Cited by 151Fatty Acid Research and HealthRetinal Diseases and TreatmentsAntioxidant Activity and Oxidative Stress

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The Eye, Oxidative Damage and Polyunsaturated Fatty Acids

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Saccà, Sergio Claudio, Cutolo, Carlo Alberto, Ferrari, Daniele, Corazza, Paolo, Traverso, Carlo Enrico·2018·Nutrients

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Abstract

Polyunsaturated fatty acids (PUFA) are known to have numerous beneficial effects, owing to their anti-inflammatory and antioxidant properties. From a metabolic standpoint, the mitochondria play a fundamental role in cellular homeostasis, and oxidative stress can affect their functioning. Indeed, the mitochondria are the main source of ROS, and an imbalance between ROS and antioxidant defenses leads to oxidative stress. In addition, aging, the decline of cellular functions, and continual exposure to light underlie many diseases, particularly those of the eye. Long-term exposure to insults, such as UV light, visible light, ionizing radiation, chemotherapeutics, and environmental toxins, contribute to oxidative damage in ocular tissues and expose the aging eye to considerable risk of pathological consequences of oxidative stress. Ample antioxidant defenses responsible for scavenging free radicals are essential for redox homeostasis in the eye, indeed, eye tissues, starting from the tear film, which normally are exposed to high oxygen levels, have strong antioxidant defenses that are efficient for protecting against ROS-related injuries. On the contrary, instead, the trabecular meshwork is not directly exposed to light and its endothelial cells are poorly equipped with antioxidant defenses. All this makes the eye a target organ of oxidative damage. This review focuses on the role of the polyunsaturated fatty acids in the human eye, particularly in such pathologies as dry eye, glaucoma, and macular degeneration, in which dietary PUFA supplementation can be a valid therapeutic aid.

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Authors: Saccà, S. C., Cutolo, C. A., Ferrari, D., Corazza, P., & Traverso, C. E.
Affiliations: Ospedale Policlinico San Martino (IT)
Corresponding author: Saccà, Sergio Claudio
ORCID: Saccà, Sergio Claudio
Cutolo, Carlo Alberto
Corazza, Paolo
Traverso, Carlo Enrico
Venue: Nutrients
Publisher: MDPI AG
Published: 2018-05-24
Volume: 10
Issue: 6
Pages: 668
ISSN: 2072-6643 (ISSN-L)
DOI: 10.3390/nu10060668
PMC: PMC6024720
OpenAlex: W2804346130
Cited by: 150
References: 114
Citations by year: 2026: 18 · 2025: 15 · 2024: 26 · 2023: 20 · 2022: 18 · 2021: 24 · 2020: 17 · 2019: 10 · 2018: 2
FWCI: 1.70
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
creativecommons.org/licenses/by/4.0/ (vor)
Locations: Nutrients (publishedVersion, cc-by)
Europe PMC (PubMed Central) (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
CINECA IRIS Institutial Research Information System (University of Genoa) (submittedVersion, other-oa)
Topics: Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
Health Sciences › Medicine › Ophthalmology › Retinal Diseases and Treatments
Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
Keywords: polyunsaturated fatty acids, oxidative stress, reactive oxygen species, eye, antioxidants, mitochondrial dysfunction, dry eye, glaucoma, macular degeneration, dietary supplementation, ocular aging, light exposure, trabecular meshwork, redox homeostasis
MeSH terms: Animals, Antioxidants, Eye, Eye Diseases, Fatty Acids, Unsaturated, Humans, Risk Factors, Reactive Oxygen Species, Oxidative Stress, Dietary Supplements, Protective Factors

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The Eye, Oxidative Damage and Polyunsaturated Fatty Acids

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