Cited by 207Microbial Metabolites in Food BiotechnologyFood composition and propertiesGut microbiota and health

Studies on the effects of polydextrose intake on physiologic functions in Chinese people

Open access
Jie, Zhong, Bang-yao, Luo, Ming-jie, Xiang, Hai-wei, Liu, Zu-kang, Zhai, Ting-song, Wang, Craig, Stuart AS·2000·The American Journal of Clinical Nutrition

Abstract

Background Previous studies showed that polydextrose has physiologic effects similar to those of dietary fiber.Objective Ingestion of 4, 8, and 12 g polydextrose/d was studied to determine the physiologic effects in Chinese subjects.Design In a placebo-controlled, randomized, double-blind study, we evaluated the effects of polydextrose ingestion on clinical biochemistry indexes, glycated hemoglobin, glucose tolerance, the glycemic index, bowel function, stool weight and pH, short-chain fatty acid production, fecal microflora, and cecal mucosa cell proliferation.Results Polydextrose had no significant effect on blood biochemistry indexes. Ingestion of 12 g polydextrose plus 50 g glucose resulted in a glycemic index of 89% (compared with a glycemic index of 100% after ingestion of 50 g glucose). Bowel function (frequency and ease of defecation) improved significantly and there were no reports of abdominal distention, abdominal cramps, diarrhea, or hypoglycemia. Fecal weight (wet and dry) increased and fecal pH decreased proportionally to polydextrose intake. Short-chain fatty acid production-notably that of butyrate, isobutyrate, and acetate-increased with polydextrose ingestion. There were substantial changes in fecal anaerobes after polydextrose intake. BACTEROIDES: species (B. fragilis, B. vulgatus, and B. intermedius) decreased, whereas LACTOBACILLUS: and BIFIDOBACTERIUM: species increased. The cecal mucosa whole-crypt labeling index increased, with colonocyte proliferation mainly occurring in base compartments, which provided an indirect confirmation of butyrate production in the colon.Conclusion Polydextrose ingestion had significant dietary fiber-like effects with no laxative problems.

Integrity signals

Registry

Crossref · 10.1093/ajcn/72.6.1503

Cites

34 of 34 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Jie, Z., Bang-yao, L., Ming-jie, X., Hai-wei, L., Zu-kang, Z., Ting-song, W., & Craig, S. A.
Affiliations
Ruijin Hospital (CN)
Venue
The American Journal of Clinical Nutrition
Publisher
Elsevier BV
Published
2000-12
Volume
72
Issue
6
Pages
1503-1509
ISSN
0002-9165 (ISSN-L)
OpenAlex
W2150887195
Cited by
207
References
34
Citations by year
2026: 2 · 2025: 9 · 2024: 3 · 2023: 5 · 2022: 8 · 2021: 7 · 2020: 9 · 2019: 8 · 2018: 11 · 2017: 7 · 2016: 14 · 2015: 14 · 2014: 13 · 2013: 9 · 2012: 15
FWCI
1.33
Type
journal article
Language
en
Open access
Locations
  • American Journal of Clinical Nutrition (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Nursing › Nutrition and Dietetics › Microbial Metabolites in Food Biotechnology
  • Health Sciences › Nursing › Nutrition and Dietetics › Food composition and properties
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Keywords
polydextrose, dietary fiber, glycemic index, glucose tolerance, bowel function, fecal short-chain fatty acids, butyrate, fecal microbiota, Bacteroides, Lactobacillus, Bifidobacterium, Chinese subjects
MeSH terms
Adult, Analysis of Variance, Blood Glucose, China, Defecation, Diet, Dietary Fiber, Double-Blind Method, Fatty Acids, Volatile, Feces, Female, Fermentation, Food Additives, Glucans, Glycated Hemoglobin, Humans, Hydrogen-Ion Concentration, Male

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review