecular mechanisms underlying hyperoxia acute lung injury
Dias-Freitas, F., Coimbra, C. M., & Roncon‐Albuquerque, R. (2016) · Respiratory Medicine · doi:10.1016/j.rmed.2016.08.010 · Cited by 120 · see citing works
Myricetin Attenuates LPS-Induced Inflammation in RAW 264.7 Macrophages and Mouse Models
Hou, W., Hu, S., Su, Z., Wang, Q., Meng, G., Guo, T., Zhang, J., & Gao, P. (2018) · Future Medicinal Chemistry · doi:10.4155/fmc-2018-0172 · Cited by 99 · see citing works
Self-citationKan, X., Liu, B., Guo, W., Wei, L., Lin, Y., Guo, Y., Gong, Q., Li, Y., Xu, D., Cao, Y., et al. (2019) · Journal of Cellular Physiology · doi:10.1002/jcp.28288 · Cited by 72 · see citing works
Komiya, K., Akaba, T., Kozaki, Y., Kadota, J., & Rubin, B. K. (2017) · Critical Care · doi:10.1186/s13054-017-1809-8 · Cited by 64 · see citing works
Park, E., Kim, Y. M., Kim, H. J., & Chang, K. C. (2018) · Inflammation Research · doi:10.1007/s00011-018-1137-8 · Cited by 61 · see citing works
Cyclooxygenase 2 (COX2)-prostanoid pathway and liver diseases
Hu, K. (2003) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1016/j.plefa.2003.07.001 · Cited by 59 · see citing works
Zheng, H., Liang, W., He, W., Huang, C., Chen, Q., Yi, H., Long, L., Deng, Y., & Zeng, M. (2019) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00253.2018 · Cited by 58 · see citing works
Inhibition of Quorum Sensing and Virulence in <i>Serratia marcescens</i> by Hordenine
Zhou, J.-W., Ruan, L.-Y., Chen, H.-J., Luo, H.-Z., Jiang, H., Wang, J.-S., & Jia, A.-Q. (2019) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.8b05922 · Cited by 56 · see citing works
Xing, J., Yu, Z., Zhang, X., Li, W., Gao, D., Wang, J., Ma, X., Nie, X., & Wang, W. (2018) · International Immunopharmacology · doi:10.1016/j.intimp.2018.11.016 · Cited by 53 · see citing works
Self-citationPark, J. H., Moon, S.-H., Kang, D. H., Um, H. J., Kang, S.-S., Kim, J. Y., & Tchah, H. (2018) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.17-22925 · Cited by 51 · see citing works
He, D., Fu, S., Zhou, A., Su, Y., Gao, X., Zhang, Y., Huang, B., Du, J., & Liu, D. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.619761 · Cited by 50 · see citing works
Kim, S., Lee, J.-H., Kim, M.-H., Lee, J.-A., Kim, Y. B., Jung, E., Kim, Y. S., Lee, J., & Park, D. (2013) · Food Chemistry · doi:10.1016/j.foodchem.2013.03.017 · Cited by 48 · see citing works
Seehase, S., Lauenstein, H.-D., Schlumbohm, C., Switalla, S., Neuhaus, V., Förster, C., Fieguth, H., Pfennig, O., Fuchs, E., Kaup, F., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0043709 · Cited by 45 · see citing works
Henes, J., Schmit, M. A., Morote–Garcia, J. C., Mirakaj, V., Köhler, D., Glover, L. E., Eldh, T., Walter, U., Karhausen, J., Colgan, S. P., et al. (2009) · The FASEB Journal · doi:10.1096/fj.09-138693 · Cited by 44 · see citing works
Zhang, Q., Zhu, S., Cheng, X., Lu, C., Tao, W., Zhang, Y., William, B. C., Cao, X., Yi, S., Liu, Y., et al. (2018) · Biochemical Pharmacology · doi:10.1016/j.bcp.2018.07.025 · Cited by 38 · see citing works
The therapeutic effects of Jaceosidin on lipopolysaccharide-induced acute lung injury in mice
Huang, X., Wei, X.-C., Guo, L., Zhao, L., Chen, X., Cui, Y. A., Yuan, J., Chen, D., & Zhang, J. (2019) · Journal of Pharmacological Sciences · doi:10.1016/j.jphs.2019.07.004 · Cited by 37 · see citing works
Self-citationSu, S., Cao, M., Wu, G., Long, Z., Cheng, X., Fan, J., Xu, Z., Su, H., Hao, Y., Li, G., et al. (2018) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2018.05.036 · Cited by 28 · see citing works
Zhang, T., Yang, S., Jin-Fu, Y. A. O., Du, J., & Yan, T. (2015) · Chinese Journal of Natural Medicines · doi:10.1016/s1875-5364(15)30094-7 · Cited by 26 · see citing works
Pan, W., Xu, X., Wang, Y., & Song, X. (2020) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2020.8407 · Cited by 9 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Agrawal, M., Singhal, M., Semwal, B. C., Arora, S., Singh, B., Sikarwar, V., Sethi, P., Chaudhary, H., Akram, W., Bhargva, S., et al. (2024) · Pharmacological Research - Modern Chinese Medicine · doi:10.1016/j.prmcm.2024.100492 · Cited by 28 · see citing works
Gianolio, S., Padrosa, D. R., & Paradisi, F. (2022) · Green Chemistry · doi:10.1039/d2gc02767d · Cited by 22 · see citing works
Boucher, R., Germain, H., & Desgagné-Penix, I. (2025) · Plants · doi:10.3390/plants14091372 · Cited by 23 · see citing works
Xie, Y., Li, X., Xu, D., He, D., Wang, J., Bi, J., Liu, J., & Fu, S. (2024) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.4c02867 · Cited by 18 · see citing works
Cai, W., Yan, M., Wang, Z., Jiang, M., Yan, B., & Shen, C. (2022) · Journal of Food Biochemistry · doi:10.1111/jfbc.14332 · Cited by 17 · see citing works
Wang, C., Zang, K., Tang, Z., Yang, T., Ye, X., & Dang, Y. (2023) · Nutrients · doi:10.3390/nu15030694 · Cited by 17 · see citing works
Zhen, D., Liu, C., Huang, T., Fu, D., Bai, X., Ma, Q., Jiang, M., & Gong, G.-H. (2022) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2022.115497 · Cited by 16 · see citing works
Beneficial Effects of Hordenine on a Model of Ulcerative Colitis
Xu, Z., Zhang, Q., Ding, C., Wen, F., Sun, F., Liu, Y., Tao, C., & Yao, J. (2023) · Molecules · doi:10.3390/molecules28062834 · Cited by 15 · see citing works
Chen, C., Li, L., Liu, X., Zhang, D., Liu, Y., & Li, Y. (2022) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2022.115725 · Cited by 12 · see citing works
Kianmehr, M., Behdadfard, M., Hedayati‐Moghadam, M., & Khazdair, M. R. (2023) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2023/7675183 · Cited by 11 · see citing works
Li, H., Gao, M., Chen, Z., Zhou, Z., Li, W., Zhang, X., Jiang, X., Luo, L., Li, F. R., Wang, G., et al. (2023) · Phytotherapy Research · doi:10.1002/ptr.7790 · Cited by 9 · see citing works
Self-citationLiang, W.-T., Li, J.-J., Lv, Z.-R., Chen, Z.-H., Yang, Y., Xie, T.-Y., Ruan, Y., Tu, X., Zeng, F.-F., Wei-Shi, et al. (2025) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2025.120522 · Cited by 4 · see citing works
Hordenine: Pharmacological, phytochemical, pharmacokinetic and analytical review of the literature
Athilli, L., & Balasubramaniam, A. (2022) · Annals of Phytomedicine An International Journal · doi:10.54085/ap.2022.11.1.12 · Cited by 4 · see citing works
Wang, P., Zhang, D., Yang, Y., Gao, D., & Zhou, Y. (2025) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-025-04146-3 · Cited by 4 · see citing works
Auda, M. A., Eleyan, M., Atia, T. A., & Sakr, H. I. (2026) · Frontiers in Pharmacology · doi:10.3389/fphar.2026.1753226 · Cited by 4 · see citing works
Pharmacology of Macroalgae Alkaloids
Kaleağasıoğlu, F., Güven, K. C., Sezik, E., Erduğan, H., & Çoban, B. (2025) · Springer eBooks · doi:10.1007/978-3-642-36202-6_3-1
Alkaloids Derived from Tyrosine: Modified Benzyltetrahydroisoquinoline Alkaloids
Singh, A., Sarfraz, A., & Khan, F. (2026) · Springer eBooks · doi:10.1007/978-3-642-36202-6_15-1
- Authors
- Zhang, X., Du, L., Zhang, J., Li, C., Zhang, J., & Lv, X.
- Affiliations
- Jilin University (CN)
- Corresponding author
- Zhang, Jie
- Lv, Xuejiao
- Venue
- Frontiers in Pharmacology
- Publisher
- Frontiers Media SA
- Published
- 2021-09-01
- Volume
- 12
- Pages
- 712232-712232
- ISSN
- 1663-9812 (ISSN-L)
- PMC
- PMC8440820
- OpenAlex
- W3198834254
- Cited by
- 17
- References
- 40
- Citations by year
- 2026: 2 · 2025: 4 · 2024: 2 · 2023: 4 · 2022: 5
- FWCI
- 3.10
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Frontiers in Pharmacology (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, other-oa)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- National Natural Science Foundation of China-China Academy of General Technology Joint Fund for Basic Research (81672297)
- Topics
- Health Sciences › Medicine › Complementary and alternative medicine › Medicinal plant effects and applications
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Phytochemistry and Biological Activities
- Health Sciences › Medicine › Pharmacology › Flavonoids in Medical Research
- Keywords
- hordenine, acute lung injury, lipopolysaccharide, anti-inflammatory activity, inflammatory cytokines, Akt, NF-κB signaling, MAPK signaling, inflammation
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
