The DOI matches its Crossref record; 191 of the 192 references it cites were found in a registry or an index.
Equol: A Bacterial Metabolite from The Daidzein Isoflavone and Its Presumed Beneficial Health Effects
Open accessAbstract
Epidemiological data suggest that regular intake of isoflavones from soy reduces the incidence of estrogen-dependent and aging-associated disorders, such as menopause symptoms in women, osteoporosis, cardiovascular diseases and cancer. Equol, produced from daidzein, is the isoflavone-derived metabolite with the greatest estrogenic and antioxidant activity. Consequently, equol has been endorsed as having many beneficial effects on human health. The conversion of daidzein into equol takes place in the intestine via the action of reductase enzymes belonging to incompletely characterized members of the gut microbiota. While all animal species analyzed so far produce equol, only between one third and one half of human subjects (depending on the community) are able to do so, ostensibly those that harbor equol-producing microbes. Conceivably, these subjects might be the only ones who can fully benefit from soy or isoflavone consumption. This review summarizes current knowledge on the microorganisms involved in, the genetic background to, and the biochemical pathways of, equol biosynthesis. It also outlines the results of recent clinical trials and meta-analyses on the effects of equol on different areas of human health and discusses briefly its presumptive mode of action.
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“A further example is the isoflavone metabolite equol, which has considerable estrogenic properties, but upwards of half of the population lack the microbiota composition to produce it (509).”
From Diet and the Microbiota–Gut–Brain Axis: Sowing the Seeds of Good Mental Health (2021) · cites this paper as [509]
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Diet and the Microbiota–Gut–Brain Axis: Sowing the Seeds of Good Mental Health
Berding, K., Vlckova, K., Marx, W., Schellekens, H., Stanton, C., Clarke, G., Jacka, F., Dinan, T. G., & Cryan, J. F. (2021) · Advances in Nutrition · doi:10.1093/advances/nmaa181 · Cited by 451
Dietary Polyphenol, Gut Microbiota, and Health Benefits
Wang, X., Qi, Y., & Zheng, H. (2022) · Antioxidants · doi:10.3390/antiox11061212 · Cited by 430
Kim, I.-S. (2021) · Antioxidants · doi:10.3390/antiox10071064 · Cited by 337
Prebiotic effect of dietary polyphenols: A systematic review
Alves, A. M., Sugizaki, C. S. D. A., Lima, G. C., & Naves, M. M. V. (2020) · Journal of Functional Foods · doi:10.1016/j.jff.2020.104169 · Cited by 316
Cortés‐Martín, A., Selma, M. V., Tomás-Barberán, F. A., González‐Sarrías, A., & Espín, J. C. (2020) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201900952 · Cited by 317
Metadata
- Authors
- Mayo, B., Vázquez, L., & Flórez, A. B.
- Affiliations
- Consejo Superior de Investigaciones Científicas (ES)
- Corresponding author
- Mayo, Baltasar
- Venue
- Nutrients
- Publisher
- MDPI AG
- Published
- 2019-09-16
- Volume
- 11
- Issue
- 9
- Pages
- 2231
- ISSN
- 2072-6643 (ISSN-L)
- PMC
- PMC6770660
- OpenAlex
- W2972497746
- Cited by
- 416
- References
- 192
- Citations by year
- 2026: 56 · 2025: 55 · 2024: 71 · 2023: 75 · 2022: 74 · 2021: 50 · 2020: 33 · 2019: 1
- FWCI
- 5.88
- Type
- journal article
- Language
- en
- Open access
- gold
- dx.doi.org
- Licence
- Locations
- Nutrients (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DIGITAL.CSIC (Spanish National Research Council (CSIC)) (submittedVersion, cc-by)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Ministerio de Economía, Industria y Competitividad, Gobierno de España (AGL2011-24300-ALI and AGL-2014-57820-R)
- Gobierno del Principado de Asturias (GRUPIN14-137 and IDI/2018/000114)
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Phytoestrogen effects and research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Biochemistry (medical) › Phytochemicals and Antioxidant Activities
- Keywords
- equol, daidzein, isoflavones, soybean, gut microbiota, estrogenic activity, antioxidant activity, menopausal symptoms, osteoporosis, cardiovascular disease, cancer prevention
- MeSH terms
- Gastrointestinal Microbiome, Animals, Bacteria, Diet, Health Status, Humans, Isoflavones, Equol
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