Efficacy of Polydextrose Supplementation on Colonic Transit Time, Bowel Movements, and Gastrointestinal Symptoms in Adults: A Double-Blind, Randomized, Placebo-Controlled Trial
Open accessAbstract
The addition of fiber is one of the most important dietary means to relieve constipation through lifestyle modification. Polydextrose (PDX) has been reported in several studies to increase fecal bulk, soften stools, and increase the number of defecations. However, there are few studies on the effect of PDX on colonic transit time (CTT). Therefore, the aim of this study was to demonstrate the effect of PDX on CTT and other aspects of gastrointestinal function during two weeks (Day 1 to Day 14), preceded by a 2-week run-in period (Day -14 to Day -1). A total of 192 adults who were diagnosed with functional constipation per Rome III criteria were recruited for the study. Participants were randomized equally into 4 groups (12 g, 8 g, or 4 g of PDX or placebo per day). The primary endpoint was CTT, assessed using radio-opaque markers and abdominal X-rays on Day 0, the baseline; and Day 15, the end of the intervention. Secondary outcomes that were measured using inventories were the patient assessment of constipation symptoms and quality of life, bowel function index, relief of constipation, bowel movement frequency (BMF), stool consistency, degree of straining, and proportion of bowel movements. Ancillary parameters and harms were also evaluated. The recruited population was not sufficiently constipated (e.g., baseline values for CTT and BMF of 42 h and 8.7 BMF/week, respectively). Despite this limitation, our results demonstrated an increased number of bowel movements when supplemented with PDX at a dosage of 12 g per day for 2 weeks. This dosage also consistently improved the secondary outcomes that were measured using inventories at Day 15, compared with the baseline. No serious or significant adverse events were reported during the study.
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Dietary fibers and probiotics may relieve constipation via optimizing gut microbiome.
“Dietary fibers/probiotics may relieve constipation via optimizing gut microbiome, yet with limited trial-based evidences.”
From Effects of dietary fibers or probiotics on functional constipation symptoms and roles of gut microbiota: a double-blinded randomized placebo trial (2023) · cites this paper as [15]
The Introduction (page unavailable) says fiber is a dietary means to relieve constipation and that studies of polydextrose’s effect on transit time are few and inconclusive. It does not say that relief occurs by optimizing the gut microbiome or establish a similar benefit for probiotics; the limited-evidence statement is specific to polydextrose and transit time. (LLM, conf=0.87)
Experimental — accuracy not yet measuredPsyllium husk, polydextrose, xylooligosaccharide, and probiotic supplementations were reported to be effective in modulating gut microbiota.
“Dietary fibers, such as psyllium husk11, polydextrose15, xylooligosaccharide16, or probiotic supplementations17, were reported to be effective in modulating gut microbiota”
From Effects of dietary fibers or probiotics on functional constipation symptoms and roles of gut microbiota: a double-blinded randomized placebo trial (2023) · cites this paper as [15]
The Introduction calls polydextrose a prebiotic fiber but discusses bowel function, not measured changes in gut microbiota. The paper’s References list a separate study on polydextrose and faecal microbiota; this trial does not report whether polydextrose effectively modulated microbiota. Searched for microbiota, microflora, and related terms in our copy. (LLM, conf=0.75)
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“While the majority of available data on the constipation-alleviating effect of PDX has been investigated in healthy subjects (Ibarra et al., 2019), data on subjects experiencing constipation are lacking.”
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Method
- Authors
- Ibarra, A., Pelipyagina, T., Rueffer, M., Evans, M., & Ouwehand, A. C.
- Affiliations
- DuPont (Finland) (FI)
- KGK Synergize (Canada) (CA)
- Corresponding author
- Ibarra, Alvin
- Venue
- Nutrients
- Publisher
- MDPI AG
- Published
- 2019-02-20
- Volume
- 11
- Issue
- 2
- Pages
- 439
- ISSN
- 2072-6643 (ISSN-L)
- PMC
- PMC6412485
- OpenAlex
- W2916705561
- Cited by
- 22
- References
- 46
- Citations by year
- 2026: 2 · 2025: 5 · 2024: 2 · 2023: 4 · 2022: 3 · 2021: 3 · 2020: 2 · 2019: 1
- FWCI
- 2.05
- Type
- journal article
- Language
- en
- Open access
- gold
- dx.doi.org
- Licence
- Locations
- Nutrients (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Health Sciences › Nursing › Nutrition and Dietetics › Food composition and properties
- Health Sciences › Nursing › Nutrition and Dietetics › Microbial Metabolites in Food Biotechnology
- Keywords
- polydextrose, dietary fiber supplementation, functional constipation, colonic transit time, stool frequency, stool consistency, straining, gastrointestinal symptoms, quality of life, Bowel Function Index, Rome III criteria
- MeSH terms
- Abdomen, Adult, Colon, Constipation, Defecation, Dietary Fiber, Double-Blind Method, Female, Gastrointestinal Transit, Glucans, Humans, Male, Quality of Life, Severity of Illness Index, Treatment Outcome, Dietary Supplements
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