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Significant Amounts of Functional Collagen Peptides Can Be Incorporated in the Diet While Maintaining Indispensable Amino Acid Balance

Paul, Cristiana, Leser, Suzane, Oesser, Steffen·2019·Nutrients

Abstract

The results of twenty years of research indicate that the inclusion of collagen peptides in the diet can lead to various improvements in health. According to the current protein quality evaluation method PDCAAS (Protein Digestibility-corrected Amino Acid Score), collagen protein lacks one indispensable amino acid (tryptophan) and is therefore categorized as an incomplete protein source. Collagen protein displays a low indispensable amino acid profile, yet as a functional food, collagen is a source of physiologically active peptides and conditionally indispensable amino acids that have the potential to optimize health and address physiological needs posed by aging and exercise. The objective of this study was to determine the maximum level of dietary collagen peptides that can be incorporated in the Western pattern diet while maintaining its indispensable amino acid balance. Iterative PDCAAS calculations showed that a level as high as 36% of collagen peptides can be used as protein substitution in the daily diet while ensuring indispensable amino acid requirements are met. This study suggests that the effective amounts of functional collagen peptides (2.5 to 15 g per day) observed in the literature are below the maximum level of collagen that may be incorporated in the standard American diet.

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Research works printed but not linked: 29

  1. Milner, 2000, Functional foods: the US perspective, Am. J. Clin. Nutr., 71, 1654S, 10.1093/ajcn/71.6.1654S · DOI
  2. Chakrabarti, S., Guha, S., and Majumder, K. (2018). Food-derived bioactive peptides in human health: Challenges and opportunities. Nutrients, 10. · DOI · Paper page
  3. Fu, 2018, Exploration of collagen recovered from animal by-products as a precursor of bioactive peptides: Successes and challenges, Crit. Rev. Food Sci. Nutr., 2, 1
  4. Proksch, 2014, Oral supplementation of specific collagen peptides has beneficial effects on human skin physiology: A double-blind, placebo-controlled study, Skin. Pharmacol. Physiol., 27, 47, 10.1159/000351376 · DOI
  5. McAlindon, 2011, Change in knee osteoarthritis cartilage detected by delayed gadolinium enhanced magnetic resonance imaging following treatment with collagen hydrolysate: A pilot randomized controlled trial, Osteoarthr. Cartil., 19, 399, 10.1016/j.joca.2011.01.001 · DOI
  6. Zdzieblik, 2017, Corrigendum: Improvement of activity-related knee joint discomfort following supplementation of specific collagen peptides, Appl. Physiol. Nutr. Metab., 42, 1237, 10.1139/apnm-2017-0693 · DOI
  7. Clark, 2008, 24-Week study on the use of collagen hydrolysate as a dietary supplement in athletes with activity-related joint pain, Curr. Med. Res. Opin., 24, 1485, 10.1185/030079908X291967 · DOI
  8. Praet, S.F.E., Purdam, C.R., Welvaert, M., Vlahovich, N., Lovell, G., Burke, L.M., Gaida, J.E., Manzanero, S., Hughes, D., and Waddington, G. (2019). Oral supplementation of specific collagen peptides combined with calf-strengthening exercises enhances function and reduces pain in Achilles tendinopathy patients. Nutrients, 11. · DOI
  9. Dressler, 2018, Improvement of functional ankle properties following supplementation with specific collagen peptides in athletes with chronic ankle instability, J. Sports Sci. Med., 17, 198
  10. Shaw, 2017, Vitamin C–enriched gelatin supplementation before intermittent activity augments collagen synthesis, Am. J. Clin. Nutr., 105, 136, 10.3945/ajcn.116.138594 · DOI · Paper page
  11. Baar, 2019, Stress relaxation and targeted nutrition to treat patellar tendinopathy, Int. J. Sports Nutr. Exerc. Metab., 4, 1
  12. König, D., Oesser, S., Scharla, S., Zdzieblik, D., and Gollhofer, A. (2018). Specific collagen peptides improve bone mineral density and bone markers in postmenopausal women-A randomized controlled study. Nutrients, 10. · DOI
  13. Siebert, 2010, Interaction of the α2A domain of integrin with small collagen fragments, Protein Cell, 1, 393, 10.1007/s13238-010-0038-6 · DOI
  14. Hou, 2015, Dietary essentiality of “nutritionally non-essential amino acids” for animals and humans, Exp. Biol. Med., 240, 997, 10.1177/1535370215587913 · DOI · Paper page
  15. Wu, 2011, Proline and hydroxyproline metabolism: implications for animal and human nutrition, Amino Acids, 4, 1053, 10.1007/s00726-010-0715-z · DOI · Paper page
  16. 2009, A weak link in metabolism: the metabolic capacity for glycine biosynthesis does not satisfy the need for collagen synthesis, J. Biosci., 34, 853, 10.1007/s12038-009-0100-9 · DOI · Paper page
  17. EFSA Panel on Dietetics Products, Nutrition and Allergies (NDA) (2012). Scientific opinion on dietary reference values for protein. EFSA J., 10, 2557–2623. · DOI · Paper page
  18. Leser, 2013, The 2013 FAO report on dietary protein quality evaluation in human nutrition: Recommendations and implications, Nutr. Bull., 38, 421, 10.1111/nbu.12063 · DOI
  19. Marinangeli, 2017, Potential impact of the digestible indispensable amino acid score as a measure of protein quality on dietary regulations and health, Nutr. Rev., 75, 658, 10.1093/nutrit/nux025 · DOI
  20. Ao, 2012, Amino acid composition and antioxidant activities of hydrolysates and peptide fractions from porcine collagen, Food Sci. Technol. Int., 18, 425, 10.1177/1082013211428219 · DOI
  21. Hu, Z., Yang, P., Zhou, C., Li, S., and Hong, P. (2017). Marine collagen peptides from the skin of Nile Tilapia (Oreochromis Niloticus): Characterization and wound healing evaluation. Mar. Drugs, 15. · DOI · Paper page
  22. Keith, 1988, Digestibility of nitrogen and amino acids in selected protein sources fed to mice, J. Nutr., 118, 561, 10.1093/jn/118.5.561 · DOI
  23. Institute of Medicine (2005). Dietary Reference Intakes for Energy, Carbohydrate, Fiber, Fat, Fatty Acids, Cholesterol, Protein and Amino Acids, National Academies Press.
  24. Wright, 2010, Trends in intake of energy and macronutrients in adults from 1999–2000 through 2007–2008, NCHS Data Brief, 49, 1
  25. Phillips, 2016, Protein “requirements” beyond the RDA: implications for optimizing health, Appl. Physiol. Nutr. Metab., 41, 565, 10.1139/apnm-2015-0550 · DOI · Paper page
  26. Moughan, 2012, Dietary protein for human health, Br. J. Nutr., 108, S1, 10.1017/S0007114512003509 · DOI
  27. 2012, Food proteins as a source of bioactive peptides with diverse functions, Br. J. Nutr., 108, S149, 10.1017/S000711451200253X · DOI
  28. Smith, 2007, New approaches and recent results concerning human-tissue collagen synthesis, Curr. Opin. Clin. Nutr. Metab. Care, 10, 582, 10.1097/MCO.0b013e328285d858 · DOI
  29. Kim, 2018, Trends in types of protein in US adults: results from the National Health and Nutrition Examination Survey 1999–2010, Public Health Nutr., 22, 191, 10.1017/S1368980018003348 · DOI

Metadata

Authors
Paul, C., Leser, S., & Oesser, S.
Venue
Nutrients
Publisher
MDPI AG
Published
2019-05-15
Volume
11
Issue
5
Pages
1079
ISSN
2072-6643
Cited by
60
References
4
Language
en

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