The DOI matches its Crossref record; 186 of the 186 references it cites were found in a registry or an index.
Signal Transducer and Activator of Transcription (STATs) Proteins in Cancer and Inflammation: Functions and Therapeutic Implication
Open accessAbstract
Signal Transducer and Activator of Transcription (STAT) pathway is connected upstream with Janus kinases (JAK) family protein and capable of integrating inputs from different signaling pathways. Each family member plays unique functions in signal transduction and crucial in mediating cellular responses to different kind of cytokines. STAT family members notably STAT3 and STAT5 have been involved in cancer progression whereas STAT1 plays opposite role by suppressing tumor growth. Persistent STAT3/5 activation is known to promote chronic inflammation, which increases susceptibility of healthy cells to carcinogenesis. Here, we review the role of STATs in cancers and inflammation while discussing current therapeutic implications in different cancers and test models, especially the delivery of STAT3/5 targeting siRNA using nanoparticulate delivery system.
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Self-citationAdvances in Targeting ‘Undruggable’ transcription Factors With Small Molecules
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Celastrol in cancer therapy: Recent developments, challenges and prospects
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Metadata
- Authors
- Loh, C.-Y., Arya, A., Naema, A. F., Wong, W. F., Sethi, G., & Looi, C. Y.
- Venue
- Frontiers in Oncology
- Publisher
- Frontiers Media SA
- Published
- 2019-02-21
- Volume
- 9
- Pages
- 48-48
- ISSN
- 2234-943X (ISSN-L)
- OpenAlex
- W2917410143
- Cited by
- 348
- References
- 186
- FWCI
- 16.69
- Type
- journal article
- Language
- en
- Open access
- gold
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- Loh, C.-Y., Arya, A., Naema, A. F., Wong, W. F., Sethi, G., & Looi, C. Y. (2019). Signal Transducer and Activator of Transcription (STATs) Proteins in Cancer and Inflammation: Functions and Therapeutic Implication. Frontiers in Oncology. https://doi.org/10.3389/fonc.2019.00048
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