Studies on the effects of polydextrose intake on physiologic functions in Chinese people
Open accessAbstract
Background Previous studies showed that polydextrose has physiologic effects similar to those of dietary fiber.Objective Ingestion of 4, 8, and 12 g polydextrose/d was studied to determine the physiologic effects in Chinese subjects.Design In a placebo-controlled, randomized, double-blind study, we evaluated the effects of polydextrose ingestion on clinical biochemistry indexes, glycated hemoglobin, glucose tolerance, the glycemic index, bowel function, stool weight and pH, short-chain fatty acid production, fecal microflora, and cecal mucosa cell proliferation.Results Polydextrose had no significant effect on blood biochemistry indexes. Ingestion of 12 g polydextrose plus 50 g glucose resulted in a glycemic index of 89% (compared with a glycemic index of 100% after ingestion of 50 g glucose). Bowel function (frequency and ease of defecation) improved significantly and there were no reports of abdominal distention, abdominal cramps, diarrhea, or hypoglycemia. Fecal weight (wet and dry) increased and fecal pH decreased proportionally to polydextrose intake. Short-chain fatty acid production-notably that of butyrate, isobutyrate, and acetate-increased with polydextrose ingestion. There were substantial changes in fecal anaerobes after polydextrose intake. BACTEROIDES: species (B. fragilis, B. vulgatus, and B. intermedius) decreased, whereas LACTOBACILLUS: and BIFIDOBACTERIUM: species increased. The cecal mucosa whole-crypt labeling index increased, with colonocyte proliferation mainly occurring in base compartments, which provided an indirect confirmation of butyrate production in the colon.Conclusion Polydextrose ingestion had significant dietary fiber-like effects with no laxative problems.
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Polydextrose positively influences stool consistency and bowel function.
“polydextrose has also been reported to positively influence stool consistency and bowel function [30]”
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Background
- Authors
- Jie, Z., Bang-yao, L., Ming-jie, X., Hai-wei, L., Zu-kang, Z., Ting-song, W., & Craig, S. A.
- Affiliations
- Ruijin Hospital (CN)
- Venue
- The American Journal of Clinical Nutrition
- Publisher
- Elsevier BV
- Published
- 2000-12
- Volume
- 72
- Issue
- 6
- Pages
- 1503-1509
- ISSN
- 0002-9165 (ISSN-L)
- OpenAlex
- W2150887195
- Cited by
- 207
- References
- 34
- Citations by year
- 2026: 2 · 2025: 9 · 2024: 3 · 2023: 5 · 2022: 8 · 2021: 7 · 2020: 9 · 2019: 8 · 2018: 11 · 2017: 7 · 2016: 14 · 2015: 14 · 2014: 13 · 2013: 9 · 2012: 15
- FWCI
- 1.33
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- American Journal of Clinical Nutrition (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Microbial Metabolites in Food Biotechnology
- Health Sciences › Nursing › Nutrition and Dietetics › Food composition and properties
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Keywords
- polydextrose, dietary fiber, glycemic index, glucose tolerance, bowel function, fecal short-chain fatty acids, butyrate, fecal microbiota, Bacteroides, Lactobacillus, Bifidobacterium, Chinese subjects
- MeSH terms
- Adult, Analysis of Variance, Blood Glucose, China, Defecation, Diet, Dietary Fiber, Double-Blind Method, Fatty Acids, Volatile, Feces, Female, Fermentation, Food Additives, Glucans, Glycated Hemoglobin, Humans, Hydrogen-Ion Concentration, Male
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