Cited by 149Gout, Hyperuricemia, Uric AcidAntioxidant Activity and Oxidative StressDialysis and Renal Disease Management

Dietary Antioxidant Supplements and Uric Acid in Chronic Kidney Disease: A Review

Open access
Roumeliotis, Stefanos, Roumeliotis, Athanasios, Dounousi, Evangelia, Eleftheriadis, Theodoros, Liakopoulos, Vassilios·2019·Nutrients

Abstract

Increased serum levels of uric acid have been associated with the onset and development of chronic kidney disease (CKD), cardiovascular disease, and mortality, through several molecular pathogenetic mechanisms, such as inflammation and oxidative stress. Oxidative stress is present even in the early stages of CKD, progresses parallelly with the deterioration of kidney function, and is even more exacerbated in end-stage renal disease patients undergoing maintenance hemodialysis. Although acting in the plasma as an antioxidant, once uric acid enters the intracellular environment; it behaves as a powerful pro-oxidant. Exogenous intake of antioxidants has been repeatedly shown to prevent inflammation, atherosclerosis and oxidative stress in CKD patients. Moreover, certain antioxidants have been proposed to exert uric acid-lowering properties. This review aims to present the available data regarding the effects of antioxidant supplements on both oxidative stress and uric acid serum levels, in a population particularly susceptible to oxidative damage such as CKD patients.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.3390/nu11081911

Cites

128 of 128 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Chronic serum hyperuricemia positively correlates with inflammation, DNA damage and OS, and has been implicated in pathogenesis of several disorders, including renal, metabolic, and cardiovascular diseases.

    “Accordingly, chronic serum hyperuricemia positively correlates with inflammation, DNA damage and OS, and has been implicated in the pathogenesis of several disorders, including renal, metabolic, and cardiovascular diseases [214,217,218].”
  • Although UA is classified as an important antioxidant molecule when circulating in plasma, it exerts potent pro-oxidant activity once inside the cell or in the form of extracellular crystals.

    “In the context of OS, although UA is classified as an important antioxidant molecule when circulating in the plasma, it exerts a potent pro-oxidant activity once inside the cell or in the form of extracellular crystals, probably due to different environmental interactions [214,215].”

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cites

Flagged first, then by citations

1 of the 129 references couldn’t be matched to a known paper.

Cited by

Sorted by citations

Authors
Roumeliotis, S., Roumeliotis, A., Dounousi, E., Eleftheriadis, T., & Liakopoulos, V.
Affiliations
  • Aristotle University of Thessaloniki (GR)
  • University of Ioannina (GR)
  • University of Thessaly (GR)
Corresponding author
Liakopoulos, Vassilios
Venue
Nutrients
Publisher
MDPI AG
Published
2019-08-15
Volume
11
Issue
8
Pages
1911
ISSN
2072-6643 (ISSN-L)
OpenAlex
W2967734709
Cited by
149
References
129
Citations by year
2026: 14 · 2025: 26 · 2024: 27 · 2023: 19 · 2022: 19 · 2021: 19 · 2020: 23 · 2019: 2
FWCI
2.46
Type
journal article
Language
en
Open access
Locations
  • Nutrients (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
  • University of Thessaly Institutional Repository (University of Thessaly) (submittedVersion)
Topics
  • Health Sciences › Medicine › Nephrology › Gout, Hyperuricemia, Uric Acid
  • Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
  • Health Sciences › Medicine › Nephrology › Dialysis and Renal Disease Management
Keywords
uric acid, chronic kidney disease, oxidative stress, inflammation, end-stage renal disease, hemodialysis, cardiovascular disease, mortality
MeSH terms
Antioxidants, Humans, Kidney, Uric Acid, Biomarkers, Up-Regulation, Treatment Outcome, Oxidative Stress, Dietary Supplements, Hyperuricemia, Renal Insufficiency, Chronic

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review