The DOI matches its Crossref record; 114 of the 114 references it cites were found in a registry or an index.
The Eye, Oxidative Damage and Polyunsaturated Fatty Acids
Open accessAbstract
Polyunsaturated fatty acids (PUFA) are known to have numerous beneficial effects, owing to their anti-inflammatory and antioxidant properties. From a metabolic standpoint, the mitochondria play a fundamental role in cellular homeostasis, and oxidative stress can affect their functioning. Indeed, the mitochondria are the main source of ROS, and an imbalance between ROS and antioxidant defenses leads to oxidative stress. In addition, aging, the decline of cellular functions, and continual exposure to light underlie many diseases, particularly those of the eye. Long-term exposure to insults, such as UV light, visible light, ionizing radiation, chemotherapeutics, and environmental toxins, contribute to oxidative damage in ocular tissues and expose the aging eye to considerable risk of pathological consequences of oxidative stress. Ample antioxidant defenses responsible for scavenging free radicals are essential for redox homeostasis in the eye, indeed, eye tissues, starting from the tear film, which normally are exposed to high oxygen levels, have strong antioxidant defenses that are efficient for protecting against ROS-related injuries. On the contrary, instead, the trabecular meshwork is not directly exposed to light and its endothelial cells are poorly equipped with antioxidant defenses. All this makes the eye a target organ of oxidative damage. This review focuses on the role of the polyunsaturated fatty acids in the human eye, particularly in such pathologies as dry eye, glaucoma, and macular degeneration, in which dietary PUFA supplementation can be a valid therapeutic aid.
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“MGF has demonstrated therapeutic benefits in preclinical models of retinal and lens injury through antioxidant and antiangiogenic mechanisms (127).”
From Mangiferin in human disease: Multifaceted mechanisms and applications (Review) (2026) · cites this paper as [127]
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Cites
Free Radicals in the Physiological Control of Cell Function
Dröge, W. (2002) · Physiological Reviews · doi:10.1152/physrev.00018.2001 · Cited by 9,855
Oxidants, oxidative stress and the biology of ageing
Finkel, T., & Holbrook, N. J. (2000) · Nature · doi:10.1038/35041687 · Cited by 9,413
Aging: a theory based on free radical and radiation chemistry
Harman, D. (1956) · Journal of Gerontology · doi:10.1093/geronj/11.3.298 · Cited by 8,567
Cillà, S. D., Farruggio, S., Vujosevic, S., Raina, G., Filippini, D. A., Gatti, V., Clemente, N., Mary, D., Vezzola, D., Casini, G., et al. (2017) · Cellular Physiology and Biochemistry · doi:10.1159/000479441 · Cited by 5,154
Oxyl radicals, redox-sensitive signalling cascades and antioxidants
Genestra, M. (2007) · Cellular Signalling · doi:10.1016/j.cellsig.2007.04.009 · Cited by 4,930
(2007) · The Ocular Surface · doi:10.1016/s1542-0124(12)70081-2 · Cited by 3,299
Baeuerle, P. A., & Baltimore, D. (1996) · Cell · doi:10.1016/s0092-8674(00)81318-5 · Cited by 3,002
Senescent cells, tumor suppression, and organismal aging: good citizens, bad neighbors
Campisi, J. (2005) · Cell · doi:10.1016/j.cell.2005.02.003 · Cited by 2,379
Oxidative stress in Parkinson's disease
Jenner, P. (2003) · Annals of Neurology · doi:10.1002/ana.10483 · Cited by 2,053
The Biologic Clock: The Mitochondria?
Harman, D. (1972) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.1972.tb00787.x · Cited by 2,026
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- Cornelli, 2010, I Modulatori Fisiologici, Prog. Nutr., 12, 99
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Oxidative stress in the eye and its role in the pathophysiology of ocular diseases
Böhm, E. W., Buonfiglio, F., Voigt, A. M., Bachmann, P., Safi, T., Pfeiffer, N., & Gericke, A. (2023) · Redox Biology · doi:10.1016/j.redox.2023.102967 · Cited by 334
The Pathomechanism, Antioxidant Biomarkers, and Treatment of Oxidative Stress-Related Eye Diseases
Hsueh, Y., Chen, Y., Tsao, Y., Cheng, C., Wu, W., & Chen, H. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23031255 · Cited by 199
Zhao, T., Guo, X., & Sun, Y. (2021) · Aging and Disease · doi:10.14336/ad.2020.0912 · Cited by 180
Anti-oxidative and anti-inflammatory micelles: break the dry eye vicious cycle
Li, S., Lu, Z., Huang, Y., Wang, Y., Jin, Q., Shentu, X., Ye, J., Ji, J., Yao, K., & Han, H. (2022) · Advanced Science · doi:10.1002/advs.202200435 · Cited by 174
Mechanistic aspects of carotenoid health benefits – where are we now?
Bohn, T., Bonet, M. L., Borel, P., Keijer, J., Landrier, J., Milisav, I., Ribot, J., Riso, P., Winklhofer‐Roob, B. M., Sharoni, Y., et al. (2021) · Nutrition Research Reviews · doi:10.1017/s0954422421000147 · Cited by 155
Metadata
- Authors
- Saccà, S. C., Cutolo, C. A., Ferrari, D., Corazza, P., & Traverso, C. E.
- Affiliations
- Ospedale Policlinico San Martino (IT)
- Corresponding author
- Saccà, Sergio Claudio
- Venue
- Nutrients
- Publisher
- MDPI AG
- Published
- 2018-05-24
- Volume
- 10
- Issue
- 6
- Pages
- 668
- ISSN
- 2072-6643 (ISSN-L)
- PMC
- PMC6024720
- OpenAlex
- W2804346130
- Cited by
- 150
- References
- 114
- Citations by year
- 2026: 18 · 2025: 15 · 2024: 26 · 2023: 20 · 2022: 18 · 2021: 24 · 2020: 17 · 2019: 10 · 2018: 2
- FWCI
- 1.70
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Nutrients (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- CINECA IRIS Institutial Research Information System (University of Genoa) (submittedVersion, other-oa)
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
- Health Sciences › Medicine › Ophthalmology › Retinal Diseases and Treatments
- Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
- Keywords
- polyunsaturated fatty acids, oxidative stress, reactive oxygen species, eye, antioxidants, mitochondrial dysfunction, dry eye, glaucoma, macular degeneration, dietary supplementation, ocular aging, light exposure, trabecular meshwork, redox homeostasis
- MeSH terms
- Animals, Antioxidants, Eye, Eye Diseases, Fatty Acids, Unsaturated, Humans, Risk Factors, Reactive Oxygen Species, Oxidative Stress, Dietary Supplements, Protective Factors
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